Details of the Drug Combination

General Information of Drug Combination (ID: DC19NQO)

Drug Combination Name
Atorvastatin Phenytoin
Indication
Disease Entry Status REF
Epilepsy Phase 1 [1]
Component Drugs Atorvastatin   DMF28YC Phenytoin   DMNOKBV
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Atorvastatin
Disease Entry ICD 11 Status REF
Acute coronary syndrome BA41 Approved [2]
Angina pectoris BA40 Approved [2]
Arteriosclerosis BD40 Approved [2]
Cardiovascular disease BA00-BE2Z Approved [3]
Coronary atherosclerosis N.A. Approved [2]
Hypercholesterolaemia 5C80.0 Approved [2]
Hyperlipidemia 5C80.Z Approved [4]
Hyperlipidemia, familial combined, LPL related N.A. Approved [2]
Hypertriglyceridemia 5C80.1 Approved [2]
Inflammation 1A00-CA43.1 Approved [2]
Non-insulin dependent diabetes 5A11 Approved [2]
Psoriasis EA90 Approved [2]
Type-1/2 diabetes 5A10-5A11 Approved [2]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 [5]
Stroke 8B20 Investigative [2]
Venous thromboembolism BD72 Investigative [2]
Atorvastatin Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
HMG-CoA reductase (HMGCR) TTPADOQ HMDH_HUMAN Inhibitor [10]
HUMAN MYD88NF-kappa-B proinflammatory pathway (MYD88-NFKB pathway) TTDJB68 N.A. Inhibitor [11]
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Atorvastatin Interacts with 7 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [12]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [13]
Organic anion transporting polypeptide 1A2 (SLCO1A2) DTE2B1D SO1A2_HUMAN Substrate [14]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [15]
Organic anion transporting polypeptide 2B1 (SLCO2B1) DTPFTEQ SO2B1_HUMAN Substrate [16]
Monocarboxylate transporter 1 (SLC16A1) DT342ZG MOT1_HUMAN Substrate [17]
Monocarboxylate transporter 2 (SLC16A7) DTLT3UG MOT2_HUMAN Substrate [18]
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⏷ Show the Full List of 7 DTP(s)
Atorvastatin Interacts with 6 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [19]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Metabolism [20]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [21]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Metabolism [22]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [23]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DEF2WXN UD13_HUMAN Metabolism [24]
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⏷ Show the Full List of 6 DME(s)
Atorvastatin Interacts with 47 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Stromelysin-1 (MMP3) OTGBI74Z MMP3_HUMAN Increases ADR [25]
Kinesin-like protein KIF6 (KIF6) OTDH3MR4 KIF6_HUMAN Increases Response To Substance [26]
Nuclear receptor subfamily 1 group I member 3 (NR1I3) OTS3SGH7 NR1I3_HUMAN Increases Activity [27]
Phospholipid-transporting ATPase ABCA1 (ABCA1) OT94G6BQ ABCA1_HUMAN Decreases Expression [28]
Sterol 26-hydroxylase, mitochondrial (CYP27A1) OT649C01 CP27A_HUMAN Decreases Expression [28]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Decreases Activity [29]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Increases Expression [30]
Solute carrier family 2, facilitated glucose transporter member 2 (SLC2A2) OTBL2W7R GTR2_HUMAN Decreases Expression [30]
Hexokinase-4 (GCK) OTR3Q0NN HXK4_HUMAN Decreases Expression [30]
Prothrombin (F2) OTNFSM49 THRB_HUMAN Decreases Activity [31]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [32]
Interleukin-2 receptor subunit alpha (IL2RA) OT0MWCHG IL2RA_HUMAN Affects Expression [33]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Increases Expression [34]
C-reactive protein (CRP) OT0RFT8F CRP_HUMAN Decreases Expression [35]
Osteocalcin (BGLAP) OTK1YLWQ OSTCN_HUMAN Increases Expression [34]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Affects Expression [36]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) OTM0GDTP IF2A_HUMAN Increases Phosphorylation [37]
