Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDG3AD)

Drug Name

BIIB131 Drug Info

Synonyms

Orniplabin; SMTP-7; SMTP7; SMTP 7; SMTP7; BIIB131; SCHEMBL2624852; GTPL12300; TMS-007; BCP33210; Stachybotrys microspora triprenyl phenol 7; HY-122311; CS-0083560; (2S)-2,5-bis[(2S,3S)-2-[(3E)-4,8-dimethylnona-3,7-dienyl]-3,5-dihydroxy-2-methyl-7-oxo-4,9-dihydro-3H-pyrano[2,3-e]isoindol-8-yl]pentanoic acid; 733805-92-0

Indication

Disease Entry	ICD 11	Status	REF
Acute ischemic stroke	8B11	Phase 2	[1]

Cross-matching ID

PubChem CID: 50898407
TTD Drug ID: DMDG3AD

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Plasminogen (PLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranolazine	DM0C9IL	Acute coronary syndrome	BA41	Approved	[3]
Aminocaproic Acid	DMFGND4	Bleeding disorder	GA20-GA21	Approved	[4]
Streptokinase	DM5JQ0D	Pulmonary embolism	BB00	Approved	[5]
Tranexamic Acid	DMFI8A7	Excessive bleeding	GA30.02	Approved	[6]
Alteplase	DMRJ3YX	Acute myocardial infarction	BA41	Approved	[7]
Tenecteplase	DMJYN25	Acute myocardial infarction	BA41	Approved	[7]
Anistreplase	DM6Q4B0	Acute coronary syndrome	BA41	Approved	[8]
Reteplase	DML0D1P	Heart attack	BA41	Approved	[9]
MELAGATRAN	DM4W8RE	N. A.	N. A.	Phase 3	[10]
Desmoteplase	DMDLU4Z	Ischemic stroke	8B11.5Z	Phase 3	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Plasminogen (PLG)	TTP86E2	PLMN_HUMAN	Activator	[2]

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References

1	ClinicalTrials.gov (NCT05764122) A Multicenter, Operationally Seamless, Double-Blind, Dose-Ranging, Placebo-Controlled, Randomized, Parallel-Group, Phase 2b Study to Evaluate the Efficacy and Safety of Intravenous BIIB131 for Participants With Ischemic Stroke Between 4.5 and 24 Hours After Last Known Well. U.S.National Institutes of Health.
2	Clinical pipeline report, company report or official report of Biogen
3	Tranexamic acid in trauma: how should we use it. J Trauma Acute Care Surg. 2013 Jun;74(6):1575-86.
4	The blockage of the high-affinity lysine binding sites of plasminogen by EACA significantly inhibits prourokinase-induced plasminogen activation. Biochim Biophys Acta. 2002 Apr 29;1596(2):182-92.
5	Acute anuric renal failure with streptokinase therapy in a patient with acute venous thromboembolic disease and the review of renal side effects of streptokinase. Tuberk Toraks. 2008;56(4):456-61.
6	Evaluation of aprotinin and tranexamic acid in different in vitro and in vivo models of fibrinolysis, coagulation and thrombus formation. J Thromb Haemost. 2007 Oct;5(10):2113-8.
7	Thrombolytic therapies: the current state of affairs. J Endovasc Ther. 2005 Apr;12(2):224-32.
8	Evaluation of thrombolytic agents. Drugs. 1997;54 Suppl 3:11-6; discussion 16-7.
9	Fibrin binding and the regulation of plasminogen activators during thrombolytic therapy. Cardiovasc Hematol Agents Med Chem. 2008 Jul;6(3):212-23.
10	Orally active thrombin inhibitors. Part 1: optimization of the P1-moiety. Bioorg Med Chem Lett. 2006 May 15;16(10):2641-7.
11	Vampire bat salivary plasminogen activator (desmoteplase): a unique fibrinolytic enzyme that does not promote neurodegeneration. Stroke. 2003 Feb;34(2):537-43.