Details of the Drug Reposition

General Information of This Drug (ID: DMUNSWV)

Drug Name
Cefradine   DMUNSWV
Synonyms
Anspor; Cefradin; Cefradina; Cefradinum; Cephradin; Cephradine; Eskacef; Sefril; Velosef; CEPHRADINE SODIUM; SKF D 39304; SQ 11436; VELOSEF 125; VELOSEF 250; VELOSEF 500; Anspor (TN); Cefradina [INN-Spanish]; Cefradinum [INN-Latin]; Cephradine (USP); Cephradine (anhydrous); Cephradine [USAN:BAN]; SQ-11436; SQ-22022; Velosef (TN); Cefradine (JAN/INN); SK&F D-39304; SK-D-39304; (6R,7R)-7-((R)-2-Amino-2-(1,4-cyclohexadien-1-yl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid; (6R,7R)-7-[[(2R)-2-amino-2-cyclohexa-1,4-dien-1-ylacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-{[(2R)-2-amino-2-cyclohexa-1,4-dien-1-ylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7-(D-2-Amino-2-(1,4-cyclohexadien-1-yl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)-oct-2-ene-2-caboxylic acid; 7-(D-2-Amino-2-(1,4-cyclohexadienyl)acetamide)desacetoxycephalosporanicacid; 7beta-[(2R)-2-(cyclohexa-1,4-dienyl)-2-phenylacetamido]-3-methyl-3,4-didehydrocepham-4-carboxylic acid
Therapeutic Class
Antibiotics
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

Information on Drug Reposition of This Drug

Molecular Interaction Atlas (MIA)
9 Approved Indication(s)
Indication Name Indication ID ICD-11 Status REF
Staphylococcus aureus infection DISK6PTH N.A. Approved [1]
Staphylococcal pneumonia DIS28ZSZ N.A. Approved [1]
Prostatitis DISL8OGN N.A. Approved [2]
Pars planitis DISF45DN N.A. Approved [3]
Bacterial infection DIS5QJ9S 1A00-1C4Z Approved [4]
Acute otitis media DISL8D8G AB00 Approved [5]
Respiratory tract infection DIS7OJYM CA45 Approved [1]
Pneumonia DIS8EF3M CA40 Approved [1]
Urinary tract infection DISMT6UV GC08 Approved [6]
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⏷ Show the Full List of 9 Indications(s)
1 Discontinued in Phase 2 Indication(s)
Indication Name Indication ID ICD-11 Status REF
Pharyngitis DISSN548 CA02.Z Discontinued in Phase 2 [7]
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References

1 Cefazolin. Ann Intern Med. 1978 Nov;89(5 Pt 1):650-6.
2 Developmental stage and infection status may affect drug distribution in the prostate of rats. Xenobiotica. 2024 Apr 25:1-9.
3 A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4830).
5 [Double-blind comparative trial of cefroxadine and cephalexin in the treatment of acute suppurative otitis media and acute exacerbation of chronic suppurative otitis media]. Jpn J Antibiot. 1983 Sep;36(9):2595-634.
6 [Bacterial pathogens and resistance patterns in community acquired pediatric urinary tract infection: experience of 152 cases]. Zhongguo Dang Dai Er Ke Za Zhi. 2006 Apr;8(2):115-7.
7 Cyclophosphamide, Doxorubicin, Vincristine w/ Irinotecan and Temozolomide in Ewings Sarcoma