Details of the Drug Combination

General Information of Drug Combination (ID: DCNBEHN)

Drug Combination Name

MG-132 Marizomib

Indication

Disease Entry	Status	REF
Diffuse intrinsic pontine glioma	Investigative	[1]

Component Drugs

MG-132 DMKA2YS

Marizomib DME9QGW

N.A.

Small molecular drug

2D MOL

3D MOL

High-throughput Screening Result

Testing Cell Line: DIPG25

Zero Interaction Potency (ZIP) Score: 27.49

Bliss Independence Score: 21.07

Loewe Additivity Score: 6.28

LHighest Single Agent (HSA) Score: 26.31

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)

MG-132 Interacts with 1 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[13]
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MG-132 Interacts with 119 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Carbonyl reductase 3 (CBR3)	OT9G6SF0	CBR3_HUMAN	Increases Expression	[14]
Actin, cytoplasmic 1 (ACTB)	OT1MCP2F	ACTB_HUMAN	Decreases Expression	[15]
Peptidyl-prolyl cis-trans isomerase A (PPIA)	OTHJMWQQ	PPIA_HUMAN	Decreases Expression	[15]
Aldo-keto reductase family 1 member B10 (AKR1B10)	OTOA4HTH	AK1BA_HUMAN	Increases Expression	[16]
Aldo-keto reductase family 1 member B1 (AKR1B1)	OTRX72TH	ALDR_HUMAN	Increases Expression	[16]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Increases Expression	[16]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Increases Expression	[16]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)	OTM0GDTP	IF2A_HUMAN	Increases Expression	[17]
Nuclear receptor subfamily 1 group I member 3 (NR1I3)	OTS3SGH7	NR1I3_HUMAN	Decreases Activity	[18]
Transcription factor Sp3 (SP3)	OTYDQZ1T	SP3_HUMAN	Increases Expression	[19]
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)	OTBPCU2O	TR10A_HUMAN	Increases Expression	[10]
26S proteasome non-ATPase regulatory subunit 11 (PSMD11)	OT8KO67V	PSD11_HUMAN	Increases Expression	[20]
26S proteasome non-ATPase regulatory subunit 12 (PSMD12)	OTWICA51	PSD12_HUMAN	Increases Expression	[20]
26S proteasome non-ATPase regulatory subunit 14 (PSMD14)	OTJWHMZ5	PSDE_HUMAN	Increases Expression	[20]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)	OTA1CPBV	TR10B_HUMAN	Increases Expression	[10]
Proteasome subunit alpha type-7 (PSMA7)	OTPHI6ST	PSA7_HUMAN	Increases Expression	[20]
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK)	OTLF4ZB1	IKKA_HUMAN	Increases Activity	[21]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Increases Expression	[22]
CASP8 and FADD-like apoptosis regulator (CFLAR)	OTX14BAS	CFLAR_HUMAN	Affects Expression	[23]
26S proteasome non-ATPase regulatory subunit 3 (PSMD3)	OT585WY8	PSMD3_HUMAN	Increases Expression	[20]
Serine protease HTRA2, mitochondrial (HTRA2)	OTC7616F	HTRA2_HUMAN	Increases Expression	[24]
E3 ubiquitin-protein ligase parkin (PRKN)	OTJBN41W	PRKN_HUMAN	Decreases Expression	[25]
E3 ubiquitin-protein ligase MARCHF6 (MARCHF6)	OTBTA03N	MARH6_HUMAN	Increases Stability	[26]
Nuclear protein 1 (NUPR1)	OT4FU8C0	NUPR1_HUMAN	Increases Expression	[20]
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (PLOD3)	OTT00T7Q	PLOD3_HUMAN	Decreases Expression	[27]
