Details of the Drug Combination

General Information of Drug Combination (ID: DC5CI57)

Drug Combination Name
obeticholic acid obeticholic acid
Indication
Disease Entry Status REF
Biliary Atresia Phase 2 [1]
Component Drugs obeticholic acid   DM3Q1SM obeticholic acid   DM3Q1SM
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL is unavailable 3D MOL is unavailable

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of obeticholic acid
Disease Entry ICD 11 Status REF
Primary biliary cholangitis DB96.1 Approved [2]
Insomnia 7A00-7A0Z Clinical trial [3]
obeticholic acid Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Farnesoid X-activated receptor (FXR) TTS4UGC NR1H4_HUMAN Modulator [2]
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obeticholic acid Interacts with 1 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Bile acid-CoA thioesterase (BAAT) DERA3OF BAAT_HUMAN Metabolism [6]
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obeticholic acid Interacts with 160 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Very long chain fatty acid elongase 7 (ELOVL7) OT89NYVC ELOV7_HUMAN Increases Expression [4]
cTAGE family member 15 (CTAGE15) OTMOMQGH CTGEF_HUMAN Increases Expression [4]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD) OTOMP6TH PK3CD_HUMAN Decreases Expression [4]
Nuclear receptor subfamily 5 group A member 2 (NR5A2) OTXAUJAS NR5A2_HUMAN Decreases Expression [4]
Suppressor of cytokine signaling 2 (SOCS2) OTBPNKJQ SOCS2_HUMAN Decreases Expression [4]
Copper chaperone for superoxide dismutase (CCS) OTXHT3QO CCS_HUMAN Decreases Expression [4]
Ectoderm-neural cortex protein 1 (ENC1) OTJEUB6U ENC1_HUMAN Increases Expression [4]
Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7) OT1Q40TZ MP2K7_HUMAN Decreases Expression [4]
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2) OT5I4Y9K PLCB_HUMAN Decreases Expression [4]
Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) OTZEPVGF ACOX3_HUMAN Increases Expression [4]
Tapasin (TAPBP) OTL81AVZ TPSN_HUMAN Decreases Expression [4]
Interleukin-1 receptor-associated kinase-like 2 (IRAK2) OT6Y1QZN IRAK2_HUMAN Decreases Expression [4]
Long-chain-fatty-acid--CoA ligase 4 (ACSL4) OTI71MUJ ACSL4_HUMAN Increases Expression [4]
Transcription factor Maf (MAF) OT1GR3IZ MAF_HUMAN Increases Expression [4]
Ribosomal protein S6 kinase alpha-4 (RPS6KA4) OTTK8MUO KS6A4_HUMAN Decreases Expression [4]
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (SLC25A12) OTB4YBVT S2512_HUMAN Decreases Expression [4]
Lathosterol oxidase (SC5D) OT41KMW4 SC5D_HUMAN Decreases Expression [4]
Phospholipid-transporting ATPase ABCA1 (ABCA1) OT94G6BQ ABCA1_HUMAN Decreases Expression [4]
Alcohol dehydrogenase 1C (ADH1C) OTO1DV7F ADH1G_HUMAN Decreases Expression [4]
Alpha-2-macroglobulin (A2M) OTFTX90K A2MG_HUMAN Decreases Expression [4]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Decreases Expression [4]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Decreases Expression [4]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [4]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Decreases Expression [4]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Decreases Expression [4]
Apolipoprotein C-II (APOC2) OTLINYIQ APOC2_HUMAN Increases Expression [4]
C-reactive protein (CRP) OT0RFT8F CRP_HUMAN Decreases Expression [4]
Albumin (ALB) OTVMM513 ALBU_HUMAN Decreases Expression [4]
Fructose-bisphosphate aldolase A (ALDOA) OTWRFTIB ALDOA_HUMAN Decreases Expression [4]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Decreases Expression [4]
Thymidine kinase, cytosolic (TK1) OTY5JFM1 KITH_HUMAN Decreases Expression [4]
Fructose-bisphosphate aldolase B (ALDOB) OT7FR69A ALDOB_HUMAN Decreases Expression [4]
Plasminogen activator inhibitor 1 (SERPINE1) OTT0MPQ3 PAI1_HUMAN Decreases Expression [4]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Expression [4]
