Details of Disease

General Information of Disease (ID: DISL8OGN)

• Disease Name: Prostatitis
• Synonyms: prostate gland inflammation; inflammation of prostate gland; prostatitis; prostatitis (disease)
• Definition: An infectious or non-infectious inflammatory process affecting the prostate gland.
• Disease Hierarchy:
  DIS184KT: Skin inflammation
  DISWD40R: Disease
  DISFVG19: Prostate disease
  DISL8OGN: Prostatitis
• Disease Identifiers:
  MONDO ID: MONDO_0005280
  UMLS CUI: C0033581
  MedGen ID: 10965
  HPO ID: HP:0000024
  SNOMED CT ID: 9713002

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 6 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Carbenicillin	DMLEDNK	Approved	Small molecular drug	[1]
Cefradine	DMUNSWV	Approved	Small molecular drug	[2]
Cephalexin	DMD5JU8	Approved	Small molecular drug	[3]
Ciprofloxacin XR	DM2NLS9	Approved	Small molecular drug	[4]
Norfloxacin	DMIZ6W2	Approved	Small molecular drug	[5]
Ofloxacin	DM0VQN3	Approved	Small molecular drug	[6]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 11 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
RICTOR	TT143WL	Limited	Biomarker	[7]
CCL11	TTCF05Y	Strong	Biomarker	[8]
CXCL1	TTLK1RW	Strong	Biomarker	[9]
DNMT3A	TTJUALD	Strong	Biomarker	[10]
DNMT3B	TT6VZ78	Strong	Biomarker	[10]
IL10	TTT0Q1F	Strong	Biomarker	[11]
NPEPPS	TT371QC	Strong	Biomarker	[12]
NQO1	TT8XK6L	Strong	Therapeutic	[13]
CYSLTR1	TTGKOY9	Definitive	Biomarker	[14]
HRC	TTR4FKD	Definitive	Biomarker	[15]
NPR1	TTM9IYA	Definitive	Biomarker	[16]

This Disease Is Related to 2 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
ACP3	DEDW5H6	Strong	Biomarker	[17]
PSAT1	DEBS17P	Strong	Biomarker	[12]

This Disease Is Related to 15 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
AMBP	OTLU8GU8	Strong	Biomarker	[15]
DYNLL1	OTR69LHT	Strong	Biomarker	[7]
GHRH	OT94U6MO	Strong	Biomarker	[18]
PLAG1	OTT9AJQY	Strong	Biomarker	[12]
SMAD4	OTWQWCKG	Strong	Biomarker	[19]
TBCA	OTCCWMGK	Strong	Biomarker	[20]
ADAMTS2	OTTK22NO	Definitive	Altered Expression	[21]
ARIH1	OTO3XDR2	Definitive	Biomarker	[22]
HADHA	OTO557N2	Definitive	Altered Expression	[23]
HADHB	OT4Y1I62	Definitive	Altered Expression	[23]
MMP26	OT9O89KU	Definitive	Altered Expression	[24]
NANOS2	OTFM2IDJ	Definitive	Altered Expression	[25]
NPHS1	OT21JD3P	Definitive	Biomarker	[26]
TLR10	OTQ1KVJO	Definitive	Biomarker	[27]
TMPO	OTL68EL4	Definitive	Altered Expression	[23]

