Details of the Drug Combinations

General Information of This Drug (ID: DMMN36E)

Drug Name
Abacavir   DMMN36E
Synonyms
Trizivir; Ziagen; Abacavir [INN]; Abacavir (INN); Ziagen (TN); Ziagen (TM)(*Succinate salt*); [(1S,4R)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-en-1-yl]methanol; {(1S-cis)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol; (+/-)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; (+/-)-Abacavir; (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; ABC
Indication
Disease Entry ICD 11 Status REF
Human immunodeficiency virus infection 1C62 Approved [1]
Therapeutic Class
Anti-HIV Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

53 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Abacavir + Gefitinib DCX75IS Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Abacavir + Dantrolene DCZ3BX6 Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Abacavir + Diethylcarbamazine DCOKAGA Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Abacavir + Epinephrine DC0DD03 Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Abacavir + Dihydroergotamine DCLVXJA Dihydroergotamine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Abacavir + Triapine DC9705Q Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Abacavir + Buspirone DCLB91U Buspirone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Abacavir + Metyrosine DCMOZP4 Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Abacavir + Flavonoid derivative 1 DCHPV19 Flavonoid derivative 1 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Abacavir + Doxapram DCIVGW5 Doxapram Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Abacavir + Memantine DC2N13Y Memantine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Abacavir + Armodafinil DCDH2UO Armodafinil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Abacavir + Triflupromazine DC22MR0 Triflupromazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Abacavir + BIO-300 DCC7NC0 BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Abacavir + Allopurinol DCWXQKO Allopurinol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Abacavir + Bortezomib DC8AA45 Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Abacavir + Methylene blue DC4ZMZZ Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Abacavir + Tropisetron DCHFRA7 Tropisetron Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Abacavir + Ethinyl estradiol DCZ0AXB Ethinyl estradiol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Abacavir + Mesalazine DCSO1C5 Mesalazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Abacavir + Brincidofovir DCPO93E Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Abacavir + Chloroquine DCFQC96 Chloroquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Abacavir + Mycophenolic acid DCRDOYW Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Abacavir + Auranofin DCQRZ23 Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Abacavir + Vorinostat DCM49F1 Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Abacavir + Cerivastatin DCKSS9F Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Abacavir + Acetohydroxamic Acid DCFK0D8 Acetohydroxamic Acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Abacavir + Cytarabine DC4WM1J Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Artemisinin + Abacavir DCJIUXI Artemisinin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Brincidofovir + Abacavir DCJV5AS Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Chlorzoxazone + Abacavir DC4RD3E Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cisatracurium + Abacavir DCQAMHW Cisatracurium Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Dactinomycin + Abacavir DCUAKNQ Dactinomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Desoxycorticosterone pivalate + Abacavir DCHCPFZ Desoxycorticosterone pivalate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Diazoxide + Abacavir DCCLUNB Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Doxorubicin + Abacavir DCNX52S Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Enalaprilat + Abacavir DCIEP1W Enalaprilat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Abacavir DCRIFBN Entacapone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fosfomycin + Abacavir DCH2524 Fosfomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GINKGOLIDE A + Abacavir DC8BHGK GINKGOLIDE A Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Hyodeoxycholic acid + Abacavir DC0XE4W Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Imatinib + Abacavir DC7F50U Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lacosamide + Abacavir DCCJLC5 Lacosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Leflunomide + Abacavir DC19LW0 Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mycophenolic acid + Abacavir DCKY8FB Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Norcisapride + Abacavir DCON96V Norcisapride Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PF-02545920 + Abacavir DCDQZH1 PF-02545920 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Picoplatin + Abacavir DCN1DBM Picoplatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pyrazinamide + Abacavir DCPRX90 Pyrazinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Raltegravir + Abacavir DCUNDG5 Raltegravir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tamoxifen + Abacavir DCAL6TJ Tamoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trimethobenzamide + Abacavir DCID6XX Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Vinblastine + Abacavir DCC64U4 Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 53 DrugCom(s)
2 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Abacavir + Raltegravir DCVCU7P Raltegravir HIV [4]
Didanosine + Abacavir DCTJVRB Didanosine HIV Infections [5]
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References

1 Abacavir (marketed as Ziagen) and Abacavir-containing Medications. FDA. 2008.
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
4 ClinicalTrials.gov (NCT00765271) Abacavir Pharmacokinetic Study in the Absence/Presence of Darunavir/Ritonavir or Raltegravir in HIV-infected Subjects
5 ClinicalTrials.gov (NCT00338390) Study to Evaluate Changes in CD4 on Replacing TDF With ABC or DDI+TDF With ABC+3TC