Details of Disease

General Information of Disease (ID: DISK6PTH)

Disease Name Staphylococcus aureus infection
Definition An infectious process in which the bacteria Staphylococcus aureus is present.
Disease Hierarchy
DISY8WGS: Staphylococcus infection
DISEM33Q: Infectious disease
DISK6PTH: Staphylococcus aureus infection
Disease Identifiers
MONDO ID
MONDO_0005545
UMLS CUI
C1318973
MedGen ID
232934
SNOMED CT ID
406602003

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 43 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Amoxicillin DMUYNEI Approved Small molecular drug [1]
Ampicillin DMHWE7P Approved Small molecular drug [2]
Cefaclor DMJXDGC Approved Small molecular drug [3]
Cefadroxil DMMC345 Approved Small molecular drug [4]
Cefamandole DMNEXZF Approved Small molecular drug [5]
Cefdinir DMJ7A0H Approved Small molecular drug [6]
Cefditoren DMSUVM1 Approved Small molecular drug [7]
Cefepime DMHVWIK Approved Small molecular drug [8]
Cefonicid DMTX2BH Approved Small molecular drug [9]
Cefotetan DM07TX3 Approved Small molecular drug [10]
Cefoxitin DMY8NC4 Approved NA [11]
Cefpodoxime DMJUNY5 Approved Small molecular drug [12]
Cefprozil DM7DSYP Approved Small molecular drug [13]
Cefradine DMUNSWV Approved Small molecular drug [14]
Ceftazidime DM41GRA Approved Small molecular drug [15]
Ceftizoxime DM3VOGS Approved Small molecular drug [16]
Cefuroxime DMSIMD8 Approved Small molecular drug [17]
Cephalexin DMD5JU8 Approved Small molecular drug [18]
Cephapirin DMV2JNY Approved Small molecular drug [19]
Ciprofloxacin XR DM2NLS9 Approved Small molecular drug [20]
Clarithromycin DM4M1SG Approved Small molecular drug [21]
Clavulanate DM2FGRT Approved Small molecular drug [22]
Clindamycin DM15HL8 Approved Small molecular drug [23]
Cloxacillin DMUTL7O Approved Small molecular drug [24]
Demeclocycline DMZEPFJ Approved Small molecular drug [25]
Dicloxacillin DM8EU0Z Approved Small molecular drug [26]
Dirithromycin DM0D9YJ Approved Small molecular drug [27]
Erythromycin DM4K7GQ Approved Small molecular drug [28]
Fusidic Acid DMWVCF3 Approved Small molecular drug [29]
Gatifloxacin DMSL679 Approved Small molecular drug [30]
Levofloxacin DMS60RB Approved Small molecular drug [31]
Linezolid DMGFPU2 Approved Small molecular drug [32]
Moxifloxacin DMU8V4S Approved Small molecular drug [33]
Nafcillin DMN9RPO Approved Small molecular drug [34]
Norfloxacin DMIZ6W2 Approved Small molecular drug [35]
Ofloxacin DM0VQN3 Approved Small molecular drug [36]
Oxacillin DMTAFY4 Approved Small molecular drug [37]
Penicillin V DMKVOYF Approved Small molecular drug [38]
Piperacillin DMTBKF3 Approved Small molecular drug [39]
Tazobactam DM3XNUI Approved Small molecular drug [40]
Ticarcillin DM4ME02 Approved Small molecular drug [41]
Tobramycin DMUI0CH Approved Small molecular drug [42]
Vancomycin DM3JFIH Approved NA [43]
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⏷ Show the Full List of 43 Drug(s)
This Disease is Treated as An Indication in 1 Drugs in Phase 3 Trial
Drug Name Drug ID Highest Status Drug Type REF
Azithromycin DMS6UOE Phase 3 Trial Small molecular drug [44]
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This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Benzylpenicillin DMS9503 Phase 3 Small molecular drug [45]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 4 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
TLR2 TTY7ZHS Limited Biomarker [46]
CD36 TTPJMCU moderate Biomarker [47]
DUSP3 TTIFAYS Strong Biomarker [48]
PDE4B TTVIAT9 Strong Genetic Variation [49]
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This Disease Is Related to 1 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC9A6 DTN0JXW Strong Genetic Variation [50]
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This Disease Is Related to 7 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ACE OTDF1964 moderate Biomarker [51]
CLDN11 OTNN6UTL Strong Biomarker [52]
FGF22 OTVIX6J0 Strong Biomarker [52]
HLA-DRB5 OTUX5TWM Strong Biomarker [53]
PSME3 OTSTC4YY Strong Biomarker [48]
SALL1 OTYYZGLH Strong Biomarker [54]
TMEM59 OTX4EKES Strong Biomarker [55]
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⏷ Show the Full List of 7 DOT(s)

