Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWCGE8)

• Drug Name: 2-ethyl-4-(thiazol-2-yl)thieno[3,2-d]pyrimidine Drug Info
• Synonyms: CHEMBL407650; 2-ethyl-4-(2-thiazolyl)thieno[3,2-d]pyrimidine; 443148-33-2; SCHEMBL3674131

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 9834769
  TTD Drug ID: DMWCGE8

Molecule-Related Drug Atlas

Drug(s) Targeting Adenosine A3 receptor (ADORA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IB-MECA	DM9G5XD	Psoriasis vulgaris	EA90	Phase 3	[2]
Tonapofylline	DMBH316	Acute and chronic heart failure	BD1Z	Phase 2	[3]
NITD609	DMQHBSX	Malaria	1F40-1F45	Phase 2	[4]
CF102	DMP56WJ	Hepatocellular carcinoma	2C12.02	Phase 2	[5]
SCH-442416	DMQ2K1V	N. A.	N. A.	Phase 1	[6]
BEMESETRON	DMSPJX9	N. A.	N. A.	Discontinued in Phase 3	[7]
BAY 60-6583	DMTEJV1	Myocardial ischemia	BA6Z	Preclinical	[8]
CF602	DM0ULO2	Inflammation	1A00-CA43.1	Preclinical	[5]
CF502	DMQSJ20	Inflammation	1A00-CA43.1	Preclinical	[5]
Methylthioadenosine	DMC8J6F	Multiple sclerosis	8A40	Terminated	[9]

Drug(s) Targeting Adenosine A2a receptor (ADORA2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Caffeine	DMKBJWP	Orthostatic hypotension	BA21	Approved	[10]
Istradefylline	DM20VSK	Parkinson disease	8A00.0	Approved	[11]
Regadenoson	DM76VHG	Radionuclide imaging	N.A.	Approved	[12]
Tozadenant	DMATC14	Parkinson disease	8A00.0	Phase 3	[13]
Binodenoson	DMVHF8G	Hypertension	BA00-BA04	Phase 3	[14]
Apadenoson	DMD8QTC	Coronary artery disease	BA80	Phase 3	[15]
Tonapofylline	DMBH316	Acute and chronic heart failure	BD1Z	Phase 2	[3]
Dexefaroxan	DMTY4KN	Parkinson disease	8A00.0	Phase 2	[16]
AMP-579	DMJ4GPR	Hyperlipidaemia	5C80	Phase 2	[17]
BIIB014	DMH7RJ1	Parkinson disease	8A00.0	Phase 2	[18]

Drug(s) Targeting Adenosine A2b receptor (ADORA2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[19]
Vidarabine	DM0N85H	Herpes simplex virus infection	1F00	Approved	[19]
Tonapofylline	DMBH316	Acute and chronic heart failure	BD1Z	Phase 2	[3]
YT-146	DM3YVKQ	Hypertension	BA00-BA04	Phase 2	[20]
AB928	DMDOXMN	Metastatic colorectal cancer	2B91	Phase 1/2	[21]
KF-17837	DMQ6DLZ	Parkinson disease	8A00.0	Phase 1	[22]
Xanthine	DMFBOQ7	Apnea	MD11.0	Phase 1	[23]
CVT-6883	DMY84TW	Asthma	CA23	Phase 1	[24]
PBF-1129	DMOPGXM	Non-small-cell lung cancer	2C25.Y	Phase 1	[21]
PF-1913539	DMXEU14	Alzheimer disease	8A20	Discontinued in Phase 3	[25]

Drug(s) Targeting Adenosine A1 receptor (ADORA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Caffeine	DMKBJWP	Orthostatic hypotension	BA21	Approved	[10]
Rolofylline	DMSZPR3	Heart failure	BD10-BD13	Phase 3	[26]
Tonapofylline	DMBH316	Acute and chronic heart failure	BD1Z	Phase 2	[3]
AMP-579	DMJ4GPR	Hyperlipidaemia	5C80	Phase 2	[17]
SELODENOSON	DMQM3IX	Cardiac arrhythmias	BC9Z	Phase 2	[27]
Apaxifylline	DMQMV9F	Cognitive impairment	6D71	Phase 2	[28]
SLV320	DM867BJ	Heart failure	BD10-BD13	Phase 2	[29]
DTI-0009	DMV84OK	Atrial fibrillation	BC81.3	Phase 2	[27]
Capadenoson	DMYWO62	Atrial fibrillation	BC81.3	Phase 2	[30]
BAY 1067197	DM4JGNH	Heart failure	BD10-BD13	Phase 2	[31]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adenosine A1 receptor (ADORA1)	TTK25J1	AA1R_HUMAN	Inhibitor	[1]
Adenosine A2a receptor (ADORA2A)	TTM2AOE	AA2AR_HUMAN	Inhibitor	[1]
Adenosine A2b receptor (ADORA2B)	TTNE7KG	AA2BR_HUMAN	Inhibitor	[1]
Adenosine A3 receptor (ADORA3)	TTJFY5U	AA3R_HUMAN	Inhibitor	[1]

References

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