Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMABMPQ)

• Drug Name: 4-methylhistamine Drug Info
• Synonyms: 4-Methylhistamine; 5-Methylhistamine; 36507-31-0; 5(4)-Methylhistamine; 1H-Imidazole-4-ethanamine, 5-methyl-; 2-(5-methyl-1H-imidazol-4-yl)ethanamine; UNII-54ST71P9EE; 1H-Imidazo-4-ethanamine, 5-methyl-; 54ST71P9EE; CHEBI:74760; IMIDAZOLE, 4-(2-AMINOETHYL)-5-METHYL-; 2-(5-Methyl-4-imidazolyl)ethylamine; 2-(4-METHYL-1H-IMIDAZOL-5-YL)ETHANAMINE; p-methylhistamine; Methylhistamine-4; 5-(2-Aminoethyl)-4-methylimidazole; AC1L1XS2; SCHEMBL606803; CHEMBL275443; GTPL1269; SCHEMBL11452941; BDBM22880; UGYXPZQILZRKJJ-UHFFFAOYSA-N

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 37463
  ChEBI ID: CHEBI:74760
  CAS Number: CAS 36507-31-0
  TTD Drug ID: DMABMPQ

Molecule-Related Drug Atlas

Drug(s) Targeting Histamine H4 receptor (H4R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PF-3893787	DMC2FAL	Atopic dermatitis	EA80	Phase 2	[5]
JNJ-38518168	DM9UMIO	Plaque psoriasis	EA90.0	Phase 2	[6]
UR-63325	DME6X27	Allergic rhinitis	CA08.0	Phase 2	[7]
Thioperamide	DM8S593	Cognitive impairment	6D71	Terminated	[8]
2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole	DMZVBPG	Discovery agent	N.A.	Investigative	[9]
impromidine	DMTDRPM	Discovery agent	N.A.	Investigative	[10]
burimamide	DMZ2VYG	Discovery agent	N.A.	Investigative	[11]
Imetit	DMMJ6NS	Discovery agent	N.A.	Investigative	[12]
[125I]iodophenpropit	DMN4ABU	Discovery agent	N.A.	Investigative	[13]
(R)-alpha-methylhistamine	DMKAW4P	Discovery agent	N.A.	Investigative	[14]

Drug(s) Affected By Interferon gamma (IFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[15]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[16]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[17]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[18]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[20]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[23]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[24]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[25]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[26]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[29]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[30]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[31]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine H4 receptor (H4R)	TTXJ178	HRH4_HUMAN	Agonist	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Gene/Protein Processing	[3]
Interferon gamma (IFNG)	OTXG9JM7	IFNG_HUMAN	Gene/Protein Processing	[4]

References

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