Rho-related GTP-binding protein RhoC (RHOC) OTOLE1FT RHOC_HUMAN Decreases Localization [38]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [39]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Decreases Expression [40]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Decreases Expression [40]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) OT2D9DOV TNR1A_HUMAN Decreases Expression [41]
Integrin alpha-X (ITGAX) OTOGIMHE ITAX_HUMAN Decreases Expression [42]
Tumor necrosis factor receptor superfamily member 5 (CD40) OT5YU2XB TNR5_HUMAN Decreases Expression [33]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Phosphorylation [39]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Phosphorylation [39]
Interleukin-12 subunit alpha (IL12A) OTDQT8GI IL12A_HUMAN Decreases Expression [43]
CD40 ligand (CD40LG) OT75Z6A6 CD40L_HUMAN Decreases Expression [44]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [37]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) OTTOMI8J PK3CA_HUMAN Decreases Expression [32]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [39]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Increases Expression [45]
Importin subunit alpha-1 (KPNA2) OTU7FOE6 IMA1_HUMAN Affects Localization [46]
Microsomal triglyceride transfer protein large subunit (MTTP) OTNUVSDT MTP_HUMAN Decreases Expression [47]
Rho-related GTP-binding protein RhoB (RHOB) OTHQFQF7 RHOB_HUMAN Increases Expression [38]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Affects Localization [36]
CD83 antigen (CD83) OT1V4WQF CD83_HUMAN Decreases Expression [33]
Sterol regulatory element-binding protein 2 (SREBF2) OTBXUNPL SRBP2_HUMAN Increases Localization [48]
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) OT7TNF0L AAPK1_HUMAN Increases Activity [49]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Increases Expression [50]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) OT0DZGY4 E2AK3_HUMAN Increases Response To Substance [37]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Increases Response To Substance [51]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Transport [52]
Solute carrier organic anion transporter family member 2B1 (SLCO2B1) OTERJ4VQ SO2B1_HUMAN Increases Uptake [53]
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) OTNEN8QK SO1B1_HUMAN Decreases Transport [54]
Solute carrier organic anion transporter family member 1B3 (SLCO1B3) OTOM3BUH SO1B3_HUMAN Increases Uptake [53]
Sister chromatid cohesion protein DCC1 (DSCC1) OTPUVLZT DCC1_HUMAN Affects Response To Substance [55]
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⏷ Show the Full List of 47 DOT(s)
Indication(s) of Phenytoin
Disease Entry ICD 11 Status REF
Epilepsy 8A60-8A68 Approved [3]
Epilepsy with generalized tonic-clonic seizures N.A. Approved [6]
Focal epilepsy N.A. Approved [6]
Primary motor cortex epilepsy N.A. Approved [6]
Phenytoin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Sodium channel unspecific (NaC) TTRK8B9 NOUNIPROTAC Blocker [60]
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Phenytoin Interacts with 3 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 1 (ABCC1) DTSYQGK MRP1_HUMAN Substrate [61]
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [62]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [63]
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Phenytoin Interacts with 9 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [64]
Glutathione S-transferase alpha-1 (GSTA1) DE4ZHS1 GSTA1_HUMAN Metabolism [65]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [66]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Metabolism [66]
Cytochrome P450 2C18 (CYP2C18) DEZMWRE CP2CI_HUMAN Metabolism [67]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [67]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [68]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Metabolism [66]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [67]
