Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5DOAF)

• Drug Name: (1S,3R)-ACPD Drug Info
• Synonyms: (1S,3R)-1-ACPD; trans-ACPD; (1S,3S)-ACPD; 1S,3R-ACPD

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 104766
  CAS Number: CAS 111900-32-4
  TTD Drug ID: DM5DOAF

Molecule-Related Drug Atlas

Drug(s) Targeting Metabotropic glutamate receptor 3 (mGluR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LY404039	DMWZIRJ	Schizophrenia	6A20	Phase 3	[7]
RO-4995819	DMNTC7O	Major depressive disorder	6A70.3	Phase 2	[8]
Oleoyl-estrone	DM0RA8F	Alzheimer disease	8A20	Phase 2	[9]
MP-101	DMYCITZ	Alzheimer disease	8A20	Phase 2	[10]
BCI-838	DMRXDN3	Major depressive disorder	6A70.3	Phase 1	[11]
Pomaglumetad	DMTOLI5	Schizophrenia	6A20	Phase 1	[12]
BCI-632	DMZYCWT	Alzheimer disease	8A20	Phase 1	[13]
PMID25435285-Compound-16	DMKFX2G	N. A.	N. A.	Patented	[14]
PMID25435285-Compound-15	DMHBWNS	N. A.	N. A.	Patented	[14]
PMID25435285-Compound-20	DMG9FYH	N. A.	N. A.	Patented	[14]

Drug(s) Targeting Metabotropic glutamate receptor 1 (mGluR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PF-1913539	DMXEU14	Alzheimer disease	8A20	Discontinued in Phase 3	[15]
AZD8529	DMEQ2N1	Schizophrenia	6A20	Discontinued in Phase 2	[16]
AZD-9272	DMYSBN3	Neuropathic pain	8E43.0	Discontinued in Phase 1	[17]
NPS-2390	DMMRY0Z	Cerebrovascular ischaemia	8B1Z	Preclinical	[18]
A-841720	DMSO8IE	Pain	MG30-MG3Z	Preclinical	[19]
LY-367385	DM98POQ	Neurological disorder	6B60	Terminated	[20]
[3H]quisqualate	DMDQBTX	Discovery agent	N.A.	Investigative	[21]
L-CCG-I	DMPZ8XH	Discovery agent	N.A.	Investigative	[2]
(+)-MCPG	DMG5QJB	Discovery agent	N.A.	Investigative	[22]
PHCCC	DMNJY79	Discovery agent	N.A.	Investigative	[23]

Drug(s) Targeting Metabotropic glutamate receptor 6 (mGluR6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-serine-O-phosphate	DMTJ1NH	Discovery agent	N.A.	Investigative	[24]
L-CCG-I	DMPZ8XH	Discovery agent	N.A.	Investigative	[25]
MAP4	DMUCE93	Discovery agent	N.A.	Investigative	[26]
MPPG	DMJHQ9T	Discovery agent	N.A.	Investigative	[4]
[3H]LY341495	DMGX0Y8	Discovery agent	N.A.	Investigative	[5]
alpha-methylserine-O-phosphate	DMCIH1X	Discovery agent	N.A.	Investigative	[26]
L-AP4	DMPJFGI	Discovery agent	N.A.	Investigative	[24]
PHCCC	DMNJY79	Discovery agent	N.A.	Investigative	[27]
LSP4-2022	DMBWHGP	Discovery agent	N.A.	Investigative	[28]
(S)-3,4-DCPG	DMG5BUA	Discovery agent	N.A.	Investigative	[29]

Drug(s) Targeting Metabotropic glutamate receptor 7 (mGluR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-serine-O-phosphate	DMTJ1NH	Discovery agent	N.A.	Investigative	[5]
[3H]quisqualate	DMDQBTX	Discovery agent	N.A.	Investigative	[30]
L-CCG-I	DMPZ8XH	Discovery agent	N.A.	Investigative	[5]
(+)-MCPG	DMG5QJB	Discovery agent	N.A.	Investigative	[5]
MAP4	DMUCE93	Discovery agent	N.A.	Investigative	[5]
MPPG	DMJHQ9T	Discovery agent	N.A.	Investigative	[5]
[3H]LY341495	DMGX0Y8	Discovery agent	N.A.	Investigative	[5]
alpha-methylserine-O-phosphate	DMCIH1X	Discovery agent	N.A.	Investigative	[5]
L-AP4	DMPJFGI	Discovery agent	N.A.	Investigative	[5]
LSP4-2022	DMBWHGP	Discovery agent	N.A.	Investigative	[28]

