Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9J50F)

• Drug Name: KT-5720 Drug Info
• Synonyms: KT 5720; KT5720; 108068-98-0; GTPL337; ZINC3873013; KT 5720, > hexyl (15R,16R,18S)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8,10,12,20,22,24-nonaene-16-carboxylate; (9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3 inverted exclamation marka,2 inverted exclamation marka,1 inverted exclamation marka-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-c

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 454202
  ChEBI ID: CHEBI:85085
  CAS Number: CAS 108068-98-0
  TTD Drug ID: DM9J50F

Molecule-Related Drug Atlas

Drug(s) Targeting Protein kinase C alpha (PRKCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[3]
Sotrastaurin acetate	DME53YS	Renal transplantation	NE84	Phase 2	[4]
PMID28460551-Compound-3	DMA1FRM	N. A.	N. A.	Patented	[5]
ISIS 3521	DMZFS69	N. A.	N. A.	Discontinued in Phase 2	[6]
BALANOL	DMDLN9E	N. A.	N. A.	Terminated	[7]
RO-320432	DMFZ1YW	N. A.	N. A.	Terminated	[8]
LY-317644	DMM20PI	N. A.	N. A.	Terminated	[9]
Acteoside	DM0YHKB	Nephritis	GB40	Terminated	[10]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[11]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole	DMN9YOB	Discovery agent	N.A.	Investigative	[12]

Drug(s) Targeting Stress-activated protein kinase JNK1 (JNK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NKP-1339	DM5AWK1	Solid tumour/cancer	2A00-2F9Z	Phase 1	[13]
PMID25991433-Compound-A1	DM89LF0	N. A.	N. A.	Patented	[14]
PMID25991433-Compound-F2	DM37VIQ	N. A.	N. A.	Patented	[14]
7-azaindole derivative 1	DMQL5B7	N. A.	N. A.	Patented	[14]
7-azaindole derivative 5	DMV3H98	N. A.	N. A.	Patented	[14]
PMID25991433-Compound-P6	DMNDVC9	N. A.	N. A.	Patented	[14]
PMID25991433-Compound-J3	DM17P3F	N. A.	N. A.	Patented	[14]
PMID25991433-Compound-P1	DMD8AX6	N. A.	N. A.	Patented	[14]
PMID25991433-Compound-O3	DMVOWS5	N. A.	N. A.	Patented	[14]
PMID25991433-Compound-L1	DM2135Y	N. A.	N. A.	Patented	[14]

Drug(s) Targeting Rho-associated protein kinase 1 (ROCK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Netarsudil	DM0LPI9	Open-angle glaucoma	9C61	Approved	[15]
SAR-407899	DMF95KD	Diabetic nephropathy	GB61.Z	Phase 2	[16]
H-1152	DM8XH3S	Pulmonary arterial hypertension	BB01.0	Phase 2	[17]
INS-117548	DMA46DO	Glaucoma/ocular hypertension	9C61	Phase 1	[18]
GSK269962A	DM5I2HL	Inflammation	1A00-CA43.1	Clinical trial	[19]
PMID28048944-Compound-19	DMPT3V9	N. A.	N. A.	Patented	[20]
PMID28048944-Compound-3	DM1BN74	N. A.	N. A.	Patented	[20]
PMID28048944-Compound-7	DMXZ368	N. A.	N. A.	Patented	[20]
PMID28048944-Compound-4	DMJAUWG	N. A.	N. A.	Patented	[20]
PMID28048944-Compound-5	DMAB987	N. A.	N. A.	Patented	[20]

Drug(s) Targeting Stress-activated protein kinase 2b (p38 beta)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
VX-745	DMJAEG6	Alzheimer disease	8A20	Phase 2	[21]
SB 235699	DMNH8XU	Psoriasis vulgaris	EA90	Discontinued in Phase 1	[21]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[2]
Bisindolylmaleimide-I	DMOQJZC	Discovery agent	N.A.	Investigative	[2]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole	DMN9YOB	Discovery agent	N.A.	Investigative	[12]
CI-1040	DMF3DZX	Discovery agent	N.A.	Investigative	[2]
KN-62	DMLZ89P	Discovery agent	N.A.	Investigative	[2]
Ro31-8220	DMDJLF0	Discovery agent	N.A.	Investigative	[2]
STAUROSPORINONE	DMU2H4K	Discovery agent	N.A.	Investigative	[2]
L-779450	DM51B74	Discovery agent	N.A.	Investigative	[22]

