Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTJDWW8Q)

• DOT Name: Stromelysin-2 (MMP10)
• Synonyms: SL-2; EC 3.4.24.22; Matrix metalloproteinase-10; MMP-10; Transin-2
• Gene Name: MMP10
• UniProt ID: MMP10_HUMAN
• PDB ID: 1Q3A; 3V96; 4ILW
• EC Number: 3.4.24.22
• Pfam ID: PF00045 ; PF00413 ; PF01471
• Sequence:
  MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIV
  KKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNY
  TPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSL
  AHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYN
  SFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAIST
  LRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFW
  AIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQG
  FPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC
• Function: Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.
• Reactome Pathway:
  Degradation of the extracellular matrix (R-HSA-1474228)
  Activation of Matrix Metalloproteinases (R-HSA-1592389)
  Collagen degradation (R-HSA-1442490)

Molecular Interaction Atlas (MIA) of This DOT

44 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Valproate	DMCFE9I	Approved	Valproate increases the expression of Stromelysin-2 (MMP10).	[1]
Ciclosporin	DMAZJFX	Approved	Ciclosporin increases the expression of Stromelysin-2 (MMP10).	[2]
Tretinoin	DM49DUI	Approved	Tretinoin increases the expression of Stromelysin-2 (MMP10).	[3]
Acetaminophen	DMUIE76	Approved	Acetaminophen increases the expression of Stromelysin-2 (MMP10).	[4]
Doxorubicin	DMVP5YE	Approved	Doxorubicin decreases the expression of Stromelysin-2 (MMP10).	[5]
Cupric Sulfate	DMP0NFQ	Approved	Cupric Sulfate increases the expression of Stromelysin-2 (MMP10).	[6]
Cisplatin	DMRHGI9	Approved	Cisplatin increases the expression of Stromelysin-2 (MMP10).	[7]
Estradiol	DMUNTE3	Approved	Estradiol increases the expression of Stromelysin-2 (MMP10).	[2]
Quercetin	DM3NC4M	Approved	Quercetin increases the expression of Stromelysin-2 (MMP10).	[8]
Carbamazepine	DMZOLBI	Approved	Carbamazepine affects the expression of Stromelysin-2 (MMP10).	[9]
Methotrexate	DM2TEOL	Approved	Methotrexate decreases the expression of Stromelysin-2 (MMP10).	[10]
Marinol	DM70IK5	Approved	Marinol decreases the expression of Stromelysin-2 (MMP10).	[11]
Zoledronate	DMIXC7G	Approved	Zoledronate increases the expression of Stromelysin-2 (MMP10).	[12]
Phenobarbital	DMXZOCG	Approved	Phenobarbital affects the expression of Stromelysin-2 (MMP10).	[13]
Progesterone	DMUY35B	Approved	Progesterone increases the expression of Stromelysin-2 (MMP10).	[14]
Cannabidiol	DM0659E	Approved	Cannabidiol increases the expression of Stromelysin-2 (MMP10).	[15]
Isotretinoin	DM4QTBN	Approved	Isotretinoin decreases the expression of Stromelysin-2 (MMP10).	[3]
Azathioprine	DMMZSXQ	Approved	Azathioprine decreases the expression of Stromelysin-2 (MMP10).	[10]
Piroxicam	DMTK234	Approved	Piroxicam decreases the expression of Stromelysin-2 (MMP10).	[10]
Sodium lauryl sulfate	DMLJ634	Approved	Sodium lauryl sulfate increases the expression of Stromelysin-2 (MMP10).	[16]
Clozapine	DMFC71L	Approved	Clozapine decreases the expression of Stromelysin-2 (MMP10).	[17]
Malathion	DMXZ84M	Approved	Malathion increases the expression of Stromelysin-2 (MMP10).	[18]
Ethinyl estradiol	DMODJ40	Approved	Ethinyl estradiol decreases the expression of Stromelysin-2 (MMP10).	[19]
Simvastatin	DM30SGU	Approved	Simvastatin increases the expression of Stromelysin-2 (MMP10).	[20]
Mifepristone	DMGZQEF	Approved	Mifepristone increases the expression of Stromelysin-2 (MMP10).	[21]
Alitretinoin	DMME8LH	Approved	Alitretinoin decreases the expression of Stromelysin-2 (MMP10).	[3]
Haloperidol	DM96SE0	Approved	Haloperidol decreases the expression of Stromelysin-2 (MMP10).	[22]
Prednisolone	DMQ8FR2	Approved	Prednisolone decreases the expression of Stromelysin-2 (MMP10).	[10]
Methylprednisolone	DM4BDON	Approved	Methylprednisolone decreases the expression of Stromelysin-2 (MMP10).	[10]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Approved	Eicosapentaenoic acid/docosa-hexaenoic acid decreases the expression of Stromelysin-2 (MMP10).	[23]
Chloramphenicol	DMFXEWT	Approved	Chloramphenicol decreases the expression of Stromelysin-2 (MMP10).	[25]
Curcumin	DMQPH29	Phase 3	Curcumin increases the expression of Stromelysin-2 (MMP10).	[26]
Genistein	DM0JETC	Phase 2/3	Genistein affects the expression of Stromelysin-2 (MMP10).	[27]
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene increases the expression of Stromelysin-2 (MMP10).	[28]
LY294002	DMY1AFS	Phase 1	LY294002 decreases the expression of Stromelysin-2 (MMP10).	[29]
Bisphenol A	DM2ZLD7	Investigative	Bisphenol A affects the expression of Stromelysin-2 (MMP10).	[30]
Trichostatin A	DM9C8NX	Investigative	Trichostatin A increases the expression of Stromelysin-2 (MMP10).	[31]
chloropicrin	DMSGBQA	Investigative	chloropicrin increases the expression of Stromelysin-2 (MMP10).	[32]
Acetaldehyde	DMJFKG4	Investigative	Acetaldehyde increases the expression of Stromelysin-2 (MMP10).	[33]
Resorcinol	DMM37C0	Investigative	Resorcinol increases the expression of Stromelysin-2 (MMP10).	[16]
U0126	DM31OGF	Investigative	U0126 decreases the expression of Stromelysin-2 (MMP10).	[23]
all-trans-4-oxo-retinoic acid	DMM2R1N	Investigative	all-trans-4-oxo-retinoic acid decreases the expression of Stromelysin-2 (MMP10).	[3]
Chrysin	DM7V2LG	Investigative	Chrysin decreases the expression of Stromelysin-2 (MMP10).	[29]
Icosapentum	DMF1CM7	Investigative	Icosapentum decreases the expression of Stromelysin-2 (MMP10).	[23]

2 Drug(s) Affected the Protein Interaction/Cellular Processes of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Dihydroxyacetone	DMM1LG2	Approved	Dihydroxyacetone decreases the secretion of Stromelysin-2 (MMP10).	[24]
acrolein	DMAMCSR	Investigative	acrolein affects the secretion of Stromelysin-2 (MMP10).	[34]

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