Alpha-enolase (ENO1) OTB1KWJS ENOA_HUMAN Decreases Expression [4]
Histone H2B type 1-J (H2BC11) OTGM083T H2B1J_HUMAN Decreases Expression [4]
Protein disulfide-isomerase (P4HB) OTTYNYPF PDIA1_HUMAN Increases Expression [4]
Interleukin-6 receptor subunit alpha (IL6R) OTCQL07Z IL6RA_HUMAN Decreases Expression [4]
Proto-oncogene tyrosine-protein kinase ROS (ROS1) OTDSKUGE ROS1_HUMAN Increases Expression [4]
3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) OTVKRET0 THIK_HUMAN Increases Expression [4]
Inhibin beta B chain (INHBB) OT2QLD11 INHBB_HUMAN Increases Expression [4]
Fructose-bisphosphate aldolase C (ALDOC) OTEC13I5 ALDOC_HUMAN Increases Expression [4]
Transforming growth factor beta-3 proprotein (TGFB3) OT2LOUQ1 TGFB3_HUMAN Increases Expression [4]
Hepatic triacylglycerol lipase (LIPC) OTZY5SC9 LIPC_HUMAN Decreases Expression [4]
Pyruvate carboxylase, mitochondrial (PC) OT6O0V51 PYC_HUMAN Decreases Expression [4]
Beta-enolase (ENO3) OT3HYKYI ENOB_HUMAN Increases Expression [4]
Farnesyl pyrophosphate synthase (FDPS) OT6CKWV5 FPPS_HUMAN Decreases Expression [4]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (PFKFB1) OTTHX4NB F261_HUMAN Increases Expression [4]
Transcription factor JunB (JUNB) OTG2JXV5 JUNB_HUMAN Decreases Expression [4]
Glutathione peroxidase 2 (GPX2) OTXI2NTI GPX2_HUMAN Decreases Expression [4]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Increases Expression [4]
Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) OTDS2EAR TNR1B_HUMAN Increases Expression [4]
Phosphatidylcholine translocator ABCB4 (ABCB4) OTE6PY83 MDR3_HUMAN Increases Expression [4]
Glycerol-3-phosphate dehydrogenase , cytoplasmic (GPD1) OTQW7TMB GPDA_HUMAN Decreases Expression [4]
Glutathione peroxidase 3 (GPX3) OT6PK94R GPX3_HUMAN Increases Expression [4]
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) OTIN6G20 CPT2_HUMAN Increases Expression [4]
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) OT5BZ1J9 P85A_HUMAN Decreases Expression [4]
Peroxiredoxin-6 (PRDX6) OTS8KC8A PRDX6_HUMAN Decreases Expression [4]
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PPP2R1B) OTFIHQGD 2AAB_HUMAN Increases Expression [4]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Decreases Expression [4]
Glycerol kinase (GK) OTK2YRA0 GLPK_HUMAN Decreases Expression [4]
Long-chain-fatty-acid--CoA ligase 1 (ACSL1) OTB06ESI ACSL1_HUMAN Decreases Expression [4]
Protein S100-A3 (S100A3) OTVIZJ2R S10A3_HUMAN Decreases Expression [4]
Phosphoenolpyruvate carboxykinase, cytosolic (PCK1) OTNWEJ5Y PCKGC_HUMAN Decreases Expression [4]
Insulin-like growth factor-binding protein complex acid labile subunit (IGFALS) OTTWCZYM ALS_HUMAN Decreases Expression [4]
Interleukin-6 receptor subunit beta (IL6ST) OT1N9C70 IL6RB_HUMAN Decreases Expression [4]
Malate dehydrogenase, cytoplasmic (MDH1) OTJEO4E8 MDHC_HUMAN Increases Expression [4]
Mitogen-activated protein kinase kinase kinase 8 (MAP3K8) OTOZTA1F M3K8_HUMAN Increases Expression [4]
Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) OTI2OREX MP2K3_HUMAN Decreases Expression [4]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) OTI862QH CPT1A_HUMAN Increases Expression [4]
Aldo-keto reductase family 1 member D1 (AKR1D1) OTBDJ6RL AK1D1_HUMAN Decreases Expression [4]
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6) OTK13JKC MP2K6_HUMAN Decreases Expression [4]
Tricarboxylate transport protein, mitochondrial (SLC25A1) OTIDXQ9F TXTP_HUMAN Decreases Expression [4]
Mitogen-activated protein kinase 12 (MAPK12) OTTCKE27 MK12_HUMAN Decreases Expression [4]
Glycogen synthase, liver (GYS2) OTCKIUYR GYS2_HUMAN Increases Expression [4]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Decreases Expression [4]
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (HSD17B7) OTV7VOV3 DHB7_HUMAN Decreases Expression [4]
Transforming growth factor beta-2 proprotein (TGFB2) OTC0TXEP TGFB2_HUMAN Decreases Expression [4]
