Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYCQR4)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Translocator protein (TSPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[2]
Flunitrazepam	DMGR5Z3	Insomnia	7A00-7A0Z	Approved	[3]
Oxazepam	DMXNZM4	Alcohol withdrawal delirium		Approved	[4]
Midazolam	DMXOELT	Agitation	6A70.3	Approved	[5]
Temazepam	DM02A65	Insomnia	7A00-7A0Z	Approved	[5]
Flumazenil	DMPCG2L	Benzodiazepine overdose	PC91	Approved	[6]
Alprazolam	DMC7XDN	Anxiety		Approved	[3]
Clotiazepam	DM59AZT	Anxiety disorder	6B00-6B0Z	Approved	[7]
Quazepam	DMY4D87	Insomnia	7A00-7A0Z	Approved	[5]
Eszopiclone	DM8RZ9H	Insomnia	7A00-7A0Z	Approved	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010 - 2015; part 2).Expert Opin Ther Pat. 2016 Nov;26(11):1353-1366.
2	Translocator protein (18 kDa) mediates the pro-growth effects of diazepam on Ehrlich tumor cells in vivo. Eur J Pharmacol. 2010 Jan 25;626(2-3):131-8.
3	Comparison of five benzodiazepine-receptor agonists on buprenorphine-induced mu-opioid receptor regulation. J Pharmacol Sci. 2009 May;110(1):36-46.
4	Effects of the combination of metyrapone and oxazepam on cocaine and food self-administration in rats. Pharmacol Biochem Behav. 2008 Nov;91(1):181-9.
5	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
6	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2879).
7	Effects of benzodiazepines and non-benzodiazepine compounds on the GABA-induced response in frog isolated sensory neurones. Br J Pharmacol. 1989 Nov;98(3):735-40.
8	New hypnotics: perspectives from sleep physiology. Vertex. 2007 Jul-Aug;18(74):294-9.