Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOGYQ0)

• Drug Name: ONO-2952 Drug Info
• Synonyms: Translocator protein 18kDr (TSPO) antagonist (irritable bowel syndrome), Ono Pharmaceutical

Indication

Disease Entry	ICD 11	Status	REF
Irritable bowel syndrome	DD91.0	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 11524127
  CAS Number: CAS 895169-20-7
  TTD Drug ID: DMOGYQ0

Molecule-Related Drug Atlas

Drug(s) Targeting Translocator protein (TSPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[3]
Flunitrazepam	DMGR5Z3	Insomnia	7A00-7A0Z	Approved	[4]
Oxazepam	DMXNZM4	Alcohol withdrawal delirium		Approved	[5]
Midazolam	DMXOELT	Agitation	6A70.3	Approved	[6]
Temazepam	DM02A65	Insomnia	7A00-7A0Z	Approved	[6]
Flumazenil	DMPCG2L	Benzodiazepine overdose	PC91	Approved	[7]
Alprazolam	DMC7XDN	Anxiety		Approved	[4]
Clotiazepam	DM59AZT	Anxiety disorder	6B00-6B0Z	Approved	[8]
Quazepam	DMY4D87	Insomnia	7A00-7A0Z	Approved	[6]
Eszopiclone	DM8RZ9H	Insomnia	7A00-7A0Z	Approved	[9]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Translocator protein (TSPO)	TTPTXIN	TSPO_HUMAN	Antagonist	[2]

References

• [1] ClinicalTrials.gov (NCT01887002) Study to Evaluate the Effects of ONO-2952 on Pain Perception Produced by Rectal Distention in Female Subjects With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D). U.S. National Institutes of Health.
• [2] Anti-stress effects of ONO-2952, a novel translocator protein 18 kDa antagonist, in rats. Neuropharmacology. 2015 Jul 17;99:51-66.
• [3] Translocator protein (18 kDa) mediates the pro-growth effects of diazepam on Ehrlich tumor cells in vivo. Eur J Pharmacol. 2010 Jan 25;626(2-3):131-8.
• [4] Comparison of five benzodiazepine-receptor agonists on buprenorphine-induced mu-opioid receptor regulation. J Pharmacol Sci. 2009 May;110(1):36-46.
• [5] Effects of the combination of metyrapone and oxazepam on cocaine and food self-administration in rats. Pharmacol Biochem Behav. 2008 Nov;91(1):181-9.
• [6] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [7] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2879).
• [8] Effects of benzodiazepines and non-benzodiazepine compounds on the GABA-induced response in frog isolated sensory neurones. Br J Pharmacol. 1989 Nov;98(3):735-40.
• [9] New hypnotics: perspectives from sleep physiology. Vertex. 2007 Jul-Aug;18(74):294-9.