Ras-related protein R-Ras2 (RRAS2) OT83NCEB RRAS2_HUMAN Increases Expression [4]
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PPP2CB) OT24GMCM PP2AB_HUMAN Increases Expression [4]
Metallothionein-1H (MT1H) OT0MVBM6 MT1H_HUMAN Decreases Expression [4]
Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2) OT6HTSJT PGBM_HUMAN Decreases Expression [4]
Nuclear factor NF-kappa-B p100 subunit (NFKB2) OTS231V7 NFKB2_HUMAN Decreases Expression [4]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1) OTCO26FV HMCS1_HUMAN Decreases Expression [4]
Sterol 26-hydroxylase, mitochondrial (CYP27A1) OT649C01 CP27A_HUMAN Decreases Expression [4]
Cytochrome P450 4A11 (CYP4A11) OTPU5J0S CP4AB_HUMAN Increases Expression [4]
Peroxiredoxin-1 (PRDX1) OTZ3BEC4 PRDX1_HUMAN Decreases Expression [4]
Cytochrome P450 4F3 (CYP4F3) OTYNSQAM CP4F3_HUMAN Decreases Expression [4]
Sterol regulatory element-binding protein 2 (SREBF2) OTBXUNPL SRBP2_HUMAN Decreases Expression [4]
TNF receptor-associated factor 2 (TRAF2) OT1MEZZN TRAF2_HUMAN Decreases Expression [4]
Protein AF1q (MLLT11) OTG5RVHC AF1Q_HUMAN Increases Expression [4]
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Decreases Expression [4]
FAS-associated death domain protein (FADD) OTV7GFHH FADD_HUMAN Increases Expression [4]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Decreases Expression [4]
Isopentenyl-diphosphate Delta-isomerase 1 (IDI1) OTGM06VJ IDI1_HUMAN Decreases Expression [4]
Phosphatidate phosphatase LPIN1 (LPIN1) OTQ75KF2 LPIN1_HUMAN Decreases Expression [4]
Delta(14)-sterol reductase LBR (LBR) OT1HG3HG LBR_HUMAN Decreases Expression [4]
Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) OTM0A0DY ACOX1_HUMAN Increases Expression [4]
Transcription elongation factor A protein 2 (TCEA2) OT1OS9TY TCEA2_HUMAN Increases Expression [4]
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) OTPM6F85 TAB1_HUMAN Decreases Expression [4]
Mitogen-activated protein kinase 11 (MAPK11) OT0AS010 MK11_HUMAN Decreases Expression [4]
Dual specificity protein phosphatase 6 (DUSP6) OT4H6RKW DUS6_HUMAN Increases Expression [4]
Meteorin-like protein (METRNL) OTB0DDL0 METRL_HUMAN Decreases Expression [4]
Cyclic AMP-responsive element-binding protein 3-like protein 3 (CREB3L3) OTDMU3GP CR3L3_HUMAN Increases Expression [4]
Single Ig IL-1-related receptor (SIGIRR) OTNC3XFD SIGIR_HUMAN Decreases Expression [4]
Ultra-long-chain fatty acid omega-hydroxylase (CYP4F22) OTMNPZQL CP4FN_HUMAN Decreases Expression [4]
SUZ domain-containing protein 1 (SZRD1) OTJMEJWT SZRD1_HUMAN Increases Expression [4]
Cytochrome P450 2U1 (CYP2U1) OT6RXLXS CP2U1_HUMAN Increases Expression [4]
Tubulin epsilon and delta complex protein 1 (TEDC1) OT2RIGR7 TEDC1_HUMAN Decreases Expression [4]
ADAMTS-like protein 2 (ADAMTSL2) OTAXNV2U ATL2_HUMAN Decreases Expression [4]
60 kDa lysophospholipase (ASPG) OT5E2EKR LPP60_HUMAN Decreases Expression [4]
Organic solute transporter subunit alpha (SLC51A) OTDJRZ0P OSTA_HUMAN Increases Expression [4]
Organic solute transporter subunit beta (SLC51B) OT4WYPSR OSTB_HUMAN Increases Expression [4]
Na(+)/citrate cotransporter (SLC13A5) OTPH1TA7 S13A5_HUMAN Decreases Expression [4]
Leucine-rich repeat LGI family member 4 (LGI4) OTZGS8BN LGI4_HUMAN Increases Expression [4]
Neuropeptide W (NPW) OTO7MT28 NPW_HUMAN Decreases Expression [4]
Sodium-dependent lysophosphatidylcholine symporter 1 (MFSD2A) OTVG1VG0 NLS1_HUMAN Increases Expression [4]
Mixed lineage kinase domain-like protein (MLKL) OTDSLC81 MLKL_HUMAN Decreases Expression [4]
Phosphatidate phosphatase LPIN2 (LPIN2) OTRRTMXX LPIN2_HUMAN Decreases Expression [4]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Decreases Expression [4]
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) OT2JHIHM CR3L1_HUMAN Decreases Expression [4]
