Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMB4ZNW)

Drug Name
Indole Naphthyridinone Drug Info
Synonyms
INDOLE NAPHTHYRIDINONE; (E)-N-METHYL-N-(1-METHYL-1H-INDOL-3-YLMETHYL)-3-(7-OXO-5,6,7,8-TETRAHYDRO-[1,8]NAPHTHYRIDIN-3-YL)-ACRYLAMIDE; IDN; (2E)-N-methyl-N-[(1-methyl-1H-indol-3-yl)methyl]-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)prop-2-enamide; AC1NRBS2; indole naphthyridinone 29; SCHEMBL725906; SCHEMBL725904; CHEMBL42208; BDBM8733; DB01691; (e)-n-methyl-n-(1-methyl-1h-indol-3-ylmethyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5288607
TTD Drug ID
DMB4ZNW

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Plasmodium Enoyl-ACP reductase (Malaria fabI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [2]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [3]
Nicotinamide-Adenine-Dinucleotide DM9LRKB N. A. N. A. Investigative [1]
Beta-D-Glucose DM5IHYP Discovery agent N.A. Investigative [1]
MORIN DM2OGZ5 Discovery agent N.A. Investigative [4]
3,7,3',4'-TETRAHYDROXYFLAVONE DMES906 Discovery agent N.A. Investigative [4]
(-)-CATECHINGALLATE DMZOGSK Discovery agent N.A. Investigative [4]
Thiolactomycin DMBAWDG Malaria 1F40-1F45 Investigative [2]
GALLOCATECHIN GALLATE DMX2084 Discovery agent N.A. Investigative [4]
Diazaborines DM5UFZX Discovery agent N.A. Investigative [5]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Bacterial Fatty acid synthetase I (Bact inhA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [6]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [7]
Ethionamide DM8K3EI Pulmonary tuberculosis 1B10.Z Approved [8]
Prothionamide DMX0EZJ Tuberculosis 1B10-1B1Z Approved [8]
AFN-1720 DM6AJKC Bacterial infection 1A00-1C4Z Phase 2 [9]
MMV00/0053 DMF27BS Malaria 1F40-1F45 Terminated [10]
Nicotinamide-Adenine-Dinucleotide DM9LRKB N. A. N. A. Investigative [1]
Beta-D-Glucose DM5IHYP Discovery agent N.A. Investigative [1]
2-Hexadecynoic acid DMTFIPZ Discovery agent N.A. Investigative [11]
4-(2-Thienyl)-1-(4-Methylbenzyl)-1h-Imidazole DMX681M Discovery agent N.A. Investigative [1]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial Fatty acid synthetase I (Bact inhA) TTVTX4N INHA_MYCTU Inhibitor [1]
Plasmodium Enoyl-ACP reductase (Malaria fabI) TTNX2CS Q965D5_PLAFA Inhibitor [1]

References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2 Novel molecular targets for antimalarial drug development. Chem Biol Drug Des. 2008 Apr;71(4):287-97.
3 Green tea catechins potentiate triclosan binding to enoyl-ACP reductase from Plasmodium falciparum (PfENR). J Med Chem. 2007 Feb 22;50(4):765-75.
4 Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53.
5 Lipid biosynthesis as a target for antibacterial agents. Prog Lipid Res. 2001 Nov;40(6):467-97.
6 Diversity in enoyl-acyl carrier protein reductases. Cell Mol Life Sci. 2009 May;66(9):1507-17.
7 Pyrazinamide inhibits the eukaryotic-like fatty acid synthetase I (FASI) of Mycobacterium tuberculosis. Nat Med. 2000 Sep;6(9):1043-7.
8 Mechanism of thioamide drug action against tuberculosis and leprosy. J Exp Med. 2007 Jan 22;204(1):73-8.
9 Affinium Pharmaceuticals Announces the Initiation of a Phase 1 Intravenous Clinical Trial of a New Antibiotic Prodrug, and the Closing of a Follow-on Financing Round. PR Newswire Sep. 4, 2013 10:16 PM.
10 SAR and pharmacophore models for the rhodanine inhibitors of Plasmodium falciparum enoyl-acyl carrier protein reductase. IUBMB Life. 2010 Mar;62(3):204-13.
11 2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections. Bioorg Med Chem. 2010 Nov 1;18(21):7475-85.