General Information of DTT (ID: TTEX6LM)

DTT Name GABA(A) receptor gamma-3 (GABRG3) DTT Info
Gene Name GABRG3

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Discontinued Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Preclinical Drug(s)
Investigative Drug(s)
14 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Allopregnanolone DMNLHAC Depression 6A70-6A7Z approved [1]
Bentazepam DMRVBWU Anxiety disorder 6B00-6B0Z Approved [2]
Clobazam - Lundbeck DMW1OQ0 Anxiety disorder 6B00-6B0Z Approved [3]
Etomidate DMZI3WO Anaesthesia 9A78.6 Approved [3]
Flumazenil DMPCG2L Benzodiazepine overdose PC91 Approved [4]
Ganaxolone DMXJMKF Epileptic seizures 8A61-8A6Z Approved [1]
Mebutamate DM0KYI4 Anxiety disorder 6B00-6B0Z Approved [3]
Metharbital DM5A38V Epilepsy 8A60-8A68 Approved [3]
Remimazolam DMLVSYX Procedural sedation JB0C.3 Approved [5]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [6]
Talbutal DM214Q8 Irritability MB24 Approved [3]
Thiamylal DMHDF7B Anaesthesia 9A78.6 Approved [3]
Zolpidem DMWOSKJ Insomnia 7A00-7A0Z Approved [4]
Zuranolone DMGR98T Postpartum depression 6E20.0 Approved [1]
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⏷ Show the Full List of 14 Approved Drug(s)
10 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arbaclofen placarbil DMO628K Fragile X syndrome LD55 Phase 3 [1]
Clomethiazole DMSPN58 Stroke 8B20 Phase 3 [7]
Pagoclone DMHWY2G Anxiety disorder 6B00-6B0Z Phase 2/3 [8]
Etazolate DMOCID7 Neurodegenerative disorder 8A20-8A23 Phase 2 [9]
EVT-201 DMQGBM1 Insomnia 7A00-7A0Z Phase 2 [4]
SARIPIDEM DM5R89X Anxiety disorder 6B00-6B0Z Phase 2 [10]
T-2007 DMF9Z2T Epilepsy 8A60-8A68 Phase 2 [4]
AZD-3043 DMXFYN0 Anaesthesia 9A78.6 Phase 1 [11]
NSD-788 DM5QHID Anxiety disorder 6B00-6B0Z Phase 1 [4]
Org-25435 DMBG534 Epilepsy 8A60-8A68 Phase 1 [12]
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⏷ Show the Full List of 10 Clinical Trial Drug(s)
21 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Suriclone DMC14HL Anxiety disorder 6B00-6B0Z Discontinued in Preregistration [13]
Ocinaplon DMQN3JX Generalized anxiety disorder 6B00 Discontinued in Phase 3 [14]
Pazinaclone DM1FST8 Anxiety disorder 6B00-6B0Z Discontinued in Phase 3 [15]
Y-23684 DM3EZ68 Anxiety disorder 6B00-6B0Z Discontinued in Phase 3 [16]
LORECLEZOLE DMCZI62 Epileptic seizures 8A61-8A6Z Discontinued in Phase 2 [17]
NGD 91-3 DMDAUCR Anxiety disorder 6B00-6B0Z Discontinued in Phase 2 [18]
RESEQUINIL DM3EAYN Epilepsy 8A60-8A68 Discontinued in Phase 2 [19]
RO-48-6791 DMH912O Anxiety disorder 6B00-6B0Z Discontinued in Phase 2 [20]
SL-65.1498 DMS8AHE Anxiety disorder 6B00-6B0Z Discontinued in Phase 2 [21]
Suritozole DMDZ7AY Major depressive disorder 6A70.3 Discontinued in Phase 2 [22]
CCD-3693 DMMEC1W Anxiety disorder 6B00-6B0Z Discontinued in Phase 1 [23]
CTP-354 DMXY43L Pain MG30-MG3Z Discontinued in Phase 1 [24]
Org-21465 DMMYI9U Anaesthesia 9A78.6 Discontinued in Phase 1 [25]
RO-48-8684 DMOX8AD Anxiety disorder 6B00-6B0Z Discontinued in Phase 1 [26]
Co-152791 DMU5TZD Epilepsy 8A60-8A68 Terminated [28]
Girisopam DMSVMF2 Anxiety disorder 6B00-6B0Z Terminated [29]
NSD-721 DMF2XMA Anxiety disorder 6B00-6B0Z Terminated [4]
Ro-19-8022 DMFRCM2 Anxiety disorder 6B00-6B0Z Terminated [30]
RU-33965 DMSWFMQ Alzheimer disease 8A20 Terminated [31]
ZK-91296 DMJYIVA Alzheimer disease 8A20 Terminated [32]
ZK-93426 DMMDQ5T Alzheimer disease 8A20 Terminated [33]