Leukocyte receptor cluster member 8 (LENG8) OT6B5K2T LENG8_HUMAN Increases Expression [4]
Peroxisomal acyl-coenzyme A oxidase 2 (ACOX2) OT3VH359 ACOX2_HUMAN Increases Expression [4]
Mitogen-activated protein kinase kinase kinase 14 (MAP3K14) OTT3DOOL M3K14_HUMAN Decreases Expression [4]
Mitogen-activated protein kinase kinase kinase 5 (MAP3K5) OTQR6ENW M3K5_HUMAN Decreases Expression [4]
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (ECSIT) OTJX1YC7 ECSIT_HUMAN Decreases Expression [4]
Receptor-transporting protein 3 (RTP3) OTZUDJ6Q RTP3_HUMAN Increases Expression [4]
Very long chain fatty acid elongase 1 (ELOVL1) OTIDTQ8R ELOV1_HUMAN Increases Expression [4]
Protein amnionless (AMN) OTS1TJXG AMNLS_HUMAN Decreases Expression [4]
Forkhead box protein P3 (FOXP3) OTA9Z9OC FOXP3_HUMAN Increases Expression [4]
3 beta-hydroxysteroid dehydrogenase type 7 (HSD3B7) OT2Y9IW4 3BHS7_HUMAN Decreases Expression [4]
Lck-interacting transmembrane adapter 1 (LIME1) OTJWUQSK LIME1_HUMAN Decreases Expression [4]
Very long chain fatty acid elongase 6 (ELOVL6) OTB26UJJ ELOV6_HUMAN Decreases Expression [4]
Cytochrome P450 4F11 (CYP4F11) OTHZ2GG2 CP4FB_HUMAN Decreases Expression [4]
Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) OTR1XD9B GPAT1_HUMAN Decreases Expression [4]
Solute carrier organic anion transporter family member 1B3 (SLCO1B3) OTOM3BUH SO1B3_HUMAN Increases Expression [4]
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5) OTNY3VMD PLCE_HUMAN Decreases Expression [4]
Very long chain fatty acid elongase 2 (ELOVL2) OTDAF6U3 ELOV2_HUMAN Increases Expression [4]
24-hydroxycholesterol 7-alpha-hydroxylase (CYP39A1) OTBAJT4I CP39A_HUMAN Decreases Expression [4]
Very-long-chain enoyl-CoA reductase (TECR) OT2NT4MV TECR_HUMAN Decreases Expression [4]
C5a anaphylatoxin chemotactic receptor 2 (C5AR2) OTP1Q82J C5AR2_HUMAN Decreases Expression [4]
7-dehydrocholesterol reductase (DHCR7) OTLILBUI DHCR7_HUMAN Increases Expression [4]
DnaJ homolog subfamily B member 11 (DNAJB11) OTDDK2SY DJB11_HUMAN Increases Expression [4]
Mitochondrial dicarboxylate carrier (SLC25A10) OTT8647H DIC_HUMAN Decreases Expression [4]
Cysteine-rich C-terminal protein 1 (CRCT1) OTPYME8V CRCT1_HUMAN Decreases Expression [4]
Fetuin-B (FETUB) OT7V07NI FETUB_HUMAN Increases Expression [4]
Polypyrimidine tract-binding protein 2 (PTBP2) OTF4S7NE PTBP2_HUMAN Decreases Expression [4]
Long-chain-fatty-acid--CoA ligase 6 (ACSL6) OT0TT8P8 ACSL6_HUMAN Increases Expression [4]
Long-chain-fatty-acid--CoA ligase 5 (ACSL5) OT3L9XO3 ACSL5_HUMAN Increases Expression [4]
Myocardin-related transcription factor B (MRTFB) OT9OXGS9 MRTFB_HUMAN Decreases Expression [4]
Carbonic anhydrase 14 (CA14) OT1TRKFN CAH14_HUMAN Increases Expression [4]
Transcription factor MafF (MAFF) OT9B7MX0 MAFF_HUMAN Increases Expression [4]
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (CYP8B1) OTRI4UR1 CP8B1_HUMAN Increases Expression [4]
Protein phosphatase 1 regulatory subunit 3C (PPP1R3C) OTEU05TX PPR3C_HUMAN Decreases Expression [4]
Long-chain fatty acid transport protein 5 (SLC27A5) OT4OK511 S27A5_HUMAN Decreases Expression [4]
Acyl-coenzyme A thioesterase 9, mitochondrial (ACOT9) OTBOQE6N ACOT9_HUMAN Increases Expression [4]
Chloride intracellular channel protein 4 (CLIC4) OT6KTPKD CLIC4_HUMAN Increases Expression [4]
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) OTNEN8QK SO1B1_HUMAN Decreases Expression [4]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Increases Expression [7]
Nuclear receptor subfamily 0 group B member 2 (NR0B2) OT7UVICX NR0B2_HUMAN Increases Expression [7]
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⏷ Show the Full List of 160 DOT(s)
Indication(s) of obeticholic acid
Disease Entry ICD 11 Status REF
Primary biliary cholangitis DB96.1 Approved [2]
Insomnia 7A00-7A0Z Clinical trial [3]
obeticholic acid Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Farnesoid X-activated receptor (FXR) TTS4UGC NR1H4_HUMAN Modulator [2]
