Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGUNIL)

Drug Name
Nitrocatechol sulfate Drug Info
Synonyms
Para-Nitrocatechol sulfate; 4-Nitrocatechol sulfate; (2-hydroxy-5-nitrophenyl) hydrogen sulfate; (2-hydroxy-5-nitrophenyl)oxidanesulfonic acid; 1pa9; 2-HYDROXY-5-NITROPHENOL SULFATE, K SALT; 2-Hydroxy-5-nitrophenyl sulfate; 2-hydroxy-5-nitrophenyl hydrogen sulfate; 4-Nitro-1,2-benzenediol, 2-(hydrogen sulfate); 4-Nitrocatechol 2-sulfate; AC1L4XH3; AC1Q6XY7; CHEBI:41733; CSN; CTK4C4465; DB01800; DTXSID50146785; N,4-DIHYDROXY-N-OXO-3-(SULFOOXY)BENZENAMINIUM; UNII-HD9MHQ536A; HD9MHQ536A; SCHEMBL4308319; ZINC2046903
Cross-matching ID
PubChem CID
165879
ChEBI ID
CHEBI:41733
CAS Number
CAS 10485-66-2
TTD Drug ID
DMGUNIL
INTEDE Drug ID
DR2063

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Affected By Steryl-sulfatase (STS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [3]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [3]
Tazarotene DM8SMD1 Acne vulgaris ED80 Approved [5]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [7]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [8]
Danazol DML8KTN Menorrhagia GA20.50 Approved [9]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [5]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Telethon sulfatase (ARSK) Main DME DEEGA13 ARSK_HUMAN Substrate [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Steryl-sulfatase (STS) OTXTJQPC STS_HUMAN Gene/Protein Processing [2]

References

1 Arylsulfatase K, a novel lysosomal sulfatase. J Biol Chem. 2013 Oct 18;288(42):30019-28.
2 Simultaneous azo-coupling method for an estrogen sulfatase in human tissues. Histochemistry. 1983;78(2):241-9. doi: 10.1007/BF00489502.
3 Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
4 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
5 Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways. J Cell Biochem. 2006 Feb 1;97(2):327-50. doi: 10.1002/jcb.20579.
6 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
7 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
8 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
9 Synthesis and steroid sulphatase inhibitory activity of C19- and C21-steroidal derivatives bearing a benzyl-inhibiting group. Eur J Med Chem. 2001 Jul-Aug;36(7-8):659-71. doi: 10.1016/s0223-5234(01)01262-4.