General Information of Drug (ID: DMTE0S3)

Drug Name
Isoindoline derivative 2 Drug Info
Synonyms PMID30185082-Compound-67
Cross-matching ID
PubChem CID
118282969
TTD Drug ID
DMTE0S3

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
VESNARINONE DMBKX3C Cardiac failure BD10-BD13 Approved [2]
M100907 DM7ZFBA Sleep-wake disorder 7A00-7B2Z Phase 3 [3]
HP-184 DMNOMV2 Multiple sclerosis 8A40 Phase 2 [4]
NITD609 DMQHBSX Malaria 1F40-1F45 Phase 2 [5]
ABT-229 DMN3S1B Pain MG30-MG3Z Phase 2 [6]
ISOQUINE DMR17YI Malaria 1F40-1F45 Phase 1 [7]
Pyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazine derivative 1 DMC8935 N. A. N. A. Patented [8]
Isoindoline derivative 5 DMIUTQW N. A. N. A. Patented [1]
Isoindoline derivative 3 DM2MYL9 N. A. N. A. Patented [1]
Isoindoline derivative 4 DMP1NKI N. A. N. A. Patented [1]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
MIN-101 DMCJY35 Schizophrenia 6A20 Phase 3 [9]
CT1812 DMBRKZ7 Alzheimer disease 8A20 Phase 2 [10]
Isoindoline derivative 5 DMIUTQW N. A. N. A. Patented [1]
Isoindoline derivative 3 DM2MYL9 N. A. N. A. Patented [1]
Isoindoline derivative 4 DMP1NKI N. A. N. A. Patented [1]
Isoindoline derivative 1 DMD19QC N. A. N. A. Patented [1]
Benzamide derivative 9 DMVFSJZ N. A. N. A. Patented [1]
Benzamide derivative 10 DM9PKU2 N. A. N. A. Patented [1]
PMID30185082-Compound-57 DMNDF1Z N. A. N. A. Patented [1]
PMID28051882-Compound-XIV DM1RN89 N. A. N. A. Patented [11]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dextromethorphan DMUDJZM Allergic rhinitis CA08.0 Approved [12]
Dextromethorphan Polistirex DMEHCY5 Dry cough MD12 Approved [13]
CM-2395 DMASPWR Schizophrenia 6A20 Phase 3 [14]
AVP-786 DMV1SOR Alzheimer disease 8A20 Phase 3 [15]
ADX N05 DMLBYRA Mood disorder 6A60-6E23 Phase 3 [16]
Igmesine DMH97XA Major depressive disorder 6A70.3 Phase 2 [17]
OPC-14523 DMB1WF3 Bulimia nervosa 6B81 Phase 2 [18]
ANAVEX 2-73 DM67OU4 Alzheimer disease 8A20 Phase 1 [19]
SSR-125047 DMSUFW6 Schizophrenia 6A20 Phase 1 [20]
SA-5845 DM6XZRL Central nervous system disease 8A04-8D87 Phase 1 [21]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Opioid receptor sigma 1 (OPRS1) TT5TPI6 SGMR1_HUMAN Ligand [1]
Sigma intracellular receptor 2 (TMEM97) TT9NXW4 SGMR2_HUMAN Ligand [1]
Voltage-gated potassium channel Kv11.1 (KCNH2) TTQ6VDM KCNH2_HUMAN Ligand [1]

References

1 The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663.
2 Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2773-5.
3 Non-basic ligands for aminergic GPCRs: the discovery and development diaryl sulfones as selective, orally bioavailable 5-HT2A receptor antagonists ... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3708-12.
4 Emerging drugs for spinal cord injury. Expert Opin Emerg Drugs. 2008 Mar;13(1):63-80.
5 Spiroindolones, a potent compound class for the treatment of malaria. Science. 2010 Sep 3;329(5996):1175-80.
6 9-Dihydroerythromycin ethers as motilin agonists--developing structure-activity relationships for potency and safety. Bioorg Med Chem. 2010 Nov 1;18(21):7651-8.
7 Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for ... J Med Chem. 2009 Mar 12;52(5):1408-15.
8 Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46.
9 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
10 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
11 Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578.
12 Dextromethorphan/quinidine: AVP 923, dextromethorphan/cytochrome P450-2D6 inhibitor, quinidine/dextromethorphan. Drugs R D. 2005;6(3):174-7.
13 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
14 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031127)
15 Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82.
16 Clinical pipeline report, company report or official report of SK BioPhamaceuticals.
17 Antiamnesic and neuroprotective effects of donepezil against learning impairments induced in mice by exposure to carbon monoxide gas. J Pharmacol Exp Ther. 2006 Jun;317(3):1307-19.
18 Antidepressant-like responses to the combined sigma and 5-HT1A receptor agonist OPC-14523. Neuropharmacology. 2001 Dec;41(8):976-88.
19 2011 Pipeline of Anavex.
20 The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22.
21 Tumor imaging with 2 sigma-receptor ligands, 18F-FE-SA5845 and 11C-SA4503: a feasibility study. J Nucl Med. 2004 Nov;45(11):1939-45.