Details of the Drug Combinations

General Information of This Drug (ID: DME4RA8)

• Drug Name: Amodiaquine (DME4RA8)
• Synonyms: Amodiachin; Amodiachinum; Amodiaquin; Amodiaquina; Amodiaquinum; Basoquin; CQA; Camochin; Camoquin; Camoquinal; Camoquine; Flavoquin; Flavoquine; Miaquin; Sunoquine; Amodiaquine hydrochloride; Amodiaquine USP24; SN 10751; AMODIAQUINE, FLAVOQUINE; Amodiaquina [INN-Spanish]; Amodiaquinum [INN-Latin]; CAM-AQ 1; CAM-AQI; Cam-AQ1; Camoquin (TN); Flavoquine (TN); SN 10,751; WR-002977; Amodiaquine (USAN/INN); Amodiaquine [USAN:INN:BAN]; Amodiaquine, ring-closed; S. N. 10751

Indication

Malaria; ICD 11: 1F40-1F45; Status: Approved [1]; Middle East Respiratory Syndrome (MERS); ICD 11: 1D64; Status: Preclinical [2]; Severe acute respiratory syndrome (SARS); ICD 11: 1D65; Status: Preclinical [2]

• Therapeutic Class: Antimalarials
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

56 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acamprosate + Amodiaquine	DCW8K4E	Acamprosate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Aprepitant	DCFGXQ7	Aprepitant	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Mebutamate	DC89NTG	Mebutamate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Acetazolamide	DC6T25W	Acetazolamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Diethylcarbamazine	DCZHWYQ	Diethylcarbamazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Ruxolitinib	DCOZFS1	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[3]
Amodiaquine + Kanamycin	DC04F16	Kanamycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Citalopram	DC1BEO5	Citalopram	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Triamterene	DC4KVWH	Triamterene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Vinblastine	DCPSUT4	Vinblastine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Ezetimibe	DC7K5ET	Ezetimibe	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Testosterone	DCWSY96	Testosterone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Triapine	DCWK62E	Triapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Acitretin	DCKJ24X	Acitretin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Metyrosine	DCMW6HL	Metyrosine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Chlorzoxazone	DC8JB2F	Chlorzoxazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + K-134	DCD4BPK	K-134	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Metformin	DCO024P	Metformin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Docetaxel	DC79OPO	Docetaxel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Phenprocoumon	DCO9ECE	Phenprocoumon	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Pazopanib	DCVQHXB	Pazopanib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + VR-776	DC8XYX9	VR-776	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Tolvaptan	DCNF32L	Tolvaptan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + PF-02545920	DC451LM	PF-02545920	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Diazoxide	DCVF1NA	Diazoxide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Idarubicin	DCZWU04	Idarubicin	Glioblastoma? (Cell Line: T98G)	[3]
Amodiaquine + Imatinib	DCQOEZ7	Imatinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Probenecid	DCDYF4P	Probenecid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Bortezomib	DCC199A	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Maprotiline	DCXCZAW	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Teriflunomide	DCWYLTX	Teriflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Ethambutol	DCC9TCE	Ethambutol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Novobiocin	DCUNON9	Novobiocin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Brincidofovir	DCK9J2H	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Hyodeoxycholic acid	DCV9LUY	Hyodeoxycholic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Mycophenolic acid	DC38EO9	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Lacosamide	DC5A445	Lacosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Doxorubicin	DCFLYC6	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Cerivastatin	DCC6YCZ	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Busulfan	DC1NKOK	Busulfan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Enoxacin	DCVT146	Enoxacin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Albendazole	DCIQW6K	Albendazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bepridil + Amodiaquine	DCLQXHP	Bepridil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cerivastatin + Amodiaquine	DCYJHSI	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Everolimus + Amodiaquine	DCS4SO7	Everolimus	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Fosfomycin + Amodiaquine	DC1SXBX	Fosfomycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Idarubicin + Amodiaquine	DCM6SX8	Idarubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Levamisole + Amodiaquine	DCBXIL7	Levamisole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Metaxalone + Amodiaquine	DCGZJVF	Metaxalone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mycophenolic acid + Amodiaquine	DC2QMAG	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Oxyphenbutazone + Amodiaquine	DCMDMVY	Oxyphenbutazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pepstatin + Amodiaquine	DC7PY05	Pepstatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pinacidil + Amodiaquine	DCJJP17	Pinacidil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PMID28460551-Compound-2 + Amodiaquine	DCZAGC1	PMID28460551-Compound-2	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
SCH 727965 + Amodiaquine	DCHMDHU	SCH 727965	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Vorinostat + Amodiaquine	DCOO77T	Vorinostat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]

1 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Amodiaquine + Artesunate	DCJDKVE	Artesunate	HIV Infections	[4]

References

• [1] Drug information of Amodiaquine, 2008. eduDrugs.
• [2] Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection. Antimicrob Agents Chemother. 2014 Aug;58(8):4885-93.
• [3] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [4] ClinicalTrials.gov (NCT00356824) Relationship Between HIV and Malaria in Ugandan Children