Details of the Drug Combination

General Information of Drug Combination (ID: DCGUXXA)

Drug Combination Name
Ibuprofen Piroxicam
Indication
Disease Entry Status REF
Hypertension Phase 4 [1]
Component Drugs Ibuprofen   DM8VCBE Piroxicam   DMTK234
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Ibuprofen
Disease Entry ICD 11 Status REF
Dysmenorrhea GA34.3 Approved [2]
Fever MG26 Approved [2]
Headache 8A80-8A84 Approved [2]
Osteoarthritis FA00-FA05 Approved [2]
Pain MG30-MG3Z Approved [3]
Patent ductus arteriosus N.A. Approved [2]
Ibuprofen Interacts with 4 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
C-X-C chemokine receptor type 1 (CXCR1) TTMWT8Z CXCR1_HUMAN Inhibitor [11]
Interleukin-8 (IL8) TTCTE1G IL8_HUMAN Inhibitor [12]
C-X-C chemokine receptor type 2 (CXCR2) TT30C9G CXCR2_HUMAN Inhibitor [11]
Prostaglandin G/H synthase 2 (COX-2) TTVKILB PGH2_HUMAN Inhibitor [13]
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Ibuprofen Interacts with 2 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Monocarboxylate transporter 2 (SLC16A7) DTLT3UG MOT2_HUMAN Substrate [14]
Probable small intestine urate exporter (SLC17A4) DTHE530 S17A4_HUMAN Substrate [15]
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Ibuprofen Interacts with 9 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [16]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [17]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [18]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [18]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DEB3CV1 UD2B7_HUMAN Metabolism [19]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DEF2WXN UD13_HUMAN Metabolism [19]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DE85D2P UD19_HUMAN Metabolism [19]
Alpha-methylacyl-CoA racemase (AMACR) DEGKWJB AMACR_HUMAN Metabolism [20]
Acyl-CoA thioesterase 2 (ACOT2) DEMEPVJ ACOT2_HUMAN Metabolism [21]
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⏷ Show the Full List of 9 DME(s)
Ibuprofen Interacts with 185 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Myeloperoxidase (MPO) OTOOXLIN PERM_HUMAN Increases ADR [22]
Solute carrier family 22 member 1 (SLC22A1) OT7817I4 S22A1_HUMAN Decreases Activity [23]
Solute carrier family 22 member 6 (SLC22A6) OTKRCBVM S22A6_HUMAN Decreases Activity [23]
Organic anion transporter 7 (SLC22A9) OTO4BJCC S22A9_HUMAN Decreases Activity [23]
Solute carrier family 22 member 11 (SLC22A11) OTAJLNJZ S22AB_HUMAN Decreases Activity [23]
Solute carrier family 22 member 7 (SLC22A7) OTKTNH1W S22A7_HUMAN Decreases Activity [23]
Aromatase (CYP19A1) OTZ6XF74 CP19A_HUMAN Decreases Expression [24]
Prostaglandin G/H synthase 1 (PTGS1) OTHCRLEC PGH1_HUMAN Decreases Activity [25]
Diamine acetyltransferase 1 (SAT1) OT52AU22 SAT1_HUMAN Increases Expression [26]
Suppressor of cytokine signaling 3 (SOCS3) OTY183WJ SOCS3_HUMAN Affects Expression [27]
Ephrin type-B receptor 6 (EPHB6) OTKNN6GC EPHB6_HUMAN Affects Expression [27]
Arachidonate 12-lipoxygenase, 12R-type (ALOX12B) OTQ0BYK6 LX12B_HUMAN Affects Expression [27]
Annexin A9 (ANXA9) OTKNYMU2 ANXA9_HUMAN Decreases Expression [27]
Metastasis-associated protein MTA2 (MTA2) OTCCYIQJ MTA2_HUMAN Increases Expression [27]
Integrin beta-like protein 1 (ITGBL1) OTJDHE17 ITGBL_HUMAN Affects Expression [27]
Complement C3 (C3) OTCH5GS0 CO3_HUMAN Affects Expression [27]
Interleukin-1 alpha (IL1A) OTPSGILV IL1A_HUMAN Increases Expression [27]
Annexin A1 (ANXA1) OT5OFDJC ANXA1_HUMAN Affects Expression [27]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Increases Expression [27]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Increases Expression [27]
Peptide YY (PYY) OTXX6AF5 PYY_HUMAN Decreases Expression [27]
Clusterin (CLU) OTQGG0JM CLUS_HUMAN Affects Expression [27]
Collagen alpha-1(XI) chain (COL11A1) OTB0DRMS COBA1_HUMAN Affects Expression [27]
Annexin A3 (ANXA3) OTDD8OI7 ANXA3_HUMAN Affects Expression [27]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Increases Expression [27]
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) OTPWI88U CEAM1_HUMAN Affects Expression [27]
Tissue factor (F3) OT3MSU3B TF_HUMAN Increases Expression [27]
Phospholipase A2, membrane associated (PLA2G2A) OT1NY7BF PA2GA_HUMAN Affects Expression [27]
Fatty acid-binding protein, adipocyte (FABP4) OT3DKFOU FABP4_HUMAN Decreases Expression [27]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Affects Expression [27]
Myelin and lymphocyte protein (MAL) OTBM30SW MAL_HUMAN Increases Expression [27]
Cadherin-3 (CDH3) OTKNLQU7 CADH3_HUMAN Affects Expression [27]
Tenascin (TNC) OTK4FSHR TENA_HUMAN Increases Expression [27]
Nitric oxide synthase 1 (NOS1) OT7M8XVG NOS1_HUMAN Affects Expression [27]
Protein PML (PML) OT6SM2GD PML_HUMAN Affects Expression [27]
Tumor necrosis factor receptor superfamily member 3 (LTBR) OT2HVZGV TNR3_HUMAN Decreases Expression [27]
Prostaglandin E2 receptor EP3 subtype (PTGER3) OTQODQUN PE2R3_HUMAN Affects Expression [27]
Protein FosB (FOSB) OTW6C05J FOSB_HUMAN Increases Expression [27]
Fractalkine (CX3CL1) OTPLGI0E X3CL1_HUMAN Affects Expression [27]
Insulinoma-associated protein 1 (INSM1) OTG8RV8E INSM1_HUMAN Decreases Expression [27]
Max dimerization protein 1 (MXD1) OTS5CTHX MAD1_HUMAN Increases Expression [27]
Desmocollin-1 (DSC1) OTNII6GZ DSC1_HUMAN Affects Expression [27]
Corneodesmosin (CDSN) OTQW4HV6 CDSN_HUMAN Affects Expression [27]
Microtubule-associated protein RP/EB family member 2 (MAPRE2) OTAE3MX4 MARE2_HUMAN Affects Expression [27]
Voltage-dependent calcium channel subunit alpha-2/delta-3 (CACNA2D3) OTEH9HGE CA2D3_HUMAN Affects Expression [27]
Secreted frizzled-related protein 3 (FRZB) OTTO3DPY SFRP3_HUMAN Affects Expression [27]
Hydroperoxide isomerase ALOXE3 (ALOXE3) OT76J52A LOXE3_HUMAN Affects Expression [27]
T-lymphocyte surface antigen Ly-9 (LY9) OT1PKGDI LY9_HUMAN Decreases Expression [27]
Transmembrane protease serine 4 (TMPRSS4) OTCCGY2K TMPS4_HUMAN Affects Expression [27]
A disintegrin and metalloproteinase with thrombospondin motifs 8 (ADAMTS8) OT2KFY1S ATS8_HUMAN Increases Expression [27]
Sulfotransferase 1E1 (SULT1E1) OTGPJ517 ST1E1_HUMAN Decreases Activity [28]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Decreases Activity [29]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Decreases Activity [29]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Decreases Activity [29]
PDZ and LIM domain protein 1 (PDLIM1) OT4EGCPG PDLI1_HUMAN Decreases Expression [9]
Excitatory amino acid transporter 5 (SLC1A7) OTVN5C6W EAA5_HUMAN Increases Expression [9]
Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2) OT8L6EGI BCAT2_HUMAN Increases Expression [9]
Monocarboxylate transporter 7 (SLC16A6) OT7BIIZX MOT7_HUMAN Increases Expression [9]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Increases Expression [9]
Cochlin (COCH) OTBEHD89 COCH_HUMAN Decreases Expression [9]
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) OTLVN68B AAKB2_HUMAN Decreases Expression [9]
NUAK family SNF1-like kinase 1 (NUAK1) OTLLHJJQ NUAK1_HUMAN Decreases Expression [9]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Increases Expression [9]
Ribosomal L1 domain-containing protein 1 (RSL1D1) OT3CL4R3 RL1D1_HUMAN Increases Expression [9]
Solute carrier organic anion transporter family member 2B1 (SLCO2B1) OTERJ4VQ SO2B1_HUMAN Decreases Expression [9]
Tumor necrosis factor alpha-induced protein 8 (TNFAIP8) OT1G9297 TFIP8_HUMAN Decreases Expression [9]
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (GCNT3) OTQ9ALTR GCNT3_HUMAN Increases Expression [9]
G1/S-specific cyclin-E2 (CCNE2) OTBBUKQQ CCNE2_HUMAN Increases Expression [9]
Protein AMBP (AMBP) OTLU8GU8 AMBP_HUMAN Decreases Expression [9]
Fructose-bisphosphate aldolase A (ALDOA) OTWRFTIB ALDOA_HUMAN Increases Expression [9]
Glucocorticoid receptor (NR3C1) OTCI2YDI GCR_HUMAN Decreases Expression [9]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Affects Activity [9]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Decreases Expression [9]
Alpha-enolase (ENO1) OTB1KWJS ENOA_HUMAN Increases Expression [9]
Bifunctional glutamate/proline--tRNA ligase (EPRS1) OTXK0FLB SYEP_HUMAN Increases Expression [9]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Increases Expression [9]
Asparagine synthetase (ASNS) OT8R922G ASNS_HUMAN Increases Expression [9]
Retinoic acid receptor alpha (RARA) OT192V9V RARA_HUMAN Decreases Expression [9]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Decreases Expression [9]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) OTA675TJ GTR1_HUMAN Increases Expression [9]
