Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOUVE7)

Drug Name

BAY-85-8102 Drug Info

Synonyms

Benzodiazepine receptor agonist (brain disease imaging), University of Sydney; DPA-714-[18F]; F-18 DPA-714; Fluorine-18-DPA-714; Translocator protein-specific ligand (brain disease imaging), University of Sydney; 18F-DPA-714

Indication

Disease Entry	ICD 11	Status	REF
Brain disease	8C70-8E61	Phase 1	[1]

Cross-matching ID

TTD Drug ID: DMOUVE7

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Translocator protein (TSPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[3]
Flunitrazepam	DMGR5Z3	Insomnia	7A00-7A0Z	Approved	[4]
Oxazepam	DMXNZM4	Alcohol withdrawal delirium		Approved	[5]
Midazolam	DMXOELT	Agitation	6A70.3	Approved	[6]
Temazepam	DM02A65	Insomnia	7A00-7A0Z	Approved	[6]
Flumazenil	DMPCG2L	Benzodiazepine overdose	PC91	Approved	[2]
Alprazolam	DMC7XDN	Anxiety		Approved	[4]
Clotiazepam	DM59AZT	Anxiety disorder	6B00-6B0Z	Approved	[7]
Quazepam	DMY4D87	Insomnia	7A00-7A0Z	Approved	[6]
Eszopiclone	DM8RZ9H	Insomnia	7A00-7A0Z	Approved	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Translocator protein (TSPO)	TTPTXIN	TSPO_HUMAN	Agonist	[2]

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References

1	ClinicalTrials.gov (NCT01009359) Evaluation of the Neuroinflammation Pattern of BAY85-8102 F-18, DPA-714 in Probable Alzheimers Disease Patients Versus Healthy Volunteers and Radiation Dosimetry of F18, DPA-714 in Healthy Volunteers. U.S. National Institutes of Health.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2879).
3	Translocator protein (18 kDa) mediates the pro-growth effects of diazepam on Ehrlich tumor cells in vivo. Eur J Pharmacol. 2010 Jan 25;626(2-3):131-8.
4	Comparison of five benzodiazepine-receptor agonists on buprenorphine-induced mu-opioid receptor regulation. J Pharmacol Sci. 2009 May;110(1):36-46.
5	Effects of the combination of metyrapone and oxazepam on cocaine and food self-administration in rats. Pharmacol Biochem Behav. 2008 Nov;91(1):181-9.
6	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
7	Effects of benzodiazepines and non-benzodiazepine compounds on the GABA-induced response in frog isolated sensory neurones. Br J Pharmacol. 1989 Nov;98(3):735-40.
8	New hypnotics: perspectives from sleep physiology. Vertex. 2007 Jul-Aug;18(74):294-9.