Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE073H6)

DME Name	Prostaglandin G/H synthase 1 (COX-1)
Synonyms	Prostaglandin H2 synthase 1; Prostaglandin-endoperoxide synthase 1; Cyclooxygenase-1; PGH synthase 1; COX-1; COX1; PGHS-1; PHS 1; PTGS1
Gene Name	PTGS1
UniProt ID	PGH1_HUMAN
INTEDE ID	DME0091
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Gene ID	5742
EC Number	EC: 1.14.99.1 Oxidoreductase Oxygen paired donor oxidoreductase Oxygen paired donor oxidoreductase EC: 1.14.99.1
Lineage	Species: Homo sapiens Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Sequence	MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTR TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL
Function	This enzyme converts arachidonate to prostaglandin H2 (PGH2).
KEGG Pathway	Arachidonic acid metabolism (hsa00590 ) Metabolic pathways (hsa01100 ) Platelet activation (hsa04611 ) Regulation of lipolysis in adipocytes (hsa04923 ) Serotonergic synapse (hsa04726 )
Reactome Pathway	Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (R-HSA-2162123 ) COX reactions (R-HSA-140180 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This DME

30 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Candesartan	DMRK8OT	Hypertension	BA00-BA04	Approved	[71]
Dapsone	DM4LT8A	Pneumocystis pneumonia	CA40.20	Approved	[71]
Diazepam	DM08E9O	Epilepsy	8A60-8A68	Approved	[71]
Diphenhydramine	DMKQTBA	Meniere disease	AB31.0	Approved	[71]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[72]
Eletriptan	DMW649X	Migraine	8A80	Approved	[71]
Etoposide	DMNH3PG	Solid tumour/cancer	2A00-2F9Z	Approved	[73]
Gamma-homolinolenic acid	DMSXKYG	Malnutrition	5B50-5B71	Approved	[72]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[72]
Hexobarbital	DMQ314B	Anaesthesia	9A78.6	Approved	[71]
Ifosfamide	DMCT3I8	Solid tumour/cancer	2A00-2F9Z	Approved	[71]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Irbesartan	DMTP1DC	Hypertension	BA00-BA04	Approved	[71]
Ketobemidone	DMM3L6Z	Pain	MG30-MG3Z	Approved	[71]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[71]
Nateglinide	DMLK2QH	Diabetic complication	5A2Y	Approved	[71]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[71]
Pioglitazone	DMKJ485	Diabetic complication	5A2Y	Approved	[71]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[71]
Rosiglitazone	DMY6EAO	Type-2 diabetes	5A11	Approved	[71]
Sulfamethoxazole	DMB08GE	Bacterial infection	1A00-1C4Z	Approved	[71]
Terbinafine	DMI6HUW	Fungal infection	1F29-1F2F	Approved	[71]
Thalidomide	DM70BU5	Multiple myeloma	2A83	Approved	[71]
Trabectedin	DMG3Y89	Solid tumour/cancer	2A00-2F9Z	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Voriconazole	DMAOL2S	Invasive aspergillosis	1F20.0	Approved	[71]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[71]
Zileuton	DMVRIC2	Asthma	CA23	Approved	[71]
Zopiclone	DMPI6Z0	Insomnia	7A00-7A0Z	Approved	[71]
Zaltoprofen	DM9RJH7	Anaesthesia	9A78.6	Phase 4	[71]
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⏷ Show the Full List of 30 Approved Drug(s)

1 Discontinued Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Seratrodast	DMPNTDL	Allergic asthma	CA23.0	Discontinued in Phase 3	[71]
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5 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alpha-linolenic acid	DMY64HE	Discovery agent	N.A.	Investigative	[72]
Arachidonic acid	DMUOQZD	Discovery agent	N.A.	Investigative	[74]
BML3-C01	DMER2WS	Discovery agent	N.A.	Investigative	[72]
Eicosadienoic acid	DMVJK9W	Discovery agent	N.A.	Investigative	[72]
Icosapentum	DMF1CM7	Discovery agent	N.A.	Investigative	[72]
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Experimental Enzyme Kinetic Data of Drugs