References

• [1] Carbenicillin FDA Label
• [2] Developmental stage and infection status may affect drug distribution in the prostate of rats. Xenobiotica. 2024 Apr 25:1-9.
• [3] Cephalexin FDA Label
• [4] Comparison of a 3-day with a 1-day regimen of an extended-release formulation of ciprofloxacin as antimicrobial prophylaxis for patients undergoing transrectal needle biopsy of the prostate. BJU Int. 2007 Jul;100(1):51-7.
• [5] Norfloxacin FDA Label
• [6] Ofloxacin FDA Label
• [7] Pathological lesions and global DNA methylation in rat prostate under streptozotocin-induced diabetes and melatonin supplementation.Cell Biol Int. 2018 Apr;42(4):470-487. doi: 10.1002/cbin.10920. Epub 2018 Feb 8.
• [8] Expression of proinflammatory genes during estrogen-induced inflammation of the rat prostate.Prostate. 2000 Jun 15;44(1):19-25. doi: 10.1002/1097-0045(20000615)44:1<19::aid-pros3>3.0.co;2-s.
• [9] Effect of a phytotherapeutic agent, Eviprostat, on prostatic and urinary cytokines/chemokines in a rat model of nonbacterial prostatitis.Prostate. 2011 Mar 1;71(4):438-44. doi: 10.1002/pros.21299. Epub 2010 Oct 28.
• [10] Vinclozolin exposure in utero induces postpubertal prostatitis and reduces sperm production via a reversible hormone-regulated mechanism.Endocrinology. 2010 Feb;151(2):783-92. doi: 10.1210/en.2009-0982. Epub 2010 Jan 7.
• [11] [Effect of danpu capsule on inflammatory factors in rat model of autoimmune prostatitis].Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008 Nov;28(11):1018-21.
• [12] Clinical significance of urine prostatic exosomal protein in the diagnosis of prostate cancer.Am J Cancer Res. 2019 May 1;9(5):1074-1078. eCollection 2019.
• [13] Procyanidin B2 ameliorates carrageenan-induced chronic nonbacterial prostatitis in rats via anti-inflammatory and activation of the Nrf2 pathway.Biochem Biophys Res Commun. 2017 Nov 4;493(1):794-799. doi: 10.1016/j.bbrc.2017.08.089. Epub 2017 Aug 24.
• [14] The anti-inflammatory effect of montelukast, a cysteinyl leukotriene receptor-1 antagonist, against estradiol-induced nonbacterial inflammation in the rat prostate.Naunyn Schmiedebergs Arch Pharmacol. 2017 Feb;390(2):197-205. doi: 10.1007/s00210-016-1325-4. Epub 2016 Dec 1.
• [15] Voiding behavior and chronic pelvic pain in two types of rat nonbacterial prostatitis models: Attenuation of chronic pelvic pain by repeated administration of tadalafil.Prostate. 2019 Apr;79(5):446-453. doi: 10.1002/pros.23750. Epub 2018 Dec 14.
• [16] Expression and Regulation of Brain Natriuretic Peptide and Natriuretic Peptide Receptor A (NPR-A) in L6-S1 Dorsal Root Ganglia in a Rat Model of Chronic Nonbacterial Prostatitis.Med Sci Monit. 2019 Nov 28;25:9042-9047. doi: 10.12659/MSM.915619.
• [17] Identification of HLA-DRB1*1501-restricted T-cell epitopes from human prostatic acid phosphatase.Prostate. 2007 Jul 1;67(10):1019-28. doi: 10.1002/pros.20575.
• [18] Growth hormone-releasing hormone antagonists reduce prostatic enlargement and inflammation in carrageenan-induced chronic prostatitis.Prostate. 2018 Sep;78(13):970-980. doi: 10.1002/pros.23655. Epub 2018 May 21.
• [19] [Expressions of transforming growth factor-beta(1) and Smad4 in rat models of chronic nonbacterial prostatitis and their clinical significance].Zhonghua Nan Ke Xue. 2010 Jun;16(6):490-4.
• [20] Establishment of a rat model of chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) induced by immunization with a novel peptide T2.Biomed Pharmacother. 2017 Jul;91:687-692. doi: 10.1016/j.biopha.2017.05.004. Epub 2017 May 9.
• [21] Commensal bacterial modulation of the host immune response to ameliorate pain in a murine model of chronic prostatitis.Pain. 2017 Aug;158(8):1517-1527. doi: 10.1097/j.pain.0000000000000944.
• [22] Pharmacological interventions for treating chronic prostatitis/chronic pelvic pain syndrome.Cochrane Database Syst Rev. 2019 Oct 6;10(10):CD012552. doi: 10.1002/14651858.CD012552.pub2.
• [23] Differential expression of the TP and TP isoforms of the human T Prostanoid receptor during chronic inflammation of the prostate: Role for FOXP1 in the transcriptional regulation of TP during monocyte-macrophage differentiation.Exp Mol Pathol. 2019 Oct;110:104277. doi: 10.1016/j.yexmp.2019.104277. Epub 2019 Jul 2.
• [24] Activation of pro-gelatinase B by endometase/matrilysin-2 promotes invasion of human prostate cancer cells.J Biol Chem. 2003 Apr 25;278(17):15056-64. doi: 10.1074/jbc.M210975200. Epub 2003 Feb 13.
• [25] Nitric oxide synthases in normal and benign hyperplastic human prostate: immunohistochemistry and molecular biology.J Pathol. 1999 Oct;189(2):224-9. doi: 10.1002/(SICI)1096-9896(199910)189:2<224::AID-PATH422>3.0.CO;2-K.
• [26] Urovirulence determinants in Escherichia coli strains causing prostatitis.J Infect Dis. 1997 Aug;176(2):464-9. doi: 10.1086/514065.
• [27] Toll-like receptor 10 (TLR10) exhibits suppressive effects on inflammation of prostate epithelial cells.Asian J Androl. 2019 Jul-Aug;21(4):393-399. doi: 10.4103/aja.aja_100_18.