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⏷ Show the Full List of 21 Discontinued Drug(s)
1 Preclinical Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
RWJ-51204 DMMVS07 Anxiety disorder 6B00-6B0Z Preclinical [27]
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25 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
AA-29504 DMI59T7 Major depressive disorder 6A70.3 Investigative [4]
alpha3IA DM257WX Discovery agent N.A. Investigative [4]
alpha5IA DMTU5QR Discovery agent N.A. Investigative [4]
C-21191 DMCAO3V Anxiety disorder 6B00-6B0Z Investigative [4]
CP-409092 DMROYD7 Discovery agent N.A. Investigative [34]
DMCM DMK3WY4 Discovery agent N.A. Investigative [4]
DOV-51892 DMQIK9S Panic disorder 6B01 Investigative [4]
GIDAZEPAM DMASR6T Anxiety disorder 6B00-6B0Z Investigative [35]
HZ-166 DMLU6VM Neuropathic pain 8E43.0 Investigative [4]
isonipecotic acid DMO1ZHE Discovery agent N.A. Investigative [4]
JM-1232(-) DMWMRO2 Anaesthesia 9A78.6 Investigative [4]
NGD 96-3 DMWD7I3 Insomnia 7A00-7A0Z Investigative [4]
piperidine-4-sulphonic acid DMMIZWE Discovery agent N.A. Investigative [4]
PNU 101017 DMKBCS2 Discovery agent N.A. Investigative [36]
Ro-15-3505 DM4NW3U Discovery agent N.A. Investigative [37]
TBPS DMFC3XP Discovery agent N.A. Investigative [4]
tetrahydrodeoxycorticosterone DMF8M0W Discovery agent N.A. Investigative [4]
TP003 DMRHDGN Discovery agent N.A. Investigative [4]
UC-1011 DMCRFT5 Alzheimer disease 8A20 Investigative [4]
UC-2024 DMJVT4K Premenstrual syndrome GA34.40 Investigative [4]
UC-2029 DMGSOZ7 Premenstrual syndrome GA34.40 Investigative [4]
[18F]fluoroethylflumazenil DMPWART Discovery agent N.A. Investigative [4]
[35S]TBPS DMSD51L Discovery agent N.A. Investigative [4]
[3H]CGS8216 DMLP68J Inflammation 1A00-CA43.1 Investigative [4]
[3H]Ro154513 DMMBWKL Discovery agent N.A. Investigative [4]
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⏷ Show the Full List of 25 Investigative Drug(s)
Molecule Interaction Atlas

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Prodynorphin gene deletion increased anxiety-like behaviours, impaired the anxiolytic effect of bromazepam and altered GABAA receptor subunits gene expression in the amygdala. J Psychopharmacol. 2011Jan;25(1):87-96.
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4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415).
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
6 Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABA-A receptor channels. Epilepsia. 2006 Apr;47(4):704-16.
7 Electrophysiological actions of gamma-aminobutyric acid and clomethiazole on recombinant GABA(A) receptors. Eur J Pharmacol. 2002 Oct 11;452(3):255-62.
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9 Etazolate, a neuroprotective drug linking GABA(A) receptor pharmacology to amyloid precursor protein processing. J Neurochem. 2008 Jul;106(1):392-404.
10 Behavioural effects of novel benzodiazepine (omega) receptor agonists and partial agonists: increases in punished responding and antagonism of the pentylenetetrazole cue. Behav Pharmacol. 1995 Mar;6(2):116-126.
11 AZD-3043: a novel, metabolically labile sedative-hypnotic agent with rapid and predictable emergence from hypnosis. Anesthesiology. 2012 Jun;116(6):1267-77.
12 First administration to man of Org 25435, an intravenous anaesthetic: A Phase 1 Clinical Trial. BMC Anesthesiol. 2010 Jun 29;10:10.
