Details of the Drug Combinations

General Information of This Drug (ID: DMLPAOB)

• Drug Name: Allopurinol (DMLPAOB)
• Synonyms: Adenock; Ailural; Ailurial; Allohexal; Allohexan; Alloprin; Allopur; Allopurin; Allopurinolum; Allorin; Allozym; Allpargin; Allural; Aloprim; Alopurinol; Aloral; Alositol; Aluline; Anoprolin; Anzief; Apulonga; Apurin; Apurol; Atisuril; Bleminol; Bloxanth; Caplenal; Capurate; Cellidrin; Cosuric; Dabrosin; Dabroson; Embarin; Epidropal; Epuric; Foligan; Geapur; Gichtex; Gotax; Hamarin; Hexanuret; Jenapurinol; Ketanrift; Ledopur; Lopurin; Lysuron; Milurit; Milurite; Miniplanor; Monarch; Nektrohan; Novopurol; Progout; Pureduct; Purinol; Remid; Riball; Rimapurinol; Roucol; Sigapurol; Suspendol; Takanarumin; Tipuric; Urbol; Uribenz; Uricemil; Uridocid; Uriprim; Uripurinol; Uritas; Urobenyl; Urolit; Urosin; Urtias; Xanthomax; Xanturat; Xanturic; Zygout; Zyloprim; Zyloric; Dura Al; Pan Quimica; A 8003; BW 56158; Urtias 100; AL-100; Allo-Puren; Allohexal (TN); Allopurinol(I); Allosig (TN); Apo-Allopurinol; BW 56-158; Ketobun-A; Progout (TN); Puricos (TN); Quimica, Pan; Zyloprim (TN); Zyloric (TN); BW-56-158; B. W. 56-158; 4-HPP

Indication

Gout; ICD 11: FA25; Status: Approved [1]; Hyperuricaemia; ICD 11: 5C55.Y; Status: Approved [2]; Recurrent adult burkitt lymphoma; ICD 11: 2A85.6; Status: Approved [1]

• Therapeutic Class: Antimetabolites
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

83 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole + Allopurinol	DC1YMUJ	1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Abacavir + Allopurinol	DCWXQKO	Abacavir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acitretin + Allopurinol	DC4CU37	Acitretin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Meclofenamic acid	DC8PDK2	Meclofenamic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Sertraline	DCP0QMP	Sertraline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Baclofen	DCTX36I	Baclofen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Bepridil	DCGK0JK	Bepridil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Citalopram	DCYNVCI	Citalopram	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Imipramine	DCCE18N	Imipramine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Furazolidone	DCIQ176	Furazolidone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + PMID28460551-Compound-2	DC4CKYS	PMID28460551-Compound-2	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Panobinostat	DCTFULJ	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
Allopurinol + Methotrexate	DC2WRIM	Methotrexate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Fomepizole	DCJ9LBV	Fomepizole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Pepstatin	DCWTSB2	Pepstatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Rifampin	DCXRQUG	Rifampin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + IT-141	DCZTSOB	IT-141	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + BHV-0223	DCGJVWB	BHV-0223	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Chlorzoxazone	DCYVFGD	Chlorzoxazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + K-134	DC9EFA6	K-134	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Memantine	DCNIKHW	Memantine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + PHA-739358	DCACD9N	PHA-739358	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Diphenidol	DCGJ27T	Diphenidol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Niclosamide	DCWLTC4	Niclosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Eflornithine	DCBQ70I	Eflornithine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Isoproterenol	DCUJA7C	Isoproterenol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Idarubicin	DCF0ELW	Idarubicin	Glioblastoma? (Cell Line: T98G)	[3]
Allopurinol + Imatinib	DC3PI46	Imatinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Darunavir	DCT8POG	Darunavir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Trimethobenzamide	DCXMRT0	Trimethobenzamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Maprotiline	DCUU5QF	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Ethambutol	DCFX8FC	Ethambutol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Novobiocin	DCV6JHY	Novobiocin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Brincidofovir	DC4DLN3	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Amantadine	DCFQT69	Amantadine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Desoxycorticosterone pivalate	DCF6PD8	Desoxycorticosterone pivalate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Mycophenolic acid	DCCD634	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Hydralazine	DC47BD2	Hydralazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Mefloquine	DCYD7VL	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Doxorubicin	DCJIIQX	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Nabilone	DCIRESQ	Nabilone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Estramustine	DCT79HP	Estramustine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + ML323	DCIH9QY	ML323	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Albendazole	DC1COHI	Albendazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Cytarabine	DCHMIAA	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + L-165041	DCV4RUY	L-165041	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Anamorelin + Allopurinol	DC300KB	Anamorelin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Asenapine + Allopurinol	DCGGE07	Asenapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bortezomib + Allopurinol	DCQPI3W	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Brincidofovir + Allopurinol	DC5N21Y	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bumetanide + Allopurinol	DCYFZOM	Bumetanide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Clascoterone + Allopurinol	DC8V8M4	Clascoterone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Clopidogrel + Allopurinol	DCWNHL6	Clopidogrel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dantrolene + Allopurinol	DC6ROCR	Dantrolene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dichlorphenamide + Allopurinol	DCBJQT7	Dichlorphenamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Docetaxel + Allopurinol	DC2GISP	Docetaxel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dopamine + Allopurinol	DCI8WAU	Dopamine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
ETHISTERONE + Allopurinol	DCA0NIK	ETHISTERONE	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
GINKGOLIDE A + Allopurinol	DCXKUX1	GINKGOLIDE A	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ginsenoside Rb1 + Allopurinol	DCU92XV	Ginsenoside Rb1	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Hydroxychloroquine + Allopurinol	DC8B542	Hydroxychloroquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Hyodeoxycholic acid + Allopurinol	DC36KHM	Hyodeoxycholic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ibutilide + Allopurinol	DCQAULI	Ibutilide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Idarubicin + Allopurinol	DC02AK8	Idarubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Leflunomide + Allopurinol	DC3YZJ6	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Loperamide + Allopurinol	DCEI3L1	Loperamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Maprotiline + Allopurinol	DCYKVHH	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Methocarbamol + Allopurinol	DCBN03H	Methocarbamol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Methylergonovine + Allopurinol	DCSMV7S	Methylergonovine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mycophenolic acid + Allopurinol	DCWW075	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Naringenin + Allopurinol	DCGC34R	Naringenin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Nizatidine + Allopurinol	DCVYFQY	Nizatidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pentamidine + Allopurinol	DCRY3LO	Pentamidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Allopurinol	DCY28TJ	PF-02545920	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pinacidil + Allopurinol	DCK5J3U	Pinacidil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pyrazinamide + Allopurinol	DCI14XG	Pyrazinamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Raltegravir + Allopurinol	DCBC3A7	Raltegravir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Rufinamide + Allopurinol	DCM6VWY	Rufinamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sulfinpyrazone + Allopurinol	DCUHWZ9	Sulfinpyrazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolazoline + Allopurinol	DC896YR	Tolazoline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tranexamic acid + Allopurinol	DCIZXCO	Tranexamic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Triapine + Allopurinol	DC8MUW5	Triapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Tropisetron + Allopurinol	DCTIPDK	Tropisetron	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]

