Details of the Drug Combination

General Information of Drug Combination (ID: DCVRUH8)

Drug Combination Name
MG-132 Idarubicin
Indication
Disease Entry Status REF
Glioblastoma? Investigative [1]
Component Drugs MG-132   DMKA2YS Idarubicin   DMM0XGL
N.A. Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: T98G
Zero Interaction Potency (ZIP) Score: 0.31
Bliss Independence Score: 0.31
Loewe Additivity Score: 0.36
LHighest Single Agent (HSA) Score: 0.45

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
MG-132 Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [12]
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MG-132 Interacts with 119 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Carbonyl reductase 3 (CBR3) OT9G6SF0 CBR3_HUMAN Increases Expression [13]
Actin, cytoplasmic 1 (ACTB) OT1MCP2F ACTB_HUMAN Decreases Expression [14]
Peptidyl-prolyl cis-trans isomerase A (PPIA) OTHJMWQQ PPIA_HUMAN Decreases Expression [14]
Aldo-keto reductase family 1 member B10 (AKR1B10) OTOA4HTH AK1BA_HUMAN Increases Expression [15]
Aldo-keto reductase family 1 member B1 (AKR1B1) OTRX72TH ALDR_HUMAN Increases Expression [15]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Increases Expression [15]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Increases Expression [15]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) OTM0GDTP IF2A_HUMAN Increases Expression [16]
Nuclear receptor subfamily 1 group I member 3 (NR1I3) OTS3SGH7 NR1I3_HUMAN Decreases Activity [17]
Transcription factor Sp3 (SP3) OTYDQZ1T SP3_HUMAN Increases Expression [18]
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) OTBPCU2O TR10A_HUMAN Increases Expression [9]
26S proteasome non-ATPase regulatory subunit 11 (PSMD11) OT8KO67V PSD11_HUMAN Increases Expression [19]
26S proteasome non-ATPase regulatory subunit 12 (PSMD12) OTWICA51 PSD12_HUMAN Increases Expression [19]
26S proteasome non-ATPase regulatory subunit 14 (PSMD14) OTJWHMZ5 PSDE_HUMAN Increases Expression [19]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Increases Expression [9]
Proteasome subunit alpha type-7 (PSMA7) OTPHI6ST PSA7_HUMAN Increases Expression [19]
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK) OTLF4ZB1 IKKA_HUMAN Increases Activity [20]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Increases Expression [21]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Affects Expression [22]
26S proteasome non-ATPase regulatory subunit 3 (PSMD3) OT585WY8 PSMD3_HUMAN Increases Expression [19]
Serine protease HTRA2, mitochondrial (HTRA2) OTC7616F HTRA2_HUMAN Increases Expression [23]
E3 ubiquitin-protein ligase parkin (PRKN) OTJBN41W PRKN_HUMAN Decreases Expression [24]
E3 ubiquitin-protein ligase MARCHF6 (MARCHF6) OTBTA03N MARH6_HUMAN Increases Stability [25]
Nuclear protein 1 (NUPR1) OT4FU8C0 NUPR1_HUMAN Increases Expression [19]
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (PLOD3) OTT00T7Q PLOD3_HUMAN Decreases Expression [26]
Microphthalmia-associated transcription factor (MITF) OT6XJCZH MITF_HUMAN Decreases Expression [19]
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1) OTY9R6FZ ERN1_HUMAN Increases Expression [27]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Increases Expression [28]
Pre-mRNA-splicing factor SPF27 (BCAS2) OTRMF2WY SPF27_HUMAN Decreases Expression [19]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Increases Expression [29]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Decreases Expression [19]
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) OTIRPN6B ROA1_HUMAN Increases Expression [30]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [31]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [32]
Retinol-binding protein 3 (RBP3) OTIWM4GT RET3_HUMAN Decreases Degradation [33]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) OTA675TJ GTR1_HUMAN Increases Expression [34]
26S proteasome regulatory subunit 6A (PSMC3) OTSKT0JI PRS6A_HUMAN Increases Expression [19]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Increases Expression [19]
Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6) OTAFHAVI ATF6A_HUMAN Increases Expression [7]
Receptor tyrosine-protein kinase erbB-3 (ERBB3) OTRSST0A ERBB3_HUMAN Decreases Expression [35]