Histone H1.2 (H1-2) OT0AVI4M H12_HUMAN Decreases Expression [9]
Aspartate aminotransferase, cytoplasmic (GOT1) OTZLM5UB AATC_HUMAN Increases Expression [9]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Affects Activity [9]
Transcription factor E3 (TFE3) OTM99ZWH TFE3_HUMAN Increases Expression [9]
Retinoic acid receptor RXR-alpha (RXRA) OTP1TBDM RXRA_HUMAN Decreases Expression [9]
Iduronate 2-sulfatase (IDS) OTZO94EO IDS_HUMAN Increases Expression [9]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Decreases Expression [9]
DnaJ homolog subfamily B member 2 (DNAJB2) OTZHPV5M DNJB2_HUMAN Increases Expression [9]
Adenylate kinase 4, mitochondrial (AK4) OTA0T02Q KAD4_HUMAN Decreases Expression [9]
ETS domain-containing protein Elk-4 (ELK4) OTVSSEOE ELK4_HUMAN Increases Expression [9]
High affinity cationic amino acid transporter 1 (SLC7A1) OTR2ZVA8 CTR1_HUMAN Increases Expression [9]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Increases Expression [9]
Long-chain-fatty-acid--CoA ligase 1 (ACSL1) OTB06ESI ACSL1_HUMAN Increases Expression [9]
Peroxisome proliferator-activated receptor gamma (PPARG) OTHMARHO PPARG_HUMAN Affects Activity [9]
Isoleucine--tRNA ligase, cytoplasmic (IARS1) OT9WXH5N SYIC_HUMAN Increases Expression [9]
Neutral amino acid transporter A (SLC1A4) OTVODHAE SATT_HUMAN Increases Expression [9]
Nicotinamide phosphoribosyltransferase (NAMPT) OTVJR3GL NAMPT_HUMAN Increases Expression [9]
ATP-binding cassette sub-family G member 1 (ABCG1) OT5BG6MK ABCG1_HUMAN Increases Expression [9]
Sodium- and chloride-dependent glycine transporter 1 (SLC6A9) OTHRUON2 SC6A9_HUMAN Increases Expression [9]
Dipeptidyl peptidase 1 (CTSC) OT79WJZZ CATC_HUMAN Decreases Expression [9]
Ataxin-1 (ATXN1) OTQF0HNR ATX1_HUMAN Increases Expression [9]
Serine/threonine-protein kinase SIK1 (SIK1) OT6FCHME SIK1_HUMAN Increases Expression [9]
Cyclin-dependent kinase 6 (CDK6) OTR95N0X CDK6_HUMAN Decreases Expression [9]
Large neutral amino acids transporter small subunit 1 (SLC7A5) OT2WPVXD LAT1_HUMAN Increases Expression [9]
1,4-alpha-glucan-branching enzyme (GBE1) OTK2N05B GLGB_HUMAN Increases Expression [9]
Adenylate cyclase type 1 (ADCY1) OTSLLFZO ADCY1_HUMAN Decreases Expression [9]
Enhancer of filamentation 1 (NEDD9) OTGCFN4M CASL_HUMAN Decreases Expression [9]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Increases Expression [9]
kinase isozyme 4, mitochondrial (PDK4) OTCMHMBZ PDK4_HUMAN Increases Expression [9]
Dual specificity protein phosphatase 5 (DUSP5) OTH96RA7 DUS5_HUMAN Increases Expression [9]
Laminin subunit alpha-3 (LAMA3) OTFME7HT LAMA3_HUMAN Decreases Expression [9]
Tumor protein D53 (TPD52L1) OTSA6U0I TPD53_HUMAN Increases Expression [9]
Glycerol-3-phosphate acyltransferase 3 (GPAT3) OTJUGPK0 GPAT3_HUMAN Increases Expression [9]
RRP12-like protein (RRP12) OTQQAEH4 RRP12_HUMAN Increases Expression [9]
Arginine/serine-rich coiled-coil protein 2 (RSRC2) OTLE0KQM RSRC2_HUMAN Increases Expression [9]
Dipeptidyl peptidase 9 (DPP9) OTBMZW2O DPP9_HUMAN Increases Expression [9]
Extracellular sulfatase Sulf-2 (SULF2) OTIXMUVL SULF2_HUMAN Decreases Expression [9]
Probable ATP-dependent RNA helicase DHX37 (DHX37) OTM1A5KP DHX37_HUMAN Increases Expression [9]
(Lyso)-N-acylphosphatidylethanolamine lipase (ABHD4) OTQK3M9X ABHD4_HUMAN Increases Expression [9]
Pantothenate kinase 1 (PANK1) OT2CZVRT PANK1_HUMAN Increases Expression [9]
SH3 domain and tetratricopeptide repeat-containing protein 1 (SH3TC1) OT0HYZIU S3TC1_HUMAN Increases Expression [9]
Sortilin-related receptor (SORL1) OTQ8FFNS SORL_HUMAN Decreases Expression [9]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1) OT2363Z9 T53I1_HUMAN Decreases Expression [9]
Carboxymethylenebutenolidase homolog (CMBL) OT8H3S3G CMBL_HUMAN Decreases Expression [9]
Protein FAM89A (FAM89A) OTNASAXT FA89A_HUMAN Increases Expression [9]
Protein FAM210B, mitochondrial (FAM210B) OT2QHEQ6 F210B_HUMAN Decreases Expression [9]
Spermatid perinuclear RNA-binding protein (STRBP) OTU7XLZL STRBP_HUMAN Increases Expression [9]
Perilipin-2 (PLIN2) OTRXJ9UN PLIN2_HUMAN Increases Expression [9]
ETS-related transcription factor Elf-4 (ELF4) OT167PR5 ELF4_HUMAN Increases Expression [9]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Increases Expression [9]
Ferroptosis suppressor protein 1 (AIFM2) OT57XWXO FSP1_HUMAN Increases Expression [9]
Angiopoietin-related protein 4 (ANGPTL4) OTQL5SPX ANGL4_HUMAN Increases Expression [9]
Sulfiredoxin-1 (SRXN1) OTYDBO4L SRXN1_HUMAN Increases Expression [9]
Dual specificity protein phosphatase 22 (DUSP22) OTEZ3U85 DUS22_HUMAN Increases Expression [9]
Phospholipase A and acyltransferase 2 (PLAAT2) OTI5RMWB PLAT2_HUMAN Increases Expression [9]
Leucine--tRNA ligase, cytoplasmic (LARS1) OT4557NF SYLC_HUMAN Increases Expression [9]
Mitochondrial fission process protein 1 (MTFP1) OT3L6F7U MTFP1_HUMAN Increases Expression [9]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Increases Expression [9]
Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (ARFGEF2) OTM3CQZT BIG2_HUMAN Increases Expression [9]
Protein piccolo (PCLO) OTXJZZ98 PCLO_HUMAN Increases Expression [9]
Prostaglandin reductase 1 (PTGR1) OTMAR351 PTGR1_HUMAN Affects Activity [30]
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK) OTLF4ZB1 IKKA_HUMAN Decreases Activity [31]
Tumor necrosis factor receptor superfamily member 21 (TNFRSF21) OT3EDGXO TNR21_HUMAN Decreases Expression [32]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Increases Expression [33]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Increases Expression [34]
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Decreases Expression [35]
Intercellular adhesion molecule 1 (ICAM1) OTTOIX77 ICAM1_HUMAN Decreases Expression [36]
Eukaryotic translation initiation factor 4E (EIF4E) OTDAWNLA IF4E_HUMAN Increases Phosphorylation [37]
L-lactate dehydrogenase B chain (LDHB) OT9B1CT3 LDHB_HUMAN Affects Expression [38]
Annexin A2 (ANXA2) OTFNS0CC ANXA2_HUMAN Affects Expression [38]
Thrombospondin-1 (THBS1) OT0ECWK3 TSP1_HUMAN Increases Expression [39]
Tumor necrosis factor receptor superfamily member 16 (NGFR) OTPKSM49 TNR16_HUMAN Increases Expression [40]
Stromelysin-1 (MMP3) OTGBI74Z MMP3_HUMAN Increases Expression [34]
Galectin-1 (LGALS1) OT8LDFWR LEG1_HUMAN Affects Expression [38]
Heat shock 70 kDa protein 1A (HSPA1A) OTKGIE76 HS71A_HUMAN Increases Expression [41]
Heat shock cognate 71 kDa protein (HSPA8) OTJI2RCI HSP7C_HUMAN Affects Localization [42]
15-hydroxyprostaglandin dehydrogenase (HPGD) OTYZI6JB PGDH_HUMAN Increases Expression [43]
Platelet glycoprotein 4 (CD36) OT5CZWKY CD36_HUMAN Increases Expression [44]
Interleukin-1 receptor antagonist protein (IL1RN) OT308CBE IL1RA_HUMAN Decreases Secretion [45]
Phosphoglycerate mutase 1 (PGAM1) OTZ5DB06 PGAM1_HUMAN Increases Expression [38]
Peroxiredoxin-6 (PRDX6) OTS8KC8A PRDX6_HUMAN Affects Expression [38]
Peroxiredoxin-2 (PRDX2) OTLWCY9T PRDX2_HUMAN Increases Expression [38]
Solute carrier family 15 member 1 (SLC15A1) OT1P16B5 S15A1_HUMAN Affects Binding [46]
Glutamate--cysteine ligase catalytic subunit (GCLC) OTESDI4D GSH1_HUMAN Increases Expression [47]
Glutamate--cysteine ligase regulatory subunit (GCLM) OT6CP234 GSH0_HUMAN Increases Expression [47]
Fatty acid synthase (FASN) OTFII9KG FAS_HUMAN Decreases Expression [38]
Beta-secretase 1 (BACE1) OTCA7B6A BACE1_HUMAN Decreases Expression [48]
Triosephosphate isomerase (TPI1) OT14KP4B TPIS_HUMAN Increases Expression [38]
GTP-binding nuclear protein Ran (RAN) OT2TER5M RAN_HUMAN Affects Expression [38]
Peptidyl-prolyl cis-trans isomerase A (PPIA) OTHJMWQQ PPIA_HUMAN Affects Expression [38]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Increases Activity [49]
POU domain, class 5, transcription factor 1 (POU5F1) OTDHHN7O PO5F1_HUMAN Decreases Expression [50]
Cytochrome P450 4A11 (CYP4A11) OTPU5J0S CP4AB_HUMAN Decreases Activity [51]
Plectin (PLEC) OTU4XDEG PLEC_HUMAN Increases Expression [38]
Receptor tyrosine-protein kinase erbB-4 (ERBB4) OT9L6C41 ERBB4_HUMAN Affects Cleavage [52]
ELAV-like protein 1 (ELAVL1) OTY55PLY ELAV1_HUMAN Increases Expression [37]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Decreases Expression [10]
Sodium-coupled monocarboxylate transporter 1 (SLC5A8) OTA0WELF SC5A8_HUMAN Decreases Activity [53]
Methylcytosine dioxygenase TET1 (TET1) OTZDHT1D TET1_HUMAN Increases Expression [50]
