DDI Drug Name |
DDI Drug ID |
Severity |
Mechanism |
Comorbidity |
REF |
Ivosidenib |
DM8S6T7
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Ivosidenib. |
Acute myeloid leukaemia [2A60]
|
[12] |
Midostaurin |
DMI6E0R
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Midostaurin. |
Acute myeloid leukaemia [2A60]
|
[13] |
Idarubicin |
DMM0XGL
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Idarubicin. |
Acute myeloid leukaemia [2A60]
|
[13] |
Daunorubicin |
DMQUSBT
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Daunorubicin. |
Acute myeloid leukaemia [2A60]
|
[13] |
Gilteritinib |
DMTI0ZO
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Gilteritinib. |
Acute myeloid leukaemia [2A60]
|
[14] |
Oliceridine |
DM6MDCF
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Oliceridine. |
Acute pain [MG31]
|
[13] |
Tacrine |
DM51FY6
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Alfuzosin and Tacrine. |
Alzheimer disease [8A20]
|
[13] |
Rivastigmine |
DMG629M
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Alfuzosin and Rivastigmine. |
Alzheimer disease [8A20]
|
[13] |
Donepezil |
DMIYG7Z
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Alfuzosin and Donepezil. |
Alzheimer disease [8A20]
|
[13] |
Metronidazole |
DMTIVEN
|
Minor |
Increased risk of prolong QT interval by the combination of Alfuzosin and Metronidazole. |
Amoebiasis [1A36]
|
[15] |
Bepridil |
DM0RKS4
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Bepridil. |
Angina pectoris [BA40]
|
[13] |
Dronedarone |
DMA8FS5
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Dronedarone. |
Angina pectoris [BA40]
|
[13] |
Bedaquiline |
DM3906J
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Bedaquiline. |
Antimicrobial drug resistance [MG50-MG52]
|
[16] |
Hydroxyzine |
DMF8Y74
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Hydroxyzine. |
Anxiety disorder [6B00-6B0Z]
|
[13] |
Promazine |
DMZAL7W
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Promazine. |
Appearance/behaviour symptom [MB23]
|
[13] |
Cilostazol |
DMZMSCT
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Cilostazol. |
Arterial occlusive disease [BD40]
|
[13] |
Voriconazole |
DMAOL2S
|
Major |
Decreased metabolism of Alfuzosin caused by Voriconazole mediated inhibition of CYP450 enzyme. |
Aspergillosis [1F20]
|
[15] |
Posaconazole |
DMUL5EW
|
Major |
Decreased metabolism of Alfuzosin caused by Posaconazole mediated inhibition of CYP450 enzyme. |
Aspergillosis [1F20]
|
[15] |
Levalbuterol |
DM5YBO1
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Alfuzosin and Levalbuterol. |
Asthma [CA23]
|
[17] |
Terbutaline |
DMD4381
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Alfuzosin and Terbutaline. |
Asthma [CA23]
|
[18] |
Pirbuterol |
DMI5678
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Pirbuterol. |
Asthma [CA23]
|
[18] |
Salbutamol |
DMN9CWF
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Alfuzosin and Salbutamol. |
Asthma [CA23]
|
[17] |
Formoterol |
DMSOURV
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Alfuzosin and Formoterol. |
Asthma [CA23]
|
[18] |
Lisdexamfetamine |
DM6W8V5
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Lisdexamfetamine. |
Attention deficit hyperactivity disorder [6A05]
|
[19] |
Desipramine |
DMT2FDC
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Desipramine. |
Attention deficit hyperactivity disorder [6A05]
|
[13] |
Ofloxacin |
DM0VQN3
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Ofloxacin. |
Bacterial infection [1A00-1C4Z]
|
[20] |
Ciprofloxacin XR |
DM2NLS9
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Ciprofloxacin XR. |
Bacterial infection [1A00-1C4Z]
|
[13] |
Dalfopristin |
DM4LTKV
|
Moderate |
Decreased metabolism of Alfuzosin caused by Dalfopristin mediated inhibition of CYP450 enzyme. |
Bacterial infection [1A00-1C4Z]
|
[11] |
Sulfamethoxazole |
DMB08GE
|
Minor |
Increased risk of prolong QT interval by the combination of Alfuzosin and Sulfamethoxazole. |
Bacterial infection [1A00-1C4Z]