Proteasome subunit alpha type-1 (PSMA1) OTNBVM2U PSA1_HUMAN Increases Expression [19]
Proteasome subunit alpha type-2 (PSMA2) OTJRT2ZL PSA2_HUMAN Increases Expression [19]
Proteasome subunit alpha type-3 (PSMA3) OT52M10V PSA3_HUMAN Increases Expression [19]
Proteasome subunit alpha type-4 (PSMA4) OTAD2XXI PSA4_HUMAN Increases Expression [19]
Aryl hydrocarbon receptor nuclear translocator (ARNT) OTMSIEZY ARNT_HUMAN Decreases Expression [36]
Calnexin (CANX) OTYP1F6J CALX_HUMAN Affects Localization [37]
Proteasome subunit beta type-9 (PSMB9) OTFV57T8 PSB9_HUMAN Increases Expression [19]
Proteasome subunit alpha type-5 (PSMA5) OT38E6Y1 PSA5_HUMAN Increases Expression [19]
Proteasome subunit beta type-4 (PSMB4) OTOJ9OHA PSB4_HUMAN Increases Expression [19]
Proteasome subunit beta type-6 (PSMB6) OT9VXPNW PSB6_HUMAN Increases Expression [19]
Proteasome subunit beta type-5 (PSMB5) OTOZXAS6 PSB5_HUMAN Decreases Expression [38]
Cystatin-D (CST5) OTHJXNJG CYTD_HUMAN Decreases Expression [19]
Retinoblastoma-like protein 1 (RBL1) OTDEBFYC RBL1_HUMAN Increases Expression [39]
Protein PML (PML) OT6SM2GD PML_HUMAN Decreases Degradation [40]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Decreases Degradation [41]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [28]
26S proteasome regulatory subunit 7 (PSMC2) OTJ4V337 PRS7_HUMAN Increases Expression [19]
Alpha-synuclein (SNCA) OTPWC1MR SYUA_HUMAN Increases Phosphorylation [42]
Proteasome subunit beta type-10 (PSMB10) OTURUR9B PSB10_HUMAN Decreases Expression [19]
26S proteasome regulatory subunit 6B (PSMC4) OTS3XN41 PRS6B_HUMAN Increases Expression [19]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Decreases Degradation [43]
Neurogenic locus notch homolog protein 1 (NOTCH1) OTI1WADQ NOTC1_HUMAN Increases Expression [44]
26S proteasome non-ATPase regulatory subunit 8 (PSMD8) OTY6X27P PSMD8_HUMAN Increases Expression [19]
CCAAT/enhancer-binding protein alpha (CEBPA) OTOM9OE4 CEBPA_HUMAN Increases Ubiquitination [45]
Proteasome subunit beta type-3 (PSMB3) OTVBON40 PSB3_HUMAN Increases Expression [19]
Proteasome subunit beta type-2 (PSMB2) OTX0UG5W PSB2_HUMAN Increases Expression [19]
Microsomal triglyceride transfer protein large subunit (MTTP) OTNUVSDT MTP_HUMAN Increases Expression [46]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) OTOWDUNT PTEN_HUMAN Increases Expression [47]
Proteasome subunit alpha type-6 (PSMA6) OTJ6RPX5 PSA6_HUMAN Increases Expression [19]
26S proteasome regulatory subunit 4 (PSMC1) OTLHD56E PRS4_HUMAN Increases Expression [19]
26S proteasome regulatory subunit 8 (PSMC5) OTJOORMR PRS8_HUMAN Increases Expression [19]
26S proteasome regulatory subunit 10B (PSMC6) OTG8997V PRS10_HUMAN Increases Expression [19]
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) OTTM6KRB ADA17_HUMAN Increases Expression [7]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Increases Activity [48]
Protein SET (SET) OTGYYQJO SET_HUMAN Decreases Expression [26]
POU domain, class 5, transcription factor 1 (POU5F1) OTDHHN7O PO5F1_HUMAN Increases Expression [44]
Heat shock factor protein 2 (HSF2) OTXNJIJ9 HSF2_HUMAN Increases Activity [48]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Decreases Activity [31]
Sex-determining region Y protein (SRY) OT516T6D SRY_HUMAN Decreases Degradation [49]
Proteasome activator complex subunit 1 (PSME1) OTDHLJWH PSME1_HUMAN Decreases Expression [19]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [50]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) OT4SO7J4 BNIP3_HUMAN Increases Expression [51]
26S proteasome non-ATPase regulatory subunit 2 (PSMD2) OT6HZHN7 PSMD2_HUMAN Increases Expression [19]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Increases Expression [20]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Increases Expression [19]
Reticulocalbin-2 (RCN2) OTIU8JWD RCN2_HUMAN Increases Expression [26]
Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1) OT1QHOS2 NF2L1_HUMAN Increases Expression [52]
Phosphatidate phosphatase LPIN1 (LPIN1) OTQ75KF2 LPIN1_HUMAN Increases Expression [53]
Proteasome activator complex subunit 4 (PSME4) OTDGF53O PSME4_HUMAN Increases Expression [19]
