Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZQ75M)

• Drug Name: Pyrophosphate 2- Drug Info
• Synonyms: pyrophosphate 2-; dihydrogen diphosphate; diphosphate(2-); AC1L1JDO; CHEBI:45212; H2P2O7(2-)

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 4995
  ChEBI ID: CHEBI:45212
  TTD Drug ID: DMZQ75M

Molecule-Related Drug Atlas

Drug(s) Targeting Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US9200020, Table 3, Compound 1B	DMEARS2	N. A.	N. A.	Patented	[2]
US9200020, Table 3, Compound 2B	DMXFB5Z	N. A.	N. A.	Patented	[2]
US9200020, Table 3 compound 8	DMCLHX5	N. A.	N. A.	Patented	[2]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[3]
Formic Acid	DMNFZC6	Discovery agent	N.A.	Investigative	[3]
Guanosine-5'-Monophosphate	DM3SLZK	Discovery agent	N.A.	Investigative	[3]
Inosinic Acid	DMLR86H	Discovery agent	N.A.	Investigative	[3]
Alpha-Phosphoribosylpyrophosphoric Acid	DMT6KI7	Discovery agent	N.A.	Investigative	[1]
Carboxylic PRPP	DMCTUR1	Discovery agent	N.A.	Investigative	[3]
5--Monophosphate-9-Beta-D-Ribofuranosyl Xanthine	DMX0EAK	Discovery agent	N.A.	Investigative	[3]

Drug(s) Targeting Virus RNA-dependent RNA polymerase (Viru RdRP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AT-527	DMARIQK	Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[4]
Guanosine-5'-Triphosphate	DMV2OJX	Discovery agent	N.A.	Investigative	[3]
Thiadiazolo[2,3-a]pyrimidine	DMKRG2C	Discovery agent	N.A.	Investigative	[5]
T-1105	DMGPQ0Y	Discovery agent	N.A.	Investigative	[5]
Pyrimidinyl acylthiourea	DM7T2VQ	Discovery agent	N.A.	Investigative	[5]
FdG	DMYXA7E	Discovery agent	N.A.	Investigative	[5]
T-1106	DMPA2E9	Virus infection	1A24-1D9Z	Investigative	[5]

Drug(s) Targeting Angiogenin (ANG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pyroglutamic Acid	DMROZUA	Discovery agent	N.A.	Investigative	[3]

Drug(s) Targeting Glutamine amidotransferase (GMPS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2,3,4-tribromo-6-(2,4-dibromophenoxy)phenol	DMQYEZP	Discovery agent	N.A.	Investigative	[6]
3,5-dibromo-2-(2,4-dibromophenoxy)phenol	DMCEY6O	Discovery agent	N.A.	Investigative	[6]
Decoyinine	DMHO3N1	Discovery agent	N.A.	Investigative	[7]
3,4,5-tribromo-2-(2', 4'-dibromo-phenoxy)phenol	DMS42CA	Discovery agent	N.A.	Investigative	[6]

Drug(s) Targeting Phosphogluconate dehydrogenase (PGD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GHRP-2	DMKGH0R	Growth hormone deficiency	5A61.3	Approved	[8]
5-deoxy-5-phosphono-D-arabinonate	DM65XZJ	Discovery agent	N.A.	Investigative	[9]
4-phospho-D-erythronate	DMW4KXQ	Discovery agent	N.A.	Investigative	[10]
6-Phosphogluconic Acid	DMB1QCY	Discovery agent	N.A.	Investigative	[3]
(2R)-2-Methyl-4,5-dideoxy	DM3K2TI	Discovery agent	N.A.	Investigative	[8]

Drug(s) Targeting Bacterial NH(3)-dependent NAD(+) synthetase (Bact nadE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[3]
[3H]alphabeta-meATP	DMWV5C3	Discovery agent	N.A.	Investigative	[3]
Diphosphate	DMHY30B	Discovery agent	N.A.	Investigative	[3]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Angiogenin (ANG)	TTURHFP	ANGI_HUMAN	Inhibitor	[1]
Bacterial NH(3)-dependent NAD(+) synthetase (Bact nadE)	TT8WCXO	NADE_ECOLI	Inhibitor	[1]
Glutamine amidotransferase (GMPS)	TTCFP0V	GUAA_HUMAN	Inhibitor	[1]
Phosphogluconate dehydrogenase (PGD)	TTZ3IFB	6PGD_HUMAN	Inhibitor	[1]
Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ)	TTBL49X	HGXR_PLAFG	Inhibitor	[1]
Plasmodium Hypoxanthine-guanine-xanthine phosphoribosyltransferase (Malaria LACZ)	TTOY91U	HGXR_PLAFK	Inhibitor	[1]
Virus RNA-dependent RNA polymerase (Viru RdRP)	TTSUKYD	POLG_HCVJA	Inhibitor	[1]

References

• [1] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [2] 6-oxopurine phosphoribosyltransferase inhibitors. US9200020.
• [3] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [4] AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19. Antimicrob Agents Chemother. 2021 Mar 18;65(4):e02479-20.
• [5] Activity of T-705 in a hamster model of yellow fever virus infection in comparison with that of a chemically related compound, T-1106. Antimicrob Agents Chemother. 2009 Jan;53(1):202-9.
• [6] Enzyme inhibitors: new and known polybrominated phenols and diphenyl ethers from four Indo-Pacific Dysidea sponges. J Nat Prod. 1995 Sep;58(9):1384-91.
• [7] High-level production from a baculovirus expression system and biochemical characterization of human GMP synthetase. Protein Expr Purif. 1995 Aug;6(4):487-95.
• [8] Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African trypanosomiasis. Bioorg Med Chem. 2003 Jul 17;11(14):3205-14.
• [9] Sugar derivatives as new 6-phosphogluconate dehydrogenase inhibitors selective for the parasite Trypanosoma brucei. Bioorg Med Chem. 2003 Apr 3;11(7):1207-14.
• [10] Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase. Bioorg Med Chem. 2010 Jul 15;18(14):5056-62.