Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOMLHJ)

Drug Name

Lymecycline Drug Info

Synonyms

Aureociclin; Aureomicina; Aurofac; Biovetin; Centraureo; Chlortetracyclin; Chrusomykine; Limeciclina; Lymecyclinum; Orospray; Acronize PD; Aurofac 10; Tetrlysal 300; Lymecycline (INN); Tetralysal 300 (TN); N(2)-(((+)-5-Amino-5-carboxypentylamino)methyl)tetracycline; N(6)-[({[(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracen-2-yl]carbonyl}amino)methyl]-L-lysine; (+)-N-(5-Amino-5-carboxypentylaminomethyl)-4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxonaphthacene-2-carboxamide

Indication

Disease Entry	ICD 11	Status	REF
Bacterial infection	1A00-1C4Z	Approved	[1]

Therapeutic Class

Antibiotics

Cross-matching ID

PubChem CID: 54707177
ChEBI ID: CHEBI:59040
CAS Number: CAS 992-21-2
TTD Drug ID: DMOMLHJ

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Staphylococcus 30S ribosomal subunit (Stap-coc pbp2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[3]
Framycetin	DMF8DNE	Acute liver failure	DB91	Approved	[4]
Netilmicin	DMRD1QK	Bacterial infection	1A00-1C4Z	Approved	[5]
Amikacin	DM5PDRB	Bacteremia	1A73	Approved	[6]
Clomocycline	DM0ZRMQ	Bacterial infection	1A00-1C4Z	Approved	[7]
Spectinomycin	DM0MQ35	Acute gonococcal cervicitis		Approved	[8]
Paromomycin	DM1AGXN	Amoebiasis	1A36	Approved	[9]
Rolitetracycline	DMBR5Q7	Acne vulgaris	ED80	Approved	[10]
Meclocycline	DMSFQ8I	Bacterial infection	1A00-1C4Z	Approved	[11]
Minocycline	DMVN5OH	Acne vulgaris	ED80	Approved	[12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Staphylococcus 30S ribosomal subunit (Stap-coc pbp2)	TTQ8KVI	F4NA87_STAAU	Binder	[2]

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References

1	Drug information of Lymecycline, 2008. eduDrugs.
2	Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
3	The glycylcyclines: a comparative review with the tetracyclines. Drugs. 2004;64(1):63-88.
4	Characterization of a 30S ribosomal subunit assembly intermediate found in Escherichia coli cells growing with neomycin or paromomycin. Arch Microbiol. 2008 May;189(5):441-9.
5	Ribosomal resistance in the gentamicin producer organism Micromonospora purpurea. Antimicrob Agents Chemother. 1982 Aug;22(2):231-6.
6	Bacterial resistance to aminoglycosides and beta-lactams: the Tn1331 transposon paradigm. Front Biosci. 2000 Jan 1;5:D20-9.
7	Molecular dynamics simulations of the 30S ribosomal subunit reveal a preferred tetracycline binding site. J Am Chem Soc. 2008 Jan 30;130(4):1114-5.
8	Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics. Nature. 2000 Sep 21;407(6802):340-8.
9	Aminoglycoside association pathways with the 30S ribosomal subunit. J Phys Chem B. 2009 May 21;113(20):7322-30.
10	Reversed-phase high-performance liquid chromatography coupled to ultraviolet and electrospray time-of-flight mass spectrometry on-line detection fo... J Chromatogr A. 2008 Jun 27;1195(1-2):107-16.
11	Detection of tetracycline resistance genes by PCR methods. Methods Mol Biol. 2004;268:3-13.
12	Functional, biophysical, and structural bases for antibacterial activity of tigecycline. Antimicrob Agents Chemother. 2006 Jun;50(6):2156-66.