ATP-dependent RNA helicase DDX1 (DDX1) OT3U8FD0 DDX1_HUMAN Affects Expression [38]
Endothelial PAS domain-containing protein 1 (EPAS1) OTRE3O8U EPAS1_HUMAN Decreases Expression [10]
DNA (DNMT3A) OTEJP0GH DNM3A_HUMAN Decreases Expression [50]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Increases Response To Substance [54]
Arylamine N-acetyltransferase 2 (NAT2) OTBPDQOY ARY2_HUMAN Increases ADR [22]
Lymphotoxin-alpha (LTA) OTUC3S76 TNFB_HUMAN Affects Response To Substance [55]
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⏷ Show the Full List of 185 DOT(s)
Indication(s) of Piroxicam
Disease Entry ICD 11 Status REF
Osteoarthritis FA00-FA05 Approved [4]
Pain MG30-MG3Z Approved [5]
Piroxicam Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Prostaglandin G/H synthase 1 (COX-1) TT8NGED PGH1_HUMAN Modulator [57]
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Piroxicam Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [58]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [59]
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Piroxicam Interacts with 465 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Solute carrier family 22 member 2 (SLC22A2) OTGFK1AL S22A2_HUMAN Decreases Activity [23]
Solute carrier family 22 member 6 (SLC22A6) OTKRCBVM S22A6_HUMAN Decreases Activity [23]
Organic anion transporter 7 (SLC22A9) OTO4BJCC S22A9_HUMAN Decreases Activity [23]
Solute carrier family 22 member 11 (SLC22A11) OTAJLNJZ S22AB_HUMAN Decreases Activity [23]
Solute carrier family 22 member 7 (SLC22A7) OTKTNH1W S22A7_HUMAN Decreases Activity [23]
Aromatase (CYP19A1) OTZ6XF74 CP19A_HUMAN Decreases Expression [24]
Sulfotransferase 1A1 (SULT1A1) OT0K7JIE ST1A1_HUMAN Decreases Activity [28]
CCN family member 1 (CCN1) OTKJBEMD CCN1_HUMAN Increases Expression [60]
Phospholipid phosphatase 3 (PLPP3) OTSSF7BK PLPP3_HUMAN Decreases Expression [60]
Calmegin (CLGN) OTEWVFQV CLGN_HUMAN Decreases Expression [60]
Receptor-interacting serine/threonine-protein kinase 2 (RIPK2) OT0KMIYQ RIPK2_HUMAN Decreases Expression [60]
Gasdermin-E (GSDME) OT1ZWY32 GSDME_HUMAN Decreases Expression [60]
Toll-like receptor 2 (TLR2) OTGO5P4R TLR2_HUMAN Decreases Expression [60]
CCN family member 5 (CCN5) OTADU8JJ CCN5_HUMAN Increases Expression [60]
Antiviral innate immune response receptor RIG-I (RIGI) OTFIIC43 RIGI_HUMAN Decreases Expression [60]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Increases Expression [60]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Decreases Expression [60]
Ubiquitin-like protein ISG15 (ISG15) OT53QQ7N ISG15_HUMAN Decreases Expression [60]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Expression [60]
Hepatocyte growth factor receptor (MET) OT7K55MU MET_HUMAN Decreases Expression [60]
Steryl-sulfatase (STS) OTXTJQPC STS_HUMAN Increases Expression [60]
Stromelysin-2 (MMP10) OTJDWW8Q MMP10_HUMAN Decreases Expression [60]
Growth-regulated alpha protein (CXCL1) OT3WCTZV GROA_HUMAN Decreases Expression [60]
Interferon alpha-inducible protein 6 (IFI6) OTWOOAM4 IFI6_HUMAN Decreases Expression [60]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Decreases Expression [60]
Interleukin-1 receptor antagonist protein (IL1RN) OT308CBE IL1RA_HUMAN Decreases Expression [60]
C-X-C motif chemokine 2 (CXCL2) OTEJCYMY CXCL2_HUMAN Decreases Expression [60]
C-X-C motif chemokine 3 (CXCL3) OTSL94KH CXCL3_HUMAN Decreases Expression [60]
Interferon-induced GTP-binding protein Mx1 (MX1) OT6X8G5T MX1_HUMAN Decreases Expression [60]
Atypical chemokine receptor 3 (ACKR3) OTA6GA4F ACKR3_HUMAN Decreases Expression [60]
11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1) OTO7FJA9 DHI1_HUMAN Decreases Expression [60]
Adenosine receptor A2a (ADORA2A) OTVRBZ0I AA2AR_HUMAN Decreases Expression [60]
Myristoylated alanine-rich C-kinase substrate (MARCKS) OT7N056G MARCS_HUMAN Decreases Expression [60]
Guanylate-binding protein 1 (GBP1) OTUM7RPJ GBP1_HUMAN Decreases Expression [60]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Decreases Expression [60]
Thrombospondin-2 (THBS2) OTXET551 TSP2_HUMAN Increases Expression [60]
Interferon alpha-inducible protein 27, mitochondrial (IFI27) OTI2XGIT IFI27_HUMAN Decreases Expression [60]
Regulator of G-protein signaling 4 (RGS4) OTG94HHL RGS4_HUMAN Decreases Expression [60]
Spermine synthase (SMS) OT8JYKNH SPSY_HUMAN Decreases Expression [60]
C-X-C chemokine receptor type 4 (CXCR4) OTUFSBX2 CXCR4_HUMAN Decreases Expression [60]
C-C motif chemokine 20 (CCL20) OTUCJY4N CCL20_HUMAN Decreases Expression [60]
Bone marrow stromal antigen 2 (BST2) OTU4LCJV BST2_HUMAN Decreases Expression [60]
Laminin subunit beta-3 (LAMB3) OTFPU6W8 LAMB3_HUMAN Decreases Expression [60]
Nidogen-2 (NID2) OTHC33FF NID2_HUMAN Increases Expression [60]
Signal transducer and activator of transcription 4 (STAT4) OTAK3VFR STAT4_HUMAN Decreases Expression [60]
Bcl-2-related protein A1 (BCL2A1) OTWRYSNA B2LA1_HUMAN Decreases Expression [60]
Lymphocyte antigen 6E (LY6E) OTMG16BZ LY6E_HUMAN Decreases Expression [60]
Interferon-induced protein 44-like (IFI44L) OTXKORJP IF44L_HUMAN Decreases Expression [60]
Collectin-12 (COLEC12) OTIQTK9G COL12_HUMAN Increases Expression [60]
Olfactomedin-like protein 2B (OLFML2B) OTDNJFR4 OLM2B_HUMAN Increases Expression [60]
E3 ubiquitin-protein ligase RNF19B (RNF19B) OTYCWKBP RN19B_HUMAN Decreases Expression [60]
Amphoterin-induced protein 2 (AMIGO2) OTPAIT1O AMGO2_HUMAN Decreases Expression [60]
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (RSAD2) OTCA9WCM RSAD2_HUMAN Decreases Expression [60]
Nuclear receptor subfamily 4 group A member 3 (NR4A3) OTPBE9R1 NR4A3_HUMAN Decreases Expression [60]
Interferon-stimulated gene 20 kDa protein (ISG20) OTCWRJJW ISG20_HUMAN Decreases Expression [60]
Latexin (LXN) OTZQ2M6Y LXN_HUMAN Increases Expression [60]
Interleukin-23 subunit alpha (IL23A) OTYO99HC IL23A_HUMAN Decreases Expression [60]
Matrix-remodeling-associated protein 5 (MXRA5) OTXZBWCU MXRA5_HUMAN Increases Expression [60]
NADH dehydrogenase 1 alpha subcomplex subunit 4-like 2 (NDUFA4L2) OTK0PG7R NUA4L_HUMAN Decreases Expression [60]
Serine/threonine-protein phosphatase 4 regulatory subunit 2 (PPP4R2) OT7FCZRM PP4R2_HUMAN Increases Expression [60]
Large neutral amino acids transporter small subunit 2 (SLC7A8) OT8XXVO8 LAT2_HUMAN Increases Expression [60]
Paired immunoglobulin-like type 2 receptor alpha (PILRA) OTBE0PLF PILRA_HUMAN Decreases Expression [60]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Decreases Expression [60]
Hypoxia-inducible lipid droplet-associated protein (HILPDA) OTEID3ZM HLPDA_HUMAN Decreases Expression [60]
ATP-dependent RNA helicase DDX39A (DDX39A) OT0Z6E1K DX39A_HUMAN Decreases Expression [56]
26S proteasome non-ATPase regulatory subunit 12 (PSMD12) OTWICA51 PSD12_HUMAN Decreases Expression [56]
DNA fragmentation factor subunit alpha (DFFA) OTFPFMT8 DFFA_HUMAN Decreases Expression [56]
Serine/threonine-protein kinase PLK4 (PLK4) OTV8KZDZ PLK4_HUMAN Decreases Expression [56]
ATP-dependent RNA helicase DDX3X (DDX3X) OTDO4TRX DDX3X_HUMAN Decreases Expression [56]
Stearoyl-CoA desaturase (SCD) OTB1073G SCD_HUMAN Decreases Expression [56]
Eukaryotic translation initiation factor 1A, Y-chromosomal (EIF1AY) OTWVDOJU IF1AY_HUMAN Decreases Expression [56]
Homeobox protein Meis2 (MEIS2) OTG4ADLM MEIS2_HUMAN Decreases Expression [56]
Kinetochore protein NDC80 homolog (NDC80) OTS7D306 NDC80_HUMAN Decreases Expression [56]
Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) OTAAS85T TIM23_HUMAN Increases Expression [56]
Histone acetyltransferase type B catalytic subunit (HAT1) OT307KEN HAT1_HUMAN Decreases Expression [56]
Aurora kinase A (AURKA) OTMX0HYT AURKA_HUMAN Decreases Expression [56]
Sphingolipid delta(4)-desaturase DES1 (DEGS1) OT4WXPKW DEGS1_HUMAN Increases Expression [56]
Membrane-associated progesterone receptor component 2 (PGRMC2) OTH6G1CV PGRC2_HUMAN Decreases Expression [56]
Serine palmitoyltransferase 2 (SPTLC2) OTBTMH1Z SPTC2_HUMAN Decreases Expression [56]
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) OT1Z1ZXE OGT1_HUMAN Decreases Expression [56]
Apoptosis regulatory protein Siva (SIVA1) OTDT0XZK SIVA_HUMAN Decreases Expression [56]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Increases Expression [56]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Decreases Expression [56]
Cytochrome b5 type B (CYB5B) OTONNAV1 CYB5B_HUMAN Decreases Expression [56]
