Details of the Drug Combinations

General Information of This Drug (ID: DMS49KH)

• Drug Name: Valproic Acid (DMS49KH)
• Synonyms: VALPROIC ACID; 2-Propylpentanoic acid; 2-Propylvaleric acid; Dipropylacetic acid; Depakine; Depakene; Valproate; Ergenyl; Di-n-propylacetic acid; Mylproin

Indication

Absence epilepsy; ICD 11: N.A.; Status: Approved [1]; Epilepsy; ICD 11: 8A60-8A68; Status: Approved [1]; Glioblastoma; ICD 11: 2A00; Status: Approved [1]; Coronavirus Disease 2019 (COVID-19); ICD 11: 1D6Y; Status: Investigative [2]; Neuroblastoma; ICD 11: 2D11.2; Status: Investigative [1]

• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

52 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acamprosate + Valproic Acid	DCVN4PG	Acamprosate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Aliskiren + Valproic Acid	DC9JTX4	Aliskiren	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
BIO-300 + Valproic Acid	DC53K6M	BIO-300	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Brincidofovir + Valproic Acid	DCSGI1I	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Chlorzoxazone + Valproic Acid	DCPW086	Chlorzoxazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Doxorubicin + Valproic Acid	DCX57WN	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Leflunomide + Valproic Acid	DCW3E8J	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Levamisole + Valproic Acid	DCBE9V6	Levamisole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mephenytoin + Valproic Acid	DCHVNSH	Mephenytoin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Metaxalone + Valproic Acid	DCOZDA9	Metaxalone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Metyrosine + Valproic Acid	DCE5ZST	Metyrosine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mycophenolic acid + Valproic Acid	DCJPE5K	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Valproic Acid	DCQSC20	Niclosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Valproic Acid	DC99OXR	PF-02545920	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ramelteon + Valproic Acid	DCPOHEN	Ramelteon	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Testosterone cypionate + Valproic Acid	DCZAN59	Testosterone cypionate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Theophylline + Valproic Acid	DCACQKZ	Theophylline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Trioxsalen + Valproic Acid	DCVJBT7	Trioxsalen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Ribavirin-TP	DCTMJSQ	Ribavirin-TP	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Gefitinib	DCR6LZD	Gefitinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Dantrolene	DCCUNNB	Dantrolene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Epinephrine	DCR0G1E	Epinephrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Furazolidone	DCKL5XJ	Furazolidone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + PMID28460551-Compound-2	DC1X6M7	PMID28460551-Compound-2	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Vinblastine	DCH1PWT	Vinblastine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Fomepizole	DCQCBKT	Fomepizole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Triapine	DCYCUR3	Triapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Terameprocol	DCUXI9L	Terameprocol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Guanfacine	DC8PZKM	Guanfacine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Ursodeoxycholic acid	DCC0TWQ	Ursodeoxycholic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Pazopanib	DCZV2GR	Pazopanib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Fluspirilene	DCVQVSF	Fluspirilene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Nizatidine	DCEJCHF	Nizatidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Tolazoline	DCARNK0	Tolazoline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Arfolitixorin	DC4WE4C	Arfolitixorin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Idarubicin	DC4U3YB	Idarubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Imatinib	DCYL1IK	Imatinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Bortezomib	DC1CSSX	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Methylene blue	DCIXW02	Methylene blue	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Artemisinin	DCB2124	Artemisinin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Cefmenoxime	DCLUHB4	Cefmenoxime	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Maprotiline	DCBC549	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Ethambutol	DCJBYYO	Ethambutol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Amiloride	DCRFALG	Amiloride	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Hyodeoxycholic acid	DC6L8XX	Hyodeoxycholic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Quinine	DC7HICM	Quinine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Cisatracurium	DC5HP8K	Cisatracurium	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Zileuton	DC0LCYC	Zileuton	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Auranofin	DCGD3CK	Auranofin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Vorinostat	DCG4F3O	Vorinostat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Cerivastatin	DCFA8TL	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zaleplon + Valproic Acid	DCIILCW	Zaleplon	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]