|
[13] |
Sparfloxacin |
DMB4HCT
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Sparfloxacin. |
Bacterial infection [1A00-1C4Z]
|
[20] |
Chloramphenicol |
DMFXEWT
|
Moderate |
Decreased metabolism of Alfuzosin caused by Chloramphenicol mediated inhibition of CYP450 enzyme. |
Bacterial infection [1A00-1C4Z]
|
[11] |
Linezolid |
DMGFPU2
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Linezolid. |
Bacterial infection [1A00-1C4Z]
|
[21] |
Gemifloxacin |
DMHT34O
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Gemifloxacin. |
Bacterial infection [1A00-1C4Z]
|
[20] |
Levofloxacin |
DMS60RB
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Levofloxacin. |
Bacterial infection [1A00-1C4Z]
|
[20] |
Troleandomycin |
DMUZNIG
|
Major |
Decreased metabolism of Alfuzosin caused by Troleandomycin mediated inhibition of CYP450 enzyme. |
Bacterial infection [1A00-1C4Z]
|
[15] |
Lomefloxacin |
DMVRH9C
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Lomefloxacin. |
Bacterial infection [1A00-1C4Z]
|
[13] |
Telithromycin |
DMZ4P3A
|
Major |
Decreased metabolism of Alfuzosin caused by Telithromycin mediated inhibition of CYP450 enzyme. |
Bacterial infection [1A00-1C4Z]
|
[15] |
Retigabine |
DMGNYIH
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Retigabine. |
Behcet disease [4A62]
|
[13] |
Cariprazine |
DMJYDVK
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Cariprazine. |
Bipolar disorder [6A60]
|
[22] |
Loperamide |
DMOJZQ9
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Loperamide. |
Bowel habit change [ME05]
|
[23] |
Lapatinib |
DM3BH1Y
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Lapatinib. |
Breast cancer [2C60-2C6Y]
|
[13] |
Tucatinib |
DMBESUA
|
Major |
Decreased metabolism of Alfuzosin caused by Tucatinib mediated inhibition of CYP450 enzyme. |
Breast cancer [2C60-2C6Y]
|
[15] |
Toremifene |
DMQYUWG
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Toremifene. |
Breast cancer [2C60-2C6Y]
|
[13] |
Bosutinib |
DMTI8YE
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Bosutinib. |
Breast cancer [2C60-2C6Y]
|
[19] |
Sotalol |
DML60TN
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Sotalol. |
Cardiac arrhythmia [BC9Z]
|
[13] |
PF-04449913 |
DMSB068
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and PF-04449913. |
Chronic myelomonocytic leukaemia [2A40]
|
[24] |
Olodaterol |
DM62B78
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Olodaterol. |
Chronic obstructive pulmonary disease [CA22]
|
[18] |
Vilanterol |
DMF5EK1
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Alfuzosin and Vilanterol. |
Chronic obstructive pulmonary disease [CA22]
|
[17] |
Salmeterol |
DMIEU69
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Alfuzosin and Salmeterol. |
Chronic obstructive pulmonary disease [CA22]
|
[18] |
Indacaterol |
DMQJHR7
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Alfuzosin and Indacaterol. |
Chronic obstructive pulmonary disease [CA22]
|
[18] |
Arformoterol |
DMYM974
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Alfuzosin and Arformoterol. |
Chronic obstructive pulmonary disease [CA22]
|
[18] |
Oxaliplatin |
DMQNWRD
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Oxaliplatin. |
Colorectal cancer [2B91]
|
[13] |
Isoproterenol |
DMK7MEY
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Isoproterenol. |
Conduction disorder [BC63]
|
[17] |
Olopatadine |
DMKMWQG
|
Moderate |
Additive CNS depression effects by the combination of Alfuzosin and Olopatadine. |
Conjunctiva disorder [9A60]
|
[25] |
Halothane |
DM80OZ5
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Halothane. |
Corneal disease [9A76-9A78]
|
[13] |
Propofol |
DMB4OLE
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Propofol. |
Corneal disease [9A76-9A78]
|
[26] |
Probucol |
DMVZQ2M
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Probucol. |
Coronary atherosclerosis [BA80]
|
[13] |
Clofazimine |
DMEBOFW
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Clofazimine. |