D-3-phosphoglycerate dehydrogenase (PHGDH) OT1LMRTG SERA_HUMAN Decreases Expression [56]
Eukaryotic translation elongation factor 1 epsilon-1 (EEF1E1) OTRA6XOB MCA3_HUMAN Decreases Expression [56]
Aflatoxin B1 aldehyde reductase member 2 (AKR7A2) OTGEDDM2 ARK72_HUMAN Decreases Expression [56]
Band 4.1-like protein 2 (EPB41L2) OT6UABPM E41L2_HUMAN Decreases Expression [56]
Tetraspanin-6 (TSPAN6) OT8X0NWN TSN6_HUMAN Decreases Expression [56]
Protein regulator of cytokinesis 1 (PRC1) OTHD0XS0 PRC1_HUMAN Decreases Expression [56]
Cleavage and polyadenylation specificity factor subunit 5 (NUDT21) OTZHKWAR CPSF5_HUMAN Decreases Expression [56]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) OT5GR4Z2 SMCA5_HUMAN Decreases Expression [56]
Dynamin-like 120 kDa protein, mitochondrial (OPA1) OTJGNWPW OPA1_HUMAN Decreases Expression [56]
Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) OTRNDZXB HNRPQ_HUMAN Increases Expression [56]
Glycylpeptide N-tetradecanoyltransferase 2 (NMT2) OTLNA39Z NMT2_HUMAN Decreases Expression [56]
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) OT8KME51 BUB1B_HUMAN Decreases Expression [56]
Eukaryotic translation initiation factor 4E type 2 (EIF4E2) OT5WULOX IF4E2_HUMAN Decreases Expression [56]
Protein diaphanous homolog 1 (DIAPH1) OTZBYPLH DIAP1_HUMAN Decreases Expression [56]
Cell cycle checkpoint protein RAD1 (RAD1) OT886MA8 RAD1_HUMAN Decreases Expression [56]
Eukaryotic translation initiation factor 5B (EIF5B) OTZTT22W IF2P_HUMAN Decreases Expression [56]
Ribonuclease H1 (RNASEH1) OTT7L25X RNH1_HUMAN Increases Expression [56]
DnaJ homolog subfamily B member 6 (DNAJB6) OTMHIIAN DNJB6_HUMAN Decreases Expression [56]
Filamin-B (FLNB) OTPCOYL6 FLNB_HUMAN Decreases Expression [56]
Cell division control protein 45 homolog (CDC45) OT6NNLOD CDC45_HUMAN Decreases Expression [56]
Histone deacetylase complex subunit SAP30 (SAP30) OT73OLML SAP30_HUMAN Decreases Expression [56]
Serine/arginine-rich splicing factor 10 (SRSF10) OTY6IJ11 SRS10_HUMAN Decreases Expression [56]
Geminin (GMNN) OTDYKNIY GEMI_HUMAN Decreases Expression [56]
Heat shock factor-binding protein 1 (HSBP1) OTHZRMOF HSBP1_HUMAN Decreases Expression [56]
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (SLC25A12) OTB4YBVT S2512_HUMAN Decreases Expression [56]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Decreases Expression [56]
Breast cancer anti-estrogen resistance protein 3 (BCAR3) OTPJ17M8 BCAR3_HUMAN Decreases Expression [56]
Ribonuclease P protein subunit p20 (POP7) OTKC7SG5 POP7_HUMAN Decreases Expression [56]
Eukaryotic translation initiation factor 3 subunit J (EIF3J) OTJ4TAWK EIF3J_HUMAN Decreases Expression [56]
PRA1 family protein 3 (ARL6IP5) OTYZ6BEQ PRAF3_HUMAN Increases Expression [56]
Cell cycle checkpoint protein RAD17 (RAD17) OT1I93DT RAD17_HUMAN Increases Expression [56]
Protein HEXIM1 (HEXIM1) OTBK7278 HEXI1_HUMAN Decreases Expression [56]
G2/mitotic-specific cyclin-B2 (CCNB2) OTIEXTDK CCNB2_HUMAN Decreases Expression [56]
Reticulon-3 (RTN3) OTGZ51QF RTN3_HUMAN Increases Expression [56]
Kinesin-like protein KIF20A (KIF20A) OTXOQHE0 KI20A_HUMAN Decreases Expression [56]
6-phosphogluconolactonase (PGLS) OTO6C0IQ 6PGL_HUMAN Increases Expression [56]
Structural maintenance of chromosomes protein 2 (SMC2) OT5S0DV4 SMC2_HUMAN Decreases Expression [56]
Importin-7 (IPO7) OTDFMQ00 IPO7_HUMAN Decreases Expression [56]
Dihydrofolate reductase (DHFR) OT3DVIGM DYR_HUMAN Decreases Expression [56]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Decreases Expression [56]
Tissue-type plasminogen activator (PLAT) OTQPDNAB TPA_HUMAN Decreases Expression [56]
Low-density lipoprotein receptor (LDLR) OTH559LU LDLR_HUMAN Decreases Expression [56]
Metallothionein-2 (MT2A) OTHOACHD MT2_HUMAN Decreases Expression [56]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) OTRT3F3U HMDH_HUMAN Decreases Expression [56]
Thymidine kinase, cytosolic (TK1) OTY5JFM1 KITH_HUMAN Decreases Expression [56]
Metallothionein-1F (MT1F) OTZVUYG1 MT1F_HUMAN Increases Expression [56]
Sodium/potassium-transporting ATPase subunit beta-1 (ATP1B1) OTTO6ZP4 AT1B1_HUMAN Decreases Expression [56]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) OTM0GDTP IF2A_HUMAN Decreases Expression [56]
Tyrosine-protein kinase Fyn (FYN) OTLSLVZS FYN_HUMAN Decreases Expression [56]
Alpha-galactosidase A (GLA) OTBSR6DT AGAL_HUMAN Decreases Expression [56]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Decreases Expression [56]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Decreases Expression [56]
Eukaryotic translation initiation factor 4E (EIF4E) OTDAWNLA IF4E_HUMAN Decreases Expression [56]
Prosaposin (PSAP) OTUOEKY7 SAP_HUMAN Decreases Expression [56]
Complement decay-accelerating factor (CD55) OTZ3HWTO DAF_HUMAN Increases Expression [56]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Decreases Expression [56]
Asparagine synthetase (ASNS) OT8R922G ASNS_HUMAN Increases Expression [56]
U1 small nuclear ribonucleoprotein A (SNRPA) OT02TSQT SNRPA_HUMAN Decreases Expression [56]
Fibroblast growth factor 2 (FGF2) OT7YUJ9F FGF2_HUMAN Decreases Expression [56]
SPARC (SPARC) OTPN90H0 SPRC_HUMAN Decreases Expression [56]
U2 small nuclear ribonucleoprotein A' (SNRPA1) OTWJZFAP RU2A_HUMAN Increases Expression [56]
Heat shock 70 kDa protein 1A (HSPA1A) OTKGIE76 HS71A_HUMAN Decreases Expression [56]
Calmodulin-1 (CALM2) OTNYA92F CALM1_HUMAN Decreases Expression [56]
Osteopontin (SPP1) OTJGC23Y OSTP_HUMAN Decreases Expression [56]
Laminin subunit gamma-1 (LAMC1) OTIG527N LAMC1_HUMAN Decreases Expression [56]
Proliferating cell nuclear antigen (PCNA) OTHZ1RIA PCNA_HUMAN Decreases Expression [56]
HLA class I histocompatibility antigen, alpha chain E (HLA-E) OTX1CTFB HLAE_HUMAN Decreases Expression [56]
Farnesyl pyrophosphate synthase (FDPS) OT6CKWV5 FPPS_HUMAN Decreases Expression [56]
Transcription factor E2-alpha (TCF3) OTW6FR32 TFE2_HUMAN Decreases Expression [56]
Replication protein A 32 kDa subunit (RPA2) OTZ54WAF RFA2_HUMAN Decreases Expression [56]
CD44 antigen (CD44) OT9TTJ41 CD44_HUMAN Increases Expression [56]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Decreases Expression [56]
SH2/SH3 adapter protein NCK1 (NCK1) OTKYZ4OP NCK1_HUMAN Decreases Expression [56]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) OTPGAU0U AT2A2_HUMAN Decreases Expression [56]
Stathmin (STMN1) OTDJ4RV0 STMN1_HUMAN Decreases Expression [56]
Transcription factor JunD (JUND) OTNKACJD JUND_HUMAN Decreases Expression [56]
CCAAT/enhancer-binding protein beta (CEBPB) OTM9MQIA CEBPB_HUMAN Decreases Expression [56]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Decreases Expression [56]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Decreases Expression [56]
Follistatin (FST) OTRIVK9Y FST_HUMAN Decreases Expression [56]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Decreases Expression [56]
Calpastatin (CAST) OTBXZZGF ICAL_HUMAN Increases Expression [56]
Midkine (MDK) OTF24HKC MK_HUMAN Increases Expression [56]
Protein-glutamine gamma-glutamyltransferase 2 (TGM2) OT6MFOWF TGM2_HUMAN Decreases Expression [56]
cAMP-dependent protein kinase catalytic subunit beta (PRKACB) OT6RMDCE KAPCB_HUMAN Decreases Expression [56]
Glycine cleavage system H protein, mitochondrial (GCSH) OTNC1OKA GCSH_HUMAN Decreases Expression [56]
40-kDa huntingtin-associated protein (F8A1) OTXTQ59R HAP40_HUMAN Decreases Expression [56]
Thymidylate kinase (DTYMK) OTJXYQYK KTHY_HUMAN Decreases Expression [56]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Increases Expression [56]
Cyclin-C (CCNC) OTMVK4K4 CCNC_HUMAN Decreases Expression [56]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Decreases Expression [56]
DNA replication licensing factor MCM3 (MCM3) OTOOHQPM MCM3_HUMAN Decreases Expression [56]
DnaJ homolog subfamily B member 1 (DNAJB1) OTCOSEVH DNJB1_HUMAN Decreases Expression [56]
Proteasome subunit alpha type-2 (PSMA2) OTJRT2ZL PSA2_HUMAN Decreases Expression [56]
DNA cytosine-5)-methyltransferase 1 (DNMT1) OTM2DGTK DNMT1_HUMAN Increases Expression [56]
ATP-binding cassette sub-family D member 3 (ABCD3) OT2PITLX ABCD3_HUMAN Decreases Expression [56]
Dual specificity protein phosphatase 1 (DUSP1) OTN6BR75 DUS1_HUMAN Decreases Expression [56]
Progranulin (GRN) OTXXSJ53 GRN_HUMAN Decreases Expression [56]
CCN family member 2 (CCN2) OTC39NSU CCN2_HUMAN Decreases Expression [56]
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PPP2R1B) OTFIHQGD 2AAB_HUMAN Decreases Expression [56]