Microphthalmia-associated transcription factor (MITF)	OT6XJCZH	MITF_HUMAN	Decreases Expression	[20]
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)	OTY9R6FZ	ERN1_HUMAN	Increases Expression	[28]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)	OTYG179K	PR15A_HUMAN	Increases Expression	[29]
Pre-mRNA-splicing factor SPF27 (BCAS2)	OTRMF2WY	SPF27_HUMAN	Decreases Expression	[20]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Increases Expression	[30]
Receptor tyrosine-protein kinase erbB-2 (ERBB2)	OTOAUNCK	ERBB2_HUMAN	Decreases Expression	[20]
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1)	OTIRPN6B	ROA1_HUMAN	Increases Expression	[31]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[32]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Increases Expression	[33]
Retinol-binding protein 3 (RBP3)	OTIWM4GT	RET3_HUMAN	Decreases Degradation	[34]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)	OTA675TJ	GTR1_HUMAN	Increases Expression	[35]
26S proteasome regulatory subunit 6A (PSMC3)	OTSKT0JI	PRS6A_HUMAN	Increases Expression	[20]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4)	OTRFV19J	ATF4_HUMAN	Increases Expression	[20]
Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)	OTAFHAVI	ATF6A_HUMAN	Increases Expression	[8]
Receptor tyrosine-protein kinase erbB-3 (ERBB3)	OTRSST0A	ERBB3_HUMAN	Decreases Expression	[36]
Proteasome subunit alpha type-1 (PSMA1)	OTNBVM2U	PSA1_HUMAN	Increases Expression	[20]
Proteasome subunit alpha type-2 (PSMA2)	OTJRT2ZL	PSA2_HUMAN	Increases Expression	[20]
Proteasome subunit alpha type-3 (PSMA3)	OT52M10V	PSA3_HUMAN	Increases Expression	[20]
Proteasome subunit alpha type-4 (PSMA4)	OTAD2XXI	PSA4_HUMAN	Increases Expression	[20]
Aryl hydrocarbon receptor nuclear translocator (ARNT)	OTMSIEZY	ARNT_HUMAN	Decreases Expression	[37]
Calnexin (CANX)	OTYP1F6J	CALX_HUMAN	Affects Localization	[38]
Proteasome subunit beta type-9 (PSMB9)	OTFV57T8	PSB9_HUMAN	Increases Expression	[20]
Proteasome subunit alpha type-5 (PSMA5)	OT38E6Y1	PSA5_HUMAN	Increases Expression	[20]
Proteasome subunit beta type-4 (PSMB4)	OTOJ9OHA	PSB4_HUMAN	Increases Expression	[20]
Proteasome subunit beta type-6 (PSMB6)	OT9VXPNW	PSB6_HUMAN	Increases Expression	[20]
Proteasome subunit beta type-5 (PSMB5)	OTOZXAS6	PSB5_HUMAN	Decreases Expression	[39]
Cystatin-D (CST5)	OTHJXNJG	CYTD_HUMAN	Decreases Expression	[20]
Retinoblastoma-like protein 1 (RBL1)	OTDEBFYC	RBL1_HUMAN	Increases Expression	[40]
Protein PML (PML)	OT6SM2GD	PML_HUMAN	Decreases Degradation	[41]
Catenin beta-1 (CTNNB1)	OTZ932A3	CTNB1_HUMAN	Decreases Degradation	[42]
DNA damage-inducible transcript 3 protein (DDIT3)	OTI8YKKE	DDIT3_HUMAN	Increases Expression	[29]
26S proteasome regulatory subunit 7 (PSMC2)	OTJ4V337	PRS7_HUMAN	Increases Expression	[20]
Alpha-synuclein (SNCA)	OTPWC1MR	SYUA_HUMAN	Increases Phosphorylation	[43]
Proteasome subunit beta type-10 (PSMB10)	OTURUR9B	PSB10_HUMAN	Decreases Expression	[20]
26S proteasome regulatory subunit 6B (PSMC4)	OTS3XN41	PRS6B_HUMAN	Increases Expression	[20]
Cyclin-dependent kinase inhibitor 1B (CDKN1B)	OTNY5LLZ	CDN1B_HUMAN	Decreases Degradation	[44]