Crohn disease [DD70]
|
[27] |
Pasireotide |
DMHM7JS
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Pasireotide. |
Cushing syndrome [5A70]
|
[13] |
Osilodrostat |
DMIJC9X
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Osilodrostat. |
Cushing syndrome [5A70]
|
[19] |
Ivacaftor |
DMZC1HS
|
Moderate |
Decreased metabolism of Alfuzosin caused by Ivacaftor mediated inhibition of CYP450 enzyme. |
Cystic fibrosis [CA25]
|
[28] |
MK-8228 |
DMOB58Q
|
Moderate |
Decreased metabolism of Alfuzosin caused by MK-8228 mediated inhibition of CYP450 enzyme. |
Cytomegaloviral disease [1D82]
|
[11] |
Aprepitant |
DM053KT
|
Moderate |
Decreased metabolism of Alfuzosin caused by Aprepitant mediated inhibition of CYP450 enzyme. |
Depression [6A70-6A7Z]
|
[11] |
Sertraline |
DM0FB1J
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Sertraline. |
Depression [6A70-6A7Z]
|
[13] |
Trimipramine |
DM1SC8M
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Trimipramine. |
Depression [6A70-6A7Z]
|
[13] |
Imipramine |
DM2NUH3
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Imipramine. |
Depression [6A70-6A7Z]
|
[13] |
Fluoxetine |
DM3PD2C
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Fluoxetine. |
Depression [6A70-6A7Z]
|
[13] |
Nortriptyline |
DM4KDYJ
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Nortriptyline. |
Depression [6A70-6A7Z]
|
[13] |
Nefazodone |
DM4ZS8M
|
Major |
Decreased metabolism of Alfuzosin caused by Nefazodone mediated inhibition of CYP450 enzyme. |
Depression [6A70-6A7Z]
|
[15] |
Selegiline |
DM6034S
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Selegiline. |
Depression [6A70-6A7Z]
|
[21] |
Isocarboxazid |
DMAF1NB
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Isocarboxazid. |
Depression [6A70-6A7Z]
|
[21] |
Escitalopram |
DMFK9HG
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Escitalopram. |
Depression [6A70-6A7Z]
|
[13] |
Tranylcypromine |
DMGB5RE
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Tranylcypromine. |
Depression [6A70-6A7Z]
|
[21] |
OPC-34712 |
DMHG57U
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and OPC-34712. |
Depression [6A70-6A7Z]
|
[22] |
Phenelzine |
DMHIDUE
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Phenelzine. |
Depression [6A70-6A7Z]
|
[21] |
Clomipramine |
DMINRKW
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Clomipramine. |
Depression [6A70-6A7Z]
|
[13] |
Trazodone |
DMK1GBJ
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Trazodone. |
Depression [6A70-6A7Z]
|
[29] |
Amoxapine |
DMKITQE
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Amoxapine. |
Depression [6A70-6A7Z]
|
[13] |
Doxepin |
DMPI98T
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Doxepin. |
Depression [6A70-6A7Z]
|
[13] |
Maprotiline |
DMPWB7T
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Maprotiline. |
Depression [6A70-6A7Z]
|
[13] |
Tetrabenazine |
DMYWQ0O
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Tetrabenazine. |
Dissociative neurological symptom disorder [6B60]
|
[13] |
Deutetrabenazine |
DMUPFLI
|
Moderate |
Additive CNS depression effects by the combination of Alfuzosin and Deutetrabenazine. |
Dystonic disorder [8A02]
|
[30] |
Ingrezza |
DMVPLNC
|
Moderate |
Additive CNS depression effects by the combination of Alfuzosin and Ingrezza. |
Dystonic disorder [8A02]
|
[31] |
Stiripentol |
DMMSDOY
|
Moderate |
Decreased metabolism of Alfuzosin caused by Stiripentol mediated inhibition of CYP450 enzyme. |
Epilepsy/seizure [8A61-8A6Z]
|
[11] |
Timolol |
DM3NXRU
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Timolol. |
Essential hypertension [BA00]
|
[32] |
Phenoxybenzamine |
DM8KSQH
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Phenoxybenzamine. |
Essential hypertension [BA00]
|
[11] |
Nadolol |
DMW6GVL
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Nadolol. |
Essential hypertension [BA00]
|
[32] |
Solifenacin |
DMG592Q
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Solifenacin. |
Functional bladder disorder [GC50]
|