13 The effect of cyclopyrrolones on GABAA receptor function is different from that of benzodiazepines. Naunyn Schmiedebergs Arch Pharmacol. 1994 Sep;350(3):294-300.
14 Discriminative stimulus properties of GABAA receptor positive allosteric modulators TPA023, ocinaplon and NG2-73 in rats trained to discriminate chlordiazepoxide or zolpidem. Eur J Pharmacol. 2011 Oct 1;668(1-2):190-3.
15 The benzodiazepine binding site of GABA(A) receptors as a target for the development of novel anxiolytics. Expert Opin Investig Drugs. 2005 May;14(5):601-18.
16 The pharmacological properties of Y-23684, a benzodiazepine receptor partial agonist. Br J Pharmacol. 1994 Apr;111(4):1170-8.
17 Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit. Neuropharmacology. 1996;35(12):1753-60.
18 Anxioselective compounds acting at the GABA(A) receptor benzodiazepine binding site. Curr Drug Targets CNS Neurol Disord. 2003 Aug;2(4):213-32.
19 WO patent application no. 2010,0024,51, Naphthyridin derivatives.
20 Integrated pharmacokinetics and pharmacodynamics of Ro 48-6791, a new benzodiazepine, in comparison with midazolam during first administration to healthy male subjects. Br J Clin Pharmacol. 1997 Nov;44(5):477-86.
21 WO patent application no. 2005,0749,31, Pharmaceutical combinations comprising (s) -pantoprazole.
22 Chronic postinjury administration of MDL 26,479 (Suritozole), a negative modulator at the GABAA receptor, and cognitive impairment in rats following traumatic brain injury. J Neurosurg. 1995 Nov;83(5):878-83.
23 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
24 Clinical pipeline report, company report or official report of Concert Pharmaceuticals.
25 Computer-controlled infusion of ORG 21465, a water soluble steroid i.v. anaesthetic agent, into human volunteers. Br J Anaesth. 1997 Oct;79(4):433-9.
26 Integrated pharmacokinetics and pharmacodynamics of Ro 48-8684, a new benzodiazepine, in comparison with midazolam during first administration to healthy male subjects. Br J Clin Pharmacol. 1997 Nov;44(5):487-93.
27 5-ethoxymethyl-7-fluoro-3-oxo-1,2,3,5-tetrahydrobenzo[4,5]imidazo[1,2a]pyridine-4-N-(2-fluorophenyl)carboxamide (RWJ-51204), a new nonbenzodiazepine anxiolytic. J Pharmacol Exp Ther. 2002 Nov;303(2):777-90.
28 Substituted 3beta-phenylethynyl derivatives of 3alpha-hydroxy-5alpha-pregnan-20-one: remarkably potent neuroactive steroid modulators of gamma-aminobutyric acidA receptors. J Pharmacol Exp Ther. 1998Oct;287(1):198-207.
29 [(3)H]-girisopam, a novel selective benzodiazepine for the 2, 3-benzodiazepine binding site. Brain Res Brain Res Protoc. 1999 Jul;4(2):230-5.
30 Partial agonist of benzodiazepine receptors Ro 19-8022 elicits withdrawal symptoms after short-term administration in immature rats. Physiol Res. 2012;61(3):319-23.
31 Discriminative stimulus properties of RU 33965, a benzodiazepine receptor weak partial inverse agonist. Pharmacol Biochem Behav. 1992 Oct;43(2):583-8.
32 Enhancement of gamma-aminobutyric acid binding by the anxiolytic beta-carbolines ZK 93423 and ZK 91296. J Neurochem. 1987 May;48(5):1355-8.
33 Actions of the beta-carboline ZK 93426 in an animal test of anxiety and the holeboard: interactions with Ro 15-1788. J Neural Transm. 1986;65(2):103-14.
34 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
35 Discriminative effects of phenazepam and gidazepam in rats: comparison with other GABA-related drugs. Pharmacol Biochem Behav. 1999 Oct;64(2):397-401.
36 Neuroprotective effects of the GABA(A) receptor partial agonist U-101017 in 3-acetylpyridine-treated rats. Neurosci Lett. 1997 May 30;228(1):45-9.
37 Molecular structure and stereoelectronic properties of sarmazenil--a weak inverse agonist at the omega modulatory sites (benzodiazepine receptors):... Bioorg Med Chem. 1998 Oct;6(10):1745-57.