Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMUOQZD)

Drug Name

Arachidonic acid Drug Info

Synonyms

arachidonic acid; 506-32-1; arachidonate; (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid; Immunocytophyte; (all-Z)-5,8,11,14-Eicosatetraenoic acid; cis-5,8,11,14-Eicosatetraenoic acid; 5,8,11,14-Eicosatetraenoic acid, (all-Z)-; 5Z,8Z,11Z,14Z-eicosatetraenoic acid; UNII-27YG812J1I; all-cis-5,8,11,14-eicosatetraenoic acid; Arachidonic Acid, 99%; CHEMBL15594; CHEBI:15843; YZXBAPSDXZZRGB-DOFZRALJSA-N; 27YG812J1I; cis,cis,cis,cis-5,8,11,14-Eicosatetraenoic acid; (5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenoic Acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 444899
ChEBI ID: CHEBI:15843
CAS Number: CAS 506-32-1
TTD Drug ID: DMUOQZD
INTEDE Drug ID: DR0129

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostaglandin G/H synthase 1 (COX-1)	TT8NGED	PGH1_HUMAN	Inhibitor	[2]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	Highest Status	REF
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Investigative	[3]
Prostaglandin G/H synthase 2 (COX-2)	DE492CE	PGH2_HUMAN	Investigative	[4]
Prostaglandin G/H synthase 1 (COX-1)	DE073H6	PGH1_HUMAN	Investigative	[5]
Arachidonate 5-lipoxygenase (ALOX5)	DE87OZS	LOX5_HUMAN	Investigative	[6]
Arachidonate 12-lipoxygenase (ALOX12B)	DEISPU8	LX12B_HUMAN	Investigative	[7]
Arachidonate 15-lipoxygenase (ALOX15)	DEH0J8X	LOX15_HUMAN	Investigative	[8]
Cytochrome P450 4F2 (CYP4F2)	DE3GT9C	CP4F2_HUMAN	Investigative	[9]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Prostaglandin G/H synthase 1 (COX-1)	DTT	PTGS1	6.09	7.747	6.04	7.023
Arachidonate 12-lipoxygenase (ALOX12B)	DME	ALOX12B	2.744	1.536	2.138	2.07
Arachidonate 15-lipoxygenase (ALOX15)	DME	ALOX15	1.888	2.104	1.963	2.585
Arachidonate 5-lipoxygenase (ALOX5)	DME	ALOX5	4.966	5.133	5.358	6.128
Cytochrome P450 2C9 (CYP2C9)	DME	CYP2C9	11.76	5.931	6.164	9.423
Prostaglandin G/H synthase 2 (COX-2)	DME	PTGS2	4.406	5.3	0.379	5.125
Cytochrome P450 4F2 (CYP4F2)	DME	CYP4F2	9.269	3.446	3.655	8.828
Prostaglandin G/H synthase 1 (COX-1)	DME	PTGS1	6.09	7.747	6.04	7.023

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Prostaglandin G/H synthase 1 (COX-1)	DTT	PTGS1	3.97E-03	0.16	0.43
Arachidonate 12-lipoxygenase (ALOX12B)	DME	ALOX12B	4.29E-05	-1.81E-01	-5.25E-01
Arachidonate 15-lipoxygenase (ALOX15)	DME	ALOX15	4.61E-01	-2.18E-02	-1.44E-01
Arachidonate 5-lipoxygenase (ALOX5)	DME	ALOX5	5.43E-08	4.11E-01	8.14E-01
Cytochrome P450 2C9 (CYP2C9)	DME	CYP2C9	1.90E-01	-9.81E-03	-5.96E-02
Prostaglandin G/H synthase 2 (COX-2)	DME	PTGS2	7.93E-04	-2.88E-01	-3.44E-01
Cytochrome P450 4F2 (CYP4F2)	DME	CYP4F2	2.43E-02	2.94E-02	1.61E-01
Prostaglandin G/H synthase 1 (COX-1)	DME	PTGS1	3.97E-03	1.56E-01	4.33E-01

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2391).
2	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3	New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part I. Curr Drug Metab. 2009 Dec;10(10):1075-126.
4	PharmGKB summary: very important pharmacogene information for PTGS2. Pharmacogenet Genomics. 2011 Sep;21(9):607-13.
5	Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1). Pharmacogenet Genomics. 2007 Feb;17(2):145-60.
6	A rat air pouch model for evaluating the efficacy and selectivity of 5-lipoxygenase inhibitors. Eur J Pharmacol. 2008 Apr 14;584(1):166-74.
7	Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers. Nat Commun. 2018 Sep 26;9(1):3931.
8	Effect of human 15-lipoxygenase-1 metabolites on vascular function in mouse mesenteric arteries and hearts. Prostaglandins Other Lipid Mediat. 2013 Oct;106:8-15.
9	Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids. Biochim Biophys Acta. 2011 Jan;1814(1):210-22.