15 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Allopurinol + Ramipril	DC59KO3	Ramipril	Diabetes	[5]
Allopurinol + Lesinurad	DCGOBYG	Lesinurad	Gout	[6]
Allopurinol + Candesartan	DCRNXU8	Candesartan	Diabetes	[5]
Allopurinol + Colchicine	DCW593F	Colchicine	Intercritical Gout	[7]
Dobutamine + Allopurinol	DC3BOJN	Dobutamine	Cardiovascular Diseases	[8]
Mycophenolate mofetil + Allopurinol	DCJKVRN	Mycophenolate mofetil	Small-cell Lung Cancer	[9]
Pyrazinamide + Allopurinol	DC2MOZL	Pyrazinamide	Tuberculosis	[10]
RDEA3170 + Allopurinol	DCBEYYR	RDEA3170	Chronic Kidney Disease	[11]
RDEA3170 + Allopurinol	DCDFC4I	RDEA3170	Chronic Kidney Disease	[12]
Allopurinol + M102	DC3S2QP	M102	Gout	[13]
Allopurinol + Colchicine	DCVDTLX	Colchicine	Gout	[14]
RDEA3170 + Allopurinol	DC7T2GK	RDEA3170	Chronic Kidney Disease	[15]
Allopurinol + Colchicine	DCKTT31	Colchicine	Gout	[16]
Febuxostat + Allopurinol	DCNHQKA	Febuxostat	Adenine Phosphoribosyltransferase Deficiency	[17]
Omeprazole + Allopurinol	DCYSVR0	Omeprazole	Gout	[18]

References

• [1] Allopurinol FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6795).
• [3] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [4] Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
• [5] ClinicalTrials.gov (NCT01052272) Impact of Diabetes on Left Ventricular Remodeling
• [6] ClinicalTrials.gov (NCT01510158) Combining Lesinurad With Allopurinol in Inadequate Responders
• [7] ClinicalTrials.gov (NCT01451645) Efficacy and Safety of Colchicine for the Prevention of Gout Flares During the Initiation of Allopurinol
• [8] ClinicalTrials.gov (NCT00281255) Intravenous Allopurinol to Improve Heart Function in Individuals With Dilated Cardiomyopathy
• [9] ClinicalTrials.gov (NCT05049863) Chemotherapy in Patients With Relapsed Small Cell Lung Cancer in Combination With Allopurinol and MycoPhenolate (CLAMP Trial)
• [10] ClinicalTrials.gov (NCT02700347) Whole Blood Bactericidal Activity Against Mycobacterium Tuberculosis of Pyrazinamide Plus Allopurinol in Healthy Volunteers
• [11] ClinicalTrials.gov (NCT04532918) Pharmacokinetics of Verinurad and Allopurinol in Combination With Cyclosporine and Rifampicin in Healthy Volunteers
• [12] ClinicalTrials.gov (NCT03836599) A Study to Assess the Safety and Pharmacokinetics of Verinurad and Allopurinol in Asian and Chinese Subjects
• [13] ClinicalTrials.gov (NCT01399008) Safety/Efficacy Study to Evaluate of MBX-102 in Combination With Allopurinol in Gout Patients
• [14] ClinicalTrials.gov (NCT02063997) Evaluate the Efficacy and Safety of Arhalofenate for Preventing Flares and Reducing Serum Uric Acid in Gout Patients
• [15] ClinicalTrials.gov (NCT03990363) A Study of Verinurad and Allopurinol in Patients With Chronic Kidney Disease and Hyperuricaemia
• [16] ClinicalTrials.gov (NCT04875702) Treat-to-Target Serum Urate Versus Treat-to-Avoid Symptoms in Gout
• [17] ClinicalTrials.gov (NCT02752633) Effect of Allopurinol and Febuxostat on Urinary 2,8-Dihydroxyadenine Excretion
• [18] ClinicalTrials.gov (NCT02500641) Intensive Urate Lowering Therapy of Febuxostat Compared to Allopurinol on Cardiovascular Risk in Patients With Gout