Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8ZRAE)

• Drug Name: 4-(Spiro[chromene-2,4'-piperidine]-4-yl)phenol Drug Info
• Synonyms: CHEMBL495074; SCHEMBL471335; BDBM50252834

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 25129433
  TTD Drug ID: DM8ZRAE

Molecule-Related Drug Atlas

Drug(s) Targeting Voltage-gated potassium channel Kv11.1 (KCNH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
VESNARINONE	DMBKX3C	Cardiac failure	BD10-BD13	Approved	[2]
M100907	DM7ZFBA	Sleep-wake disorder	7A00-7B2Z	Phase 3	[3]
HP-184	DMNOMV2	Multiple sclerosis	8A40	Phase 2	[4]
NITD609	DMQHBSX	Malaria	1F40-1F45	Phase 2	[5]
ABT-229	DMN3S1B	Pain	MG30-MG3Z	Phase 2	[6]
ISOQUINE	DMR17YI	Malaria	1F40-1F45	Phase 1	[7]
Pyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazine derivative 1	DMC8935	N. A.	N. A.	Patented	[8]
Isoindoline derivative 5	DMIUTQW	N. A.	N. A.	Patented	[9]
Isoindoline derivative 3	DM2MYL9	N. A.	N. A.	Patented	[9]
Isoindoline derivative 4	DMP1NKI	N. A.	N. A.	Patented	[9]

Drug(s) Targeting Opioid receptor mu (MOP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[10]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[11]
Hydromorphone	DMHP21E	Back pain	ME84.Z	Approved	[12]
Tapentadol hydrochloride	DMXLSH3	Acute pain	MG31	Approved	[13]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[14]
Alfentanil	DMVO0UB	Anaesthesia	9A78.6	Approved	[15]
Naloxegol	DML0B41	Opioid-induced constipation	DB32.1	Approved	[16]
Eluxadoline	DMYZ0P1	Diarrhea-predominant irritable bowel syndrome	DD91.01	Approved	[17]
Nalfurafine hcl	DMA9DHW	Uremic pruritus	EC90.10	Approved	[18]
Oxycodone	DMXLKHV	Osteoarthritis	FA00-FA05	Approved	[19]

Drug(s) Targeting Opioid receptor delta (OPRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Codeine	DMJX6ZG	Allergic rhinitis	CA08.0	Approved	[20]
Hydromorphone	DMHP21E	Back pain	ME84.Z	Approved	[21]
Loperamide	DMOJZQ9	Diarrhea	ME05.1	Approved	[22]
Eluxadoline	DMYZ0P1	Diarrhea-predominant irritable bowel syndrome	DD91.01	Approved	[17]
Oxycodone	DMXLKHV	Osteoarthritis	FA00-FA05	Approved	[23]
Butorphanol	DM5KYPJ	Pain	MG30-MG3Z	Approved	[20]
Carfentanil	DM7ADGX	N. A.	N. A.	Phase 2	[24]
Met-enkephalin	DMSZFTP	Pain	MG30-MG3Z	Phase 2	[25]
AZD-2327	DM8FZOG	Anxiety disorder	6B00-6B0Z	Phase 2	[26]
ADL-5747	DMMUPTN	Pain	MG30-MG3Z	Phase 2	[27]

Drug(s) Targeting Opioid receptor kappa (OPRK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nalbuphine	DMOSQGU	Pain	MG30-MG3Z	Approved	[28]
Nalfurafine hcl	DMA9DHW	Uremic pruritus	EC90.10	Approved	[18]
CHLOROXINE	DMFZBMQ	Erythema	ME64.0	Approved	[29]
Difelikefalin	DMHZBEO	Pruritus	EC90	Approved	[30]
Dezocine	DMJDB0Y	Pain	MG30-MG3Z	Approved	[31]
Asimadoline	DMND3AB	Diarrhea-predominant irritable bowel syndrome	DD91.01	Phase 3	[32]
JNJ 67953964	DMJ8Y5N	Major depressive disorder	6A70.3	Phase 3	[33]
PHN-131	DM1SV8I	Pain	MG30-MG3Z	Phase 2/3	[34]
CR-845	DMJYTUQ	Pain	MG30-MG3Z	Phase 2/3	[35]
Carfentanil	DM7ADGX	N. A.	N. A.	Phase 2	[24]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Opioid receptor delta (OPRD1)	TT27RFC	OPRD_HUMAN	Inhibitor	[1]
Opioid receptor kappa (OPRK1)	TTQW87Y	OPRK_HUMAN	Inhibitor	[1]
Opioid receptor mu (MOP)	TTKWM86	OPRM_HUMAN	Inhibitor	[1]
Voltage-gated potassium channel Kv11.1 (KCNH2)	TTQ6VDM	KCNH2_HUMAN	Inhibitor	[1]

References

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