Drug Name	Indication	Highest Status	Kinetic Data	REF
Alpha-linolenic acid	Discovery agent [N.A.]	Investigative	Km = 0.0031 microM	[72]
Arachidonic acid	Discovery agent [N.A.]	Investigative	Km = 0.0017 microM	[72]
Eicosapentaenoic acid/docosa-hexaenoic acid	Hypertriglyceridemia [5C80.1]	Approved	Km = 0.0011 microM	[72]
Gamma-homolinolenic acid	Malnutrition [5B50-5B71]	Approved	Km = 0.002 microM	[72]
Gamolenic acid	Allergy [4A80-4A85]	Approved	Km = 0.0048 microM	[72]

Molecular Expression Atlas (MEA) of This DME

Molecular Expression Atlas (MEA)

MEA Detail

Jump to Detail Molecular Expression Atlas of This DME

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	1.43E-05	4.18E-01	6.74E-01
Alopecia	ED70	Skin from scalp	5.55E-02	2.50E-01	4.84E-01
Alzheimer's disease	8A20	Entorhinal cortex	3.97E-03	1.56E-01	4.33E-01
Ankylosing spondylitis	FA92.0	Pheripheral blood	1.13E-01	2.70E-01	5.97E-01
Aortic stenosis	BB70	Calcified aortic valve	5.42E-01	4.22E-01	4.02E-01
Apnea	7A40	Hyperplastic tonsil	5.40E-01	7.90E-01	7.97E-01
Arthropathy	FA00-FA5Z	Peripheral blood	4.14E-02	3.87E-01	8.07E-01
Asthma	CA23	Nasal and bronchial airway	5.11E-09	5.07E-01	9.56E-01
Atopic dermatitis	EA80	Skin	4.11E-05	-3.71E-01	-1.66E+00
Autism	6A02	Whole blood	6.65E-02	2.29E-01	4.16E-01
Autoimmune uveitis	9A96	Peripheral monocyte	1.10E-01	3.78E-01	1.92E+00
Autosomal dominant monocytopenia	4B04	Whole blood	3.28E-01	2.30E-01	5.74E-01
Bacterial infection of gingival	1C1H	Gingival tissue	2.03E-03	-1.94E-01	-4.45E-01
Batten disease	5C56.1	Whole blood	6.89E-01	1.82E-01	2.17E-01
Behcet's disease	4A62	Peripheral blood	8.88E-01	-2.70E-02	-6.39E-02
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	1.89E-01	-1.32E-01	-2.24E-01
Bladder cancer	2C94	Bladder tissue	7.05E-03	-1.89E+00	-1.28E+00
Breast cancer	2C60-2C6Z	Breast tissue	9.97E-01	-9.62E-02	-1.94E-01
Cardioembolic stroke	8B11.20	Whole blood	3.86E-01	-2.04E-01	-4.61E-01
Cervical cancer	2C77	Cervical tissue	6.69E-03	-9.05E-01	-1.05E+00
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	1.32E-02	5.08E-01	7.11E-01
Chronic hepatitis C	1E51.1	Whole blood	5.16E-01	6.87E-03	1.28E-02
Chronic obstructive pulmonary disease	CA22	Lung tissue	2.04E-01	-8.41E-02	-1.63E-01
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	8.46E-05	2.14E-01	6.23E-01
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	1.58E-01	9.51E-02	8.30E-01
Colon cancer	2B90	Colon tissue	1.24E-37	-8.46E-01	-1.61E+00
Coronary artery disease	BA80-BA8Z	Peripheral blood	1.88E-01	9.39E-01	1.19E+00
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	9.45E-01	-6.62E-02	-9.47E-02
Endometriosis	GA10	Endometrium tissue	2.17E-01	6.85E-01	4.32E-01
