Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKBZDP)

• Drug Name: PMID27607364-Compound-4 Drug Info
• Cross-matching ID:
  PubChem CID: 3016
  ChEBI ID: CHEBI:49575
  CAS Number: CAS 439-14-5
  TTD Drug ID: DMKBZDP
  ACDINA Drug ID: D00190

Molecule-Related Drug Atlas

Drug(s) Targeting Translocator protein (TSPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Epilepsy	8A60-8A68	Approved	[2]
Flunitrazepam	DMGR5Z3	Insomnia	7A00-7A0Z	Approved	[3]
Oxazepam	DMXNZM4	Anxiety disorder	6B00-6B0Z	Approved	[4]
Midazolam	DMXOELT	Irritability	MB24	Approved	[5]
Temazepam	DM02A65	Insomnia	7A00-7A0Z	Approved	[5]
Flumazenil	DMPCG2L	Benzodiazepine overdose	PC91	Approved	[6]
Alprazolam	DMC7XDN	Anxiety disorder	6B00-6B0Z	Approved	[3]
Clotiazepam	DM59AZT	Anxiety disorder	6B00-6B0Z	Approved	[7]
Quazepam	DMY4D87	Insomnia	7A00-7A0Z	Approved	[5]
Eszopiclone	DM8RZ9H	Insomnia	7A00-7A0Z	Approved	[8]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Translocator protein (TSPO)	TTPTXIN	TSPO_HUMAN	Ligand	[1]

References

• [1] Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351.
• [2] Translocator protein (18 kDa) mediates the pro-growth effects of diazepam on Ehrlich tumor cells in vivo. Eur J Pharmacol. 2010 Jan 25;626(2-3):131-8.
• [3] Comparison of five benzodiazepine-receptor agonists on buprenorphine-induced mu-opioid receptor regulation. J Pharmacol Sci. 2009 May;110(1):36-46.
• [4] Effects of the combination of metyrapone and oxazepam on cocaine and food self-administration in rats. Pharmacol Biochem Behav. 2008 Nov;91(1):181-9.
• [5] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [6] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2879).
• [7] Effects of benzodiazepines and non-benzodiazepine compounds on the GABA-induced response in frog isolated sensory neurones. Br J Pharmacol. 1989 Nov;98(3):735-40.
• [8] New hypnotics: perspectives from sleep physiology. Vertex. 2007 Jul-Aug;18(74):294-9.