Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMB7GPA)

• Drug Name: Selenious acid Drug Info
• Synonyms: Monohydrated selenium dioxide; SELENIOUS ACID; Selenious acid (H2SeO3); Selenious acid (USP); Selenious acid [USP]; Selenious acid, 98%; Selenite (SeO32-); Selenite ion(2-); Selenium dioxide, monohydrated; Selenous acid; Selenous acid, 98%; dihydroxidooxidoselenium; selenige Saeure; selenige Saure; 7783-00-8; AC1L1APE; CCRIS 5530; CHEBI:26642; DSSTox_CID_4300; EINECS 231-974-7; F6A27P4Q4R; HSDB 6065; MFCD00011331; Selenium, Reference Standard Solution; UNII-F6A27P4Q4R; selenious acid,selenous acid,monohydrated selenium dioxide
• Cross-matching ID:
  PubChem CID: 1091
  ChEBI ID: CHEBI:26642
  CAS Number: CAS 7783-00-8
  TTD Drug ID: DMB7GPA
  INTEDE Drug ID: DR1468

Molecule-Related Drug Atlas

Drug(s) Metabolized By Thioredoxin reductase TR1 (TXNRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[1]

Drug(s) Affected By Band 3 anion transport protein (SLC4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[5]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[6]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[7]
Adefovir	DMM278X	N. A.	N. A.	Approved	[8]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[9]
CHLORIDE	DM1TJXA	Solid tumour/cancer	2A00-2F9Z	Phase 3	[10]
AMG 386	DMQJXL4	Breast cancer	2C60-2C65	Phase 3	[11]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
D-glucose	DMMG2TO	Discovery agent	N.A.	Investigative	[13]

Drug(s) Affected By Aquaporin-9 (AQP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[15]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[17]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[14]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[18]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[19]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[20]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[22]

Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Thioredoxin reductase TR1 (TXNRD1) Main DME	DEUP4DA	TRXR1_HUMAN	Substrate	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Aquaporin-9 (AQP9)	OTLGH5ZY	AQP9_HUMAN	Regulation of Drug Effects	[2]
Band 3 anion transport protein (SLC4A1)	OT3EFUK8	B3AT_HUMAN	Regulation of Drug Effects	[3]

References

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• [2] Role of AQP9 in transport of monomethyselenic acid and selenite. Biometals. 2017 Oct;30(5):747-755. doi: 10.1007/s10534-017-0042-x. Epub 2017 Aug 10.
• [3] Human red blood cell uptake and sequestration of arsenite and selenite: Evidence of seleno-bis(S-glutathionyl) arsinium ion formation in human cells. Biochem Pharmacol. 2020 Oct;180:114141. doi: 10.1016/j.bcp.2020.114141. Epub 2020 Jul 8.
• [4] Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
• [5] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
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• [7] Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
• [8] ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
• [9] Resveratrol induces human K562 cell apoptosis, erythroid differentiation, and autophagy. Tumour Biol. 2014 Jun;35(6):5381-8. doi: 10.1007/s13277-014-1701-y. Epub 2014 Feb 15.
• [10] Lysine 539 of human band 3 is not essential for ion transport or inhibition by stilbene disulfonates. J Biol Chem. 1989 Nov 25;264(33):19607-13.
• [11] Monovalent cation leaks in human red cells caused by single amino-acid substitutions in the transport domain of the band 3 chloride-bicarbonate exchanger, AE1. Nat Genet. 2005 Nov;37(11):1258-63. doi: 10.1038/ng1656. Epub 2005 Oct 9.
• [12] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [13] Novel oxolane derivative DMTD mitigates high glucose-induced erythrocyte apoptosis by regulating oxidative stress. Toxicol Appl Pharmacol. 2017 Nov 1;334:167-179.
• [14] Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
• [15] Relationship of expression of aquaglyceroporin 9 with arsenic uptake and sensitivity in leukemia cells. Blood. 2007 Jan 15;109(2):740-6. doi: 10.1182/blood-2006-04-019588. Epub 2006 Sep 12.
• [16] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [17] Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
• [18] Drug uptake and pharmacological modulation of drug sensitivity in leukemia by AQP9. Biochem Biophys Res Commun. 2004 Sep 24;322(3):836-41. doi: 10.1016/j.bbrc.2004.08.002.
• [19] Azacytidine sensitizes acute myeloid leukemia cells to arsenic trioxide by up-regulating the arsenic transporter aquaglyceroporin 9. J Hematol Oncol. 2015 May 8;8:46. doi: 10.1186/s13045-015-0143-3.
• [20] Association between In Utero arsenic exposure, placental gene expression, and infant birth weight: a US birth cohort study. Environ Health. 2013 Jul 16;12:58. doi: 10.1186/1476-069X-12-58.
• [21] Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
• [22] Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259. doi: 10.3390/ijms24076259.