Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMB8MNU)

• Drug Name: CHIR-99021 Drug Info
• Synonyms: CHIR99021; CHIR 99021; CT-99021; CT99021

Indication

Disease Entry	ICD 11	Status	REF
Allergic inflammation	4A80-4A85	Patented	[1]
Graft rejection	NE84	Patented	[1]

• Cross-matching ID:
  PubChem CID: 9956119
  ChEBI ID: CHEBI:91091
  CAS Number: CAS 252917-06-9
  TTD Drug ID: DMB8MNU

Molecule-Related Drug Atlas

Drug(s) Targeting Cyclin-dependent kinase 1 (CDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
R-roscovitine	DMSH108	Non-small-cell lung cancer	2C25.Y	Phase 2	[3]
Ro 31-7453	DM83QCL	Solid tumour/cancer	2A00-2F9Z	Phase 2	[4]
P276-00	DM9DJL2	Mantle cell lymphoma	2A85.5	Phase 2	[3]
P-276	DMMJUHD	Breast cancer	2C60-2C65	Phase 2	[5]
RGB-286638	DMEGOQP	Haematological malignancy	2B33.Y	Phase 1	[6]
AG-024322	DMY4WVK	Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]
PHA-793887	DM2Y4FG	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
Oxazolyl methylthiothiazole derivative 1	DMZM6FW	N. A.	N. A.	Patented	[8]
PMID25991433-Compound-A1	DM89LF0	N. A.	N. A.	Patented	[9]
KENPAULLONE	DMAGVXW	Discovery agent	N.A.	Patented	[10]

Drug(s) Targeting Extracellular signal-regulated kinase 2 (ERK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BVD-523	DMNB4XK	Melanoma	2C30	Phase 2	[11]
HH2710	DM0C5MV	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[12]
ASTX029	DMVZXIA	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[13]
VAN-10-4-eluting stent	DM3ZW6A	Artery stenosis	BD52	Phase 1	[14]
GDC-0994	DMFC2OY	Solid tumour/cancer	2A00-2F9Z	Phase 1	[15]
JSI-1187	DMVJWBS	Solid tumour/cancer	2A00-2F9Z	Phase 1	[16]
LY3214996	DMFDAY7	Solid tumour/cancer	2A00-2F9Z	Phase 1	[17]
COR-D	DMLXMCB	T-cell leukaemia	2A90	Preclinical	[18]
SB220025	DMSBUET	Arthritis	FA20	Terminated	[19]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[20]

Drug(s) Targeting Glycogen synthase kinase-3 beta (GSK-3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AMO-02	DMJRU3A	Myotonic dystrophy	8C71.0	Phase 2/3	[21]
LY2090314	DMTBFE4	Acute myeloid leukaemia	2A60	Phase 2	[1]
Lithium	DMZ3OU6	Fragile X syndrome	LD55	Phase 2	[22]
Tideglusib	DME4LA1	Osteosarcoma	2B51	Phase 2	[23]
9-ING-41	DM57TY3	Myelofibrosis	2A20.2	Phase 2	[24]
Neu-120	DMXKOUC	Parkinson disease	8A00.0	Phase 1/2	[25]
KENPAULLONE	DMAGVXW	Discovery agent	N.A.	Patented	[26]
TDZD-8	DMG6Q45	Malignant glioma	2A00.0	Patented	[27]
AR-A014418	DMUPN01	Ovarian cancer	2C73	Patented	[28]
PMID26161698-Compound-18	DM6JVR5	N. A.	N. A.	Patented	[8]

