Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWE6V1)

• Drug Name: Putrescine Drug Info
• Synonyms: putrescine; 1,4-diaminobutane; 1,4-butanediamine; butane-1,4-diamine; 110-60-1; tetramethylenediamine; Butylenediamine; Putrescin; 1,4-Butylenediamine; Tetramethyldiamine; 1,4-Tetramethylenediamine; putrescina; Putreszin; Tetramethylendiamin; UNII-V10TVZ52E4; NSC 60545; BRN 0605282; H2N(CH2)4NH2; CCRIS 6751; AI3-25444; 1,4-Diamino-n-butane; EINECS 203-782-3; 1,4-Diaminobutane, 99%; CHEMBL46257; V10TVZ52E4; CHEBI:17148; KIDHWZJUCRJVML-UHFFFAOYSA-N; MFCD00008235; 1,4-butanediammonium; Diaminobutane dihydrochloride; PUT; HSDB 7865

Indication

Disease Entry	ICD 11	Status	REF
Burn and burn infection	ND90-NE2Z	Discontinued in Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 1045
  ChEBI ID: CHEBI:17148
  CAS Number: CAS 110-60-1
  TTD Drug ID: DMWE6V1
  INTEDE Drug ID: DR1790

Molecule-Related Drug Atlas

Drug(s) Targeting S-adenosylmethionine decarboxylase proenzyme (AMD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tromethamine	DMOBLGK	Acidosis	5C73	Approved	[2]
ORG 34517/34850	DMR3P98	Mood disorder	6A60-6E23	Phase 2	[5]
MGBG	DM9GOT6	Head and neck cancer	2D42	Terminated	[5]
CGP-40215A	DM69YWS	Pneumocystis pneumonia	CA40.20	Terminated	[6]
5'-deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine	DM6HGUL	Discovery agent	N.A.	Investigative	[7]
5'-Deoxy-5'-(N,N-dimethylamino)adenosine	DMF7JPO	Discovery agent	N.A.	Investigative	[8]
Hydroxyalanine	DM5HWZY	Discovery agent	N.A.	Investigative	[9]
5'-Deoxy-5'-dimethylsulfonioadenosine chloride	DM1NAMK	Discovery agent	N.A.	Investigative	[8]
[(2-aminooxyethyl)methylamino]-5'-deoxyadenosine	DM3WDOY	Discovery agent	N.A.	Investigative	[8]
5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine	DMT6D5V	Discovery agent	N.A.	Investigative	[7]

Drug(s) Targeting Ornithine decarboxylase (ODC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eflornithine	DMJOQM3	African trypanosomiasis	1F51	Approved	[10]
N'-Pyridoxyl-Lysine-5'-Monophosphate	DM3ZHBO	Discovery agent	N.A.	Investigative	[2]
G418	DMKTJBU	Discovery agent	N.A.	Investigative	[2]
Pyridoxine-5'-Phosphate	DMFUNL1	Discovery agent	N.A.	Investigative	[2]
APA	DMVG3K1	Discovery agent	N.A.	Investigative	[11]
AMXT-1501	DMPSRZ0	Head and neck cancer	2D42	Investigative	[12]
(2R,5R)-delta-methyl-alpha-acetylenic putrescine	DMSFXEO	Discovery agent	N.A.	Investigative	[10]
ZAPOTIN	DMM4ZKU	Discovery agent	N.A.	Investigative	[13]
LONCHOCARPUSONE	DMWFAPJ	Discovery agent	N.A.	Investigative	[14]
Alpha-monofluoromethyl-3,4-dehydroornithine methyl ester	DMGI9SM	Discovery agent	N.A.	Investigative	[10]

Drug(s) Metabolized By Amiloride-sensitive amine oxidase (AOC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[15]

Drug(s) Affected By Diamine oxidase (AOC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Amiloride	DMRTSGP	Congestive heart failure	BD10	Approved	[4]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[18]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[19]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[20]
Aminoguanidine	DMJQDUC	Diabetic retinopathy	9B71.0	Phase 1	[4]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[22]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[23]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Ornithine decarboxylase (ODC1)	TTUMGNO	DCOR_HUMAN	Inhibitor	[2]
S-adenosylmethionine decarboxylase proenzyme (AMD1)	TTBFROQ	DCAM_HUMAN	Inhibitor	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Amiloride-sensitive amine oxidase (AOC1) Main DME	DETECWH	AOC1_HUMAN	Substrate	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Diamine oxidase (AOC1)	OTRC220K	AOC1_HUMAN	Regulation of Drug Effects	[4]

References

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• [2] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [3] Putrescine metabolism and the study of diamine oxidase activity in vivo. Agents Actions. 1981 Apr;11(1-2):20-7.
• [4] Diamine oxidase is the amiloride-binding protein and is inhibited by amiloride analogues. J Biol Chem. 1994 Apr 1;269(13):9921-5.
• [5] A phase I study of a new polyamine biosynthesis inhibitor, SAM486A, in cancer patients with solid tumours. Br J Cancer. 2000 Sep;83(5):594-601.
• [6] Antileishmanial effect of a potent S-adenosylmethionine decarboxylase inhibitor: CGP 40215A. Pharmacol Res. 1996 Jan;33(1):67-70.
• [7] S-adenosylmethionine decarboxylase as an enzyme target for therapy. Pharmacol Ther. 1992 Dec;56(3):359-77.
• [8] New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues ... J Med Chem. 2009 Mar 12;52(5):1388-407.
• [9] DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
• [10] Plasmodium falciparum and Plasmodium berghei: effects of ornithine decarboxylase inhibitors on erythrocytic schizogony. Exp Parasitol. 1987 Oct;64(2):237-43.
• [11] 2-substituted 3-(aminooxy)propanamines as inhibitors of ornithine decarboxylase: synthesis and biological activity. J Med Chem. 1992 Apr 17;35(8):1339-44.
• [12] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1276).
• [13] Synthesis and cancer chemopreventive activity of zapotin, a natural product from Casimiroa edulis. J Med Chem. 2007 Jan 25;50(2):350-5.
• [14] New bioactive flavonoids and stilbenes in cub resin insecticide. J Nat Prod. 1999 Feb;62(2):205-10.
• [15] Human kidney diamine oxidase: heterologous expression, purification, and characterization. J Biol Inorg Chem. 2002 Jun;7(6):565-79.
• [16] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
• [17] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [18] Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
• [19] Comparative Analysis of Transcriptomic Changes including mRNA and microRNA Expression Induced by the Xenoestrogens Zearalenone and Bisphenol A in Human Ovarian Cells. Toxins (Basel). 2023 Feb 9;15(2):140. doi: 10.3390/toxins15020140.
• [20] Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
• [21] Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
• [22] Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
• [23] DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.