Familial hypercholesterolemia	5C80.00	Peripheral blood	1.39E-01	-3.44E-02	-1.13E-01
Familial hypercholesterolemia	5C80.00	Whole blood	2.71E-04	1.92E+00	2.05E+00
Gastric cancer	2B72	Gastric tissue	3.42E-01	-3.96E-01	-6.06E-01
Glioblastopma	2A00.00	Nervous tissue	1.72E-63	7.14E-01	1.48E+00
Glioma	2A00.0Y-2A00.0Z	Brain stem tissue	2.54E-09	-1.15E+00	-2.94E+01
Glioma	2A00.0Y-2A00.0Z	White matter tissue	4.59E-01	-3.48E-01	-1.94E-01
Head and neck cancer	2D42	Head and neck tissue	6.06E-12	1.05E+00	7.98E-01
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	4.53E-01	-1.03E-01	-6.11E-01
Huntington's disease	8A01.10	Whole blood	3.48E-01	4.02E-02	8.75E-02
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	1.71E-02	7.25E-01	2.30E+00
Immunodeficiency	4A00-4A20	Peripheral blood	2.56E-02	6.56E-02	7.65E-01
Influenza	1E30	Whole blood	9.98E-02	-9.07E-01	-1.93E+00
Interstitial cystitis	GC00.3	Bladder tissue	2.79E-01	1.05E+00	1.20E+00
Intracranial aneurysm	8B01.0	Intracranial artery	6.28E-05	1.18E+00	2.10E+00
Irritable bowel syndrome	DD91.0	Rectal colon tissue	4.10E-01	-3.87E-02	-1.51E-01
Ischemic stroke	8B11	Peripheral blood	2.89E-01	1.83E-01	3.08E-01
Juvenile idiopathic arthritis	FA24	Peripheral blood	6.53E-09	4.11E-01	8.73E-01
Lateral sclerosis	8B60.4	Skin	2.46E-01	7.05E-01	9.44E-01
Lateral sclerosis	8B60.4	Cervical spinal cord	8.19E-01	-1.40E-02	-9.21E-02
Liver cancer	2C12.0	Liver tissue	2.45E-08	-4.69E-01	-1.88E+00
Liver failure	DB99.7-DB99.8	Liver tissue	3.79E-03	1.24E+00	2.72E+00
Lung cancer	2C25	Lung tissue	2.29E-28	-5.62E-01	-1.35E+00
Lupus erythematosus	4A40	Whole blood	1.46E-05	4.28E-01	4.47E-01
Major depressive disorder	6A70-6A7Z	Hippocampus	7.89E-01	9.78E-02	1.72E-01
Major depressive disorder	6A70-6A7Z	Whole blood	8.64E-02	2.18E-01	4.45E-01
Melanoma	2C30	Skin	2.96E-03	-1.12E+00	-9.55E-01
Multiple myeloma	2A83.1	Peripheral blood	3.72E-01	1.33E-01	7.30E-01
Multiple myeloma	2A83.1	Bone marrow	2.87E-02	-2.83E-01	-7.80E-01
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	9.00E-02	1.81E-01	6.37E-01
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	6.17E-02	1.24E-01	2.01E-01
Myelofibrosis	2A20.2	Whole blood	8.38E-01	-8.65E-02	-2.75E-01
Myocardial infarction	BA41-BA50	Peripheral blood	5.95E-04	1.79E+00	9.84E-01
Myopathy	8C70.6	Muscle tissue	3.14E-03	2.65E-01	1.10E+00
Neonatal sepsis	KA60	Whole blood	1.95E-16	6.27E-01	1.29E+00
Neuroectodermal tumour	2A00.11	Brain stem tissue	3.17E-12	-1.26E+00	-5.98E+00
Non-alcoholic fatty liver disease	DB92	Liver tissue	2.71E-01	-6.56E-02	-3.30E-01
Obesity related type 2 diabetes	5A11	Omental adipose tissue	1.16E-01	-2.08E-01	-5.93E-01
Olive pollen allergy	CA08.00	Peripheral blood	7.93E-01	-1.56E-01	-2.98E-01
Oral cancer	2B6E	Oral tissue	1.72E-06	8.99E-01	1.12E+00