Neurogenic locus notch homolog protein 1 (NOTCH1)	OTI1WADQ	NOTC1_HUMAN	Increases Expression	[45]
26S proteasome non-ATPase regulatory subunit 8 (PSMD8)	OTY6X27P	PSMD8_HUMAN	Increases Expression	[20]
CCAAT/enhancer-binding protein alpha (CEBPA)	OTOM9OE4	CEBPA_HUMAN	Increases Ubiquitination	[46]
Proteasome subunit beta type-3 (PSMB3)	OTVBON40	PSB3_HUMAN	Increases Expression	[20]
Proteasome subunit beta type-2 (PSMB2)	OTX0UG5W	PSB2_HUMAN	Increases Expression	[20]
Microsomal triglyceride transfer protein large subunit (MTTP)	OTNUVSDT	MTP_HUMAN	Increases Expression	[47]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)	OTOWDUNT	PTEN_HUMAN	Increases Expression	[48]
Proteasome subunit alpha type-6 (PSMA6)	OTJ6RPX5	PSA6_HUMAN	Increases Expression	[20]
26S proteasome regulatory subunit 4 (PSMC1)	OTLHD56E	PRS4_HUMAN	Increases Expression	[20]
26S proteasome regulatory subunit 8 (PSMC5)	OTJOORMR	PRS8_HUMAN	Increases Expression	[20]
26S proteasome regulatory subunit 10B (PSMC6)	OTG8997V	PRS10_HUMAN	Increases Expression	[20]
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17)	OTTM6KRB	ADA17_HUMAN	Increases Expression	[8]
Heat shock factor protein 1 (HSF1)	OTYNJ4KP	HSF1_HUMAN	Increases Activity	[49]
Protein SET (SET)	OTGYYQJO	SET_HUMAN	Decreases Expression	[27]
POU domain, class 5, transcription factor 1 (POU5F1)	OTDHHN7O	PO5F1_HUMAN	Increases Expression	[45]
Heat shock factor protein 2 (HSF2)	OTXNJIJ9	HSF2_HUMAN	Increases Activity	[49]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Decreases Activity	[32]
Sex-determining region Y protein (SRY)	OT516T6D	SRY_HUMAN	Decreases Degradation	[50]
Proteasome activator complex subunit 1 (PSME1)	OTDHLJWH	PSME1_HUMAN	Decreases Expression	[20]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Decreases Expression	[51]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)	OT4SO7J4	BNIP3_HUMAN	Increases Expression	[52]
26S proteasome non-ATPase regulatory subunit 2 (PSMD2)	OT6HZHN7	PSMD2_HUMAN	Increases Expression	[20]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Increases Expression	[21]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)	OTXEE550	APR_HUMAN	Increases Expression	[20]
Reticulocalbin-2 (RCN2)	OTIU8JWD	RCN2_HUMAN	Increases Expression	[27]
Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1)	OT1QHOS2	NF2L1_HUMAN	Increases Expression	[53]
Phosphatidate phosphatase LPIN1 (LPIN1)	OTQ75KF2	LPIN1_HUMAN	Increases Expression	[54]
Proteasome activator complex subunit 4 (PSME4)	OTDGF53O	PSME4_HUMAN	Increases Expression	[20]
26S proteasome non-ATPase regulatory subunit 6 (PSMD6)	OTX59EGK	PSMD6_HUMAN	Increases Expression	[20]
Prostaglandin E synthase 3 (PTGES3)	OTPPQWI0	TEBP_HUMAN	Decreases Degradation	[55]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Increases Ubiquitination	[56]
Rab-like protein 6 (RABL6)	OTJLVIQ1	RABL6_HUMAN	Decreases Expression	[20]
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)	OTLS7C99	LRRK2_HUMAN	Increases Ubiquitination	[57]
E3 ubiquitin-protein ligase RNF144B (RNF144B)	OTN7FCDE	R144B_HUMAN	Decreases Degradation	[58]
