Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJEN45)

Drug Name
Cyclohexyl-(3,4-dichloro-phenyl)-acetonitrile Drug Info
Synonyms CHEMBL432482; Cyclohexyl-(3,4-dichloro-phenyl)-acetonitrile; SCHEMBL5903164; BDBM50126935
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
10084369
TTD Drug ID
DMJEN45

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Serotonin transporter (SERT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [2]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [3]
Fluoxetine DM3PD2C Bipolar depression Approved [4]
Vortioxetine DM6F1PU Major depressive disorder 6A70.3 Approved [5]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [6]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [7]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [8]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [4]
Nortriptyline DM4KDYJ Depression 6A70-6A7Z Approved [4]
Trazodone DMK1GBJ Depression 6A70-6A7Z Approved [4]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Serotonin transporter (SERT) TT3ROYC SC6A4_HUMAN Inhibitor [1]

References

1 Synthesis and evaluation of dopamine and serotonin transporter inhibition by oxacyclic and carbacyclic analogues of methylphenidate. J Med Chem. 2003 Apr 10;46(8):1538-45.
2 Augmentation effect of combination therapy of aripiprazole and antidepressants on forced swimming test in mice. Psychopharmacology (Berl). 2009 Sep;206(1):97-107.
3 Treatment of comorbid pain with serotonin norepinephrine reuptake inhibitors. CNS Spectr. 2008 Jul;13(7 Suppl 11):22-6.
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
5 Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651.
6 Psychopharmacological treatment of dermatological patients--when simply talking does not help. J Dtsch Dermatol Ges. 2007 Dec;5(12):1101-6.
7 Differential involvement of the norepinephrine, serotonin and dopamine reuptake transporter proteins in cocaine-induced taste aversion. Pharmacol Biochem Behav. 2009 Jul;93(1):75-81.
8 Clinically relevant drug interactions with new generation antidepressants and antipsychotics. Ther Umsch. 2009 Jun;66(6):485-92.