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⏷ Show the Full List of 9 DME(s)
Phenytoin Interacts with 74 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Decreases Hydroxylation [69]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Metabolism [70]
HLA class I histocompatibility antigen, C alpha chain (HLA-C) OTV38BUJ HLAC_HUMAN Increases ADR [71]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Increases Activity [72]
Neurocan core protein (NCAN) OT8OO6ZE NCAN_HUMAN Increases Expression [58]
Plexin-B2 (PLXNB2) OT56I2VD PLXB2_HUMAN Decreases Expression [58]
Calpain-5 (CAPN5) OTQ8QM7K CAN5_HUMAN Decreases Expression [58]
Leucine-rich repeat transmembrane protein FLRT2 (FLRT2) OTGD8TID FLRT2_HUMAN Increases Expression [58]
Fibroblast growth factor receptor substrate 3 (FRS3) OTTNP6H7 FRS3_HUMAN Decreases Expression [58]
Lathosterol oxidase (SC5D) OT41KMW4 SC5D_HUMAN Increases Expression [58]
Eomesodermin homolog (EOMES) OTB9VQFA EOMES_HUMAN Increases Expression [58]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Increases Expression [73]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Increases Expression [74]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Decreases Expression [75]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Decreases Expression [76]
Creatine kinase M-type (CKM) OTME0KO7 KCRM_HUMAN Increases Expression [77]
Collagen alpha-2(I) chain (COL1A2) OTY7G382 CO1A2_HUMAN Increases Expression [58]
Chymotrypsin-like elastase family member 2A (CELA2A) OTY8QG2J CEL2A_HUMAN Decreases Expression [58]
Stromelysin-1 (MMP3) OTGBI74Z MMP3_HUMAN Decreases Expression [76]
Small ribosomal subunit protein uS2 (RPSA) OTJZHEGT RSSA_HUMAN Increases Expression [58]
Annexin A4 (ANXA4) OTUCRYXL ANXA4_HUMAN Increases Expression [58]
Homeobox protein Hox-B7 (HOXB7) OTC7WYU8 HXB7_HUMAN Increases Expression [57]
Transforming growth factor beta-3 proprotein (TGFB3) OT2LOUQ1 TGFB3_HUMAN Increases Expression [58]
Fibroblast growth factor 5 (FGF5) OTQXGHBY FGF5_HUMAN Increases Expression [58]
Collagen alpha-1(XI) chain (COL11A1) OTB0DRMS COBA1_HUMAN Increases Expression [58]
Collagen alpha-1(VI) chain (COL6A1) OTYKSCOB CO6A1_HUMAN Decreases Expression [58]
Collagen alpha-2(VI) chain (COL6A2) OTQC6PPO CO6A2_HUMAN Increases Expression [78]
Collagen alpha-3(VI) chain (COL6A3) OTAS6R6I CO6A3_HUMAN Increases Expression [78]
Interferon gamma receptor 1 (IFNGR1) OTCTQBWW INGR1_HUMAN Increases Expression [58]
Methylated-DNA--protein-cysteine methyltransferase (MGMT) OT40A9WH MGMT_HUMAN Increases Methylation [79]
Homeobox protein Hox-B9 (HOXB9) OTMVHQOU HXB9_HUMAN Increases Expression [57]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Increases Expression [58]
Midkine (MDK) OTF24HKC MK_HUMAN Increases Expression [58]
Paired box protein Pax-3 (PAX3) OTN5PJZV PAX3_HUMAN Decreases Expression [57]
Paired box protein Pax-6 (PAX6) OTOC9876 PAX6_HUMAN Increases Expression [57]
Protein S100-A4 (S100A4) OTLRGFSQ S10A4_HUMAN Increases Expression [58]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Phosphorylation [76]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Phosphorylation [76]
Fibroblast growth factor 9 (FGF9) OT2SKDGM FGF9_HUMAN Increases Expression [58]
Keratin, type II cytoskeletal 2 epidermal (KRT2) OTG2EZEN K22E_HUMAN Increases Expression [58]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Decreases Expression [58]
Collagen alpha-1(XVIII) chain (COL18A1) OTJFUH6O COIA1_HUMAN Decreases Expression [58]
Large ribosomal subunit protein eL28 (RPL28) OTEVRCBO RL28_HUMAN Increases Expression [58]
Microtubule-associated protein 1B (MAP1B) OTVXW089 MAP1B_HUMAN Increases Expression [58]
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A) OTO9JO9U PI42A_HUMAN Increases Expression [58]