[13] |
Pentamidine |
DMHZJCG
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Pentamidine. |
Fungal infection [1F29-1F2F]
|
[13] |
Ketoconazole |
DMPZI3Q
|
Major |
Decreased metabolism of Alfuzosin caused by Ketoconazole mediated inhibition of CYP450 enzyme. |
Fungal infection [1F29-1F2F]
|
[15] |
Phentolamine |
DMXYJOB
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Phentolamine. |
Gangrene [MC85]
|
[11] |
Cisapride |
DMY7PED
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Cisapride. |
Gastro-oesophageal reflux disease [DA22]
|
[13] |
Sunitinib |
DMCBJSR
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Sunitinib. |
Gastrointestinal stromal tumour [2B5B]
|
[13] |
Carteolol |
DMFMDOB
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Carteolol. |
Glaucoma [9C61]
|
[32] |
Metipranolol |
DMJMVKI
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Metipranolol. |
Glaucoma [9C61]
|
[32] |
Levobetaxolol |
DMSREPX
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Levobetaxolol. |
Glaucoma [9C61]
|
[32] |
Levobunolol |
DMTNFCQ
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Levobunolol. |
Glaucoma [9C61]
|
[32] |
Prazosin |
DMCD9YG
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Prazosin. |
Heart failure [BD10-BD1Z]
|
[11] |
Carvedilol |
DMHTEAO
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Carvedilol. |
Heart failure [BD10-BD1Z]
|
[32] |
Boceprevir |
DMBSHMF
|
Major |
Decreased metabolism of Alfuzosin caused by Boceprevir mediated inhibition of CYP450 enzyme. |
Hepatitis virus infection [1E50-1E51]
|
[15] |
Telaprevir |
DMMRV29
|
Major |
Decreased metabolism of Alfuzosin caused by Telaprevir mediated inhibition of CYP450 enzyme. |
Hepatitis virus infection [1E50-1E51]
|
[15] |
Rifapentine |
DMCHV4I
|
Moderate |
Increased metabolism of Alfuzosin caused by Rifapentine mediated induction of CYP450 enzyme. |
HIV-infected patients with tuberculosis [1B10-1B14]
|
[33] |
Procarbazine |
DMIK367
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Procarbazine. |
Hodgkin lymphoma [2B30]
|
[21] |
Delavirdine |
DM3NF5G
|
Major |
Decreased metabolism of Alfuzosin caused by Delavirdine mediated inhibition of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[15] |
Fosamprenavir |
DM4W9B3
|
Major |
Decreased metabolism of Alfuzosin caused by Fosamprenavir mediated inhibition of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[15] |
Cobicistat |
DM6L4H2
|
Major |
Decreased metabolism of Alfuzosin caused by Cobicistat mediated inhibition of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[15] |
Efavirenz |
DMC0GSJ
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Efavirenz. |
Human immunodeficiency virus disease [1C60-1C62]
|
[34] |
Saquinavir |
DMG814N
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Saquinavir. |
Human immunodeficiency virus disease [1C60-1C62]
|
[35] |
Etravirine |
DMGV8QU
|
Moderate |
Increased metabolism of Alfuzosin caused by Etravirine mediated induction of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[36] |
Rilpivirine |
DMJ0QOW
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Rilpivirine. |
Human immunodeficiency virus disease [1C60-1C62]
|
[13] |
Amprenavir |
DMLMXE0
|
Major |
Decreased metabolism of Alfuzosin caused by Amprenavir mediated inhibition of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[15] |
Atazanavir |
DMSYRBX
|
Major |
Decreased metabolism of Alfuzosin caused by Atazanavir mediated inhibition of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[15] |
Ritonavir |
DMU764S
|
Major |
Decreased metabolism of Alfuzosin caused by Ritonavir mediated inhibition of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[15] |
Acebutolol |
DM0TI4U
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Acebutolol. |
Hypertension [BA00-BA04]
|
[32] |
Moexipril |
DM26E4B
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Moexipril. |
Hypertension [BA00-BA04]
|
[37] |
Bisoprolol |
DM3UZ95
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Bisoprolol. |