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obeticholic acid Interacts with 1 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Bile acid-CoA thioesterase (BAAT) DERA3OF BAAT_HUMAN Metabolism [6]
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obeticholic acid Interacts with 160 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Very long chain fatty acid elongase 7 (ELOVL7) OT89NYVC ELOV7_HUMAN Increases Expression [4]
cTAGE family member 15 (CTAGE15) OTMOMQGH CTGEF_HUMAN Increases Expression [4]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD) OTOMP6TH PK3CD_HUMAN Decreases Expression [4]
Nuclear receptor subfamily 5 group A member 2 (NR5A2) OTXAUJAS NR5A2_HUMAN Decreases Expression [4]
Suppressor of cytokine signaling 2 (SOCS2) OTBPNKJQ SOCS2_HUMAN Decreases Expression [4]
Copper chaperone for superoxide dismutase (CCS) OTXHT3QO CCS_HUMAN Decreases Expression [4]
Ectoderm-neural cortex protein 1 (ENC1) OTJEUB6U ENC1_HUMAN Increases Expression [4]
Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7) OT1Q40TZ MP2K7_HUMAN Decreases Expression [4]
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2) OT5I4Y9K PLCB_HUMAN Decreases Expression [4]
Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) OTZEPVGF ACOX3_HUMAN Increases Expression [4]
Tapasin (TAPBP) OTL81AVZ TPSN_HUMAN Decreases Expression [4]
Interleukin-1 receptor-associated kinase-like 2 (IRAK2) OT6Y1QZN IRAK2_HUMAN Decreases Expression [4]
Long-chain-fatty-acid--CoA ligase 4 (ACSL4) OTI71MUJ ACSL4_HUMAN Increases Expression [4]
Transcription factor Maf (MAF) OT1GR3IZ MAF_HUMAN Increases Expression [4]
Ribosomal protein S6 kinase alpha-4 (RPS6KA4) OTTK8MUO KS6A4_HUMAN Decreases Expression [4]
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (SLC25A12) OTB4YBVT S2512_HUMAN Decreases Expression [4]
Lathosterol oxidase (SC5D) OT41KMW4 SC5D_HUMAN Decreases Expression [4]
Phospholipid-transporting ATPase ABCA1 (ABCA1) OT94G6BQ ABCA1_HUMAN Decreases Expression [4]
Alcohol dehydrogenase 1C (ADH1C) OTO1DV7F ADH1G_HUMAN Decreases Expression [4]
Alpha-2-macroglobulin (A2M) OTFTX90K A2MG_HUMAN Decreases Expression [4]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Decreases Expression [4]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Decreases Expression [4]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [4]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Decreases Expression [4]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Decreases Expression [4]
Apolipoprotein C-II (APOC2) OTLINYIQ APOC2_HUMAN Increases Expression [4]
C-reactive protein (CRP) OT0RFT8F CRP_HUMAN Decreases Expression [4]
Albumin (ALB) OTVMM513 ALBU_HUMAN Decreases Expression [4]
Fructose-bisphosphate aldolase A (ALDOA) OTWRFTIB ALDOA_HUMAN Decreases Expression [4]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Decreases Expression [4]
Thymidine kinase, cytosolic (TK1) OTY5JFM1 KITH_HUMAN Decreases Expression [4]
Fructose-bisphosphate aldolase B (ALDOB) OT7FR69A ALDOB_HUMAN Decreases Expression [4]
Plasminogen activator inhibitor 1 (SERPINE1) OTT0MPQ3 PAI1_HUMAN Decreases Expression [4]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Expression [4]
Alpha-enolase (ENO1) OTB1KWJS ENOA_HUMAN Decreases Expression [4]
Histone H2B type 1-J (H2BC11) OTGM083T H2B1J_HUMAN Decreases Expression [4]
Protein disulfide-isomerase (P4HB) OTTYNYPF PDIA1_HUMAN Increases Expression [4]
Interleukin-6 receptor subunit alpha (IL6R) OTCQL07Z IL6RA_HUMAN Decreases Expression [4]
Proto-oncogene tyrosine-protein kinase ROS (ROS1) OTDSKUGE ROS1_HUMAN Increases Expression [4]
3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) OTVKRET0 THIK_HUMAN Increases Expression [4]
Inhibin beta B chain (INHBB) OT2QLD11 INHBB_HUMAN Increases Expression [4]
Fructose-bisphosphate aldolase C (ALDOC) OTEC13I5 ALDOC_HUMAN Increases Expression [4]