Homeobox protein MOX-1 (MEOX1) OTJEMT2D MEOX1_HUMAN Decreases Expression [57]
Small ribosomal subunit protein mS29 (DAP3) OTNPEZYM RT29_HUMAN Increases Expression [58]
Protein S100-A10 (S100A10) OTI71243 S10AA_HUMAN Increases Expression [58]
Disintegrin and metalloproteinase domain-containing protein 8 (ADAM8) OT24S8YN ADAM8_HUMAN Decreases Expression [58]
Transcription factor Sp3 (SP3) OTYDQZ1T SP3_HUMAN Increases Expression [58]
Fibromodulin (FMOD) OT9EJ5H8 FMOD_HUMAN Decreases Expression [58]
Transcription factor 15 (TCF15) OTA6UCWC TCF15_HUMAN Decreases Expression [57]
Phosphatidate phosphatase LPIN1 (LPIN1) OTQ75KF2 LPIN1_HUMAN Increases Expression [58]
Signal transducer and activator of transcription 4 (STAT4) OTAK3VFR STAT4_HUMAN Decreases Expression [58]
Nuclear receptor subfamily 1 group I member 3 (NR1I3) OTS3SGH7 NR1I3_HUMAN Increases Activity [80]
Oligodendrocyte transcription factor 3 (OLIG3) OTU8XLAF OLIG3_HUMAN Increases Expression [57]
Sodium channel protein type 2 subunit alpha (SCN2A) OTUSYE4Z SCN2A_HUMAN Decreases Activity [81]
Eyes absent homolog 1 (EYA1) OTHU807A EYA1_HUMAN Decreases Expression [57]
Neurogenin-2 (NEUROG2) OTAEMIGT NGN2_HUMAN Increases Expression [57]
Sodium channel protein type 3 subunit alpha (SCN3A) OT4C2LCB SCN3A_HUMAN Affects Binding [82]
Death-associated protein kinase 2 (DAPK2) OTWODUQG DAPK2_HUMAN Decreases Expression [58]
Structural maintenance of chromosomes protein 3 (SMC3) OTWGFRHD SMC3_HUMAN Increases Expression [58]
Glutathione S-transferase kappa 1 (GSTK1) OTDNGWAF GSTK1_HUMAN Decreases Expression [58]
Adiponectin receptor protein 2 (ADIPOR2) OT2HDTL8 PAQR2_HUMAN Increases ADR [59]
Protein kinase C-binding protein NELL1 (NELL1) OTF3TX3N NELL1_HUMAN Increases ADR [59]
Sodium channel subunit beta-1 (SCN1B) OTGD78J3 SCN1B_HUMAN Decreases Response To Substance [82]
Bis(5'-adenosyl)-triphosphatase (FHIT) OTGWBSLA FHIT_HUMAN Increases ADR [59]
Sodium channel protein type 1 subunit alpha (SCN1A) OTJ9ZTYI SCN1A_HUMAN Affects Response To Substance [83]
Dachshund homolog 1 (DACH1) OTMKNAGG DACH1_HUMAN Increases ADR [59]
V-type proton ATPase subunit d 2 (ATP6V0D2) OTMOZJO0 VA0D2_HUMAN Increases ADR [59]
A disintegrin and metalloproteinase with thrombospondin motifs 20 (ADAMTS20) OTU0EKLN ATS20_HUMAN Increases ADR [59]
Probable E3 ubiquitin-protein ligase IRF2BPL (IRF2BPL) OTV8MNT1 I2BPL_HUMAN Increases ADR [59]
Glutathione hydrolase 7 (GGT7) OTW4IO3I GGT7_HUMAN Increases ADR [25]
cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B) OTZEXEFH KAP3_HUMAN Increases ADR [59]
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⏷ Show the Full List of 74 DOT(s)

References

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2 Atorvastatin FDA Label
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41 The effects of atorvastatin (10 mg) on systemic inflammation in heart failure. Am J Cardiol. 2005 Dec 15;96(12):1699-704. doi: 10.1016/j.amjcard.2005.07.092. Epub 2005 Oct 28.
42 Integrin expression on monocytes and lymphocytes in unstable angina short term effects of atorvastatin. Rom J Intern Med. 2007;45(2):193-9.
43 Treatment with atorvastatin alters the ratio of interleukin-12/interleukin-10 gene expression [corrected]. Eur J Clin Invest. 2003 Jan;33(1):88-91. doi: 10.1046/j.1365-2362.2003.01105.x.
44 Effect of atorvastatin on circulating proinflammatory T-lymphocyte subsets and soluble CD40 ligand in patients with stable coronary artery disease--a randomized, placebo-controlled study. Am Heart J. 2006 Jan;151(1):139. doi: 10.1016/j.ahj.2005.10.006.
45 Decreased circulating Fas ligand in patients with familial combined hyperlipidemia or carotid atherosclerosis: normalization by atorvastatin. J Am Coll Cardiol. 2004 Apr 7;43(7):1188-94. doi: 10.1016/j.jacc.2003.10.046.
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