Osteoarthritis	FA00-FA0Z	Synovial tissue	7.89E-01	2.37E-02	2.18E-02
Osteoporosis	FB83.1	Bone marrow	9.61E-01	2.43E-01	2.96E-01
Ovarian cancer	2C73	Ovarian tissue	1.07E-03	3.59E+00	2.32E+00
Pancreatic cancer	2C10	Pancreas	1.81E-05	6.59E-01	1.75E+00
Parkinson's disease	8A00.0	Substantia nigra tissue	2.19E-01	1.72E-01	5.16E-01
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	1.40E-02	1.83E-01	2.94E-01
Pituitary cancer	2D12	Pituitary tissue	8.83E-01	-3.81E-01	-5.18E-01
Pituitary gonadotrope tumour	2D12	Pituitary tissue	7.70E-02	-6.66E-01	-8.56E-01
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	6.05E-02	8.15E-02	8.50E-01
Polycythemia vera	2A20.4	Whole blood	1.79E-06	3.88E-01	1.16E+00
Pompe disease	5C51.3	Biceps muscle	2.82E-01	-1.65E-01	-2.27E-01
Preterm birth	KA21.4Z	Myometrium	4.81E-01	-1.01E+00	-8.48E-01
Prostate cancer	2C82	Prostate	4.46E-01	-5.00E-02	-3.97E-02
Psoriasis	EA90	Skin	7.86E-02	1.05E-01	2.02E-01
Rectal cancer	2B92	Rectal colon tissue	4.06E-03	-9.04E-01	-2.26E+00
Renal cancer	2C90-2C91	Kidney	2.36E-03	3.80E-01	6.29E-01
Retinoblastoma	2D02.2	Uvea	8.66E-04	6.83E-01	2.70E+00
Rheumatoid arthritis	FA20	Synovial tissue	7.25E-01	-4.31E-02	-5.74E-02
Rhinovirus infection	CA42.1	Nasal epithelium tissue	6.31E-02	4.23E-02	3.47E-01
Schizophrenia	6A20	Prefrontal cortex	3.26E-01	1.33E-01	1.12E-01
Schizophrenia	6A20	Superior temporal cortex	2.34E-01	4.46E-02	4.03E-01
Scleroderma	4A42.Z	Whole blood	2.48E-01	1.88E-01	3.76E-01
Seizure	8A60-8A6Z	Whole blood	2.73E-02	-3.80E-01	-6.89E-01
Sensitive skin	EK0Z	Skin	2.13E-02	2.40E-01	9.13E-01
Sepsis with septic shock	1G41	Whole blood	5.73E-12	2.65E-01	6.23E-01
Shwachman-Diamond syndrome	3A70.0	Bone marrow	1.24E-02	-3.26E-01	-7.78E-01
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	5.55E-03	4.44E-01	1.35E+00
Simpson golabi behmel syndrome	LD2C	Adipose tissue	3.37E-01	1.03E-02	3.76E-02
Sjogren's syndrome	4A43.2	Salivary gland tissue	5.62E-02	4.69E-01	1.62E+00
Skin cancer	2C30-2C3Z	Skin	2.54E-99	-2.57E+00	-4.16E+00
Thrombocythemia	3B63	Whole blood	1.94E-03	5.49E-01	1.74E+00
Thrombocytopenia	3B64	Whole blood	5.27E-02	8.16E-01	5.49E-01
Thyroid cancer	2D10	Thyroid	1.39E-12	4.87E-01	1.04E+00
Tibial muscular dystrophy	8C75	Muscle tissue	1.18E-07	6.15E-01	4.12E+00
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	3.28E-02	1.04E+00	6.58E+00
Type 2 diabetes	5A11	Liver tissue	3.77E-01	3.23E-01	7.35E-01
Ureter cancer	2C92	Urothelium	5.77E-01	1.18E-02	8.93E-02
Uterine cancer	2C78	Endometrium tissue	2.10E-03	-3.85E-01	-2.74E-01
Vitiligo	ED63.0	Skin	3.51E-02	1.75E-01	6.04E-01
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⏷ Show the Full List of DME Expression Under 107 Diseases