Hypertension [BA00-BA04]
|
[32] |
Captopril |
DM458UM
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Captopril. |
Hypertension [BA00-BA04]
|
[37] |
Penbutolol |
DM4ES8F
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Penbutolol. |
Hypertension [BA00-BA04]
|
[32] |
Trandolapril |
DM4L6EU
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Trandolapril. |
Hypertension [BA00-BA04]
|
[37] |
Nebivolol |
DM7F1PA
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Nebivolol. |
Hypertension [BA00-BA04]
|
[32] |
Fosinopril |
DM9NJ52
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Fosinopril. |
Hypertension [BA00-BA04]
|
[37] |
Doxazosin |
DM9PLRH
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Doxazosin. |
Hypertension [BA00-BA04]
|
[11] |
Pindolol |
DMD2NV7
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Pindolol. |
Hypertension [BA00-BA04]
|
[32] |
Benazepril |
DMH1M9B
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Benazepril. |
Hypertension [BA00-BA04]
|
[37] |
Labetalol |
DMK8U72
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Labetalol. |
Hypertension [BA00-BA04]
|
[32] |
Enalapril |
DMNFUZR
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Enalapril. |
Hypertension [BA00-BA04]
|
[37] |
Perindopril |
DMOPZDT
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Perindopril. |
Hypertension [BA00-BA04]
|
[37] |
Quinapril |
DMR8H31
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Quinapril. |
Hypertension [BA00-BA04]
|
[37] |
Conivaptan |
DM1V329
|
Moderate |
Decreased metabolism of Alfuzosin caused by Conivaptan mediated inhibition of CYP450 enzyme. |
Hypo-osmolality/hyponatraemia [5C72]
|
[11] |
Propiomazine |
DMKY8V1
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Propiomazine. |
Insomnia [7A00-7A0Z]
|
[22] |
ITI-007 |
DMUQ1DO
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and ITI-007. |
Insomnia [7A00-7A0Z]
|
[22] |
Polyethylene glycol |
DM4I1JP
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Alfuzosin and Polyethylene glycol. |
Irritable bowel syndrome [DD91]
|
[19] |
Phenolphthalein |
DM5SICT
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Alfuzosin and Phenolphthalein. |
Irritable bowel syndrome [DD91]
|
[13] |
Crizotinib |
DM4F29C
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Crizotinib. |
Lung cancer [2C25]
|
[38] |
Ceritinib |
DMB920Z
|
Major |
Decreased metabolism of Alfuzosin caused by Ceritinib mediated inhibition of CYP450 enzyme. |
Lung cancer [2C25]
|
[15] |
PF-06463922 |
DMKM7EW
|
Moderate |
Increased metabolism of Alfuzosin caused by PF-06463922 mediated induction of CYP450 enzyme. |
Lung cancer [2C25]
|
[39] |
Osimertinib |
DMRJLAT
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Osimertinib. |
Lung cancer [2C25]
|
[40] |
Selpercatinib |
DMZR15V
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Selpercatinib. |
Lung cancer [2C25]
|
[19] |
Halofantrine |
DMOMK1V
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Halofantrine. |
Malaria [1F40-1F45]
|
[41] |
Chloroquine |
DMSI5CB
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Chloroquine. |
Malaria [1F40-1F45]
|
[42] |
Hydroxychloroquine |
DMSIVND
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Hydroxychloroquine. |
Malaria [1F40-1F45]
|
[42] |
Quinine |
DMSWYF5
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Quinine. |
Malaria [1F40-1F45]
|
[13] |
Primaquine |
DMWQ16I
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Primaquine. |
Malaria [1F40-1F45]
|
[13] |
Mefloquine |
DMWT905
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Mefloquine. |
Malaria [1F40-1F45]
|
[13] |
Inotuzumab ozogamicin |
DMAC130
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Inotuzumab ozogamicin. |
Malignant haematopoietic neoplasm [2B33]
|
[19] |
Idelalisib |
DM602WT
|
Major |
Decreased metabolism of Alfuzosin caused by Idelalisib mediated inhibition of CYP450 enzyme. |
Mature B-cell leukaemia [2A82]
|
[15] |
IPI-145 |
DMWA24P
|
Moderate |