G1/S-specific cyclin-D3 (CCND3) OTNKPQ22 CCND3_HUMAN Decreases Expression [56]
M-phase inducer phosphatase 1 (CDC25A) OTSLKKCO MPIP1_HUMAN Decreases Expression [56]
Transmembrane 4 L6 family member 1 (TM4SF1) OTY0ECQN T4S1_HUMAN Decreases Expression [56]
Homeobox protein Hox-A9 (HOXA9) OTKNK5H0 HXA9_HUMAN Decreases Expression [56]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2) OTOB6J6R RIR2_HUMAN Decreases Expression [56]
DnaJ homolog subfamily A member 1 (DNAJA1) OT38BZQQ DNJA1_HUMAN Decreases Expression [56]
Stress-induced-phosphoprotein 1 (STIP1) OT7TXLOX STIP1_HUMAN Increases Expression [56]
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (DUT) OT0THBVA DUT_HUMAN Decreases Expression [56]
Cyclin-dependent kinases regulatory subunit 2 (CKS2) OTPTMHIV CKS2_HUMAN Decreases Expression [56]
ER lumen protein-retaining receptor 2 (KDELR2) OT9QW7Q0 ERD22_HUMAN Decreases Expression [56]
Dual specificity protein kinase TTK (TTK) OTBY1Z5H TTK_HUMAN Decreases Expression [56]
DNA replication licensing factor MCM4 (MCM4) OT19PNNG MCM4_HUMAN Decreases Expression [56]
DNA replication licensing factor MCM5 (MCM5) OTAHLB62 MCM5_HUMAN Increases Expression [56]
Polycomb group RING finger protein 2 (PCGF2) OTIY1J5L PCGF2_HUMAN Increases Expression [56]
Prohibitin 1 (PHB1) OTZNXYS2 PHB1_HUMAN Decreases Expression [56]
Replication factor C subunit 2 (RFC2) OTJ9N6BD RFC2_HUMAN Decreases Expression [56]
Pro-adrenomedullin (ADM) OT7T0TA4 ADML_HUMAN Increases Expression [56]
Prostaglandin E2 receptor EP4 subtype (PTGER4) OT2GBV06 PE2R4_HUMAN Decreases Expression [56]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Decreases Expression [56]
26S proteasome regulatory subunit 7 (PSMC2) OTJ4V337 PRS7_HUMAN Decreases Expression [56]
Squalene synthase (FDFT1) OTGDISIT FDFT_HUMAN Decreases Expression [56]
Stress-70 protein, mitochondrial (HSPA9) OT4TMVS9 GRP75_HUMAN Decreases Expression [56]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Affects Localization [56]
Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A) OTRHPFO2 AN32A_HUMAN Decreases Expression [56]
Flap endonuclease 1 (FEN1) OT6QGG7O FEN1_HUMAN Decreases Expression [56]
Macrophage-capping protein (CAPG) OTJ86KI6 CAPG_HUMAN Decreases Expression [56]
Pre-B-cell leukemia transcription factor 1 (PBX1) OTORABGO PBX1_HUMAN Increases Expression [56]
Replication factor C subunit 5 (RFC5) OTAD79RT RFC5_HUMAN Decreases Expression [56]
Replication factor C subunit 3 (RFC3) OT1MS7AO RFC3_HUMAN Decreases Expression [56]
Lamina-associated polypeptide 2, isoform alpha (TMPO) OTL68EL4 LAP2A_HUMAN Increases Expression [56]
Condensin-2 complex subunit D3 (NCAPD3) OTOZY2UL CNDD3_HUMAN Decreases Expression [56]
Platelet-activating factor acetylhydrolase IB subunit beta (PAFAH1B1) OT9T2TCJ LIS1_HUMAN Decreases Expression [56]
Cell surface glycoprotein MUC18 (MCAM) OTT8XKGE MUC18_HUMAN Decreases Expression [56]
DNA mismatch repair protein Msh2 (MSH2) OT10H1AB MSH2_HUMAN Decreases Expression [56]
Ran-specific GTPase-activating protein (RANBP1) OTQE226K RANG_HUMAN Decreases Expression [56]
Proliferation marker protein Ki-67 (MKI67) OTA8N1QI KI67_HUMAN Decreases Expression [56]
ATP-dependent DNA helicase Q1 (RECQL) OTPCH3JH RECQ1_HUMAN Decreases Expression [56]
Lys-63-specific deubiquitinase BRCC36 (BRCC3) OTK0ZN7Y BRCC3_HUMAN Decreases Expression [56]
F-actin-capping protein subunit alpha-2 (CAPZA2) OTHAO4V2 CAZA2_HUMAN Decreases Expression [56]
Eukaryotic translation initiation factor 1A, X-chromosomal (EIF1AX) OTWG2LAB IF1AX_HUMAN Decreases Expression [56]
Retinaldehyde dehydrogenase 3 (ALDH1A3) OT1C9NKQ AL1A3_HUMAN Decreases Expression [56]
Glioma pathogenesis-related protein 1 (GLIPR1) OT0FGQK7 GLIP1_HUMAN Decreases Expression [56]
Nuclear receptor-interacting protein 1 (NRIP1) OTIZOJQV NRIP1_HUMAN Decreases Expression [56]
Casein kinase I isoform alpha (CSNK1A1) OTJ6O1IC KC1A_HUMAN Increases Expression [56]
Ribose-5-phosphate isomerase (RPIA) OT805SMH RPIA_HUMAN Decreases Expression [56]
Nuclear autoantigenic sperm protein (NASP) OTNE4THC NASP_HUMAN Decreases Expression [56]
Alanine--tRNA ligase, cytoplasmic (AARS1) OTW8D813 SYAC_HUMAN Decreases Expression [56]
Serine--tRNA ligase, cytoplasmic (SARS1) OTFKXQ1O SYSC_HUMAN Decreases Expression [56]
RNA-binding protein 25 (RBM25) OTVOUOAG RBM25_HUMAN Decreases Expression [56]
Isocitrate dehydrogenase subunit alpha, mitochondrial (IDH3A) OT5QQB5L IDH3A_HUMAN Decreases Expression [56]
H(+)/Cl(-) exchange transporter 3 (CLCN3) OTEEXNMU CLCN3_HUMAN Decreases Expression [56]
Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3) OT4O4NFS ROA3_HUMAN Decreases Expression [56]
Importin subunit alpha-1 (KPNA2) OTU7FOE6 IMA1_HUMAN Decreases Expression [56]
Importin subunit alpha-5 (KPNA1) OTEMVAJ6 IMA5_HUMAN Decreases Expression [56]
Arf-GAP domain and FG repeat-containing protein 1 (AGFG1) OTI8ZKC4 AGFG1_HUMAN Decreases Expression [56]
DNA mismatch repair protein Msh6 (MSH6) OT46FP09 MSH6_HUMAN Decreases Expression [56]
Kinesin-like protein KIF11 (KIF11) OTHRGLCQ KIF11_HUMAN Decreases Expression [56]
CCAAT/enhancer-binding protein gamma (CEBPG) OTGNAX3H CEBPG_HUMAN Increases Expression [56]
Dipeptidyl peptidase 1 (CTSC) OT79WJZZ CATC_HUMAN Decreases Expression [56]
Sodium/myo-inositol cotransporter (SLC5A3) OT6FY2KA SC5A3_HUMAN Increases Expression [56]
Monocarboxylate transporter 1 (SLC16A1) OTW1UTZ7 MOT1_HUMAN Increases Expression [56]
Adenylate kinase 2, mitochondrial (AK2) OTZG3X2H KAD2_HUMAN Increases Expression [56]
Eukaryotic translation initiation factor 5 (EIF5) OT79PQUN IF5_HUMAN Decreases Expression [56]
Mesencephalic astrocyte-derived neurotrophic factor (MANF) OT2AH8VJ MANF_HUMAN Decreases Expression [56]
Nucleosome assembly protein 1-like 1 (NAP1L1) OTI7WBZV NP1L1_HUMAN Increases Expression [56]
Methionine--tRNA ligase, cytoplasmic (MARS1) OTLJ6MHJ SYMC_HUMAN Decreases Expression [56]
DNA polymerase epsilon subunit 2 (POLE2) OTAC9V6L DPOE2_HUMAN Increases Expression [56]
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P (PIGP) OTGYAH4X PIGP_HUMAN Decreases Expression [56]
Ribose-phosphate pyrophosphokinase 1 (PRPS1) OTN3A6CN PRPS1_HUMAN Decreases Expression [56]
Ras-related protein Rab-8A (RAB8A) OTPB54Y3 RAB8A_HUMAN Increases Expression [56]
Protein mago nashi homolog (MAGOH) OTWRYTOX MGN_HUMAN Increases Expression [56]
Rho-related GTP-binding protein RhoE (RND3) OTXMXPIH RND3_HUMAN Increases Expression [56]
10 kDa heat shock protein, mitochondrial (HSPE1) OT7JSZLB CH10_HUMAN Increases Expression [56]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 (GNG11) OTHIXBGW GBG11_HUMAN Decreases Expression [56]
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB) OTYFTYFR PP1B_HUMAN Decreases Expression [56]
Protein BTG1 (BTG1) OTVJ2CDM BTG1_HUMAN Decreases Expression [56]
Histone H4 (H4C1) OTB71W46 H4_HUMAN Decreases Expression [56]
Ras-related protein Rab-1A (RAB1A) OTKPHRD0 RAB1A_HUMAN Decreases Expression [56]
S-phase kinase-associated protein 1 (SKP1) OT5BPAZ4 SKP1_HUMAN Decreases Expression [56]
Selenoprotein W (SELENOW) OTVSKPAN SELW_HUMAN Decreases Expression [56]
Metallothionein-1X (MT1X) OT9AKFVS MT1X_HUMAN Decreases Expression [56]
Serine/arginine-rich splicing factor 3 (SRSF3) OTOFT707 SRSF3_HUMAN Decreases Expression [56]
Transcription factor A, mitochondrial (TFAM) OTXXV5V7 TFAM_HUMAN Decreases Expression [56]
Receptor expression-enhancing protein 5 (REEP5) OTZU4TJI REEP5_HUMAN Decreases Expression [56]
Serine/arginine-rich splicing factor 2 (SRSF2) OTVDHO6U SRSF2_HUMAN Decreases Expression [56]
Large neutral amino acids transporter small subunit 1 (SLC7A5) OT2WPVXD LAT1_HUMAN Decreases Expression [56]
RNA-binding protein EWS (EWSR1) OT7SRHV3 EWS_HUMAN Decreases Expression [56]
Centromere-associated protein E (CENPE) OTQ7AP04 CENPE_HUMAN Decreases Expression [56]
Kinesin-like protein KIF23 (KIF23) OTY850JC KIF23_HUMAN Decreases Expression [56]
A-kinase anchor protein 12 (AKAP12) OTCVRDDX AKA12_HUMAN Decreases Expression [56]
Caveolin-1 (CAV1) OTEZUR1L CAV1_HUMAN Decreases Expression [56]
Urokinase plasminogen activator surface receptor (PLAUR) OTIRKKEQ UPAR_HUMAN Decreases Expression [56]
Exosome complex component RRP45 (EXOSC9) OTFKB37F EXOS9_HUMAN Decreases Expression [56]
Amyloid beta precursor like protein 2 (APLP2) OTTFE53M APLP2_HUMAN Decreases Expression [56]
Serine/arginine-rich splicing factor 1 (SRSF1) OTF61HOV SRSF1_HUMAN Increases Expression [56]
ATP-dependent RNA helicase A (DHX9) OT5AAOQI DHX9_HUMAN Decreases Expression [56]
