Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMX681M)

• Drug Name: 4-(2-Thienyl)-1-(4-Methylbenzyl)-1h-Imidazole Drug Info
• Synonyms: 4-(2-THIENYL)-1-(4-METHYLBENZYL)-1H-IMIDAZOLE; Disubstituted imidazole 1; AC1L9J9C; CHEMBL66526; SCHEMBL4319860; BDBM8738; DB03030; 1-(4-methylbenzyl)-4-(2-thienyl)-1h-imidazole; 1-(4-methylbenzyl)-4-thiophen-2-yl-1H-imidazole; 1-[(4-methylphenyl)methyl]-4-thiophen-2-ylimidazole; 1-[(4-methylphenyl)methyl]-4-(thiophen-2-yl)imidazole

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 446185
  TTD Drug ID: DMX681M

Molecule-Related Drug Atlas

Drug(s) Targeting Plasmodium Enoyl-ACP reductase (Malaria fabI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[2]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[3]
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[1]
Beta-D-Glucose	DM5IHYP	Discovery agent	N.A.	Investigative	[1]
MORIN	DM2OGZ5	Discovery agent	N.A.	Investigative	[4]
3,7,3',4'-TETRAHYDROXYFLAVONE	DMES906	Discovery agent	N.A.	Investigative	[4]
(-)-CATECHINGALLATE	DMZOGSK	Discovery agent	N.A.	Investigative	[4]
Thiolactomycin	DMBAWDG	Malaria	1F40-1F45	Investigative	[2]
GALLOCATECHIN GALLATE	DMX2084	Discovery agent	N.A.	Investigative	[4]
Diazaborines	DM5UFZX	Discovery agent	N.A.	Investigative	[5]

Drug(s) Targeting Bacterial Fatty acid synthetase I (Bact inhA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[6]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[7]
Ethionamide	DM8K3EI	Pulmonary tuberculosis	1B10.Z	Approved	[8]
Prothionamide	DMX0EZJ	Tuberculosis	1B10-1B1Z	Approved	[8]
AFN-1720	DM6AJKC	Bacterial infection	1A00-1C4Z	Phase 2	[9]
MMV00/0053	DMF27BS	Malaria	1F40-1F45	Terminated	[10]
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[1]
Beta-D-Glucose	DM5IHYP	Discovery agent	N.A.	Investigative	[1]
2-Hexadecynoic acid	DMTFIPZ	Discovery agent	N.A.	Investigative	[11]
Indole Naphthyridinone	DMB4ZNW	Discovery agent	N.A.	Investigative	[1]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Fatty acid synthetase I (Bact inhA)	TTVTX4N	INHA_MYCTU	Inhibitor	[1]
Plasmodium Enoyl-ACP reductase (Malaria fabI)	TTNX2CS	Q965D5_PLAFA	Inhibitor	[1]

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [2] Novel molecular targets for antimalarial drug development. Chem Biol Drug Des. 2008 Apr;71(4):287-97.
• [3] Green tea catechins potentiate triclosan binding to enoyl-ACP reductase from Plasmodium falciparum (PfENR). J Med Chem. 2007 Feb 22;50(4):765-75.
• [4] Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53.
• [5] Lipid biosynthesis as a target for antibacterial agents. Prog Lipid Res. 2001 Nov;40(6):467-97.
• [6] Diversity in enoyl-acyl carrier protein reductases. Cell Mol Life Sci. 2009 May;66(9):1507-17.
• [7] Pyrazinamide inhibits the eukaryotic-like fatty acid synthetase I (FASI) of Mycobacterium tuberculosis. Nat Med. 2000 Sep;6(9):1043-7.
• [8] Mechanism of thioamide drug action against tuberculosis and leprosy. J Exp Med. 2007 Jan 22;204(1):73-8.
• [9] Affinium Pharmaceuticals Announces the Initiation of a Phase 1 Intravenous Clinical Trial of a New Antibiotic Prodrug, and the Closing of a Follow-on Financing Round. PR Newswire Sep. 4, 2013 10:16 PM.
• [10] SAR and pharmacophore models for the rhodanine inhibitors of Plasmodium falciparum enoyl-acyl carrier protein reductase. IUBMB Life. 2010 Mar;62(3):204-13.
• [11] 2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections. Bioorg Med Chem. 2010 Nov 1;18(21):7475-85.