Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXJMKF)

Drug Name

Ganaxolone Drug Info

Synonyms

Ganaxolone [USAN]; CCD 1042; CCD-1042; Ganaxolone (USAN/INN); (3alpha,5alpha)-3-Hydroxy-3-methylpregnan-20-one; 1-[(3R,5S,10S,13S,17S)-3-hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone; 1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone; 3alpha-Hydroxy-3-methyl-5alpha-pregnan-20-one; 3alpha-Hydroxy-3beta-methyl-5alpha-pregnan-20-one

Indication

Disease Entry	ICD 11	Status	REF
Complex partial seizure	8A68.0	Phase 3	[1]
Postpartum depression	6E20.0	Phase 2	[2]

Cross-matching ID

PubChem CID: 6918305
CAS Number: CAS 38398-32-2
TTD Drug ID: DMXJMKF

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting GABA(A) receptor delta (GABRD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	Approved	[6]
Gaboxadol	DMI53FU	Insomnia	7A00-7A0Z	Approved	[7]
SAGE-217b	DMRFK0B	Major depressive disorder	6A70.3	Phase 2	[6]
PF-4480682	DMWYJHC	Neuropathic pain	8E43.0	Discontinued in Phase 2	[8]
PF-2393296	DM5R2MG	Neuropathic pain	8E43.0	Discontinued in Phase 1	[9]
Co-60549	DMGIZHX	Anxiety disorder	6B00-6B0Z	Terminated	[10]
Org-20599	DMQU8AR	Anaesthesia	9A78.6	Terminated	[11]
TBPS	DMFC3XP	Discovery agent	N.A.	Investigative	[9]
RU-5135	DMCASRD	Discovery agent	N.A.	Investigative	[12]
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Drug(s) Targeting GABA(A) receptor gamma-3 (GABRG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolpidem	DMWOSKJ	Insomnia	7A00-7A0Z	Approved	[13]
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	Approved	[2]
Clobazam - Lundbeck	DMW1OQ0	Anxiety disorder	6B00-6B0Z	Approved	[14]
Flumazenil	DMPCG2L	Benzodiazepine overdose	PC91	Approved	[13]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[15]
Thiamylal	DMHDF7B	Anaesthesia	9A78.6	Approved	[14]
Mebutamate	DM0KYI4	Anxiety disorder	6B00-6B0Z	Approved	[14]
Metharbital	DM5A38V	Epilepsy	8A60-8A68	Approved	[14]
Etomidate	DMZI3WO	Anaesthesia	9A78.6	Approved	[14]
Remimazolam	DMLVSYX	Procedural sedation	JB0C.3	Approved	[16]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
GABA(A) receptor delta (GABRD)	TTGXH6N	GBRD_HUMAN	Modulator	[3]
GABA(A) receptor gamma-3 (GABRG3)	TTEX6LM	GBRG3_HUMAN	Agonist	[2] , [4] , [5]

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References

1	ClinicalTrials.gov (NCT01963208) Phase 3 Study of Adjunctive Ganaxolone in Adults With Drug-resistant Partial Onset Seizures and Open-label Extension. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Ganaxolone, a selective, high-affinity steroid modulator of the gamma-aminobutyric acid-A receptor, exacerbates seizures in animal models of absence. Ann Neurol. 1998 Oct;44(4):688-91.
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6	Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
7	Gaboxadol--a new awakening in sleep.Curr Opin Pharmacol.2006 Feb;6(1):30-6.
8	WO patent application no. 2014,1515,17, Methods of improving microvascular integrity.
9	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 416).
10	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007012)
11	The anaesthetic action and modulation of GABAA receptor activity by the novel water-soluble aminosteroid Org 20599. Neuropharmacology. 1996;35(9-10):1209-22.
12	Complex interactions between the steroid derivative RU 5135 and the GABAA-receptor complex. Eur J Pharmacol. 1992 Oct 1;227(2):147-51.
13	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415).
14	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
15	Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABA-A receptor channels. Epilepsia. 2006 Apr;47(4):704-16.
16	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020