Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7XZY5)

• Drug Name: Triapine Drug Info
• Synonyms: Triapine; 236392-56-6; 143621-35-6; 3-Apct; Pan 811; 3-Aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP; UNII-U4XIL4091C; NSC 663249; 200933-27-3; OCX 191; 2-((3-Aminopyridin-2-yl)methylene)hydrazinecarbothioamide; C7H9N5S; PAN-811; U4XIL4091C; 3-aminopyridine-2-carbaldehyde-thiosemicarbazone; [(E)-(3-amino-2-pyridyl)methyleneamino]thiourea; 3-Aminopyridine-2-carboxaldehyde- thiosemicarbazone; Hydrazinecarbothioamide, 2-((3-amino-2-pyridinyl)methylene)-; (E)-2-((3-aminopyridin-2-yl)methylene)hydrazinecarbothioamide

Indication

Disease Entry	ICD 11	Status	REF
Nerve injury	ND56.4	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 9571836
  CAS Number: CAS 143621-35-6
  TTD Drug ID: DM7XZY5

Molecule-Related Drug Atlas

Drug(s) Targeting Ribonucleoside-diphosphate reductase M2 (RRM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[4]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[4]
CO-101	DMH5GQU	Pancreatic cancer	2C10	Phase 2	[5]
CALAA-01	DMT4Z5B	Solid tumour/cancer	2A00-2F9Z	Phase 1	[6]
LY-2334737	DMCBV20	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
Gallium maltolate	DMX0Z51	Human immunodeficiency virus infection	1C62	Discontinued in Phase 2	[8]
MDL 101,731	DMKEYSX	Gastric adenocarcinoma	2B72	Discontinued in Phase 2	[9]
NKP-46	DMK8UD0	Solid tumour/cancer	2A00-2F9Z	Preclinical	[10]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[11]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[12]
Selenium	DM25CGV	N. A.	N. A.	Approved	[13]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[14]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[15]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[16]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[17]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[18]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[20]

Drug(s) Affected By Thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[28]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[29]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[30]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Ribonucleoside-diphosphate reductase M2 (RRM2)	TTBWDI0	RIR2_HUMAN	Modulator	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Gene/Protein Processing	[2]
Thioredoxin, mitochondrial	OTE9A5XQ	THIOM_HUMAN	Post-Translational Modifications	[3]
Thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3)	OTLB2WEU	PRDX3_HUMAN	Post-Translational Modifications	[3]

References

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