Drug(s) Targeting Extracellular signal-regulated kinase 2 (ERK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BVD-523	DMNB4XK	Melanoma	2C30	Phase 2	[23]
HH2710	DM0C5MV	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[24]
ASTX029	DMVZXIA	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[25]
VAN-10-4-eluting stent	DM3ZW6A	Artery stenosis	BD52	Phase 1	[26]
GDC-0994	DMFC2OY	Solid tumour/cancer	2A00-2F9Z	Phase 1	[27]
JSI-1187	DMVJWBS	Solid tumour/cancer	2A00-2F9Z	Phase 1	[28]
LY3214996	DMFDAY7	Solid tumour/cancer	2A00-2F9Z	Phase 1	[29]
CHIR-99021	DMB8MNU	Allergic inflammation	4A80-4A85	Patented	[30]
COR-D	DMLXMCB	T-cell leukaemia	2A90	Preclinical	[31]
SB220025	DMSBUET	Arthritis	FA20	Terminated	[32]

Drug(s) Targeting Stress-activated protein kinase 2a (p38 alpha)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ozagrel	DMIGKA1	Xerophthalmia	5B55.Y	Phase 4	[33]
Losmapimod	DMIL37Z	Acute coronary syndrome	BA41	Phase 3	[33]
VX-702	DMKJDR6	Coronary artery disease	BA80	Phase 2a	[34]
VX-745	DMJAEG6	Alzheimer disease	8A20	Phase 2	[21]
Dilmapimod	DMBYJ92	Acute lung injury	NB32.3	Phase 2	[33]
PMID25991433-Compound-A1	DM89LF0	N. A.	N. A.	Patented	[14]
PMID25991433-Compound-F2	DM37VIQ	N. A.	N. A.	Patented	[14]
PMID25991433-Compound-L2	DM58UO9	N. A.	N. A.	Patented	[14]
PMID25991433-Compound-L3	DM3LWUR	N. A.	N. A.	Patented	[14]
PMID25991433-Compound-L1	DM2135Y	N. A.	N. A.	Patented	[14]

Drug(s) Targeting MAP kinase p38 (MAPK12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SM-101	DMFX9O6	Idiopathic thrombocytopenic purpura	3B64.10	Approved (orphan drug)	[35]
VX-745	DMJAEG6	Alzheimer disease	8A20	Phase 2	[36]
ARRY-797	DMJ48AB	Dilated cardiomyopathy	BC43.0	Phase 2	[37]
KC706	DMBX6C7	Cardiovascular disease	BA00-BE2Z	Discontinued in Phase 2	[38]
SB 235699	DMNH8XU	Psoriasis vulgaris	EA90	Discontinued in Phase 1	[39]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[2]
Bisindolylmaleimide-I	DMOQJZC	Discovery agent	N.A.	Investigative	[2]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole	DMN9YOB	Discovery agent	N.A.	Investigative	[12]
CI-1040	DMF3DZX	Discovery agent	N.A.	Investigative	[2]
AMP-PNP	DMTOK1D	Discovery agent	N.A.	Investigative	[40]

Drug(s) Targeting Ribosomal protein S6 kinase beta-1 (S6K1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
M2698	DM3PVBJ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[29]
PF-4708671	DMO0892	Ulcerative colitis	DD71	Clinical trial	[41]
PMID27410995-Compound-Figure3c	DMDQMZT	N. A.	N. A.	Patented	[42]
Pyrimido[4,5-d] pyrimidines and pyrido[4,3-d] pyrimidine derivative 1	DM6O2Q9	N. A.	N. A.	Patented	[42]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[2]
4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol	DMSKJ1X	Discovery agent	N.A.	Investigative	[43]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole	DMN9YOB	Discovery agent	N.A.	Investigative	[12]
CI-1040	DMF3DZX	Discovery agent	N.A.	Investigative	[2]
KN-62	DMLZ89P	Discovery agent	N.A.	Investigative	[2]
Ro31-8220	DMDJLF0	Discovery agent	N.A.	Investigative	[2]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Extracellular signal-regulated kinase 2 (ERK2)	TT4TQBX	MK01_HUMAN	Inhibitor	[2]
MAP kinase p38 (MAPK12)	TTYT93M	MK12_HUMAN	Inhibitor	[2]
Protein kinase C alpha (PRKCA)	TTFJ8Q1	KPCA_HUMAN	Inhibitor	[2]
Rho-associated protein kinase 1 (ROCK1)	TTZN7RP	ROCK1_HUMAN	Inhibitor	[2]
Ribosomal protein S6 kinase beta-1 (S6K1)	TTG0U4H	KS6B1_HUMAN	Inhibitor	[2]
Stress-activated protein kinase 2a (p38 alpha)	TTQBR95	MK14_HUMAN	Inhibitor	[2]
Stress-activated protein kinase 2b (p38 beta)	TT73U6C	MK11_HUMAN	Inhibitor	[2]
Stress-activated protein kinase JNK1 (JNK1)	TT0K6EO	MK08_HUMAN	Inhibitor	[2]

References

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