Drug(s) Targeting Metabotropic glutamate receptor 2 (mGluR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RO-4995819	DMNTC7O	Major depressive disorder	6A70.3	Phase 2	[8]
Oleoyl-estrone	DM0RA8F	Alzheimer disease	8A20	Phase 2	[9]
MP-101	DMYCITZ	Alzheimer disease	8A20	Phase 2	[10]
JNJ-64281802	DMNMSVX	Dengue	1D20-1D2Z	Phase 2	[31]
BCI-838	DMRXDN3	Major depressive disorder	6A70.3	Phase 1	[11]
Pomaglumetad	DMTOLI5	Schizophrenia	6A20	Phase 1	[12]
BCI-632	DMZYCWT	Alzheimer disease	8A20	Phase 1	[13]
LY-2979165	DM16IX2	Bipolar disorder	6A60	Phase 1	[32]
JNJ-42491293	DMOL9JR	Psychiatric disorder	6E8Z	Phase 1	[33]
ADX71149	DMBUOX4	Epilepsy	8A60-8A68	Phase 1	[34]

Drug(s) Targeting Metabotropic glutamate receptor 8 (mGluR8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-serine-O-phosphate	DMTJ1NH	Discovery agent	N.A.	Investigative	[35]
[3H]quisqualate	DMDQBTX	Discovery agent	N.A.	Investigative	[30]
L-CCG-I	DMPZ8XH	Discovery agent	N.A.	Investigative	[35]
MAP4	DMUCE93	Discovery agent	N.A.	Investigative	[36]
MPPG	DMJHQ9T	Discovery agent	N.A.	Investigative	[6]
alpha-methylserine-O-phosphate	DMCIH1X	Discovery agent	N.A.	Investigative	[26]
L-AP4	DMPJFGI	Discovery agent	N.A.	Investigative	[35]
(S)-3,4-DCPG	DMG5BUA	Discovery agent	N.A.	Investigative	[29]
ACPT-I	DM264XN	Discovery agent	N.A.	Investigative	[37]
CPPG	DMVHX5T	Discovery agent	N.A.	Investigative	[36]

Drug(s) Targeting Metabotropic glutamate receptor 5 (mGluR5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AFQ056	DMMHSLC	Fragile X syndrome	LD55	Phase 2/3	[38]
ADX-48621	DM6GTMD	Parkinson disease	8A00.0	Phase 2/3	[39]
RG-7090	DMX8JYN	Fragile X syndrome	LD55	Phase 2	[40]
STX-107	DMLNKX7	Autism spectrum disorder	6A02	Phase 2	[41]
ADX10059	DMGVKHQ	Anxiety disorder	6B00-6B0Z	Phase 2	[42]
McN3377	DMTCADJ	Fragile X syndrome	LD55	Phase 1/2	[43]
MK-3328	DMW2O5D	Alzheimer disease	8A20	Phase 1	[44]
[3H]fenobam	DMBOXA1	Allodynia	MB40.1	Phase 1	[45]
RG7342	DMIW5NG	Schizophrenia	6A20	Phase 1	[46]
BMS-984923	DMFNDUL	Alzheimer disease	8A20	Phase 1	[47]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Metabotropic glutamate receptor 1 (mGluR1)	TTVBPDM	GRM1_HUMAN	Agonist	[2]
Metabotropic glutamate receptor 2 (mGluR2)	TTXJ47W	GRM2_HUMAN	Agonist	[3]
Metabotropic glutamate receptor 3 (mGluR3)	TT8A9EF	GRM3_HUMAN	Agonist	[3]
Metabotropic glutamate receptor 5 (mGluR5)	TTHS256	GRM5_HUMAN	Agonist	[2]
Metabotropic glutamate receptor 6 (mGluR6)	TTWRP2F	GRM6_HUMAN	Agonist	[4]
Metabotropic glutamate receptor 7 (mGluR7)	TT0I76D	GRM7_HUMAN	Agonist	[5]
Metabotropic glutamate receptor 8 (mGluR8)	TT0IFKL	GRM8_HUMAN	Agonist	[6]

References

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