Decreased metabolism of Alfuzosin caused by IPI-145 mediated inhibition of CYP450 enzyme. |
Mature B-cell leukaemia [2A82]
|
[11] |
Arsenic trioxide |
DM61TA4
|
Major |
Increased risk of ventricular arrhythmias by the combination of Alfuzosin and Arsenic trioxide. |
Mature B-cell lymphoma [2A85]
|
[43] |
Vemurafenib |
DM62UG5
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Vemurafenib. |
Melanoma [2C30]
|
[13] |
LGX818 |
DMNQXV8
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and LGX818. |
Melanoma [2C30]
|
[44] |
Dabrafenib |
DMX6OE3
|
Moderate |
Increased metabolism of Alfuzosin caused by Dabrafenib mediated induction of CYP450 enzyme. |
Melanoma [2C30]
|
[19] |
Danazol |
DML8KTN
|
Moderate |
Decreased metabolism of Alfuzosin caused by Danazol mediated inhibition of CYP450 enzyme. |
Menstrual cycle bleeding disorder [GA20]
|
[11] |
Propranolol |
DM79NTF
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Propranolol. |
Migraine [8A80]
|
[32] |
Exjade |
DMHPRWG
|
Moderate |
Decreased metabolism of Alfuzosin caused by Exjade mediated inhibition of CYP450 enzyme. |
Mineral absorption/transport disorder [5C64]
|
[45] |
Panobinostat |
DM58WKG
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Panobinostat. |
Multiple myeloma [2A83]
|
[46] |
Thalidomide |
DM70BU5
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Alfuzosin and Thalidomide. |
Multiple myeloma [2A83]
|
[15] |
Fingolimod |
DM5JVAN
|
Major |
Increased risk of ventricular arrhythmias by the combination of Alfuzosin and Fingolimod. |
Multiple sclerosis [8A40]
|
[13] |
Ozanimod |
DMT6AM2
|
Major |
Increased risk of ventricular arrhythmias by the combination of Alfuzosin and Ozanimod. |
Multiple sclerosis [8A40]
|
[47] |
Fedratinib |
DM4ZBK6
|
Moderate |
Decreased metabolism of Alfuzosin caused by Fedratinib mediated inhibition of CYP450 enzyme. |
Myeloproliferative neoplasm [2A20]
|
[11] |
Imatinib |
DM7RJXL
|
Moderate |
Decreased metabolism of Alfuzosin caused by Imatinib mediated inhibition of CYP450 enzyme. |
Myeloproliferative neoplasm [2A20]
|
[11] |
Dasatinib |
DMJV2EK
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Dasatinib. |
Myeloproliferative neoplasm [2A20]
|
[13] |
Modafinil |
DMYILBE
|
Minor |
Increased metabolism of Alfuzosin caused by Modafinil mediated induction of CYP450 enzyme. |
Narcolepsy [7A20]
|
[48] |
Prochlorperazine |
DM53SRA
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Prochlorperazine. |
Nausea/vomiting [MD90]
|
[13] |
Promethazine |
DM6I5GR
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Promethazine. |
Nausea/vomiting [MD90]
|
[22] |
Palonosetron |
DMBHMOX
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Palonosetron. |
Nausea/vomiting [MD90]
|
[13] |
Granisetron |
DMIUW25
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Granisetron. |
Nausea/vomiting [MD90]
|
[13] |
Dolasetron |
DMMG26Z
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Dolasetron. |
Nausea/vomiting [MD90]
|
[13] |
Ondansetron |
DMOTQ1I
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Ondansetron. |
Nausea/vomiting [MD90]
|
[13] |
Entrectinib |
DMMPTLH
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Entrectinib. |
Non-small cell lung cancer [2C25]
|
[15] |
Levomethadyl Acetate |
DM06HG5
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Levomethadyl Acetate. |
Opioid use disorder [6C43]
|
[19] |
Lofexidine |
DM1WXA6
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Lofexidine. |
Opioid use disorder [6C43]
|
[13] |
Rucaparib |
DM9PVX8
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Rucaparib. |
Ovarian cancer [2C73]
|
[13] |
Dextropropoxyphene |
DM23HCX
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Dextropropoxyphene. |
Pain [MG30-MG3Z]
|
[13] |
Buprenorphine |
DMPRI8G
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Buprenorphine. |
Pain [MG30-MG3Z]
|
[13] |
Triclabendazole |
DMPWGBR
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Triclabendazole. |
Parasitic worm infestation [1F90]
|
[13] |
Safinamide |
DM0YWJC