Histone-binding protein RBBP4 (RBBP4) OTG3BT3M RBBP4_HUMAN Decreases Expression [56]
Heat shock 70 kDa protein 14 (HSPA14) OTZCA5LK HSP7E_HUMAN Increases Expression [56]
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (MGAT2) OTKXMSM7 MGAT2_HUMAN Decreases Expression [56]
Nuclear pore complex protein Nup160 (NUP160) OTUKVV3I NU160_HUMAN Decreases Expression [56]
Splicing factor 3A subunit 3 (SF3A3) OTHBGNXE SF3A3_HUMAN Decreases Expression [56]
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1) OTTA5C3U AIMP1_HUMAN Decreases Expression [56]
Interleukin enhancer-binding factor 3 (ILF3) OTKMZ5K5 ILF3_HUMAN Decreases Expression [56]
Protein tyrosine phosphatase type IVA 2 (PTP4A2) OTSSGJAP TP4A2_HUMAN Decreases Expression [56]
Protein AF1q (MLLT11) OTG5RVHC AF1Q_HUMAN Decreases Expression [56]
Serine/arginine-rich splicing factor 6 (SRSF6) OTGLOSYE SRSF6_HUMAN Decreases Expression [56]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) OTXNGZCG MD2L1_HUMAN Increases Expression [56]
S-phase kinase-associated protein 2 (SKP2) OTD5B41X SKP2_HUMAN Decreases Expression [56]
Centromere protein R (ITGB3BP) OT6Q7GR3 CENPR_HUMAN Decreases Expression [56]
Sequestosome-1 (SQSTM1) OTGY5D5J SQSTM_HUMAN Decreases Expression [56]
Mediator of RNA polymerase II transcription subunit 21 (MED21) OT0XWLMK MED21_HUMAN Decreases Expression [56]
NGFI-A-binding protein 1 (NAB1) OTEWHIZR NAB1_HUMAN Decreases Expression [56]
Serine/threonine-protein kinase PRP4 homolog (PRP4K) OT4C7XNK PRP4B_HUMAN Decreases Expression [56]
G/T mismatch-specific thymine DNA glycosylase (TDG) OTJB0YIH TDG_HUMAN Decreases Expression [56]
KRR1 small subunit processome component homolog (KRR1) OTCMJ3K3 KRR1_HUMAN Increases Expression [56]
Cullin-4B (CUL4B) OT2QX4DO CUL4B_HUMAN Decreases Expression [56]
Isopentenyl-diphosphate Delta-isomerase 1 (IDI1) OTGM06VJ IDI1_HUMAN Decreases Expression [56]
Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) OT5UO1FA HNRPD_HUMAN Decreases Expression [56]
Eukaryotic initiation factor 4A-II (EIF4A2) OT08H03R IF4A2_HUMAN Decreases Expression [56]
Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1) OT1QHOS2 NF2L1_HUMAN Decreases Expression [56]
DNA replication licensing factor MCM6 (MCM6) OTKLIAWT MCM6_HUMAN Decreases Expression [56]
Next to BRCA1 gene 1 protein (NBR1) OTVRL7J9 NBR1_HUMAN Decreases Expression [56]
Plastin-1 (PLS1) OTWURB8U PLSI_HUMAN Decreases Expression [56]
DNA replication complex GINS protein PSF1 (GINS1) OTVQZMMQ PSF1_HUMAN Decreases Expression [56]
Delta(14)-sterol reductase LBR (LBR) OT1HG3HG LBR_HUMAN Increases Expression [56]
Importin subunit beta-1 (KPNB1) OTBT2HFL IMB1_HUMAN Decreases Expression [56]
Nucleolar and coiled-body phosphoprotein 1 (NOLC1) OTKDZU0D NOLC1_HUMAN Increases Expression [56]
Condensin complex subunit 2 (NCAPH) OTXOS97C CND2_HUMAN Decreases Expression [56]
PCNA-associated factor (PCLAF) OTMVIOUU PAF15_HUMAN Decreases Expression [56]
Signal peptidase complex subunit 2 (SPCS2) OTCGTTLY SPCS2_HUMAN Decreases Expression [56]
IQ calmodulin-binding motif-containing protein 1 (IQCB1) OTYQ28V9 IQCB1_HUMAN Decreases Expression [56]
DNA polymerase delta subunit 3 (POLD3) OTEQEFQ2 DPOD3_HUMAN Decreases Expression [56]
Kinesin-like protein KIF14 (KIF14) OTXHT4JM KIF14_HUMAN Decreases Expression [56]
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) OTSMGKXQ EBP_HUMAN Decreases Expression [56]
Disks large-associated protein 5 (DLGAP5) OTWCN39U DLGP5_HUMAN Increases Expression [56]
Calponin-3 (CNN3) OTJTAXAP CNN3_HUMAN Decreases Expression [56]
Telomeric repeat-binding factor 2 (TERF2) OTBSAS0V TERF2_HUMAN Decreases Expression [56]
Homeobox protein TGIF1 (TGIF1) OTN9VHAG TGIF1_HUMAN Decreases Expression [56]
High mobility group nucleosome-binding domain-containing protein 3 (HMGN3) OTA2TBWS HMGN3_HUMAN Decreases Expression [56]
Methylsterol monooxygenase 1 (MSMO1) OTKV62RZ MSMO1_HUMAN Decreases Expression [56]
Coiled-coil domain-containing protein 85B (CCDC85B) OTKEQLNK CC85B_HUMAN Increases Expression [56]
Histone-lysine N-methyltransferase EZH2 (EZH2) OTIEHTKW EZH2_HUMAN Decreases Expression [56]
Dihydropyrimidinase-related protein 2 (DPYSL2) OTWNQ74H DPYL2_HUMAN Decreases Expression [56]
Serine/arginine-rich splicing factor 7 (SRSF7) OTRS4W4S SRSF7_HUMAN Decreases Expression [56]
Cleavage and polyadenylation specificity factor subunit 6 (CPSF6) OTM6QYNQ CPSF6_HUMAN Decreases Expression [56]
NADH dehydrogenase 1 alpha subcomplex subunit 5 (NDUFA5) OTR848KZ NDUA5_HUMAN Decreases Expression [56]
Centrosomal protein of 55 kDa (CEP55) OTGSG2PA CEP55_HUMAN Decreases Expression [56]
Pleckstrin homology-like domain family A member 2 (PHLDA2) OTMV9DPP PHLA2_HUMAN Decreases Expression [56]
Borealin (CDCA8) OT17D55D BOREA_HUMAN Decreases Expression [56]
Mesoderm-specific transcript homolog protein (MEST) OT8Q4U8Y MEST_HUMAN Decreases Expression [56]
Centrosomal protein of 170 kDa (CEP170) OTNTK4Q6 CE170_HUMAN Increases Expression [56]
All trans-polyprenyl-diphosphate synthase PDSS1 (PDSS1) OTXGVHAB DPS1_HUMAN Decreases Expression [56]
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (JMJD6) OTILR7E4 JMJD6_HUMAN Increases Expression [56]
ATPase family AAA domain-containing protein 2 (ATAD2) OT8MCRNY ATAD2_HUMAN Decreases Expression [56]
CREB-regulated transcription coactivator 3 (CRTC3) OTVIGVUW CRTC3_HUMAN Increases Expression [56]
LHFPL tetraspan subfamily member 2 protein (LHFPL2) OTDWEEBQ LHPL2_HUMAN Increases Expression [56]
PAX-interacting protein 1 (PAXIP1) OTRHTKG3 PAXI1_HUMAN Decreases Expression [56]
Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) OTHOU8I2 HS2ST_HUMAN Decreases Expression [56]
L-xylulose reductase (DCXR) OTYVXRXB DCXR_HUMAN Decreases Expression [56]
Neuroepithelial cell-transforming gene 1 protein (NET1) OTZHNMJV ARHG8_HUMAN Decreases Expression [56]
Adiponectin receptor protein 2 (ADIPOR2) OT2HDTL8 PAQR2_HUMAN Decreases Expression [56]
Cullin-associated NEDD8-dissociated protein 1 (CAND1) OTGB6NU0 CAND1_HUMAN Increases Expression [56]
Abnormal spindle-like microcephaly-associated protein (ASPM) OTKXQMNA ASPM_HUMAN Decreases Expression [56]
RING1 and YY1-binding protein (RYBP) OTZZ4P2Z RYBP_HUMAN Decreases Expression [56]
Misshapen-like kinase 1 (MINK1) OTKB0RA8 MINK1_HUMAN Increases Expression [56]
SHC SH2 domain-binding protein 1 (SHCBP1) OT3A21CM SHCBP_HUMAN Increases Expression [56]
THO complex subunit 2 (THOC2) OTNXE5G2 THOC2_HUMAN Increases Expression [56]
Atypical kinase COQ8A, mitochondrial (COQ8A) OT1ETSA2 COQ8A_HUMAN Increases Expression [56]
Kinesin-like protein KIF18A (KIF18A) OTSMBJ24 KI18A_HUMAN Decreases Expression [56]
Serine/threonine-protein kinase Nek9 (NEK9) OT4VQCL5 NEK9_HUMAN Increases Expression [56]
E3 ubiquitin-protein ligase RNF139 (RNF139) OT0PR1X5 RN139_HUMAN Decreases Expression [56]
PH-interacting protein (PHIP) OTZY806Z PHIP_HUMAN Increases Expression [56]
Palladin (PALLD) OTZ2MUJZ PALLD_HUMAN Decreases Expression [56]
DnaJ homolog subfamily C member 9 (DNAJC9) OTDBQBNZ DNJC9_HUMAN Increases Expression [56]
Transmembrane protein 158 (TMEM158) OT0KUBBI TM158_HUMAN Decreases Expression [56]
C-type lectin domain family 2 member B (CLEC2B) OT0W0M0L CLC2B_HUMAN Increases Expression [56]
DNA topoisomerase 2-binding protein 1 (TOPBP1) OT6UPZPD TOPB1_HUMAN Decreases Expression [56]
Heat shock protein 105 kDa (HSPH1) OTVRR73T HS105_HUMAN Decreases Expression [56]
DNA repair protein RAD50 (RAD50) OTYMU9G1 RAD50_HUMAN Decreases Expression [56]
Rho guanine nucleotide exchange factor 2 (ARHGEF2) OTBQTFRT ARHG2_HUMAN Decreases Expression [56]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1) OTAX4ITH SMCE1_HUMAN Decreases Expression [56]
RAD51-associated protein 1 (RAD51AP1) OTXM7UTD R51A1_HUMAN Decreases Expression [56]
Optineurin (OPTN) OT2UXWH9 OPTN_HUMAN Decreases Expression [56]
U5 small nuclear ribonucleoprotein 40 kDa protein (SNRNP40) OTSRL6QO SNR40_HUMAN Decreases Expression [56]
Protein Spindly (SPDL1) OTI0JNTM SPDLY_HUMAN Increases Expression [56]
Kinetochore-associated protein NSL1 homolog (NSL1) OT5L56A1 NSL1_HUMAN Decreases Expression [56]
Lymphokine-activated killer T-cell-originated protein kinase (PBK) OT5Z27TW TOPK_HUMAN Decreases Expression [56]
Serine protease FAM111A (FAM111A) OTVLARLG F111A_HUMAN Increases Expression [56]
Sperm-associated antigen 5 (SPAG5) OTCLJ56M SPAG5_HUMAN Decreases Expression [56]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Decreases Expression [56]