26S proteasome non-ATPase regulatory subunit 6 (PSMD6) OTX59EGK PSMD6_HUMAN Increases Expression [19]
Prostaglandin E synthase 3 (PTGES3) OTPPQWI0 TEBP_HUMAN Decreases Degradation [54]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Increases Ubiquitination [55]
Rab-like protein 6 (RABL6) OTJLVIQ1 RABL6_HUMAN Decreases Expression [19]
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) OTLS7C99 LRRK2_HUMAN Increases Ubiquitination [56]
E3 ubiquitin-protein ligase RNF144B (RNF144B) OTN7FCDE R144B_HUMAN Decreases Degradation [57]
FUN14 domain-containing protein 1 (FUNDC1) OTA6IVKQ FUND1_HUMAN Increases Expression [58]
Regulatory-associated protein of mTOR (RPTOR) OT4TQZ9F RPTOR_HUMAN Increases Expression [29]
COMM domain-containing protein 1 (COMMD1) OT7WUD5R COMD1_HUMAN Increases Expression [59]
Programmed cell death 6-interacting protein (PDCD6IP) OTS8T6A7 PDC6I_HUMAN Increases Expression [26]
Type II iodothyronine deiodinase (DIO2) OTGPNSLH IOD2_HUMAN Increases Expression [60]
Histone acetyltransferase KAT5 (KAT5) OTL7257A KAT5_HUMAN Increases Expression [61]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Decreases Expression [19]
Proteasome subunit beta type-7 (PSMB7) OT2NKD2K PSB7_HUMAN Increases Expression [19]
26S proteasome non-ATPase regulatory subunit 1 (PSMD1) OTW258OV PSMD1_HUMAN Increases Expression [19]
Krueppel-like factor 6 (KLF6) OTQY9S7F KLF6_HUMAN Increases Expression [19]
Equilibrative nucleoside transporter 1 (SLC29A1) OTLOOZZS S29A1_HUMAN Increases Expression [19]
Endothelial PAS domain-containing protein 1 (EPAS1) OTRE3O8U EPAS1_HUMAN Increases Expression [62]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) OTUYHB84 MLP3B_HUMAN Increases Expression [63]
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) OT4U7SBG GBRL1_HUMAN Increases Expression [19]
Thiol S-methyltransferase TMT1A (TMT1A) OT4IAAZP TMT1A_HUMAN Decreases Expression [19]
Anillin (ANLN) OTXJY54C ANLN_HUMAN Decreases Expression [19]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) OT0DZGY4 E2AK3_HUMAN Increases Phosphorylation [7]
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) OTHCDQ22 PRGC1_HUMAN Decreases Degradation [64]
Proteasome activator complex subunit 2 (PSME2) OTYPP33T PSME2_HUMAN Decreases Expression [19]
26S proteasome non-ATPase regulatory subunit 13 (PSMD13) OTNQ351N PSD13_HUMAN Increases Expression [19]
E3 ubiquitin-protein ligase ARIH1 (ARIH1) OTO3XDR2 ARI1_HUMAN Increases Expression [65]
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) OTNEN8QK SO1B1_HUMAN Decreases Degradation [66]
Parkinson disease protein 7 (PARK7) OT0SKNTG PARK7_HUMAN Decreases Response To Substance [67]
Polyamine-transporting ATPase 13A2 (ATP13A2) OTKWBUGK AT132_HUMAN Decreases Response To Substance [68]
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⏷ Show the Full List of 119 DOT(s)
Indication(s) of Idarubicin
Disease Entry ICD 11 Status REF
Acute myelogenous leukaemia 2A41 Approved [2]
Acute myeloid leukaemia 2A60 Approved [3]
Adult acute monocytic leukemia N.A. Approved [2]
Childhood acute megakaryoblastic leukemia N.A. Approved [2]
Leukemia N.A. Approved [2]
Idarubicin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
DNA topoisomerase II (TOP2) TT0IHXV TOP2A_HUMAN; TOP2B_HUMAN Modulator [70]
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Idarubicin Interacts with 3 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 1 (ABCC1) DTSYQGK MRP1_HUMAN Substrate [71]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [72]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [72]
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Idarubicin Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [73]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [73]
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Idarubicin Interacts with 2 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Natriuretic peptides B (NPPB) OTSN2IPY ANFB_HUMAN Increases Expression [74]
Bile acid receptor (NR1H4) OTWZLPTB NR1H4_HUMAN Decreases Activity [69]
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References

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2 Idarubicin FDA Label
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