Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM471P5)

Drug Name

4-hydroxybenzaldehyde Drug Info

Synonyms

4-hydroxybenzaldehyde; p-Hydroxybenzaldehyde; 123-08-0; 4-Formylphenol; p-Formylphenol; p-Oxybenzaldehyde; Benzaldehyde, 4-hydroxy-; Parahydroxybenzaldehyde; Benzaldehyde, p-hydroxy-; 4-HYDROXY-BENZALDEHYDE; USAF M-6; 4-Hydroxy benzaldehyde; NSC 2127; p-Hydroxy-benzaldehyde; UNII-O1738X3Y38; Para-Hydroxybenzaldehyde; 4-Hydroxybenzenecarbonal; EINECS 204-599-1; BRN 0471352; CHEMBL14193; AI3-15366; PARA-HYDROXY BENZALDEHYDE; CHEBI:17597; RGHHSNMVTDWUBI-UHFFFAOYSA-N; MFCD00006939; O1738X3Y38; 4-Hydroxybenzaldehyde, 99%; Benzaldehyde, 4-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 126
ChEBI ID: CHEBI:17597
CAS Number: CAS 123-08-0
TTD Drug ID: DM471P5

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting GABA transaminase (ABAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Alanine	DMZDN4W	Dietary shortage	5B5K	Approved	[3]
Pyridoxal Phosphate	DMO2K0J	Malnutrition	5B50-5B71	Approved	[3]
Pyruvic acid	DM7Q41G	Malnutrition	5B50-5B71	Approved	[3]
Vigabatrin	DMYT0OG	Alcohol dependence	6C40.2	Approved	[4]
Divalproex sodium	DM4RK0G	Seizure disorder	8A6Z	Approved	[3]
CPP-115	DMK9NQI	Tourette syndrome	8A05.00	Phase 2	[5]
K-828-AB	DMJLNZQ	Dementia	6D80-6D86	Phase 2	[6]
CPP -15	DMQCHU3	Infantile spasm	8A62.0	Phase 1	[5]
T83193	DMHO29Y	Discovery agent	N.A.	Patented	[7]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[8]
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Drug(s) Targeting Monoamine oxidase type B (MAO-B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selegiline Hydrochloride	DM3VR1L	Parkinson disease	8A00.0	Approved	[9]
Phenelzine	DMHIDUE	Depression	6A70-6A7Z	Approved	[10]
Tranylcypromine	DMGB5RE	Major depressive disorder	6A70.3	Approved	[11]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[12]
Safinamide mesylate	DM0J2ZT	Parkinson disease	8A00.0	Approved	[13]
Rasagiline	DM3WKQ4	Parkinson disease	8A00.0	Approved	[14]
Sulphadoxine	DMZI2UF	Malaria	1F40-1F45	Approved	[15]
Pargyline	DMM0HR1	Hypertension	BA00-BA04	Approved	[16]
Indeloxazine	DMWO3N6	Dementia	6D80-6D86	Approved	[17]
Budipine	DMODHQI	Migraine	8A80	Approved	[18]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
GABA transaminase (ABAT)	TTT2LD9	GABT_HUMAN	Inhibitor	[1]
Monoamine oxidase type B (MAO-B)	TTGP7BY	AOFB_HUMAN	Inhibitor	[2]

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References

1	Inactivation of GABA transaminase by 3-chloro-1-(4-hydroxyphenyl)propan-1-one. Bioorg Med Chem Lett. 2009 Feb 1;19(3):731-4.
2	Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110.
3	DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6.
4	Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
5	Clinical pipeline report, company report or official report of Catalyst Pharma.
6	Phase II clinical trial of K-828-AB for treating behavioral and psychological symptoms of dementia. Kowa Co. Ltd.
7	Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives. Bioorg Med Chem Lett. 2006 Feb;16(3):592-5.
8	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
9	Emerging drugs for Parkinson's disease. Expert Opin Emerg Drugs. 2006 Sep;11(3):403-17.
10	Limitation of adipose tissue enlargement in rats chronically treated with semicarbazide-sensitive amine oxidase and monoamine oxidase inhibitors. Pharmacol Res. 2008 Jun;57(6):426-34.
11	Tranylcypromine: new perspectives on an "old" drug. Eur Arch Psychiatry Clin Neurosci. 2006 Aug;256(5):268-73.
12	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2490).
13	2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
14	Glyceraldehyde-3-phosphate dehydrogenase-monoamine oxidase B-mediated cell death-induced by ethanol is prevented by rasagiline and 1-R-aminoindan. Neurotox Res. 2009 Aug;16(2):148-59.
15	Novel monoamine oxidase inhibitors, 3-(2-aminoethoxy)-1,2-benzisoxazole derivatives, and their differential reversibility. Jpn J Pharmacol. 2002 Feb;88(2):174-82.
16	Dose-dependent activation of distinct hypertrophic pathways by serotonin in cardiac cells. Am J Physiol Heart Circ Physiol. 2009 Aug;297(2):H821-8.
17	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
18	Multiple mechanisms of action: the pharmacological profile of budipine. J Neural Transm Suppl. 1999;56:83-105.