22 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Carboplatin + Valproic Acid	DCTA74T	Carboplatin	Solid Tumors	[4]
Decitabine + Valproic Acid	DC7CA1A	Decitabine	Leukemia	[5]
Decitabine + Valproic Acid	DCEYDE2	Decitabine	Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities	[6]
Enfuvirtide + Valproic Acid	DCB6WEX	Enfuvirtide	HIV Infections	[7]
HKI-272 + Valproic Acid	DC35CCS	HKI-272	Solid Tumor, Adult	[8]
Karenitecin + Valproic Acid	DC6L3OW	Karenitecin	Malignant Melanoma	[9]
Lapatinib + Valproic Acid	DCGINTW	Lapatinib	Solid Tumors	[10]
Lenalidomide + Valproic Acid	DCYP3D5	Lenalidomide	Solid Tumors	[10]
Liothyronine + Valproic Acid	DC2HOCZ	Liothyronine	Thyroid Neoplasm	[11]
Lithium Carbonate + Valproic Acid	DCMYYA0	Lithium Carbonate	Bipolar Disorder	[12]
Olanzapine + Valproic Acid	DC1ZXZ6	Olanzapine	Bipolar I Disorder	[13]
Pyrimethamine + Valproic Acid	DCBBK0X	Pyrimethamine	HIV-1-infection	[14]
Temozolomide + Valproic Acid	DCLD8OY	Temozolomide	High Grade Gliomas	[15]
Temsirolimus + Valproic Acid	DCBALU3	Temsirolimus	Brain and Central Nervous System Tumors	[16]
Valproic Acid + Azacitidine	DCJU0V3	Azacitidine	Acute Myelogenous Leukemia	[17]
Valproic Acid + Dasatinib	DCQR8UB	Dasatinib	Solid Tumors	[10]
Valproic Acid + Capecitabine	DCRRO6O	Capecitabine	Colorectal Cancer	[18]
Zidovudine + Valproic Acid	DCDLUVT	Zidovudine	Lymphoma	[19]
Dihydroergotamine + Valproic Acid	DC5I0RU	Dihydroergotamine	Migraine in Children	[20]
Gabapentin + Valproic Acid	DC69F6S	Gabapentin	Alcohol Withdrawal Syndrome	[21]
Haloperidol + Valproic Acid	DCEM9L5	Haloperidol	Hyperactive Delirium	[22]
Phenytoin + Valproic Acid	DCABJX7	Phenytoin	Drug Resistant Epilepsy	[23]

References

• [1] Valproic Acid FDA Label
• [2] Immunopharmacological management of COVID-19: Potential therapeutic role of valproic acid. Med Hypotheses. 2020 May 27;143:109891.
• [3] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [4] ClinicalTrials.gov (NCT00529022) Azacitidine and Valproic Acid Plus Carboplatin in Patients With Ovarian Cancer
• [5] ClinicalTrials.gov (NCT00075010) Phase I/II Study of Decitabine and Valproic Acid in Relapsed/Refractory Leukemia or Myelodysplastic Syndromes
• [6] ClinicalTrials.gov (NCT00079378) Decitabine and Valproic Acid in Treating Patients With Refractory or Relapsed Acute Myeloid Leukemia or Previously Treated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
• [7] ClinicalTrials.gov (NCT00312546) Study of Valproic Acid to Treat HIV Infected Adults
• [8] ClinicalTrials.gov (NCT03919292) Neratinib + Valproate in Advanced Solid Tumors, w/Expansion Cohort in Ras-Mutated Ca
• [9] ClinicalTrials.gov (NCT00358319) Phase I/II Trial of Valproic Acid and Karenitecin for Melanoma
• [10] ClinicalTrials.gov (NCT00495872) Valproic Acid-Based 2-Agent Oral Regimens for Patients With Advanced Solid Tumor
• [11] ClinicalTrials.gov (NCT01182285) A Phase II Trial of Valproic Acid in Patients With Advanced Thyroid Cancers of Follicular Cell Origin
• [12] ClinicalTrials.gov (NCT00221975) Combination Therapy in Dual Diagnosis Bipolar Rapid Cycling
• [13] ClinicalTrials.gov (NCT00402324) A Comparison of Olanzapine in Combination With a Mood Stabilizer vs Mood Stabilizer Alone, in Mixed Bipolar Patients
• [14] ClinicalTrials.gov (NCT03525730) LRAs United as a Novel Anti-HIV Strategy.
• [15] ClinicalTrials.gov (NCT00302159) Valproic Acid With Temozolomide and Radiation Therapy to Treat Brain Tumors
• [16] ClinicalTrials.gov (NCT01204450) Temsirolimus and Valproic Acid in Treating Young Patients With Relapsed Neuroblastoma, Bone Sarcoma, or Soft Tissue Sarcoma
• [17] ClinicalTrials.gov (NCT00382590) Azacytidine With Valproic Acid Versus Ara-C in Acute Myeloid Leukemia (AML)/ Myelodysplastic Syndrome (MDS) Patients
• [18] ClinicalTrials.gov (NCT01898104) Preoperative Valproic Acid and Radiation Therapy for Rectal Cancer
• [19] ClinicalTrials.gov (NCT00854581) Zidovudine, Interferon Alfa-2b, PEG-Interferon Alfa-2b in Patients With HTLV-I Associated Adult T-Cell Leukemia/Lymphoma
• [20] ClinicalTrials.gov (NCT03885154) Valproic Acid and Dihydroergotamine as Abortive Therapy in Pediatric Migraine
• [21] ClinicalTrials.gov (NCT03012815) Gabapentin for Alcohol Withdrawal Syndrome
• [22] ClinicalTrials.gov (NCT02343575) Valproic Acid for Treatment of Hyperactive or Mixed Delirium in ICU
• [23] ClinicalTrials.gov (NCT05697614) The Benefit and Safety of Older Generation Anti-Epileptic Drugs (AEDs) in Drug-Resistant Epilepsy Children