Details of the Drug Combinations

General Information of This Drug (ID: DMHZJCG)

Drug Name
Pentamidine   DMHZJCG
Synonyms
Lomidine; Nebupent; PENTAM; PNT; Pentacarinat; Pentamide; Pentamidin; Pentamidina; Pentamidinum; Pneumopent; PENTAMIDINE ISETHIONATE; Pentamidina [DCIT]; Pentamidine isetionate; Pentamidine mesylate; MB 800; Pentam 300; Lomidine (TN); MB-800; Nebupent (as isethionate); Pentacarinat (as isethionate); Pentam 300 (as isethionate); Pentamidine (INN); Pentamidinum [INN-Latin]; RP-2512; Nebupent (*Isethionate); Pentacarinat (*Isethionate); Pentam 300 (*Isethionate); Pentamidine Isethionate 2-Hydroxy-Ethanesulfonic Acid;Pentamidine [INN:BAN:DCF]; RP 2512 (*Isethionate); P,p'-(Pentamethylenedioxy)bis[benzamidine]; P,p'-(Pentamethylenedioxy)dibenzamidine; P,p'-(Pentamethylene-dioxy)bis-benzamidine; Benzenecarboximidamide, 4,4'-(1,5-pentanediylbis(oxy))bis-(9CI); 1,3-BIS(4-AMIDINOPHENOXY)PENTANE; 4, 4'-Diamidinodiphenoxypentane; 4,4'-(1,5-Pentanediylbis(oxy))bis-benzenecarboximidamide; 4,4'-(Pentamethylenedioxy)dibenzamide; 4,4'-(Pentamethylenedioxy)dibenzamidine; 4,4'-Diamidino-.alpha.,.omega.-diphenoxypentane; 4,4'-Diamidinodiphenoxypentane; 4,4'-[pentane-1,5-diylbis(oxy)]dibenzenecarboximidamide; 4-[5-(4-Carbamimidoylphenoxy)pentoxy]benzenecarboximidamide
Indication
Disease Entry ICD 11 Status REF
African trypanosomiasis 1F51 Approved [1]
Fungal infection 1F29-1F2F Approved [2]
Pneumocystis pneumonia CA40.20 Approved [1]
Human immunodeficiency virus infection 1C62 Withdrawn from market [3]
Therapeutic Class
Antifungal Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