References

1 Amoxicillin FDA Label
2 Ampicillin FDA Label
3 Cefaclor FDA Label
4 Cefadroxil FDA Label
5 Cefamandole FDA Label
6 Cefdinir FDA Label
7 Cefditoren FDA Label
8 Cefepime FDA Label
9 Cefonicid FDA Label
10 Cefotetan FDA Label
11 Cefoxitin FDA Label
12 Cefpodoxime FDA Label
13 Cefprozil FDA Label
14 Cefazolin. Ann Intern Med. 1978 Nov;89(5 Pt 1):650-6.
15 Ceftazidime FDA Label
16 Ceftizoxime FDA Label
17 Cefuroxime FDA Label
18 Cephalexin FDA Label
19 Cephapirin FDA Label
20 A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
21 Clarithromycin FDA Label
22 Clavulanate FDA Label
23 Clindamycin FDA Label
24 Cloxacillin FDA Label
25 Demeclocycline FDA Label
26 Dicloxacillin FDA Label
27 Dirithromycin FDA Label
28 Erythromycin FDA Label
29 Registered and investigational drugs for the treatment of methicillin-resistant Staphylococcus aureus infection. Recent Pat Antiinfect Drug Discov. 2008 Jan;3(1):10-33.
30 Gatifloxacin FDA Label
31 Levofloxacin FDA Label
32 Linezolid FDA Label
33 Moxifloxacin FDA Label
34 Nafcillin FDA Label
35 Norfloxacin FDA Label
36 Ofloxacin FDA Label
37 Oxacillin FDA Label
38 Penicillin V FDA Label
39 Piperacillin FDA Label
40 Tazobactam FDA Label
41 Ticarcillin FDA Label
42 Tobramycin FDA Label
43 Vancomycin FDA Label
44 Azithromycin FDA Label
45 In vivo synergy between 6 beta-amidinopenicillanic acid derivatives and other antibiotics. Antimicrob Agents Chemother. 1976 Apr;9(4):589-94.
46 A novel CCR-2/TLR-2 triggered signaling in murine peritoneal macrophages intensifies bacterial (Staphylococcus aureus) killing by reactive oxygen species through TNF-R1.Immunol Lett. 2017 Oct;190:93-107. doi: 10.1016/j.imlet.2017.07.011. Epub 2017 Jul 20.
47 CD36 is a sensor of diacylglycerides.Nature. 2005 Feb 3;433(7025):523-7. doi: 10.1038/nature03253.
48 Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis.PLoS Pathog. 2014 Jun 5;10(6):e1004149. doi: 10.1371/journal.ppat.1004149. eCollection 2014 Jun.
49 Genome wide association study of SNP-, gene-, and pathway-based approaches to identify genes influencing susceptibility to Staphylococcus aureus infections.Front Genet. 2014 May 9;5:125. doi: 10.3389/fgene.2014.00125. eCollection 2014.
50 Septic Arthritis of the Hip-Risk Factors Associated With Secondary Surgery.J Am Acad Orthop Surg. 2019 May 1;27(9):321-326. doi: 10.5435/JAAOS-D-18-00058.
51 Activity of serum angiotensin converting enzyme in septic pigs treated with intrapulmonary corticosteroid.Eur J Surg. 1994 Jan;160(1):3-7.
52 An OMICS-based study of the role of C3dg in keratinocytes: RNA sequencing, antibody-chip array, and bioinformatics approaches.Int J Biol Macromol. 2019 Jul 15;133:391-411. doi: 10.1016/j.ijbiomac.2019.04.039. Epub 2019 Apr 8.
53 Aberrantly Expressed Genes and miRNAs in Slow Transit Constipation Based on RNA-Seq Analysis.Biomed Res Int. 2018 Aug 14;2018:2617432. doi: 10.1155/2018/2617432. eCollection 2018.
54 Antibacterial properties of a pre-formulated recombinant phage endolysin, SAL-1.Int J Antimicrob Agents. 2013 Feb;41(2):156-61. doi: 10.1016/j.ijantimicag.2012.10.011. Epub 2012 Dec 28.
55 TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3.EMBO J. 2013 Feb 20;32(4):566-82. doi: 10.1038/emboj.2013.8. Epub 2013 Feb 1.