DDI Drug Name |
DDI Drug ID |
Severity |
Mechanism |
Comorbidity |
REF |
Remdesivir |
DMBFZ6L
|
Moderate |
Increased risk of hepatotoxicity by the combination of Tecfidera and Remdesivir. |
1D6YCoronavirus Disease 2019 [1D6YCoronavirus Disease 2019]
|
[6] |
Emapalumab |
DMZG5WL
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Emapalumab. |
Adaptive immunity immunodeficiency [4A01]
|
[9] |
Siltuximab |
DMGEATB
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Siltuximab. |
Anemia [3A00-3A9Z]
|
[9] |
Dupilumab |
DMOAD2Y
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Dupilumab. |
Atopic eczema [EA80]
|
[9] |
Pexidartinib |
DMS2J0Z
|
Major |
Increased risk of hepatotoxicity by the combination of Tecfidera and Pexidartinib. |
Bone/articular cartilage neoplasm [2F7B]
|
[10] |
Talazoparib |
DM1KS78
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Talazoparib. |
Breast cancer [2C60-2C6Y]
|
[9] |
LY2835219 |
DM93VBZ
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and LY2835219. |
Breast cancer [2C60-2C6Y]
|
[9] |
Palbociclib |
DMD7L94
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Palbociclib. |
Breast cancer [2C60-2C6Y]
|
[9] |
Polatuzumab vedotin |
DMF6Y0L
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Polatuzumab vedotin. |
Diffuse large B-cell lymphoma [2A81]
|
[9] |
Axicabtagene ciloleucel |
DMYHN59
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Axicabtagene ciloleucel. |
Diffuse large B-cell lymphoma [2A81]
|
[9] |
Cannabidiol |
DM0659E
|
Moderate |
Increased risk of hepatotoxicity by the combination of Tecfidera and Cannabidiol. |
Epileptic encephalopathy [8A62]
|
[8] |
Bay 80-6946 |
DMLOS5R
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Bay 80-6946. |
Follicular lymphoma [2A80]
|
[9] |
Avapritinib |
DMK2GZX
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Avapritinib. |
Gastrointestinal stromal tumour [2B5B]
|
[9] |
177Lu-DOTATATE |
DMT8GVU
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and 177Lu-DOTATATE. |
Hepatitis virus infection [1E50-1E51]
|
[9] |
Brigatinib |
DM7W94S
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Brigatinib. |
Lung cancer [2C25]
|
[9] |
Lurbinectedin |
DMEFRTZ
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Lurbinectedin. |
Lung cancer [2C25]
|
[9] |
Osimertinib |
DMRJLAT
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Osimertinib. |
Lung cancer [2C25]
|
[9] |
Calaspargase pegol |
DMQZBXI
|
Moderate |
Increased risk of hepatotoxicity by the combination of Tecfidera and Calaspargase pegol. |
Malignant haematopoietic neoplasm [2B33]
|
[11] |
Obinutuzumab |
DM3BVAE
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Obinutuzumab. |
Mature B-cell leukaemia [2A82]
|
[9] |
Idelalisib |
DM602WT
|
Moderate |
Increased risk of hepatotoxicity by the combination of Tecfidera and Idelalisib. |
Mature B-cell leukaemia [2A82]
|
[12] |
GDC-0199 |
DMH0QKA
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and GDC-0199. |
Mature B-cell leukaemia [2A82]
|
[9] |
IPI-145 |
DMWA24P
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and IPI-145. |
Mature B-cell leukaemia [2A82]
|
[9] |
Acalabrutinib |
DM7GCVW
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Acalabrutinib. |
Mature B-cell lymphoma [2A85]
|
[9] |
Blinatumomab |
DMGECIJ
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Blinatumomab. |
Mature B-cell lymphoma [2A85]
|
[9] |
Ibrutinib |
DMHZCPO
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Ibrutinib. |
Mature B-cell lymphoma [2A85]
|
[9] |
Tisagenlecleucel |
DMM9BJD
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Tisagenlecleucel. |
Mature B-cell lymphoma [2A85]
|
[9] |
Selinexor |
DMBD4K3
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Selinexor. |
Multiple myeloma [2A83]
|
[9] |
Belantamab mafodotin |
DMBT3AI
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Belantamab mafodotin. |
Multiple myeloma [2A83]
|
[9] |
Daratumumab |
DMKCIUZ
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Daratumumab. |
Multiple myeloma [2A83]
|
[9] |
Deflazacort |
DMV0RNS
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Deflazacort. |
Muscular dystrophy [8C70]
|
[9] |
Inebilizumab |
DMI0RHA
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Inebilizumab. |
Nervous system paraneoplastic/autoimmune disorder [8E4A]
|
[9] |
Atezolizumab |
DMMF8U0
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Atezolizumab. |
Non-small cell lung cancer [2C25]
|
[9] |
Olaparib |
DM8QB1D
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Olaparib. |
Ovarian cancer [2C73]
|
[9] |
Rucaparib |
DM9PVX8
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Rucaparib. |
Ovarian cancer [2C73]
|
[9] |
MK-4827 |
DMLYGH4
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and MK-4827. |
Ovarian cancer [2C73]
|
[9] |
Brodalumab |
DMASDQ6
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Brodalumab. |
Psoriasis [EA90]
|
[9] |
Tildrakizumab |
DMLW9HG
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Tildrakizumab. |
Psoriasis [EA90]
|
[9] |
Risankizumab |
DMM32GT
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Risankizumab. |
Psoriasis [EA90]
|
[9] |
Ixekizumab |
DMXW92T
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Ixekizumab. |
Psoriasis [EA90]
|
[9] |
Sarilumab |
DMOGNXY
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Sarilumab. |
Rheumatoid arthritis [FA20]
|
[9] |
Anthrax vaccine |
DM9GSWY
|
Moderate |
Antagonize the effect of Tecfidera when combined with Anthrax vaccine. |
Sepsis [1G40-1G41]
|
[13] |
Mogamulizumab |
DMISH0Z
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Mogamulizumab. |
Sezary syndrome [2B02]
|
[9] |
LEE011 |
DMMX75K
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and LEE011. |
Solid tumour/cancer [2A00-2F9Z]
|
[9] |
Pomalidomide |
DMTGBAX
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Pomalidomide. |
Systemic sclerosis [4A42]
|
[9] |
Durvalumab |
DM4PVDY
|
Moderate |
Additive immunosuppressive effects by the combination of Tecfidera and Durvalumab. |
Ureteral cancer [2C92]
|
[9] |
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