c-Myc-binding protein (MYCBP) OT4IZR4R MYCBP_HUMAN Decreases Expression [56]
Nuclear pore complex protein Nup88 (NUP88) OT647WOR NUP88_HUMAN Decreases Expression [56]
Phosphoinositide 3-kinase regulatory subunit 4 (PIK3R4) OTRL8QP8 PI3R4_HUMAN Decreases Expression [56]
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) OTVFRL8G TI17A_HUMAN Decreases Expression [56]
Cell division cycle-associated protein 3 (CDCA3) OTUI8QK3 CDCA3_HUMAN Decreases Expression [56]
Pre-mRNA-splicing factor 18 (PRPF18) OTX4VZ4R PRP18_HUMAN Decreases Expression [56]
Kinesin-like protein KIF2C (KIF2C) OTJ8G3NP KIF2C_HUMAN Increases Expression [56]
BRCA1-associated RING domain protein 1 (BARD1) OTTC0Z9Y BARD1_HUMAN Decreases Expression [56]
Cell division control protein 6 homolog (CDC6) OTX93FE7 CDC6_HUMAN Increases Expression [56]
Endothelial PAS domain-containing protein 1 (EPAS1) OTRE3O8U EPAS1_HUMAN Decreases Expression [56]
Probable rRNA-processing protein EBP2 (EBNA1BP2) OTBRVMZH EBP2_HUMAN Decreases Expression [56]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Decreases Expression [56]
Condensin complex subunit 3 (NCAPG) OT1AI9EO CND3_HUMAN Decreases Expression [56]
DNA replication complex GINS protein PSF3 (GINS3) OT8NVXTD PSF3_HUMAN Increases Expression [56]
TIMELESS-interacting protein (TIPIN) OT9PZHXV TIPIN_HUMAN Decreases Expression [56]
Nuclear pore complex protein Nup85 (NUP85) OTB5ZHC8 NUP85_HUMAN Decreases Expression [56]
N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) OT53SIZG NAA15_HUMAN Increases Expression [56]
Cell division cycle-associated protein 4 (CDCA4) OT0AAXAC CDCA4_HUMAN Increases Expression [56]
Charged multivesicular body protein 4a (CHMP4A) OTBCSG50 CHM4A_HUMAN Increases Expression [56]
Cell adhesion molecule 1 (CADM1) OTRWG9QS CADM1_HUMAN Decreases Expression [56]
Large ribosomal subunit protein uL13m (MRPL13) OT6D8Y9G RM13_HUMAN Decreases Expression [56]
Pantothenate kinase 2, mitochondrial (PANK2) OTFBW889 PANK2_HUMAN Increases Expression [56]
Protein Niban 1 (NIBAN1) OTYOLI12 NIBA1_HUMAN Decreases Expression [56]
Rac GTPase-activating protein 1 (RACGAP1) OTQE8IEH RGAP1_HUMAN Increases Expression [56]
Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15) OTGMPVNR S6A15_HUMAN Decreases Expression [56]
Pinin (PNN) OT0HXICH PININ_HUMAN Decreases Expression [56]
Thioredoxin-related transmembrane protein 1 (TMX1) OTX4FHYQ TMX1_HUMAN Decreases Expression [56]
MOB kinase activator 1A (MOB1A) OTSPBZ4Z MOB1A_HUMAN Decreases Expression [56]
Protein ECT2 (ECT2) OTQDUCT6 ECT2_HUMAN Decreases Expression [56]
Calcyclin-binding protein (CACYBP) OTJMZD2T CYBP_HUMAN Decreases Expression [56]
NTF2-related export protein 2 (NXT2) OTK82YVT NXT2_HUMAN Increases Expression [56]
Endothelial cell-specific molecule 1 (ESM1) OT331Y8V ESM1_HUMAN Decreases Expression [56]
Neural proliferation differentiation and control protein 1 (NPDC1) OT788NC8 NPDC1_HUMAN Decreases Expression [56]
GTP-binding protein SAR1a (SAR1A) OTSSRVGV SAR1A_HUMAN Decreases Expression [56]
DNA polymerase epsilon subunit 3 (POLE3) OTOELRF6 DPOE3_HUMAN Decreases Expression [56]
Bromodomain adjacent to zinc finger domain protein 1A (BAZ1A) OTWHOVZS BAZ1A_HUMAN Decreases Expression [56]
BMP-2-inducible protein kinase (BMP2K) OT0IRJBY BMP2K_HUMAN Increases Expression [56]
ATP-dependent RNA helicase DDX19A (DDX19A) OTBTDR44 DD19A_HUMAN Decreases Expression [56]
Fanconi anemia group I protein (FANCI) OTW8E3SC FANCI_HUMAN Increases Expression [56]
Notchless protein homolog 1 (NLE1) OT1BV82K NLE1_HUMAN Decreases Expression [56]
E3 ubiquitin-protein ligase FANCL (FANCL) OTJC7QPQ FANCL_HUMAN Increases Expression [56]
Large ribosomal subunit protein uL16m (MRPL16) OTIQORWI RM16_HUMAN Decreases Expression [56]
H/ACA ribonucleoprotein complex subunit 1 (GAR1) OTA580RX GAR1_HUMAN Decreases Expression [56]
Dipeptidyl peptidase 3 (DPP3) OTUIVL1C DPP3_HUMAN Decreases Expression [56]
Protein downstream neighbor of Son (DONSON) OTN5HE0W DONS_HUMAN Increases Expression [56]
Protein Mis18-alpha (MIS18A) OTD80K5X MS18A_HUMAN Decreases Expression [56]
Denticleless protein homolog (DTL) OTC29RYE DTL_HUMAN Decreases Expression [56]
BRCA2 and CDKN1A-interacting protein (BCCIP) OTFFKG79 BCCIP_HUMAN Decreases Expression [56]
Succinate--CoA ligase subunit beta, mitochondrial (SUCLA2) OTMZD4PW SUCB1_HUMAN Decreases Expression [56]
Homologous-pairing protein 2 homolog (PSMC3IP) OT9UB5UO HOP2_HUMAN Increases Expression [56]
Alpha-catulin (CTNNAL1) OTESJ6JD CTNL1_HUMAN Decreases Expression [56]
Protein DBF4 homolog A (DBF4) OTBL7JHQ DBF4A_HUMAN Increases Expression [56]
Protein sel-1 homolog 1 (SEL1L) OTC0FB7T SE1L1_HUMAN Decreases Expression [56]
Tight junction protein ZO-2 (TJP2) OTQUY6BV ZO2_HUMAN Increases Expression [56]
Serine/threonine-protein kinase 17A (STK17A) OTS87MOT ST17A_HUMAN Decreases Expression [56]
General transcription factor II-I repeat domain-containing protein 1 (GTF2IRD1) OTEG9KU1 GT2D1_HUMAN Decreases Expression [56]
E3 ISG15--protein ligase HERC5 (HERC5) OTZ5PR39 HERC5_HUMAN Increases Expression [56]
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (SLC25A13) OTTZVSK6 S2513_HUMAN Increases Expression [56]
F-box only protein 9 (FBXO9) OTW5P5JF FBX9_HUMAN Increases Expression [56]
PR domain zinc finger protein 4 (PRDM4) OTD9PAZJ PRDM4_HUMAN Decreases Expression [56]
Thyrotropin-releasing hormone-degrading ectoenzyme (TRHDE) OTOPNZDD TRHDE_HUMAN Decreases Expression [56]
Nuclear pore complex protein Nup50 (NUP50) OTOZ98K3 NUP50_HUMAN Decreases Expression [56]
BAG family molecular chaperone regulator 5 (BAG5) OT0J97C6 BAG5_HUMAN Decreases Expression [56]
Cip1-interacting zinc finger protein (CIZ1) OT3UKHPI CIZ1_HUMAN Increases Expression [56]
Nuclear pore complex-interacting protein family member A1 (NPIPA1) OTAUFC2I NPIA1_HUMAN Decreases Expression [56]
Protein kinase C and casein kinase substrate in neurons protein 2 (PACSIN2) OTC2R00C PACN2_HUMAN Increases Expression [56]
Translocon-associated protein subunit gamma (SSR3) OTJQP0IZ SSRG_HUMAN Decreases Expression [56]
COP9 signalosome complex subunit 3 (COPS3) OTZWPJ24 CSN3_HUMAN Decreases Expression [56]
Proliferation-associated protein 2G4 (PA2G4) OT7IG7HT PA2G4_HUMAN Increases Expression [56]
Structural maintenance of chromosomes protein 3 (SMC3) OTWGFRHD SMC3_HUMAN Decreases Expression [56]
SH2B adapter protein 3 (SH2B3) OT4ALHBQ SH2B3_HUMAN Increases Expression [56]
DNA replication complex GINS protein PSF2 (GINS2) OT974IYI PSF2_HUMAN Decreases Expression [56]
Histone chaperone ASF1A (ASF1A) OT4S44GP ASF1A_HUMAN Decreases Expression [56]
Trafficking protein particle complex subunit 4 (TRAPPC4) OT3THRCA TPPC4_HUMAN Decreases Expression [56]
Afadin- and alpha-actinin-binding protein (SSX2IP) OTEIZ7N1 ADIP_HUMAN Decreases Expression [56]
DNA-directed RNA polymerase III subunit RPC10 (POLR3K) OTZCSF6A RPC10_HUMAN Decreases Expression [56]
Endophilin-B1 (SH3GLB1) OTAZ5OP8 SHLB1_HUMAN Decreases Expression [56]
Transmembrane emp24 domain-containing protein 7 (TMED7) OTONO8E6 TMED7_HUMAN Increases Expression [56]
Insulin receptor substrate 2 (IRS2) OT46MJBE IRS2_HUMAN Decreases Expression [56]
V-type proton ATPase subunit D (ATP6V1D) OT4JDG0W VATD_HUMAN Decreases Expression [56]
Origin recognition complex subunit 6 (ORC6) OTKQN3KP ORC6_HUMAN Decreases Expression [56]
Sorting nexin-5 (SNX5) OT6ZOWMU SNX5_HUMAN Decreases Expression [56]
Phosphoserine aminotransferase (PSAT1) OTVV1YV9 SERC_HUMAN Decreases Expression [56]
EP300-interacting inhibitor of differentiation 1 (EID1) OT3OI5H4 EID1_HUMAN Decreases Expression [56]
Calpain-7 (CAPN7) OTA9WHGF CAN7_HUMAN Decreases Expression [56]
HLA class I histocompatibility antigen, B alpha chain (HLA-B) OTNXFWY2 HLAB_HUMAN Affects Expression [61]
L-selectin (SELL) OT6RAJZR LYAM1_HUMAN Affects Expression [62]
HLA class II histocompatibility antigen, DM beta chain (HLA-DMB) OT17HGXJ DMB_HUMAN Affects Expression [61]
Sodium channel protein type 5 subunit alpha (SCN5A) OTGYZWR6 SCN5A_HUMAN Decreases Activity [63]
Major histocompatibility complex class I-related gene protein (MR1) OTZU3XX7 HMR1_HUMAN Affects Expression [61]
Glycogen synthase, muscle (GYS1) OTJZJRWK GYS1_HUMAN Increases ADR [22]
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References

1 ClinicalTrials.gov (NCT00631514) Interaction Between Antihypertensives and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
2 Ibuprofen FDA Label
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2713).