120 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acamprosate + Pentamidine DCYIC5P Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Acetohydroxamic Acid + Pentamidine DCGD42P Acetohydroxamic Acid Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Aciclovir + Pentamidine DCCGJR1 Aciclovir Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Amiloride + Pentamidine DCM07CO Amiloride Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Artemisinin + Pentamidine DC9J3TT Artemisinin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
AS-1949490 + Pentamidine DC4F7TP AS-1949490 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Asenapine + Pentamidine DCRMZPI Asenapine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
BIO-300 + Pentamidine DCJQ7HB BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Brincidofovir + Pentamidine DCIIG5N Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Chlorzoxazone + Pentamidine DCFPDUJ Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Cilostazol + Pentamidine DC5WXXU Cilostazol Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Crotamiton + Pentamidine DCARPU7 Crotamiton Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Darunavir + Pentamidine DC4Y5CN Darunavir Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Dichlorphenamide + Pentamidine DCAHCDJ Dichlorphenamide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Diethylcarbamazine + Pentamidine DCRSX7Z Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Docetaxel + Pentamidine DCCV3C0 Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Epinephrine + Pentamidine DCLDEEY Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Ethambutol + Pentamidine DCVZOR5 Ethambutol Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Fenoprofen + Pentamidine DCGBKSL Fenoprofen Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Flavonoid derivative 1 + Pentamidine DCWFIBM Flavonoid derivative 1 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Fluspirilene + Pentamidine DCCVM3O Fluspirilene Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Fomepizole + Pentamidine DCMS6OI Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Furazolidone + Pentamidine DCRZBC7 Furazolidone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Gefitinib + Pentamidine DC88D6J Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
GYKI-52466 + Pentamidine DCF4IL6 GYKI-52466 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Hyodeoxycholic acid + Pentamidine DCQ763B Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Idarubicin + Pentamidine DC974PF Idarubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
IT-141 + Pentamidine DCJPUKN IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Leflunomide + Pentamidine DCB7E28 Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Levamisole + Pentamidine DC643A2 Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Mebutamate + Pentamidine DCMZX09 Mebutamate Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Mefloquine + Pentamidine DCM3A5M Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Metyrosine + Pentamidine DCA0OOG Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Moricizine + Pentamidine DCYLIKN Moricizine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Mycophenolic acid + Pentamidine DCADHG5 Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Nitisinone + Pentamidine DC6DNMV Nitisinone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Nizatidine + Pentamidine DCL5NL6 Nizatidine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Norcisapride + Pentamidine DCQEZ6C Norcisapride Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Olmesartan medoxomil + Pentamidine DC9NARA Olmesartan medoxomil Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Oseltamivir + Pentamidine DCKBFSZ Oseltamivir Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Palonosetron + Pentamidine DC944QS Palonosetron Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pamidronate + Pentamidine DCOQ3SB Pamidronate Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Paromomycin + Pentamidine DCW5STI Paromomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Sertraline DC4AKT1 Sertraline Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Bepridil DCKF00L Bepridil Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Ruxolitinib DCLGKSK Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [4]
Pentamidine + Lumefantrine DCKF4U3 Lumefantrine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Kanamycin DCQ49R8 Kanamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Epinephrine DCPFDX9 Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + PMID28460551-Compound-2 DCIX375 PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Mephenytoin DCG0GYU Mephenytoin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Pazopanib HCl DCRTRW8 Pazopanib HCl Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Fomepizole DCFN3TU Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Triapine DCCHMSP Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Acitretin DCID040 Acitretin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Everolimus DCPS2GH Everolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Dexmedetomidine DCR8A2Y Dexmedetomidine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + IT-141 DCT9Z9I IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Buspirone DC0F1Q1 Buspirone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Metyrosine DCCRC15 Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Terameprocol DCQ5QN8 Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + SCH 727965 DCMJPJW SCH 727965 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Emetine DC29TSQ Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Docetaxel DC1JP9M Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Cilastatin DCTS2JW Cilastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Pazopanib DCEYXF5 Pazopanib Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + WAY-100635 DCU1BZX WAY-100635 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Naringenin DCTNJ4D Naringenin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Arfolitixorin DCJVZQC Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + PF-02545920 DCRPQKG PF-02545920 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Trifluoperazine DC8SMFS Trifluoperazine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Tiagabine DCTFBT4 Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Diazoxide DCVPH61 Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Allopurinol DCRY3LO Allopurinol Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Methocarbamol DCLL4S1 Methocarbamol Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Imatinib DCMTA4A Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Pramipexole DCAYUOR Pramipexole Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Bortezomib DC4YW0P Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Methylene blue DCKK9NY Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Artemisinin DCCVNUT Artemisinin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Topotecan DCETIPX Topotecan Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Trimethobenzamide DCPQC0I Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Enalaprilat DCT00M6 Enalaprilat Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Maprotiline DCYKEC8 Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Amantadine DCUC0VT Amantadine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Desoxycorticosterone pivalate DCR0FND Desoxycorticosterone pivalate Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Naltrexone DCFK2KD Naltrexone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Maraviroc DC9WUT0 Maraviroc Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Chlormezanone DC1YE6J Chlormezanone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Mycophenolic acid DCCN8PJ Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Cisatracurium DCL9TLH Cisatracurium Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Mefloquine DCVFQAL Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Pizotyline DCH9110 Pizotyline Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Lacosamide DC6A4CR Lacosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Doxorubicin DCCSQL4 Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Zileuton DCPHI5R Zileuton Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Sumatriptan DCSF2PU Sumatriptan Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Olmesartan medoxomil DC4KR16 Olmesartan medoxomil Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Auranofin DCXR1SF Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Vorinostat DC525JH Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Cerivastatin DCYKGLO Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Aciclovir DCHDOYV Aciclovir Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + AS-1949490 DCAGB1B AS-1949490 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Nitrosoglutathione DCLYY4B Nitrosoglutathione Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pentamidine + Cytarabine DCCI60M Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
PF-02545920 + Pentamidine DCBDIVJ PF-02545920 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Phenprocoumon + Pentamidine DCLX0OX Phenprocoumon Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Picoplatin + Pentamidine DCZHTYU Picoplatin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pramipexole + Pentamidine DCQ5FG4 Pramipexole Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pyrazinamide + Pentamidine DC9EFOL Pyrazinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Quinine + Pentamidine DC6CU7A Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Ribavirin-TP + Pentamidine DCAMA4X Ribavirin-TP Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
SCH 727965 + Pentamidine DC8G3IV SCH 727965 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Testolactone + Pentamidine DC4RFDK Testolactone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Tindamax + Pentamidine DCZUYDJ Tindamax Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Triapine + Pentamidine DCFW9O8 Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Triflupromazine + Pentamidine DC03EGW Triflupromazine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Triiodothyronine + Pentamidine DC0ZY6N Triiodothyronine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Tropisetron + Pentamidine DCIVGMO Tropisetron Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Vorinostat + Pentamidine DCRGT27 Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
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⏷ Show the Full List of 120 DrugCom(s)

References

1 Pentamidine FDA Label
2 Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40.
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
4 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
5 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.