Drug(s) Targeting Glycogen synthase kinase-3 alpha (GSK-3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
LY2090314	DMTBFE4	Acute myeloid leukaemia	2A60	Phase 2	[1]
Lithium	DMZ3OU6	Fragile X syndrome	LD55	Phase 2	[22]
KENPAULLONE	DMAGVXW	Discovery agent	N.A.	Patented	[1]
TDZD-8	DMG6Q45	Malignant glioma	2A00.0	Patented	[1]
AR-A014418	DMUPN01	Ovarian cancer	2C73	Patented	[1]
PMID27828716-Compound-21	DMO1NAR	N. A.	N. A.	Patented	[1]
Thiadiazolidindione derivative 2	DM5AUL0	N. A.	N. A.	Patented	[1]
PMID27828716-Compound-18	DMNR6KL	N. A.	N. A.	Patented	[1]
PMID27828716-Compound-BIO-acetoxime	DMUM5L6	Malignant glioma	2A00.0	Patented	[1]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cyclin-dependent kinase 1 (CDK1)	TTH6V3D	CDK1_HUMAN	Inhibitor	[2]
Extracellular signal-regulated kinase 2 (ERK2)	TT4TQBX	MK01_HUMAN	Inhibitor	[2]
Glycogen synthase kinase-3 alpha (GSK-3A)	TTRZQE3	GSK3A_HUMAN	Inhibitor	[1]
Glycogen synthase kinase-3 beta (GSK-3B)	TTRSMW9	GSK3B_HUMAN	Inhibitor	[2]

References

• [1] Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666.
• [2] Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95.
• [3] Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66.
• [4] A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
• [5] P276-00, a novel cyclin-dependent inhibitor induces G1-G2 arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models. Mol Cancer Ther. 2007 Mar;6(3):926-34.
• [6] Small-molecule multi-targeted kinase inhibitor RGB-286638 triggers P53-dependent and -independent anti-multiple myeloma activity through inhibition of transcriptional CDKs. Leukemia. 2013 Dec;27(12):2366-75.
• [7] A first in man, phase I dose-escalation study of PHA-793887, an inhibitor of multiple cyclin-dependent kinases (CDK2, 1 and 4) reveals unexpected h... Cell Cycle. 2011 Mar 15;10(6):963-70.
• [8] Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70.
• [9] c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72.
• [10] Discovery of novel CDK1 inhibitors by combining pharmacophore modeling, QSAR analysis and in silico screening followed by in vitro bioassay. Eur J Med Chem. 2010 Sep;45(9):4316-30.
• [11] DOI: 10.1158/1538-7445.AM2015-4693
• [12] Clinical pipeline report, company report or official report of HaiHe Biopharma.
• [13] Clinical pipeline report, company report or official report of Astex Pharmaceuticals.
• [14] WO patent application no. 2013,1850,32, Nanotherapeutics for drug targeting.
• [15] ERK Mutations Confer Resistance to Mitogen-Activated Protein Kinase Pathway Inhibitors
• [16] National Cancer Institute Drug Dictionary (drug name JSI1187).
• [17] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [18] Corchorusin-D directed apoptosis of K562 cells occurs through activation of mitochondrial and death receptor pathways and suppression of AKT/PKB pathway. Cell Physiol Biochem. 2012;30(4):915-26.
• [19] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [20] Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105.
• [21] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [22] The GSK3 kinase inhibitor lithium produces unexpected hyperphosphorylation of -catenin, a GSK3 substrate, in human glioblastoma cells. Biol Open. 2018 Jan 26;7(1):bio030874.
• [23] Evidence for irreversible inhibition of glycogen synthase kinase-3beta by tideglusib. J Biol Chem. 2012 Jan 6;287(2):893-904.
• [24] 9-ING-41, a small molecule inhibitor of GSK-3beta, potentiates the effects of anticancer therapeutics in bladder cancer. Sci Rep. 2019 Dec 27;9(1):19977.
• [25] Company report (Neurim Pharmaceuticals)
• [26] 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta. Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6.
• [27] Identification of novel scaffold of benzothiazepinones as non-ATP competitive glycogen synthase kinase-3beta inhibitors through virtual screening. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7232-6.
• [28] Fragment and knowledge-based design of selective GSK-3beta inhibitors using virtual screening models. Eur J Med Chem. 2009 Jun;44(6):2361-71.
• [29] Challenges and new opportunities in the investigation of new drug therapies to treat frontotemporal dementia. Expert Opin Ther Targets. 2008 Nov;12(11):1367-76.