The Drug Therapeutic Target (DTT) Role of This DME

DME DTT Name

Prostaglandin G/H synthase 1 (COX-1) DTT Info

DME DTT Type

Successful

15 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aminosalicylic acid	DMENSL5	Inflammatory bowel disease	DD72	Approved	[1]
Balsalazide	DMO091F	Inflammatory bowel disease	DD72	Approved	[2]
Bromfenac	DMKB79O	Postoperative inflammation	1A00-CA43.1	Approved	[3]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[4]
Fenbufen	DMXGDFK	Arthritis	FA20	Approved	[5]
Flufenamic Acid	DMC8VNH	Dysmenorrhea	GA34.3	Approved	[6]
Gamma-homolinolenic acid	DMSXKYG	Malnutrition	5B50-5B71	Approved	[7], [8], [9]
Meclofenamate sodium	DMNL98G	Arthritis	FA20	Approved	[10]
Mesalazine	DMOL5IU	Ulcerative colitis	DD71	Approved	[11]
Naproxen	DMZ5RGV	Osteoarthritis	FA00-FA05	Approved	[12]
Piroxicam	DMTK234	Pain	MG30-MG3Z	Approved	[1]
Salicyclic acid	DM2F8XZ	Seborrhoeic dermatitis	EA81	Approved	[13]
Salsalate	DM13P4C	Rheumatoid arthritis	FA20	Approved	[14], [15]
Suprofen	DMKXJZ7	Miosis	LA11.62	Approved	[16]
Imrecoxib	DMVXLOD	N. A.	N. A.	Phase 4	[17]
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⏷ Show the Full List of 15 Approved Drug(s)

6 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(S)-FLURBIPROFEN	DMF2O4T	Myalgia	FB56.2	Preregistration	[18]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[19]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[20]
ThermoProfen	DMPGH7N	Pain	MG30-MG3Z	Phase 3	[21]
Epicatechin	DMN0EMP	Duchenne dystrophy	8C70	Phase 1/2	[22]
EXO-230	DM64PM7	Diabetic neuropathy	8C0Z	Phase 1/2	[23]
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⏷ Show the Full List of 6 Clinical Trial Drug(s)

1 Patented Agent(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamate derivative 2	DMEWPQ6	N. A.	N. A.	Patented	[24]
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8 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
INDOPROFEN	DM5QSKN	Gout	FA25	Withdrawn from market	[18]
Metamizole	DM79GRO	Fever	MG26	Withdrawn from market	[25]
Phenacetin	DMRQAM0	Analgesia	MB40.8	Withdrawn from market	[26]
CRx-401	DM39N7W	Type-2 diabetes	5A11	Discontinued in Phase 2	[27]
R-ketoprofen	DMHSUQ1	N. A.	N. A.	Discontinued in Phase 2	[18]
TEBUFELONE	DMMUE8P	Pain	MG30-MG3Z	Discontinued in Phase 2	[28]
ATLIPROFEN METHYL ESTER	DMS2FB3	Inflammation	1A00-CA43.1	Terminated	[1]
SC-58451	DMVGK24	N. A.	N. A.	Terminated	[29]
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⏷ Show the Full List of 8 Discontinued Drug(s)