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Safinamide. |
Parkinsonism [8A00]
|
[21] |
Rasagiline |
DM3WKQ4
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Rasagiline. |
Parkinsonism [8A00]
|
[21] |
Pimavanserin |
DMR7IVC
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Pimavanserin. |
Parkinsonism [8A00]
|
[49] |
Apomorphine |
DMX38HQ
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Apomorphine. |
Parkinsonism [8A00]
|
[13] |
Abametapir |
DM2RX0I
|
Moderate |
Decreased metabolism of Alfuzosin caused by Abametapir mediated inhibition of CYP450 enzyme. |
Pediculosis [1G00]
|
[50] |
Famotidine |
DMRL3AB
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Famotidine. |
Peptic ulcer [DA61]
|
[15] |
Lefamulin |
DME6G97
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Lefamulin. |
Pneumonia [CA40]
|
[51] |
Lonafarnib |
DMGM2Z6
|
Major |
Decreased metabolism of Alfuzosin caused by Lonafarnib mediated inhibition of CYP450 enzyme. |
Premature ageing appearance [LD2B]
|
[15] |
Ritodrine |
DM4V6RL
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Alfuzosin and Ritodrine. |
Preterm labour/delivery [JB00]
|
[18] |
Degarelix |
DM3O8QY
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Degarelix. |
Prostate cancer [2C82]
|
[19] |
ABIRATERONE |
DM8V75C
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and ABIRATERONE. |
Prostate cancer [2C82]
|
[19] |
Nilutamide |
DMFN07X
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Nilutamide. |
Prostate cancer [2C82]
|
[19] |
Enzalutamide |
DMGL19D
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Enzalutamide. |
Prostate cancer [2C82]
|
[19] |
Flutamide |
DMK0O7U
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Flutamide. |
Prostate cancer [2C82]
|
[19] |
Bicalutamide |
DMZMSPF
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Bicalutamide. |
Prostate cancer [2C82]
|
[19] |
Levomepromazine |
DMIKFEL
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Levomepromazine. |
Psychotic disorder [6A20-6A25]
|
[13] |
Fluphenazine |
DMIT8LX
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Fluphenazine. |
Psychotic disorder [6A20-6A25]
|
[13] |
Triflupromazine |
DMKFQJP
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Triflupromazine. |
Psychotic disorder [6A20-6A25]
|
[13] |
Tolazoline |
DMI40NL
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Tolazoline. |
Pulmonary hypertension [BB01]
|
[11] |
Sorafenib |
DMS8IFC
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Sorafenib. |
Renal cell carcinoma [2C90]
|
[13] |
Gatifloxacin |
DMSL679
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Gatifloxacin. |
Respiratory infection [CA07-CA4Z]
|
[52] |
Mesoridazine |
DM2ZGAN
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Mesoridazine. |
Schizophrenia [6A20]
|
[13] |
Thioridazine |
DM35M8J
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Thioridazine. |
Schizophrenia [6A20]
|
[13] |
Aripiprazole |
DM3NUMH
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Aripiprazole. |
Schizophrenia [6A20]
|
[22] |
Iloperidone |
DM6AUFY
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Iloperidone. |
Schizophrenia [6A20]
|
[13] |
Paliperidone |
DM7NPJS
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Paliperidone. |
Schizophrenia [6A20]
|
[53] |
Loxapine |
DM8AI9U
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Loxapine. |
Schizophrenia [6A20]
|
[22] |
Haloperidol |
DM96SE0
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Haloperidol. |
Schizophrenia [6A20]
|
[13] |
Perphenazine |
DMA4MRX
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Perphenazine. |
Schizophrenia [6A20]
|
[13] |
Molindone |
DMAH70G
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Molindone. |
Schizophrenia [6A20]
|
[22] |
Chlorpromazine |
DMBGZI3
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Chlorpromazine. |
Schizophrenia [6A20]
|
[13] |
Thiothixene |
DMDINC4
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Thiothixene. |
Schizophrenia [6A20]
|
[22] |
Clozapine |
DMFC71L
