Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0MQ35)

Drug Name

Spectinomycin Drug Info

Synonyms

Actinospectacin; Actinospectacina; Adspec; Espectinomicina; Prospec; SCM; SPCM; Spectam; Spectinomicina; Spectinomycine; Spectinomycinum; Spectogard; Stanilo; Togamycin; Trobicin; Actinospectacina [Italian]; Spectam Scour Halt; Spectinomicina [Italian]; Spectinomycin Di HCl; Spectinomycin HCl; Spectinomycin dihydrochloride; Spectinomycin hydrochloride; Spectinomycin hydrochloride anhydrous; Spectinomycin monohydrochloride; Spectinomycin sulfate; Antibiotic 2233wp; M 141; U 18409; U 18409 E; Actinospectacin, hydrochloride; Adspec (TN); Espectinomicina [INN-Spanish]; M-141; Prospec (TN); Spectinomycin (INN); Spectinomycin Dihydrochloride, Anhydrous; Spectinomycin Dihydrochloride, Pentahydrate; SpectinomycinHCl/ Sulphate; Spectinomycin Hydrochloride (anhydrous); Spectinomycin [INN:BAN]; Spectinomycine [INN-French]; Spectinomycinum [INN-Latin]; Trobicin (TN); U-18409AE; XK 43-1; Togamycin sulfate (1:1); ACTINOSPECTACIN, ESPECTINOMICINA, CHX-3101; (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)decahydro-4H-pyrano[2,3-b][1,4]benzodioxin-4-one; (2R-(2alpha,4abeta,5abeta,6beta,7beta,8beta,9alpha,9aalpha,10abeta))-Decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-4H-pyrano(2,3-b)(1,4)benzodioxin-4-one monohydrochloride; 4H-Pyrano[2,3-b][1,4]benzodioxin-4-one, decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-, [2R-(2.alpha.,4a.beta.,5a.beta.,6.beta.,7.beta.,8.beta.,9.alpha.,9a.alpha.,10a.beta.)]-, sulfate (1:1) (salt)

Indication

Disease Entry	ICD 11	Status	REF
Acute gonococcal cervicitis		Approved	[1]
Bacterial infection	1A00-1C4Z	Approved	[2]

Therapeutic Class

Antibiotics

Cross-matching ID

PubChem CID: 15541
ChEBI ID: CHEBI:9215
CAS Number: CAS 1695-77-8
TTD Drug ID: DM0MQ35

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Staphylococcus 30S ribosomal subunit (Stap-coc pbp2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[5]
Framycetin	DMF8DNE	Acute liver failure	DB91	Approved	[6]
Netilmicin	DMRD1QK	Bacterial infection	1A00-1C4Z	Approved	[7]
Amikacin	DM5PDRB	Bacteremia	1A73	Approved	[8]
Clomocycline	DM0ZRMQ	Bacterial infection	1A00-1C4Z	Approved	[9]
Paromomycin	DM1AGXN	Amoebiasis	1A36	Approved	[10]
Lymecycline	DMOMLHJ	Bacterial infection	1A00-1C4Z	Approved	[11]
Rolitetracycline	DMBR5Q7	Acne vulgaris	ED80	Approved	[12]
Meclocycline	DMSFQ8I	Bacterial infection	1A00-1C4Z	Approved	[13]
Minocycline	DMVN5OH	Acne vulgaris	ED80	Approved	[14]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Metabolized By Aminoglycoside adenylyltransferase (aadA1a)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Streptomycin	DME1LQN	Bacterial infection	1A00-1C4Z	Approved	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Staphylococcus 30S ribosomal subunit (Stap-coc pbp2)	TTQ8KVI	F4NA87_STAAU	Binder	[3]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Aminoglycoside adenylyltransferase (aadA1a)^{Main DME}	DEYWTIQ	Q6YLD2_SALER	Substrate	[4]

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References

1	Spectinomycin FDA Label
2	FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 050347.
3	Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics. Nature. 2000 Sep 21;407(6802):340-8.
4	Structural mechanism of AadA, a dual-specificity aminoglycoside adenylyltransferase from Salmonella enterica. J Biol Chem. 2018 Jul 20;293(29):11481-11490.
5	The glycylcyclines: a comparative review with the tetracyclines. Drugs. 2004;64(1):63-88.
6	Characterization of a 30S ribosomal subunit assembly intermediate found in Escherichia coli cells growing with neomycin or paromomycin. Arch Microbiol. 2008 May;189(5):441-9.
7	Ribosomal resistance in the gentamicin producer organism Micromonospora purpurea. Antimicrob Agents Chemother. 1982 Aug;22(2):231-6.
8	Bacterial resistance to aminoglycosides and beta-lactams: the Tn1331 transposon paradigm. Front Biosci. 2000 Jan 1;5:D20-9.
9	Molecular dynamics simulations of the 30S ribosomal subunit reveal a preferred tetracycline binding site. J Am Chem Soc. 2008 Jan 30;130(4):1114-5.
10	Aminoglycoside association pathways with the 30S ribosomal subunit. J Phys Chem B. 2009 May 21;113(20):7322-30.
11	Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
12	Reversed-phase high-performance liquid chromatography coupled to ultraviolet and electrospray time-of-flight mass spectrometry on-line detection fo... J Chromatogr A. 2008 Jun 27;1195(1-2):107-16.
13	Detection of tetracycline resistance genes by PCR methods. Methods Mol Biol. 2004;268:3-13.
14	Functional, biophysical, and structural bases for antibacterial activity of tigecycline. Antimicrob Agents Chemother. 2006 Jun;50(6):2156-66.