106 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(-)-3-O-acetylspectaline	DMKRTBM	Discovery agent	N.A.	Investigative	[30]
(11H-Dibenzo[b,e][1,4]dioxepin-2-yl)-acetic acid	DMSUPVE	Discovery agent	N.A.	Investigative	[31]
(11H-Dibenzo[b,e][1,4]dioxepin-7-yl)-acetic acid	DM5ZTXL	Discovery agent	N.A.	Investigative	[31]
(11H-Dibenzo[b,e][1,4]dioxepin-8-yl)-acetic acid	DMBY623	Discovery agent	N.A.	Investigative	[31]
(3-Chloro-4-Propoxy-Phenyl)-Acetic Acid	DMHODXG	Discovery agent	N.A.	Investigative	[32]
(R)-2-(4-Isobutyl-phenyl)-N-phenyl-propionamide	DMAD4JY	Discovery agent	N.A.	Investigative	[18]
(Z)-2'-des-methyl sulindac sulfide	DM0OEQJ	Discovery agent	N.A.	Investigative	[33]
1,2-dihydro-3-(2,3,4-trimethoxyphenyl)naphthalene	DMST60D	Discovery agent	N.A.	Investigative	[34]
1-(4-(methylsulfonyl)phenyl)-3-p-tolylurea	DMMSQLC	Discovery agent	N.A.	Investigative	[35]
1-(4-(methylsulfonyl)phenyl)-3-phenylurea	DMH7RY0	Discovery agent	N.A.	Investigative	[35]
1-(4-aminosulfonylphenyl)-2-(2-pyridyl)acetylene	DMWA6G1	Discovery agent	N.A.	Investigative	[36]
1-(4-aminosulfonylphenyl)-2-(4-pyridyl)acetylene	DMP93E2	Discovery agent	N.A.	Investigative	[36]
2'-epi-guianin	DMNVJY0	Discovery agent	N.A.	Investigative	[37]
2,4'-Dimethoxy-5,3'-di-(2-propenyl)-biphenyl	DMWNJ84	Discovery agent	N.A.	Investigative	[38]
2-(1,1'-Biphenyl-4-Yl)Propanoic Acid	DMUE0D6	Discovery agent	N.A.	Investigative	[32], [39]
2-(2,3,4-trimethoxyphenyl)-1H-indene	DMFU1PK	Discovery agent	N.A.	Investigative	[34]
2-(2-(2,6-dimethylphenylamino)phenyl)acetic acid	DMJ2DE4	Discovery agent	N.A.	Investigative	[40]
2-(2-methoxyphenyl)-1H-indene	DMXFYN8	Discovery agent	N.A.	Investigative	[34]
2-(2-Methylpropanoyl)-1,3,5-benzenetriol	DMPH63G	Discovery agent	N.A.	Investigative	[41]
2-(3'-Allyl-biphenyl-4-yl)-propionic acid	DMAGFUH	Discovery agent	N.A.	Investigative	[42]
2-(3'-Ethyl-biphenyl-4-yl)-propionic acid	DMPLN58	Discovery agent	N.A.	Investigative	[42]
2-(3'-Ethylsulfanyl-biphenyl-4-yl)-propionic acid	DMPGYDA	Discovery agent	N.A.	Investigative	[42]
2-(3'-Vinyl-biphenyl-4-yl)-propionic acid	DM7NGV1	Discovery agent	N.A.	Investigative	[42]
2-(3-Phenyl-propyl)-1,2-dihydro-indazol-3-one	DMIQBXD	Discovery agent	N.A.	Investigative	[43]
2-(N-(2-Ffuorophenyl)pyrrol-3-yl) acetic acid	DMRNOM6	Discovery agent	N.A.	Investigative	[44]
2-(N-(2-fluorophenyl)pyrrol-2-yl) acetic acid	DMCL9E6	Discovery agent	N.A.	Investigative	[44]
2-(p-Methylsulfonylbenzoyl)furan	DMLT635	Discovery agent	N.A.	Investigative	[45]
2-Benzyl-1,2-dihydro-indazol-3-one	DM1CB5J	Discovery agent	N.A.	Investigative	[43]
2-Bromoacetyl Group	DMIHJSA	Discovery agent	N.A.	Investigative	[46]
2-Furan-2-ylmethyl-1,2-dihydro-indazol-3-one	DMQIRY7	Discovery agent	N.A.	Investigative	[43]
2-Methyl-1,2-dihydro-indazol-3-one	DMDJHFQ	Discovery agent	N.A.	Investigative	[43]
2-Naphthalen-2-ylmethyl-1,2-dihydro-indazol-3-one	DM1EJ6W	Discovery agent	N.A.	Investigative	[43]
2-Phenethyl-1,2-dihydro-indazol-3-one	DM0WMBC	Discovery agent	N.A.	Investigative	[43]