Transforming growth factor beta-3 proprotein (TGFB3) OT2LOUQ1 TGFB3_HUMAN Increases Expression [4]
Hepatic triacylglycerol lipase (LIPC) OTZY5SC9 LIPC_HUMAN Decreases Expression [4]
Pyruvate carboxylase, mitochondrial (PC) OT6O0V51 PYC_HUMAN Decreases Expression [4]
Beta-enolase (ENO3) OT3HYKYI ENOB_HUMAN Increases Expression [4]
Farnesyl pyrophosphate synthase (FDPS) OT6CKWV5 FPPS_HUMAN Decreases Expression [4]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (PFKFB1) OTTHX4NB F261_HUMAN Increases Expression [4]
Transcription factor JunB (JUNB) OTG2JXV5 JUNB_HUMAN Decreases Expression [4]
Glutathione peroxidase 2 (GPX2) OTXI2NTI GPX2_HUMAN Decreases Expression [4]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Increases Expression [4]
Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) OTDS2EAR TNR1B_HUMAN Increases Expression [4]
Phosphatidylcholine translocator ABCB4 (ABCB4) OTE6PY83 MDR3_HUMAN Increases Expression [4]
Glycerol-3-phosphate dehydrogenase , cytoplasmic (GPD1) OTQW7TMB GPDA_HUMAN Decreases Expression [4]
Glutathione peroxidase 3 (GPX3) OT6PK94R GPX3_HUMAN Increases Expression [4]
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) OTIN6G20 CPT2_HUMAN Increases Expression [4]
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) OT5BZ1J9 P85A_HUMAN Decreases Expression [4]
Peroxiredoxin-6 (PRDX6) OTS8KC8A PRDX6_HUMAN Decreases Expression [4]
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PPP2R1B) OTFIHQGD 2AAB_HUMAN Increases Expression [4]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Decreases Expression [4]
Glycerol kinase (GK) OTK2YRA0 GLPK_HUMAN Decreases Expression [4]
Long-chain-fatty-acid--CoA ligase 1 (ACSL1) OTB06ESI ACSL1_HUMAN Decreases Expression [4]
Protein S100-A3 (S100A3) OTVIZJ2R S10A3_HUMAN Decreases Expression [4]
Phosphoenolpyruvate carboxykinase, cytosolic (PCK1) OTNWEJ5Y PCKGC_HUMAN Decreases Expression [4]
Insulin-like growth factor-binding protein complex acid labile subunit (IGFALS) OTTWCZYM ALS_HUMAN Decreases Expression [4]
Interleukin-6 receptor subunit beta (IL6ST) OT1N9C70 IL6RB_HUMAN Decreases Expression [4]
Malate dehydrogenase, cytoplasmic (MDH1) OTJEO4E8 MDHC_HUMAN Increases Expression [4]
Mitogen-activated protein kinase kinase kinase 8 (MAP3K8) OTOZTA1F M3K8_HUMAN Increases Expression [4]
Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) OTI2OREX MP2K3_HUMAN Decreases Expression [4]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) OTI862QH CPT1A_HUMAN Increases Expression [4]
Aldo-keto reductase family 1 member D1 (AKR1D1) OTBDJ6RL AK1D1_HUMAN Decreases Expression [4]
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6) OTK13JKC MP2K6_HUMAN Decreases Expression [4]
Tricarboxylate transport protein, mitochondrial (SLC25A1) OTIDXQ9F TXTP_HUMAN Decreases Expression [4]
Mitogen-activated protein kinase 12 (MAPK12) OTTCKE27 MK12_HUMAN Decreases Expression [4]
Glycogen synthase, liver (GYS2) OTCKIUYR GYS2_HUMAN Increases Expression [4]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Decreases Expression [4]
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (HSD17B7) OTV7VOV3 DHB7_HUMAN Decreases Expression [4]
Transforming growth factor beta-2 proprotein (TGFB2) OTC0TXEP TGFB2_HUMAN Decreases Expression [4]
Ras-related protein R-Ras2 (RRAS2) OT83NCEB RRAS2_HUMAN Increases Expression [4]
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PPP2CB) OT24GMCM PP2AB_HUMAN Increases Expression [4]
Metallothionein-1H (MT1H) OT0MVBM6 MT1H_HUMAN Decreases Expression [4]
Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2) OT6HTSJT PGBM_HUMAN Decreases Expression [4]
Nuclear factor NF-kappa-B p100 subunit (NFKB2) OTS231V7 NFKB2_HUMAN Decreases Expression [4]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1) OTCO26FV HMCS1_HUMAN Decreases Expression [4]
Sterol 26-hydroxylase, mitochondrial (CYP27A1) OT649C01 CP27A_HUMAN Decreases Expression [4]
