Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVNR20)

• Drug Name: Epipodophyllotoxins Drug Info
• Synonyms: (-)-epipodophyllotoxin; 137513-EP2272827A1; 137513-EP2292088A1; AC1L2Y2E; AJ-42064; BRN 0099162; C22H22O8; CHEMBL282256; Epipodophyllotoxin; Etopside; Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R,5aR,8aR,9S)-; Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R-(5-alpha,5a-beta,8a-alpha,9-beta))-; LS-70861; SCHEMBL5792464; VP16; ZINC2572657
• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 105111
  CAS Number: CAS 4375-07-9
  TTD Drug ID: DMVNR20
  VARIDT Drug ID: DR00345

Molecule-Related Drug Atlas

Drug(s) Transported By Multidrug resistance-associated protein 3 (ABCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[3]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[4]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[5]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[6]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[7]
Glibenclamide	DM8JXPZ	Diabetic complication	5A2Y	Approved	[8]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[9]
Cefadroxil	DMMC345	Bacterial infection	1A00-1C4Z	Approved	[10]
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[2]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[11]

Drug(s) Transported By Multidrug resistance-associated protein 6 (ABCC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[1]
Benzbromarone	DMC3YUA	Gout	FA25	Approved	[12]

Molecular Interaction Atlas of This Drug

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Multidrug resistance-associated protein 6 (ABCC6)	DT582KR	MRP6_HUMAN	Substrate	[1]
Multidrug resistance-associated protein 3 (ABCC3)	DTQ3ZHF	MRP3_HUMAN	Substrate	[2]

References

• [1] Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6). Cancer Res. 2002 Nov 1;62(21):6172-7.
• [2] Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3). J Biol Chem. 2001 Dec 7;276(49):46400-7.
• [3] Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)prostaglandin J2 in MCF7 breast cancer cells. Biochemistry. 2003 May 13;42(18):5429-37.
• [4] Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. Cancer Res. 2001 Oct 1;61(19):7225-32.
• [5] ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology. 2009;9(1-2):136-44.
• [6] Functional reconstitution of human ABCC3 into proteoliposomes reveals a transport mechanism with positive cooperativity. Biochemistry. 2009 May 26;48(20):4423-30.
• [7] Complex pharmacokinetic behavior of ezetimibe depends on abcc2, abcc3, and abcg2. Drug Metab Dispos. 2009 Aug;37(8):1698-702.
• [8] Transport of glyburide by placental ABC transporters: implications in fetal drug exposure. Placenta. 2006 Nov-Dec;27(11-12):1096-102.
• [9] Multidrug resistance-associated proteins 3, 4, and 5. Pflugers Arch. 2007 Feb;453(5):661-73.
• [10] Oral availability of cefadroxil depends on ABCC3 and ABCC4. Drug Metab Dispos. 2012 Mar;40(3):515-21.
• [11] Involvement of multiple efflux transporters in hepatic disposition of fexofenadine. Mol Pharmacol. 2008 May;73(5):1474-83.
• [12] The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 3.A.1.208.10)