2-Phenyl-1,2-dihydro-indazol-3-one	DM28CLZ	Discovery agent	N.A.	Investigative	[43]
2-[4-(1H-Indol-5-yl)-phenyl]-propionic acid	DMUHECR	Discovery agent	N.A.	Investigative	[42]
3 beta-O-acetyloleanolic acid	DM1L5IJ	Discovery agent	N.A.	Investigative	[47]
3-(4-Methanesulfonyl-phenyl)-1-phenyl-propynone	DMSR2O3	Discovery agent	N.A.	Investigative	[48]
4'-Methoxy-5,3'-dipropyl-biphenyl-2ol	DM5FRV2	Discovery agent	N.A.	Investigative	[38]
4,5-Bis(4-chlorophenyl)-1,2-selenazole	DMIO254	Discovery agent	N.A.	Investigative	[49]
4,5-Bis(4-chlorophenyl)isothiazole	DMENLFY	Discovery agent	N.A.	Investigative	[50]
4,5-Bis(4-methoxyphenyl)-1,2-selenazole	DMKHD1M	Discovery agent	N.A.	Investigative	[49]
4,5-Bis(4-methoxyphenyl)-3H-1,2-dithiol-3-one	DMI39QT	Discovery agent	N.A.	Investigative	[50]
4,5-Bis(4-methoxyphenyl)-3H-1,2-dithiole-3-thione	DMPW145	Discovery agent	N.A.	Investigative	[50]
4,5-Bis(4-methoxyphenyl)isothiazole	DM90DV6	Discovery agent	N.A.	Investigative	[50]
4-(4-Chlorophenyl)-5-(4-methoxyphenyl)isothiazole	DMODVGN	Discovery agent	N.A.	Investigative	[50]
4-(4-Chlorophenyl)-5-p-tolyl-1,2-selenazole	DMZBEYO	Discovery agent	N.A.	Investigative	[49]
4-(4-Chlorophenyl)-5-p-tolyl-3H-1,2-dithiol-3-one	DMVDF9Q	Discovery agent	N.A.	Investigative	[50]
4-(4-Chlorophenyl)-5-p-tolylisothiazole	DMMK9RC	Discovery agent	N.A.	Investigative	[50]
4-(5-(4-Hydroxyphenyl)isothiazol-4-yl)phenol	DMK1ZF2	Discovery agent	N.A.	Investigative	[50]
4-amino-N-(2-chlorophenyl)benzenesulfonamide	DM6PQ5V	Discovery agent	N.A.	Investigative	[51]
4-amino-N-(4-chlorophenyl)benzenesulfonamide	DMCUSD4	Discovery agent	N.A.	Investigative	[51]
4-amino-N-p-tolylbenzenesulfonamide	DMLW651	Discovery agent	N.A.	Investigative	[51]
5,3'-Dipropyl-biphenyl-2,4'-diol	DMJRXLD	Discovery agent	N.A.	Investigative	[38]
5-(2-1H-indenyl)-1,3-benzodioxole	DM149IX	Discovery agent	N.A.	Investigative	[34]
5-(2-Imidazol-1-yl-ethyl)-7,8-dihydro-quinoline	DMCP5U8	Discovery agent	N.A.	Investigative	[52]
5-(4-Chlorophenyl)-4-(4-methoxyphenyl)isothiazole	DMSTG03	Discovery agent	N.A.	Investigative	[50]
5-(4-Chlorophenyl)-4-p-tolyl-1,2-selenazole	DMY0P86	Discovery agent	N.A.	Investigative	[49]
5-(4-Chlorophenyl)-4-p-tolyl-3H-1,2-dithiol-3-one	DMFYEL8	Discovery agent	N.A.	Investigative	[50]
5-(4-Chlorophenyl)-4-p-tolylisothiazole	DMA1N75	Discovery agent	N.A.	Investigative	[50]
5-(4-Methoxyphenyl)-4-p-tolyl-1,2-selenazole	DMEV8WS	Discovery agent	N.A.	Investigative	[49]
5-(4-Methoxyphenyl)-4-p-tolylisothiazole	DMJSTCK	Discovery agent	N.A.	Investigative	[50]
5-Ethyl-3,4-diphenyl-isoxazole	DMRIGXA	Discovery agent	N.A.	Investigative	[53]
5-Methyl-3,4-diphenyl-isoxazole	DM0G2N5	Discovery agent	N.A.	Investigative	[53]
5-Phenyl-pentanoic acid benzyl-hydroxy-amide	DM3B6A8	Discovery agent	N.A.	Investigative	[54]
Acetic acid 2-hept-2-ynylsulfanyl-phenyl ester	DM97DJL	Discovery agent	N.A.	Investigative	[55]
Acetic acid 2-hept-3-ynylsulfanyl-phenyl ester	DMD89A1	Discovery agent	N.A.	Investigative	[55]
Acetic acid 2-heptylselanyl-phenyl ester	DM50BTA	Discovery agent	N.A.	Investigative	[55]