FUN14 domain-containing protein 1 (FUNDC1)	OTA6IVKQ	FUND1_HUMAN	Increases Expression	[59]
Regulatory-associated protein of mTOR (RPTOR)	OT4TQZ9F	RPTOR_HUMAN	Increases Expression	[30]
COMM domain-containing protein 1 (COMMD1)	OT7WUD5R	COMD1_HUMAN	Increases Expression	[60]
Programmed cell death 6-interacting protein (PDCD6IP)	OTS8T6A7	PDC6I_HUMAN	Increases Expression	[27]
Type II iodothyronine deiodinase (DIO2)	OTGPNSLH	IOD2_HUMAN	Increases Expression	[61]
Histone acetyltransferase KAT5 (KAT5)	OTL7257A	KAT5_HUMAN	Increases Expression	[62]
Tribbles homolog 3 (TRIB3)	OTG5OS7X	TRIB3_HUMAN	Decreases Expression	[20]
Proteasome subunit beta type-7 (PSMB7)	OT2NKD2K	PSB7_HUMAN	Increases Expression	[20]
26S proteasome non-ATPase regulatory subunit 1 (PSMD1)	OTW258OV	PSMD1_HUMAN	Increases Expression	[20]
Krueppel-like factor 6 (KLF6)	OTQY9S7F	KLF6_HUMAN	Increases Expression	[20]
Equilibrative nucleoside transporter 1 (SLC29A1)	OTLOOZZS	S29A1_HUMAN	Increases Expression	[20]
Endothelial PAS domain-containing protein 1 (EPAS1)	OTRE3O8U	EPAS1_HUMAN	Increases Expression	[63]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)	OTUYHB84	MLP3B_HUMAN	Increases Expression	[64]
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1)	OT4U7SBG	GBRL1_HUMAN	Increases Expression	[20]
Thiol S-methyltransferase TMT1A (TMT1A)	OT4IAAZP	TMT1A_HUMAN	Decreases Expression	[20]
Anillin (ANLN)	OTXJY54C	ANLN_HUMAN	Decreases Expression	[20]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)	OT0DZGY4	E2AK3_HUMAN	Increases Phosphorylation	[8]
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)	OTHCDQ22	PRGC1_HUMAN	Decreases Degradation	[65]
Proteasome activator complex subunit 2 (PSME2)	OTYPP33T	PSME2_HUMAN	Decreases Expression	[20]
26S proteasome non-ATPase regulatory subunit 13 (PSMD13)	OTNQ351N	PSD13_HUMAN	Increases Expression	[20]
E3 ubiquitin-protein ligase ARIH1 (ARIH1)	OTO3XDR2	ARI1_HUMAN	Increases Expression	[66]
Solute carrier organic anion transporter family member 1B1 (SLCO1B1)	OTNEN8QK	SO1B1_HUMAN	Decreases Degradation	[67]
Parkinson disease protein 7 (PARK7)	OT0SKNTG	PARK7_HUMAN	Decreases Response To Substance	[68]
Polyamine-transporting ATPase 13A2 (ATP13A2)	OTKWBUGK	AT132_HUMAN	Decreases Response To Substance	[69]
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⏷ Show the Full List of 119 DOT(s)

Indication(s) of Marizomib

Disease Entry	ICD 11	Status	REF
Glioblastoma of brain	2A00.00	Phase 3	[2]
Malignant glioma	2A00.0	Phase 1	[3]
Multiple myeloma	2A83	Phase 1	[3]
Solid tumour/cancer	2A00-2F9Z	Phase 1	[4]

Marizomib Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Proteasome (PS)	TTU7ZMG	NOUNIPROTAC	Inhibitor	[70]
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References

1	CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966
2	ClinicalTrials.gov (NCT03345095) A Phase III Trial of With Marizomib in Patients With Newly Diagnosed Glioblastoma (MIRAGE). U.S. National Institutes of Health.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Clinical pipeline report, company report or official report of Triphase Accelerator .
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