Cytochrome P450 4A11 (CYP4A11) OTPU5J0S CP4AB_HUMAN Increases Expression [4]
Peroxiredoxin-1 (PRDX1) OTZ3BEC4 PRDX1_HUMAN Decreases Expression [4]
Cytochrome P450 4F3 (CYP4F3) OTYNSQAM CP4F3_HUMAN Decreases Expression [4]
Sterol regulatory element-binding protein 2 (SREBF2) OTBXUNPL SRBP2_HUMAN Decreases Expression [4]
TNF receptor-associated factor 2 (TRAF2) OT1MEZZN TRAF2_HUMAN Decreases Expression [4]
Protein AF1q (MLLT11) OTG5RVHC AF1Q_HUMAN Increases Expression [4]
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Decreases Expression [4]
FAS-associated death domain protein (FADD) OTV7GFHH FADD_HUMAN Increases Expression [4]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Decreases Expression [4]
Isopentenyl-diphosphate Delta-isomerase 1 (IDI1) OTGM06VJ IDI1_HUMAN Decreases Expression [4]
Phosphatidate phosphatase LPIN1 (LPIN1) OTQ75KF2 LPIN1_HUMAN Decreases Expression [4]
Delta(14)-sterol reductase LBR (LBR) OT1HG3HG LBR_HUMAN Decreases Expression [4]
Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) OTM0A0DY ACOX1_HUMAN Increases Expression [4]
Transcription elongation factor A protein 2 (TCEA2) OT1OS9TY TCEA2_HUMAN Increases Expression [4]
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) OTPM6F85 TAB1_HUMAN Decreases Expression [4]
Mitogen-activated protein kinase 11 (MAPK11) OT0AS010 MK11_HUMAN Decreases Expression [4]
Dual specificity protein phosphatase 6 (DUSP6) OT4H6RKW DUS6_HUMAN Increases Expression [4]
Meteorin-like protein (METRNL) OTB0DDL0 METRL_HUMAN Decreases Expression [4]
Cyclic AMP-responsive element-binding protein 3-like protein 3 (CREB3L3) OTDMU3GP CR3L3_HUMAN Increases Expression [4]
Single Ig IL-1-related receptor (SIGIRR) OTNC3XFD SIGIR_HUMAN Decreases Expression [4]
Ultra-long-chain fatty acid omega-hydroxylase (CYP4F22) OTMNPZQL CP4FN_HUMAN Decreases Expression [4]
SUZ domain-containing protein 1 (SZRD1) OTJMEJWT SZRD1_HUMAN Increases Expression [4]
Cytochrome P450 2U1 (CYP2U1) OT6RXLXS CP2U1_HUMAN Increases Expression [4]
Tubulin epsilon and delta complex protein 1 (TEDC1) OT2RIGR7 TEDC1_HUMAN Decreases Expression [4]
ADAMTS-like protein 2 (ADAMTSL2) OTAXNV2U ATL2_HUMAN Decreases Expression [4]
60 kDa lysophospholipase (ASPG) OT5E2EKR LPP60_HUMAN Decreases Expression [4]
Organic solute transporter subunit alpha (SLC51A) OTDJRZ0P OSTA_HUMAN Increases Expression [4]
Organic solute transporter subunit beta (SLC51B) OT4WYPSR OSTB_HUMAN Increases Expression [4]
Na(+)/citrate cotransporter (SLC13A5) OTPH1TA7 S13A5_HUMAN Decreases Expression [4]
Leucine-rich repeat LGI family member 4 (LGI4) OTZGS8BN LGI4_HUMAN Increases Expression [4]
Neuropeptide W (NPW) OTO7MT28 NPW_HUMAN Decreases Expression [4]
Sodium-dependent lysophosphatidylcholine symporter 1 (MFSD2A) OTVG1VG0 NLS1_HUMAN Increases Expression [4]
Mixed lineage kinase domain-like protein (MLKL) OTDSLC81 MLKL_HUMAN Decreases Expression [4]
Phosphatidate phosphatase LPIN2 (LPIN2) OTRRTMXX LPIN2_HUMAN Decreases Expression [4]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Decreases Expression [4]
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) OT2JHIHM CR3L1_HUMAN Decreases Expression [4]
Leukocyte receptor cluster member 8 (LENG8) OT6B5K2T LENG8_HUMAN Increases Expression [4]
Peroxisomal acyl-coenzyme A oxidase 2 (ACOX2) OT3VH359 ACOX2_HUMAN Increases Expression [4]
Mitogen-activated protein kinase kinase kinase 14 (MAP3K14) OTT3DOOL M3K14_HUMAN Decreases Expression [4]
Mitogen-activated protein kinase kinase kinase 5 (MAP3K5) OTQR6ENW M3K5_HUMAN Decreases Expression [4]
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (ECSIT) OTJX1YC7 ECSIT_HUMAN Decreases Expression [4]
Receptor-transporting protein 3 (RTP3) OTZUDJ6Q RTP3_HUMAN Increases Expression [4]
Very long chain fatty acid elongase 1 (ELOVL1) OTIDTQ8R ELOV1_HUMAN Increases Expression [4]