Acetic acid 2-heptylsulfanyl-phenyl ester	DMLPRIG	Discovery agent	N.A.	Investigative	[55]
Acetic acid 2-hex-2-ynylsulfanyl-phenyl ester	DMFQE1C	Discovery agent	N.A.	Investigative	[55]
Acetic acid 2-hexylsulfanyl-phenyl ester	DMAKNUH	Discovery agent	N.A.	Investigative	[55]
Acetic acid 2-pentylsulfanyl-phenyl ester	DMFKRIH	Discovery agent	N.A.	Investigative	[55]
Acetic Acid Salicyloyl-Amino-Ester	DMLTNHY	Discovery agent	N.A.	Investigative	[32]
Alpha-D-Mannose	DMF5DLW	Discovery agent	N.A.	Investigative	[46]
Arachidonic acid	DMUOQZD	Discovery agent	N.A.	Investigative	[46]
B-Octylglucoside	DMMO75G	Discovery agent	N.A.	Investigative	[46]
Beta-D-Glucose	DM5IHYP	Discovery agent	N.A.	Investigative	[46]
Beta-D-Mannose	DMHIG9K	Discovery agent	N.A.	Investigative	[46]
CATECHIN	DMY38SB	Discovery agent	N.A.	Investigative	[22]
DEMETHOXYCURCUMIN	DMO5UGV	Discovery agent	N.A.	Investigative	[19]
FR122047	DMAYTWN	Discovery agent	N.A.	Investigative	[56]
Heme	DMGC287	Discovery agent	N.A.	Investigative	[32]
HONOKIOL	DMJWT3X	Discovery agent	N.A.	Investigative	[38]
Hyperforin	DM2L3PE	Discovery agent	N.A.	Investigative	[57]
IODOINDOMETHACIN	DM3BL0G	Discovery agent	N.A.	Investigative	[39]
IODOSUPROFEN	DMOE8LT	Discovery agent	N.A.	Investigative	[39]
METHYLHONOKIOL	DM9YE6K	Discovery agent	N.A.	Investigative	[38]
N-(1H-indazol-5-yl)acetamide	DMIMJNU	Discovery agent	N.A.	Investigative	[58]
N-(3-(phenylthio)pyridin-4-yl)methanesulfonamide	DMSJX1H	Discovery agent	N.A.	Investigative	[59]
N-(3-phenoxy-4-pyridinyl)ethanesulfonamide	DMXF46V	Discovery agent	N.A.	Investigative	[60]
N-(3-phenoxy-4-pyridinyl)propanesulfonamide	DMN1DPJ	Discovery agent	N.A.	Investigative	[60]
N-(3-phenoxypyridin-4-yl)methanesulfonamide	DM7CM3F	Discovery agent	N.A.	Investigative	[59]
N-(3-phenylamino-4-pyridinyl)methanesulfonamide	DMJB7SE	Discovery agent	N.A.	Investigative	[59]
Nitroflurbiprofen	DMWCV48	Discovery agent	N.A.	Investigative	[61], [62], [63]
O-Acetylserine	DMAEHFT	Discovery agent	N.A.	Investigative	[46]
Oxametacin	DMWVLG1	Discovery agent	N.A.	Investigative	[64]
P-(2'-Iodo-5'-Thenoyl)Hydrotropic Acid	DMJ0W43	Discovery agent	N.A.	Investigative	[32]
Phenazone	DMCE985	Discovery agent	N.A.	Investigative	[65]
PHENIDONE	DMJD8XN	Discovery agent	N.A.	Investigative	[43]
Prifelone	DMLI4RF	Discovery agent	N.A.	Investigative	[66]
Primary alcohol metabolite of celecoxib	DMA8GI6	Discovery agent	N.A.	Investigative	[67]
Protoporphyrin Ix Containing Co	DMJ8TP3	Discovery agent	N.A.	Investigative	[46]
Resorcinol	DMM37C0	Discovery agent	N.A.	Investigative	[22]
Resveratrol Potassium3-Sulfate	DMN1RLA	Discovery agent	N.A.	Investigative	[68]
Resveratrol Potassium4,-Sulfate	DMMFP57	Discovery agent	N.A.	Investigative	[68]
SC-560	DMT1GJL	Discovery agent	N.A.	Investigative	[69]
TRL-382	DMU3E1M	Neuropathic pain	8E43.0	Investigative	[70]
------------------------------------------------------------------------------------


⏷ Show the Full List of 106 Investigative Drug(s)

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