4 Piroxicam FDA Label
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7273).
6 Glucuronidation of nonsteroidal anti-inflammatory drugs: identifying the enzymes responsible in human liver microsomes. Drug Metab Dispos. 2005 Jul;33(7):1027-35.
7 Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs. J Pharmacol Exp Ther. 1993 Jan;264(1):475-9.
8 Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation. J Biol Chem. 2004 Jul 2;279(27):28320-9. doi: 10.1074/jbc.M401396200. Epub 2004 Apr 26.
9 Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
10 Ibuprofen-mediated reduction of hypoxia-inducible factors HIF-1alpha and HIF-2alpha in prostate cancer cells. Clin Cancer Res. 2003 Aug 1;9(8):3150-7.
11 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31.
12 Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4026-30.
13 Maternal toxicity of nonsteroidal anti-inflammatory drugs as an important factor affecting prenatal development. Reprod Toxicol. 2009 Sep;28(2):239-44.
14 Monocarboxylate Transporters in Drug Disposition: Role in the Toxicokinetics and Toxicodynamics of the Drug of Abuse GHB.
15 A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter. Am J Physiol Cell Physiol. 2012 Jun 1;302(11):C1652-60.
16 PharmGKB summary: ibuprofen pathways. Pharmacogenet Genomics. 2015 Feb;25(2):96-106.
17 Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide and ibuprofen enantiomers in vitro. Biopharm Drug Dispos. 2013 Jul;34(5):278-87.
18 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
19 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
20 Ibuprofen: pharmacology, efficacy and safety. Inflammopharmacology. 2009 Dec;17(6):275-342.
21 A study on the chiral inversion of mandelic acid in humans. Org Biomol Chem. 2014 Sep 14;12(34):6737-44.
22 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
23 Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther. 2002 Nov;303(2):534-9.
24 Translational studies on aromatase, cyclooxygenases, and enzyme inhibitors in breast cancer. J Steroid Biochem Mol Biol. 2005 May;95(1-5):129-36.
25 Cloning, expression, and functional characterization of human cyclooxygenase-1 splicing variants: evidence for intron 1 retention. J Pharmacol Exp Ther. 2005 Dec;315(3):1298-305.
26 Induction of spermidine/spermine N1-acetyltransferase (SSAT) by aspirin in Caco-2 colon cancer cells. Biochem J. 2006 Feb 15;394(Pt 1):317-24.
27 Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
28 Inhibition of human phenol and estrogen sulfotransferase by certain non-steroidal anti-inflammatory agents. Curr Drug Metab. 2006 Oct;7(7):745-53.
29 Type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs. Chem Biol Interact. 2009 Mar 16;178(1-3):221-7.
30 Human prostaglandin reductase 1 (PGR1): Substrate specificity, inhibitor analysis and site-directed mutagenesis. Chem Biol Interact. 2015 Jun 5;234:105-13.
31 Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen. Oncogene. 1999 Dec 2;18(51):7389-94. doi: 10.1038/sj.onc.1203160.
32 Tumor necrosis factor-alpha induces the expression of DR6, a member of the TNF receptor family, through activation of NF-kappaB. Oncogene. 2001 Nov 29;20(55):7965-75. doi: 10.1038/sj.onc.1204985.
33 Effects of ibuprofen and hypoxia on neutrophil apoptosis in neonates. Biol Neonate. 2004;86(4):235-9. doi: 10.1159/000079831. Epub 2004 Jul 15.
34 Rofecoxib regulates the expression of genes related to the matrix metalloproteinase pathway in humans: implication for the adverse effects of cyclooxygenase-2 inhibitors. Clin Pharmacol Ther. 2006 Apr;79(4):303-15. doi: 10.1016/j.clpt.2005.12.306.
35 Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice. Brain. 2005 Jun;128(Pt 6):1442-53. doi: 10.1093/brain/awh452. Epub 2005 Apr 7.
36 Upregulation of ICAM-1 expression in bronchial epithelial cells by airway secretions in bronchiectasis. Respir Med. 2008 Feb;102(2):287-98. doi: 10.1016/j.rmed.2007.08.013. Epub 2007 Oct 10.
37 The p38 MAPK pathway mediates aryl propionic acid induced messenger rna stability of p75 NTR in prostate cancer cells. Cancer Res. 2007 Dec 1;67(23):11402-10. doi: 10.1158/0008-5472.CAN-07-1792.
38 Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease. Proteomics. 2008 Apr;8(8):1595-607. doi: 10.1002/pmic.200700556.
39 Growth compensatory role of sulindac sulfide-induced thrombospondin-1 linked with ERK1/2 and RhoA GTPase signaling pathways. Life Sci. 2008 Mar 12;82(11-12):591-9. doi: 10.1016/j.lfs.2007.11.030. Epub 2007 Dec 23.
40 A comparison of the effectiveness of selected non-steroidal anti-inflammatory drugs and their derivatives against cancer cells in vitro. Cancer Chemother Pharmacol. 2008 Feb;61(2):203-14. doi: 10.1007/s00280-007-0462-3. Epub 2007 Apr 20.
41 Induction of HSP70 expression and recruitment of HSC70 and HSP70 in the nucleus reduce aggregation of a polyalanine expansion mutant of PABPN1 in HeLa cells. Hum Mol Genet. 2005 Dec 1;14(23):3673-84. doi: 10.1093/hmg/ddi395. Epub 2005 Oct 20.
42 Indomethacin and ibuprofen induce Hsc70 nuclear localization and activation of the heat shock response in HeLa cells. Biochem Biophys Res Commun. 2004 Jan 23;313(4):863-70. doi: 10.1016/j.bbrc.2003.12.018.
43 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is up-regulated by flurbiprofen and other non-steroidal anti-inflammatory drugs in human colon cancer HT29 cells. Arch Biochem Biophys. 2009 Jul 15;487(2):139-45. doi: 10.1016/j.abb.2009.05.017. Epub 2009 Jun 6.
44 Regulation of CD36 expression in human melanoma cells. Adv Exp Med Biol. 2002;507:337-42. doi: 10.1007/978-1-4615-0193-0_52.
45 Indomethacin and ibuprofen effect on IL-1ra production by mononuclear cells of preterm newborns and adults. Biol Neonate. 2002 Aug;82(2):73-7. doi: 10.1159/000063090.
46 Affinity and translocation relationships via hPEPT1 of H-X aa-Ser-OH dipeptides: evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic acid prodrugs. Eur J Pharm Biopharm. 2011 Feb;77(2):327-31. doi: 10.1016/j.ejpb.2010.12.009. Epub 2010 Dec 13.
47 Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase. Free Radic Biol Med. 2002 Apr 1;32(7):650-62. doi: 10.1016/s0891-5849(02)00755-4.
48 Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase. J Neurosci. 2003 Oct 29;23(30):9796-804. doi: 10.1523/JNEUROSCI.23-30-09796.2003.
49 Non-steroidal anti-inflammatory drugs inhibit the expression of cytokines and induce HSP70 in human monocytes. Cytokine. 1999 May;11(5):347-58. doi: 10.1006/cyto.1998.0437.
50 Effects of Exposure to Acetaminophen and Ibuprofen on Fetal Germ Cell Development in Both Sexes in Rodent and Human Using Multiple Experimental Systems. Environ Health Perspect. 2018 Apr 16;126(4):047006. doi: 10.1289/EHP2307.
51 Effects of acidic non-steroidal anti-inflammatory drugs on human cytochrome P450 4A11 activity: Roles of carboxylic acid and a sulfur atom in potent inhibition by sulindac sulfide. Chem Biol Interact. 2023 Sep 1;382:110644. doi: 10.1016/j.cbi.2023.110644. Epub 2023 Jul 25.
52 Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain. J Biol Chem. 2003 Aug 15;278(33):30748-54. doi: 10.1074/jbc.M304824200. Epub 2003 May 31.
53 The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter. J Physiol. 2004 Jun 15;557(Pt 3):719-31. doi: 10.1113/jphysiol.2004.063859. Epub 2004 Apr 16.
54 Genetically mediated interindividual variation in analgesic responses to cyclooxygenase inhibitory drugs. Clin Pharmacol Ther. 2006 May;79(5):407-18.
55 Nonsteroidal antiinflammatory drugs and decreased risk of advanced prostate cancer: modification by lymphotoxin alpha. Am J Epidemiol. 2006 Nov 15;164(10):984-9. doi: 10.1093/aje/kwj294. Epub 2006 Aug 24.
56 Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS One. 2011;6(8):e23569.
57 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
58 Efficacy of piroxicam for postoperative pain after lower third molar surgery associated with CYP2C8*3 and CYP2C9 J Pain Res. 2017 Jul 6;10:1581-1589.
59 Functional characterization of human CYP2C9 allelic variants in COS-7 cells. Front Pharmacol. 2016 Apr 25;7:98.
60 Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
61 Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. Chem Res Toxicol. 2015 May 18;28(5):927-34. doi: 10.1021/tx5005248. Epub 2015 Apr 3.
62 Structure-function relationship and role of tumor necrosis factor-alpha-converting enzyme in the down-regulation of L-selectin by non-steroidal anti-inflammatory drugs. J Biol Chem. 2002 Oct 11;277(41):38212-21. doi: 10.1074/jbc.M205142200. Epub 2002 Jul 29.
63 Regulatory effects of non-steroidal anti-inflammatory drugs on cardiac ion channels Nav1.5 and Kv11.1. Chem Biol Interact. 2021 Apr 1;338:109425. doi: 10.1016/j.cbi.2021.109425. Epub 2021 Feb 19.