Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM27TH9)

• Drug Name: (2,6-Dichloro-phenyl)-(1H-imidazol-2-yl)-amine Drug Info
• Synonyms: CHEMBL1022; (2,6-Dichloro-phenyl)-(1H-imidazol-2-yl)-amine; SCHEMBL13767327

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 10489502
  TTD Drug ID: DM27TH9

Molecule-Related Drug Atlas

Drug(s) Targeting Adrenergic receptor alpha-2C (ADRA2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MOXONIDINE	DMGFB0E	Alcohol dependence	6C40.2	Approved	[2]
Dihydroergocristine	DM5SQ1G	Alcohol dependence	6C40.2	Approved	[3]
Brimonidine	DMQLT4N	Ocular hypertension	9C61.01	Approved	[4]
Amosulalol	DML8QSZ	Hypertension	BA00-BA04	Approved	[5]
Amezinium	DM6I2WQ	Hypotension	BA20-BA21	Approved	[6]
Propylhexedrine	DMTBW2O	Obesity	5B81	Approved	[7]
Tetrahydrozoline	DMT57WC	Ocular disease	1F00.1Z	Approved	[8]
Rilmenidine	DM13PQW	Hypertension	BA00-BA04	Approved	[9]
Xylometazoline	DMKV32D	Allergic rhinitis	CA08.0	Phase 4	[10]
TNX-102	DMO1234	Fibromyalgia	MG30.01	Phase 3	[11]

Drug(s) Targeting Adrenergic receptor alpha-2A (ADRA2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lofexidine	DM1WXA6	Heroin and opiate withdrawal	6C43	Approved	[12]
MOXONIDINE	DMGFB0E	Alcohol dependence	6C40.2	Approved	[2]
Connexyn	DMF29Q5	Attention deficit hyperactivity disorder	6A05.Z	Approved	[13]
Guanfacine	DMPN5IH	Attention deficit hyperactivity disorder	6A05.Z	Phase 4	[14]
A295	DM55GO2	Aggressive cancer	2A00-2F9Z	IND submitted	[15]
MEDETOMIDINE	DMX9Y7V	Pain	MG30-MG3Z	Phase 2	[16]
DSP-1200	DM4WSHG	Depression	6A70-6A7Z	Phase 1	[17]
MAZAPERTINE	DMRHYAU	N. A.	N. A.	Discontinued in Phase 2	[18]
NMI-870	DMU596F	Sexual dysfunction	HA00-HA01	Discontinued in Phase 2	[19]
SNAP-5089	DMROJEN	Heart arrhythmia	BC65	Terminated	[20]

Drug(s) Targeting Adrenergic receptor alpha-1B (ADRA1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methamphetamine	DMPM4SK	Anxiety		Approved	[21]
Propericiazine	DME9JNL	Psychiatric disorder	6E8Z	Approved	[22]
Methoxamine	DMF5XQH	Hypertension	BA00-BA04	Approved	[23]
Phendimetrazine	DM6TS1N	Obesity	5B81	Approved	[24]
MEDETOMIDINE	DMX9Y7V	Pain	MG30-MG3Z	Phase 2	[16]
TIOSPIRONE	DME5QDP	N. A.	N. A.	Discontinued in Phase 3	[25]
Sunepitron	DM6M8ZX	N. A.	N. A.	Discontinued in Phase 3	[26]
MAZAPERTINE	DMRHYAU	N. A.	N. A.	Discontinued in Phase 2	[18]
SOU-001	DMPAEK5	Urinary incontinence	MF50.2	Discontinued in Phase 2	[27]
SNAP-5089	DMROJEN	Heart arrhythmia	BC65	Terminated	[28]

Drug(s) Targeting Adrenergic receptor alpha-1D (ADRA1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxazosin	DM9PLRH	Benign prostatic hyperplasia	GA90	Approved	[29]
Armodafinil	DMGB035	Malignant glioma	2A00.0	Approved	[30]
Alfuzosin	DMZVMKF	Benign prostatic hyperplasia	GA90	Approved	[31]
Moxisylyte	DMFCLYW	Erectile dysfunction	HA01.1	Approved	[32]
Terazosin	DM3JCVS	Benign prostatic hyperplasia	GA90	Approved	[33]
Bunazosin	DM4I8O7	Glaucoma/ocular hypertension	9C61	Approved	[34]
Trimazosin	DM1QLST	Congestive heart failure	BD10	Approved	[35]
MEDETOMIDINE	DMX9Y7V	Pain	MG30-MG3Z	Phase 2	[16]
DL-017	DMM8GZT	Hypertension	BA00-BA04	Phase 1	[36]
PMID30124346-Compound-LDT8	DM5MUNG	Benign prostatic hyperplasia	GA90	Patented	[37]

Drug(s) Targeting Adrenergic receptor alpha-1A (ADRA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SILODOSIN	DMJSBT6	Benign prostatic hyperplasia	GA90	Approved	[38]
NAFTOPIDIL	DMQ8R4E	Hypertension	BA00-BA04	Approved	[38]
Tamsulosin	DM5QF9V	Benign prostatic hyperplasia	GA90	Approved	[39]
Xatral	DMLHOA0	Benign prostatic hyperplasia	GA90	Approved	[40]
Dutasteride + tamsulosin	DM6P8HU	Benign prostatic hyperplasia	GA90	Phase 3	[41]
Besipirdine	DMLVNTA	Cognitive impairment	6D71	Phase 3	[42]
MEDETOMIDINE	DMX9Y7V	Pain	MG30-MG3Z	Phase 2	[16]
PMID30124346-Compound-LDT8	DM5MUNG	Benign prostatic hyperplasia	GA90	Patented	[37]
PMID30124346-Compound-LDT66	DMJMTNL	Benign prostatic hyperplasia	GA90	Patented	[37]
TIOSPIRONE	DME5QDP	N. A.	N. A.	Discontinued in Phase 3	[25]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor alpha-1A (ADRA1A)	TTNGILX	ADA1A_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-1B (ADRA1B)	TTBRKXS	ADA1B_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-1D (ADRA1D)	TT34BHT	ADA1D_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-2A (ADRA2A)	TTWG9A4	ADA2A_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-2C (ADRA2C)	TT2NUT5	ADA2C_HUMAN	Inhibitor	[1]

References

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