Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM4R6UV)

Drug Name
BRADYKININ Drug Info
Synonyms
BRADYKININ; Kallidin I; 58-82-2; L-Bradykinin; Synthetic bradykinin; Bradykinin (synthetic); Callidin I; UNII-S8TIM42R2W; Kallidin 9; BRS 640; PRS 640; S8TIM42R2W; CHEBI:3165; CHEMBL406291; Bradykinin, Lysyl; BK; Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg; EINECS 200-398-8; L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-L-arginine
Cross-matching ID
PubChem CID
439201
ChEBI ID
CHEBI:3165
CAS Number
CAS 58-82-2
TTD Drug ID
DM4R6UV
INTEDE Drug ID
DR1812

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
B2 bradykinin receptor (BDKRB2) TTGY8IW BKRB2_HUMAN Inhibitor [1]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID Highest Status REF
Cathepsin K (CTSK) DEG3S8C CATK_HUMAN Phase 1 [2]
Angiotensin-converting enzyme 2 (ACE2) DEGPI81 ACE2_HUMAN Phase 1 [3]
Arginine carboxypeptidase (CPN1) DEPWYLT CBPN_HUMAN Phase 1 [4]
Soluble aminopeptidase P (sAmp) DE8E6X9 XPP1_HUMAN Phase 1 [5]
Carboxypeptidase M (CPM) DE1TNRG CBPM_HUMAN Phase 1 [6]
Cathepsin H (CTSH) DEHEZPI CATH_HUMAN Phase 1 [7]
Dipeptidyl peptidase II (DPP7) DEIORCK DPP2_HUMAN Phase 1 [8]
PABA peptide hydrolase (MEP1B) DEKBXUC MEP1B_HUMAN Phase 1 [9]
Prolyl endopeptidase (PREP) DEVSCNZ PPCE_HUMAN Phase 1 [10]
Thimet oligopeptidase (THOP1) DE95LJC THOP1_HUMAN Phase 1 [11]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
B2 bradykinin receptor (BDKRB2) DTT BDKRB2 2.433 6.359 6.755 6.664
Prolyl endopeptidase (PREP) DME PREP 5.999 7.193 6.399 6.606
Arginine carboxypeptidase (CPN1) DME CPN1 8.682 5.209 6.202 6.223
PABA peptide hydrolase (MEP1B) DME MEP1B 5.536 5.343 3.991 10.027
Cathepsin H (CTSH) DME CTSH 7.564 8.144 10.877 9.309
Angiotensin-converting enzyme 2 (ACE2) DME ACE2 5.213 5.722 6.793 9.692
Cathepsin K (CTSK) DME CTSK 7.502 8.157 6.955 8.046
Thimet oligopeptidase (THOP1) DME THOP1 6.567 5.892 4.954 6.109
Soluble aminopeptidase P (sAmp) DME XPNPEP1 6.715 7.264 7.191 8.059
Carboxypeptidase M (CPM) DME CPM 5.18 6.408 6.818 3.935
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
B2 bradykinin receptor (BDKRB2) DTT BDKRB2 6.64E-04 -0.24 -0.54
Prolyl endopeptidase (PREP) DME PREP 2.85E-01 -8.06E-02 -1.15E-01
Arginine carboxypeptidase (CPN1) DME CPN1 6.02E-16 -1.48E-01 -4.63E-01
PABA peptide hydrolase (MEP1B) DME MEP1B 5.94E-07 -1.76E-01 -4.20E-01
Dipeptidyl peptidase II (DPP7) DME DPP7 2.50E-59 4.02E-01 1.17E+00
Cathepsin H (CTSH) DME CTSH 5.92E-01 -8.46E-02 -1.10E-01
Angiotensin-converting enzyme 2 (ACE2) DME ACE2 6.32E-01 6.30E-03 2.97E-02
Cathepsin K (CTSK) DME CTSK 3.42E-104 1.01E+00 1.64E+00
Thimet oligopeptidase (THOP1) DME THOP1 2.83E-06 -1.78E-01 -4.15E-01
Soluble aminopeptidase P (sAmp) DME XPNPEP1 6.11E-02 -8.81E-02 -1.40E-01
Carboxypeptidase M (CPM) DME CPM 6.33E-05 1.36E-01 2.10E-01
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Synthesis and biological evaluation of bradykinin B(1)/B(2) and selective B(1) receptor antagonists. J Med Chem. 2000 Jun 15;43(12):2382-6.
2 A cysteine-type carboxypeptidase, cathepsin X, generates peptide receptor agonists. Int Immunopharmacol. 2010 Jan;10(1):134-9.
3 Nunn's Applied Respiratory Physiology (Eighth Edition). Chapter 11 - Nonrespiratory Functions of the Lung.2017, Pages 203-214.e2
4 Regulation of chemerin bioactivity by plasma carboxypeptidase N, carboxypeptidase B (activated thrombin-activable fibrinolysis inhibitor), and platelets. J Biol Chem. 2009 Jan 9;284(2):751-8.
5 Cloning, expression, and characterization of human cytosolic aminopeptidase P: a single manganese(II)-dependent enzyme. Biochemistry. 2000 Dec 12;39(49):15121-8.
6 Interactions between carboxypeptidase M and kinin B1 receptor in endothelial cells. Inflamm Res. 2019 Oct;68(10):845-855.
7 Human brain cathepsin H as a neuropeptide and bradykinin metabolizing enzyme. Peptides. 2003 Dec;24(12):1977-84.
8 Purification of two dipeptidyl aminopeptidases II from rat brain and their action on proline-containing neuropeptides. J Neurochem. 1989 Apr;52(4):1284-93.
9 Human and mouse homo-oligomeric meprin A metalloendopeptidase: substrate and inhibitor specificities. Biol Chem. 2007 Nov;388(11):1163-72.
10 Bradykinin release and inactivation in brain of rats submitted to an experimental model of Alzheimer's disease. Peptides. 2006 Dec;27(12):3363-9.
11 Expression and activity of thimet oligopeptidase (TOP) are modified in the hippocampus of subjects with temporal lobe epilepsy (TLE). Epilepsia. 2014 May;55(5):754-62.