Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM672AH)

Drug Name
Aspirin Drug Info
Synonyms
ACETYLSALICYLIC ACID; 50-78-2; 2-Acetoxybenzoic acid; o-Acetoxybenzoic acid; O-Acetylsalicylic acid; Polopiryna; Acylpyrin; Ecotrin; Easprin; Acetylsalicylate; Acetophen; Acenterine; Acetosal; Colfarit; Salicylic acid acetate; o-Carboxyphenyl acetate; Enterosarein; Aspergum; Salcetogen; Pharmacin; Acetosalin; Premaspin; Micristin; Benaspir; Aspirdrops; Acetonyl; Aceticyl; Temperal; Acetylin; Empirin; Ecolen; Rhodine; Endydol; Saletin; Rheumintabletten; Solprin acid; Acidum acetylsalicylicum; Globentyl; Pravigard
Indication
Disease Entry ICD 11 Status REF
Myocardial infarction BA41-BA43 Approved [1]
Pain MG30-MG3Z Approved [2] , [1]
Cardiovascular disease BA00-BE2Z Phase 3 [2] , [3] , [4]
Therapeutic Class
Analgesics
Cross-matching ID
PubChem CID
2244
ChEBI ID
CHEBI:15365
CAS Number
CAS 50-78-2
TTD Drug ID
DM672AH
VARIDT Drug ID
DR00203
INTEDE Drug ID
DR1749
ACDINA Drug ID
D00046

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
HMG-CoA reductase (HMGCR) TTPADOQ HMDH_HUMAN Inhibitor [1]
Prostaglandin G/H synthase (COX) TTK0943 PGH1_HUMAN; PGH2_HUMAN Inhibitor [5] , [1]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID Highest Status REF
Probable small intestine urate exporter (SLC17A4) DTHE530 S17A4_HUMAN Approved [6]
Sodium-dependent phosphate transport protein 1 (SLC17A1) DT8ARWJ NPT1_HUMAN Approved [7]
Organic anion transporter 2 (SLC22A7) DT0OC1Q S22A7_HUMAN Approved [8]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Approved [9]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID Highest Status REF
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Approved [10]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Approved [11]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Approved [12]
Sulfotransferase 1A1 (SULT1A1) DEYWLRK ST1A1_HUMAN Approved [13]
UDP-glucuronosyltransferase 1A6 (UGT1A6) DESD26P UD16_HUMAN Approved [10]
N-acetyltransferase 2 (NAT2) DER7TA0 ARY2_HUMAN Approved [10]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
HMG-CoA reductase (HMGCR) DTT HMGCR 6.357 6.256 5.17 6.85
P-glycoprotein 1 (ABCB1) DTP P-GP 7.009 6.988 7.442 8.135
Probable small intestine urate exporter (SLC17A4) DTP SLC17A4 6.717 7.107 6.747 7.338
Sodium-dependent phosphate transport protein 1 (SLC17A1) DTP NPT1 6.713 6.158 8.709 6.635
Organic anion transporter 2 (SLC22A7) DTP OAT2 6.588 1.202 4.42 4.07
Sulfotransferase 1A1 (SULT1A1) DME SULT1A1 9.814 9.348 7.196 10.468
N-acetyltransferase 2 (NAT2) DME NAT2 8.344 7.451 3.154 8.135
Mephenytoin 4-hydroxylase (CYP2C19) DME CYP2C19 7.867 5.142 5.52 7.08
Cytochrome P450 2C9 (CYP2C9) DME CYP2C9 11.76 5.931 6.164 9.423
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Myocardial infarction
ICD Disease Classification BA41-BA43
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
HMG-CoA reductase (HMGCR) DTT HMGCR 1.01E-05 0.65 1.53
P-glycoprotein 1 (ABCB1) DTP P-GP 3.29E-14 -7.08E-01 -1.99E+00
Probable small intestine urate exporter (SLC17A4) DTP SLC17A4 1.00E-02 -1.74E-01 -8.13E-01
Sodium-dependent phosphate transport protein 1 (SLC17A1) DTP NPT1 3.04E-01 -5.95E-02 -5.29E-01
Organic anion transporter 2 (SLC22A7) DTP OAT2 8.78E-06 -2.19E-01 -6.62E-01
Sulfotransferase 1A1 (SULT1A1) DME SULT1A1 1.61E-12 1.01E+00 1.51E+00
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME UGT1A1 2.00E-01 5.79E-02 3.00E-01
N-acetyltransferase 2 (NAT2) DME NAT2 3.49E-01 -8.28E-02 -3.71E-01
Mephenytoin 4-hydroxylase (CYP2C19) DME CYP2C19 4.03E-02 -1.19E-01 -5.11E-01
Cytochrome P450 2C9 (CYP2C9) DME CYP2C9 2.63E-03 -1.18E-01 -3.80E-01
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Emerging drugs in peripheral arterial disease. Expert Opin Emerg Drugs. 2006 Mar;11(1):75-90.
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4139).
3 The mechanism of action of aspirin. Thromb Res. 2003 Jun 15;110(5-6):255-8.
4 Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol. 1971 Jun 23;231(25):232-5.
5 Cyclooxygenase inhibitors: instrumental drugs to understand cardiovascular homeostasis and arterial thrombosis. Cardiovasc Hematol Disord Drug Targets. 2008 Dec;8(4):268-77.
6 A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter. Am J Physiol Cell Physiol. 2012 Jun 1;302(11):C1652-60.
7 Type 1 sodium-dependent phosphate transporter (SLC17A1 Protein) is a Cl(-)-dependent urate exporter. J Biol Chem. 2010 Aug 20;285(34):26107-13.
8 Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett. 1998 Jun 12;429(2):179-82.
9 Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22.
10 Polymorphisms of Aspirin-Metabolizing Enzymes CYP2C9, NAT2 and UGT1A6 in Aspirin-Intolerant Urticaria. Allergy Asthma Immunol Res. 2011 Oct;3(4):273-6.
11 Pharmacogenomics in aspirin intolerance. Curr Drug Metab. 2009 Nov;10(9):998-1008.
12 Isozyme-specific induction of low-dose aspirin on cytochrome P450 in healthy subjects. Clin Pharmacol Ther. 2003 Mar;73(3):264-71.
13 Inhibition of human phenol and estrogen sulfotransferase by certain non-steroidal anti-inflammatory agents. Curr Drug Metab. 2006 Oct;7(7):745-53.