Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM98FQO)

• Drug Name: 6-Methoxy-4,9-dihydro-3H-beta-carboline Drug Info
• Synonyms: 6-Methoxy-4,9-dihydro-3H-beta-carboline; CHEMBL6717; SCHEMBL8369162; BDBM50136505; AKOS023554679; 3,4-Dihydro-6-methoxy-beta-carboline

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 15160217
  TTD Drug ID: DM98FQO

Molecule-Related Drug Atlas

Drug(s) Targeting Monoamine oxidase type B (MAO-B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selegiline Hydrochloride	DM3VR1L	Parkinson disease	8A00.0	Approved	[2]
Phenelzine	DMHIDUE	Depression	6A70-6A7Z	Approved	[3]
Tranylcypromine	DMGB5RE	Major depressive disorder	6A70.3	Approved	[4]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[5]
Safinamide mesylate	DM0J2ZT	Parkinson disease	8A00.0	Approved	[6]
Rasagiline	DM3WKQ4	Parkinson disease	8A00.0	Approved	[7]
Sulphadoxine	DMZI2UF	Malaria	1F40-1F45	Approved	[8]
Pargyline	DMM0HR1	Hypertension	BA00-BA04	Approved	[9]
Indeloxazine	DMWO3N6	Dementia	6D80-6D86	Approved	[10]
Budipine	DMODHQI	Migraine	8A80	Approved	[11]

Drug(s) Targeting Monoamine oxidase type A (MAO-A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Moclobemide	DMNZWL7	Depression	6A70-6A7Z	Approved	[12]
Tranylcypromine	DMGB5RE	Major depressive disorder	6A70.3	Approved	[13]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[14]
Isocarboxazid	DMAF1NB	Depression	6A70-6A7Z	Approved	[15]
TRYPTAMINE	DMAFPHB	N. A.	N. A.	Phase 3	[16]
Psoralen	DMIZJ8M	N. A.	N. A.	Phase 3	[17]
CHF-3381	DMQ2O8V	Neuropathic pain	8E43.0	Phase 2	[18]
Ladostigil	DMJSY3Q	Alzheimer disease	8A20	Phase 2	[19]
CX157	DMS2WB5	Mood disorder	6A60-6E23	Phase 2	[20]
PIPERINE	DMYEAB1	Vitiligo	ED63.0	Phase 1/2	[21]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Monoamine oxidase type A (MAO-A)	TT3WG5C	AOFA_HUMAN	Inhibitor	[1]
Monoamine oxidase type B (MAO-B)	TTGP7BY	AOFB_HUMAN	Inhibitor	[1]

References

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• [11] Multiple mechanisms of action: the pharmacological profile of budipine. J Neural Transm Suppl. 1999;56:83-105.
• [12] Efficacy of citalopram and moclobemide in patients with social phobia: some preliminary findings. Hum Psychopharmacol. 2002 Dec;17(8):401-5.
• [13] Tramadol and another atypical opioid meperidine have exaggerated serotonin syndrome behavioural effects, but decreased analgesic effects, in genetically deficient serotonin transporter (SERT) mice. Int J Neuropsychopharmacol. 2009 Mar 11:1-11.
• [14] Further investigation into the mechanism of tachykinin NK(2) receptor-triggered serotonin release from guinea-pig proximal colon. J Pharmacol Sci. 2009 May;110(1):122-6.
• [15] MAOIs in the contemporary treatment of depression. Neuropsychopharmacology. 1995 May;12(3):185-219.
• [16] Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002.
• [17] Inhibition of rat brain monoamine oxidase activities by psoralen and isopsoralen: implications for the treatment of affective disorders. Pharmacol Toxicol. 2001 Feb;88(2):75-80.
• [18] Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.
• [19] Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment. Curr Drug Targets. 2012 Apr;13(4):483-94.
• [20] Reversible inhibitors of monoamine oxidase-A (RIMAs): robust, reversible inhibition of human brain MAO-A by CX157. Neuropsychopharmacology. 2010 Feb;35(3):623-31.
• [21] Proposed structural basis of interaction of piperine and related compounds with monoamine oxidases. Bioorg Med Chem Lett. 2010 Jan 15;20(2):537-40.