Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMZJY3)

• Drug Name: CGS-17867A Drug Info
• Synonyms: Cgs-17867A; CHEMBL116842; 2-(4-Chloro-phenyl)-2,5,6,7,8,9-hexahydro-pyrazolo[4,3-c]quinolin-3-one; AC1L2T4E; SCHEMBL2287621; OJVURBSORBSWLX-UHFFFAOYSA-N; CGS-17867; BDBM50148320; 2-p-Tolyl-2,5,6,7,8,9-hexahydro-pyrazolo[4,3-c]quinolin-3-one; 2-(4-chlorophenyl)-6,7,8,9-tetrahydro-1H-pyrazolo[4,3-c]quinolin-3-one

Indication

Disease Entry	ICD 11	Status	REF
Alcohol dependence	6C40.2	Terminated	[1]

• Cross-matching ID:
  PubChem CID: 128064
  TTD Drug ID: DMMZJY3

Molecule-Related Drug Atlas

Drug(s) Targeting GABA(A) receptor gamma-2 (GABRG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[3]
THIOCOLCHICOSIDE	DMEPWYA	Muscle spasm	MB47.3	Approved	[4]
ZK-93423	DMFWMKZ	Epileptic seizures	8A61-8A6Z	Phase 3	[5]
GSK683699	DMTW79H	Inflammatory bowel disease	DD72	Phase 2	[4]
ELTANOLONE	DM38CIV	Premenstrual syndrome	GA34.40	Discontinued in Phase 3	[3]
U-78875	DM2WOPX	Anxiety disorder	6B00-6B0Z	Discontinued in Phase 1	[6]
CGS-9896	DM39PQI	N. A.	N. A.	Terminated	[7]
TBPS	DMFC3XP	Discovery agent	N.A.	Investigative	[8]
AMENTOFLAVONE	DMLRNV2	Discovery agent	N.A.	Investigative	[9]
Ro-15-3505	DM4NW3U	Discovery agent	N.A.	Investigative	[10]

Drug(s) Targeting GABA(A) receptor alpha-2 (GABRA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flumazenil	DMPCG2L	Benzodiazepine overdose	PC91	Approved	[11]
GSK683699	DMTW79H	Inflammatory bowel disease	DD72	Phase 2	[12]
PF-4480682	DMWYJHC	Neuropathic pain	8E43.0	Discontinued in Phase 2	[13]
TBPS	DMFC3XP	Discovery agent	N.A.	Investigative	[11]
AMENTOFLAVONE	DMLRNV2	Discovery agent	N.A.	Investigative	[9]
Ro-15-3505	DM4NW3U	Discovery agent	N.A.	Investigative	[14]
isonipecotic acid	DMO1ZHE	Discovery agent	N.A.	Investigative	[11]
[3H]Ro154513	DMMBWKL	Discovery agent	N.A.	Investigative	[15]
[3H]CGS8216	DMLP68J	Inflammation	1A00-CA43.1	Investigative	[11]
CI-218872	DM0RH3S	Discovery agent	N.A.	Investigative	[16]

Drug(s) Targeting Gamma-aminobutyric acid receptor (GAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[17]
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[18]
THIOCOLCHICOSIDE	DMEPWYA	Muscle spasm	MB47.3	Approved	[4]
Clonazepam	DMTO13J	Absence epilepsy		Approved	[19]
Piperazine	DMTY9LU	Ascariasis	1F62	Approved	[20]
Alpidem	DMN7Y9K	Anxiety disorder	6B00-6B0Z	Approved	[21]
Moxidectin	DMYGHX5	Onchocerciasis	1F6A	Approved	[22]
DP-VPA	DMGOXPQ	Bipolar disorder	6A60	Approved	[23]
ANDROSTERONE	DMITJAK	N. A.	N. A.	Phase 3	[18]
ZK-93423	DMFWMKZ	Epileptic seizures	8A61-8A6Z	Phase 3	[5]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
GABA(A) receptor alpha-2 (GABRA2)	TTBMV1G	GBRA2_HUMAN	Inhibitor	[2]
GABA(A) receptor gamma-2 (GABRG2)	TT06RH5	GBRG2_HUMAN	Inhibitor	[2]
Gamma-aminobutyric acid receptor (GAR)	TTNJYV2	NOUNIPROTAC	Inhibitor	[2]

References

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• [18] Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. J Med Chem. 2006 Jul 27;49(15):4595-605.
• [19] Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17.
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• [22] 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
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