Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8YGOI)

• Drug Name: Quinolinic Acid Drug Info
• Synonyms: quinolinic acid; Pyridine-2,3-dicarboxylic acid; 2,3-pyridinedicarboxylic acid; 89-00-9; quinolinate; Pyridine-2,3-dicarboxylate; 339155-13-4; UNII-F6F0HK1URN; AI3-63017; 2,3-PyridinedicarboxylicAcid; EINECS 201-874-8; pyridine-2,3-carboxylate; NSC 13127; F6F0HK1URN; CHEMBL286204; 2,3-pyridine dicarboxylic acid; CHEBI:16675; GJAWHXHKYYXBSV-UHFFFAOYSA-N; 2,3-Pyridinedicarboxylic acid, 99%; Pyridin-2,3-dicarbonsaeure; 2,3-pyridinedicarboxylate; SMR000112287; 2,3-pyridindicarbons; SR-01000075472; HSDB 7511; PubChem8035

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 1066
  ChEBI ID: CHEBI:16675
  CAS Number: CAS 89-00-9
  TTD Drug ID: DM8YGOI

Molecule-Related Drug Atlas

Drug(s) Targeting Mycobacterium Nicotinate-nucleotide pyrophosphorylase (MycB nadC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Namn	DM1EZ3N	Discovery agent	N.A.	Investigative	[1]
5-Phosphoribosyl-1-(Beta-Methylene) Pyrophosphate	DMGK05W	Discovery agent	N.A.	Investigative	[1]
Phthalic Acid	DMF9T64	Discovery agent	N.A.	Investigative	[1]

Drug(s) Affected By Fibroblast growth factor 1 (FGF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[4]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[5]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[6]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[6]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[10]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[6]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[12]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[13]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[14]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[15]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[16]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[20]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[21]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Mycobacterium Nicotinate-nucleotide pyrophosphorylase (MycB nadC)	TTH29K0	NADC_MYCTU	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Gene/Protein Processing	[2]
Fibroblast growth factor 1 (FGF1)	OT8I64X8	FGF1_HUMAN	Protein Interaction/Cellular Processes	[3]

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [2] Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors activate the aryl hydrocarbon receptor. Toxicol Appl Pharmacol. 2017 May 15;323:74-80. doi: 10.1016/j.taap.2017.03.012. Epub 2017 Mar 20.
• [3] Kynurenic acid inhibits the release of the neurotrophic fibroblast growth factor (FGF)-1 and enhances proliferation of glia cells, in vitro. Cell Mol Neurobiol. 2005 Sep;25(6):981-93. doi: 10.1007/s10571-005-8469-y.
• [4] Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
• [5] Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
• [6] Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
• [7] Aberrantly expressed genes in HaCaT keratinocytes chronically exposed to arsenic trioxide. Biomark Insights. 2011 Feb 8;6:7-16.
• [8] Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
• [9] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [10] WNT7A/-catenin signaling induces FGF1 and influences sensitivity to niclosamide in ovarian cancer. Oncogene. 2015 Jun;34(26):3452-62. doi: 10.1038/onc.2014.277. Epub 2014 Sep 1.
• [11] Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
• [12] Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
• [13] Oxidative stress modulates expression of immune checkpoint genes via activation of AhR signaling. Toxicol Appl Pharmacol. 2022 Dec 15;457:116314. doi: 10.1016/j.taap.2022.116314. Epub 2022 Nov 9.
• [14] Profiling of enantiopure drugs towards aryl hydrocarbon (AhR), glucocorticoid (GR) and pregnane X (PXR) receptors in human reporter cell lines. Chem Biol Interact. 2014 Feb 5;208:64-76. doi: 10.1016/j.cbi.2013.11.018. Epub 2013 Dec 6.
• [15] Involvement of cytoskeleton in AhR-dependent CYP1A1 expression. Curr Drug Metab. 2006 Apr;7(3):301-13. doi: 10.2174/138920006776359310.
• [16] Sulindac and its metabolites induce carcinogen metabolizing enzymes in human colon cancer cells. Int J Cancer. 2008 Mar 1;122(5):990-8.
• [17] Quercetin, quercetin glycosides and taxifolin differ in their ability to induce AhR activation and CYP1A1 expression in HepG2 cells. Phytother Res. 2012 Nov;26(11):1746-52.
• [18] Omeprazole inhibits pancreatic cancer cell invasion through a nongenomic aryl hydrocarbon receptor pathway. Chem Res Toxicol. 2015 May 18;28(5):907-18.
• [19] Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
• [20] Expression and inducibility of cytochrome P450s (CYP1A1, 2B6, 2E1, 3A4) in human cord blood CD34(+) stem cell-derived differentiating neuronal cells. Toxicol Sci. 2012 Oct;129(2):392-410.
• [21] Induction of paraoxonase 1 and apolipoprotein A-I gene expression by aspirin. J Lipid Res. 2008 Oct;49(10):2142-8.