Protein amnionless (AMN) OTS1TJXG AMNLS_HUMAN Decreases Expression [4]
Forkhead box protein P3 (FOXP3) OTA9Z9OC FOXP3_HUMAN Increases Expression [4]
3 beta-hydroxysteroid dehydrogenase type 7 (HSD3B7) OT2Y9IW4 3BHS7_HUMAN Decreases Expression [4]
Lck-interacting transmembrane adapter 1 (LIME1) OTJWUQSK LIME1_HUMAN Decreases Expression [4]
Very long chain fatty acid elongase 6 (ELOVL6) OTB26UJJ ELOV6_HUMAN Decreases Expression [4]
Cytochrome P450 4F11 (CYP4F11) OTHZ2GG2 CP4FB_HUMAN Decreases Expression [4]
Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) OTR1XD9B GPAT1_HUMAN Decreases Expression [4]
Solute carrier organic anion transporter family member 1B3 (SLCO1B3) OTOM3BUH SO1B3_HUMAN Increases Expression [4]
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5) OTNY3VMD PLCE_HUMAN Decreases Expression [4]
Very long chain fatty acid elongase 2 (ELOVL2) OTDAF6U3 ELOV2_HUMAN Increases Expression [4]
24-hydroxycholesterol 7-alpha-hydroxylase (CYP39A1) OTBAJT4I CP39A_HUMAN Decreases Expression [4]
Very-long-chain enoyl-CoA reductase (TECR) OT2NT4MV TECR_HUMAN Decreases Expression [4]
C5a anaphylatoxin chemotactic receptor 2 (C5AR2) OTP1Q82J C5AR2_HUMAN Decreases Expression [4]
7-dehydrocholesterol reductase (DHCR7) OTLILBUI DHCR7_HUMAN Increases Expression [4]
DnaJ homolog subfamily B member 11 (DNAJB11) OTDDK2SY DJB11_HUMAN Increases Expression [4]
Mitochondrial dicarboxylate carrier (SLC25A10) OTT8647H DIC_HUMAN Decreases Expression [4]
Cysteine-rich C-terminal protein 1 (CRCT1) OTPYME8V CRCT1_HUMAN Decreases Expression [4]
Fetuin-B (FETUB) OT7V07NI FETUB_HUMAN Increases Expression [4]
Polypyrimidine tract-binding protein 2 (PTBP2) OTF4S7NE PTBP2_HUMAN Decreases Expression [4]
Long-chain-fatty-acid--CoA ligase 6 (ACSL6) OT0TT8P8 ACSL6_HUMAN Increases Expression [4]
Long-chain-fatty-acid--CoA ligase 5 (ACSL5) OT3L9XO3 ACSL5_HUMAN Increases Expression [4]
Myocardin-related transcription factor B (MRTFB) OT9OXGS9 MRTFB_HUMAN Decreases Expression [4]
Carbonic anhydrase 14 (CA14) OT1TRKFN CAH14_HUMAN Increases Expression [4]
Transcription factor MafF (MAFF) OT9B7MX0 MAFF_HUMAN Increases Expression [4]
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (CYP8B1) OTRI4UR1 CP8B1_HUMAN Increases Expression [4]
Protein phosphatase 1 regulatory subunit 3C (PPP1R3C) OTEU05TX PPR3C_HUMAN Decreases Expression [4]
Long-chain fatty acid transport protein 5 (SLC27A5) OT4OK511 S27A5_HUMAN Decreases Expression [4]
Acyl-coenzyme A thioesterase 9, mitochondrial (ACOT9) OTBOQE6N ACOT9_HUMAN Increases Expression [4]
Chloride intracellular channel protein 4 (CLIC4) OT6KTPKD CLIC4_HUMAN Increases Expression [4]
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) OTNEN8QK SO1B1_HUMAN Decreases Expression [4]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Increases Expression [7]
Nuclear receptor subfamily 0 group B member 2 (NR0B2) OT7UVICX NR0B2_HUMAN Increases Expression [7]
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References

1 ClinicalTrials.gov (NCT05321524) Obeticholic Acid in Pediatric Subjects With Biliary Atresia
2 2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76.
3 Nuclear receptors and lipid physiology: opening the X-files. Science. 2001 Nov 30;294(5548):1866-70.
4 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
5 UGT-dependent regioselective glucuronidation of ursodeoxycholic acid and obeticholic acid and selective transport of the consequent acyl glucuronides by OATP1B1 and 1B3. Chem Biol Interact. 2019 Sep 1;310:108745. doi: 10.1016/j.cbi.2019.108745. Epub 2019 Jul 9.
6 Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase. J Biol Chem. 1994 Jul 29;269(30):19375-9.
7 The methyl transferase PRMT1 functions as co-activator of farnesoid X receptor (FXR)/9-cis retinoid X receptor and regulates transcription of FXR responsive genes. Mol Pharmacol. 2005 Aug;68(2):551-8. doi: 10.1124/mol.105.012104. Epub 2005 May 23.