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Clozapine. |
Schizophrenia [6A20]
|
[13] |
Trifluoperazine |
DMKBYWI
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Trifluoperazine. |
Schizophrenia [6A20]
|
[13] |
Risperidone |
DMN6DXL
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Risperidone. |
Schizophrenia [6A20]
|
[53] |
Amisulpride |
DMSJVAM
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Amisulpride. |
Schizophrenia [6A20]
|
[54] |
Asenapine |
DMSQZE2
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Asenapine. |
Schizophrenia [6A20]
|
[13] |
Pimozide |
DMW83TP
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Pimozide. |
Schizophrenia [6A20]
|
[19] |
Larotrectinib |
DM26CQR
|
Moderate |
Decreased metabolism of Alfuzosin caused by Larotrectinib mediated inhibition of CYP450 enzyme. |
Solid tumour/cancer [2A00-2F9Z]
|
[15] |
Armodafinil |
DMGB035
|
Minor |
Increased metabolism of Alfuzosin caused by Armodafinil mediated induction of CYP450 enzyme. |
Solid tumour/cancer [2A00-2F9Z]
|
[48] |
LEE011 |
DMMX75K
|
Major |
Decreased metabolism of Alfuzosin caused by LEE011 mediated inhibition of CYP450 enzyme. |
Solid tumour/cancer [2A00-2F9Z]
|
[13] |
Epirubicin |
DMPDW6T
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Epirubicin. |
Solid tumour/cancer [2A00-2F9Z]
|
[13] |
Vandetanib |
DMRICNP
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Vandetanib. |
Solid tumour/cancer [2A00-2F9Z]
|
[13] |
Triptorelin |
DMTK4LS
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Triptorelin. |
Solid tumour/cancer [2A00-2F9Z]
|
[19] |
Doxorubicin |
DMVP5YE
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Doxorubicin. |
Solid tumour/cancer [2A00-2F9Z]
|
[13] |
Pitolisant |
DM8RFNJ
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Pitolisant. |
Somnolence [MG42]
|
[19] |
Telavancin |
DM58VQX
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Telavancin. |
Staphylococcal/streptococcal disease [1B5Y]
|
[13] |
Adenosine |
DMM2NSK
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Alfuzosin and Adenosine. |
Supraventricular tachyarrhythmia [BC81]
|
[13] |
Fostamatinib |
DM6AUHV
|
Moderate |
Decreased metabolism of Alfuzosin caused by Fostamatinib mediated inhibition of CYP450 enzyme. |
Thrombocytopenia [3B64]
|
[55] |
Lenvatinib |
DMB1IU4
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Lenvatinib. |
Thyroid cancer [2D10]
|
[13] |
Cabozantinib |
DMIYDT4
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Cabozantinib. |
Thyroid cancer [2D10]
|
[19] |
Papaverine |
DMCA9QP
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Papaverine. |
Tonus and reflex abnormality [MB47]
|
[56] |
Tizanidine |
DMR2IQ4
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Tizanidine. |
Tonus and reflex abnormality [MB47]
|
[11] |
Tacrolimus |
DMZ7XNQ
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Tacrolimus. |
Transplant rejection [NE84]
|
[13] |
Astemizole |
DM2HN6Q
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Astemizole. |
Vasomotor/allergic rhinitis [CA08]
|
[13] |
Methdilazine |
DMAUHQX
|
Moderate |
Additive hypotensive effects by the combination of Alfuzosin and Methdilazine. |
Vasomotor/allergic rhinitis [CA08]
|
[22] |
Trimeprazine |
DMEMV9D
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Trimeprazine. |
Vasomotor/allergic rhinitis [CA08]
|
[13] |
Procainamide |
DMNMXR8
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Procainamide. |
Ventricular tachyarrhythmia [BC71]
|
[13] |
Propafenone |
DMPIBJK
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Propafenone. |
Ventricular tachyarrhythmia [BC71]
|
[13] |
Flecainide |
DMSQDLE
|
Moderate |
Increased risk of prolong QT interval by the combination of Alfuzosin and Flecainide. |
Ventricular tachyarrhythmia [BC71]
|
[13] |
Amiodarone |
DMUTEX3
|
Major |
Increased risk of prolong QT interval by the combination of Alfuzosin and Amiodarone. |
Ventricular tachyarrhythmia [BC71]
|
[13] |
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